tetracycline and Labyrinthitis

The inbred CBA/J mouse has become a standard experimental animal for auditory study because of its lifelong good hearing. In a newly established mouse breeding colony that housed CBA/J and CBA/CaJ mice to reared as auditory subjects, otitis media frequently afflicted CBA/J mice, reaching an incidence of 90% in animals greater than 400 days of age. Otitis media was not found in CBA/CaJ mice. Three attempts to establish a colony that was free of otitis were unsuccessful. Although the primary pathogen was not clearly established, Pasteurella pneumotropica was isolated from infected bullae. Partial control of otitis media followed the introduction of tetracycline prophylaxis. The CBA/CaJ mice may be suitable replacements for CBA/J mice in studies that require inbred mice with good hearing, since their auditory thresholds did not differ significantly from those of otitis-free CBA/J mice.

Topics: Animals; Auditory Threshold; Evoked Potentials, Auditory, Brain Stem; Labyrinthitis; Mice; Mice, Inbred CBA; Otitis Media; Pasteurella Infections; Species Specificity; Tetracycline

Microbiologic and histologic studies were made of fire-bellied toads with signs of ocular and central nervous system disease. Providencia alcalifaciens, Citrobacter freundii, Aeromonas hydrophila, and other gram-negative bacilli were isolated from the eyes and multiple tissues of ill toads. The histologic evaluations revealed severe panophthalmitis and otitis interna.

Topics: Animals; Anura; Bacterial Infections; Disease Outbreaks; Gram-Negative Bacteria; Labyrinth Diseases; Labyrinthitis; Panophthalmitis; Tetracycline

Topics: Animals; Herpesviridae Infections; Immune Sera; Labyrinth Diseases; Labyrinthitis; Postural Balance; Rabbits; Tetracycline