tetracycline and Kidney-Diseases

Bone histomorphometry has been the gold standard in the evaluation and diagnosis of renal osteodystrophy. The recent new definition of renal osteodystrophy as chronic kidney disease-mineral and bone disorder has once again highlighted the use of bone biopsy as a powerful and diagnostic tool to determine skeletal abnormalities in chronic kidney disease. The procedure of iliac crest bone biopsy has been proved safe and associated with very minimal morbidity. In this review, the clinical indications, preparation, instrumentation, and potential complications are discussed. Because current biochemical markers are poor predictors of bone turnover, volume, and mineralization, a wider use of bone biopsy and histomorphometry will lead to a better understanding of the bone and mineral disorders that are associated with chronic kidney disease.

Topics: Biopsy; Chronic Kidney Disease-Mineral and Bone Disorder; Humans; Ilium; Kidney Diseases; Parathyroid Hormone; Specimen Handling; Tetracycline

Topics: Allopurinol; Aminoglycosides; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Captopril; Cephalosporins; Cisplatin; Diuretics; Glomerulonephritis; Gold; Humans; Kidney; Kidney Diseases; Kidney Tubular Necrosis, Acute; Lithium; Nephritis, Interstitial; Penicillamine; Penicillins; Rifampin; Semustine; Sulfonamides; Tetracycline; Trimethadione

Topics: Acute Kidney Injury; Aminoglycosides; Animals; Anti-Bacterial Agents; Antifungal Agents; Cephalosporins; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Gentamicins; Humans; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Methicillin; Penicillins; Rabbits; Rats; Tetracycline; Urinary Tract Infections

Topics: Animals; Arginine; Carbamazepine; Chlorpropamide; Clofibrate; Cyclic AMP; Diabetes Insipidus; Hypothalamus; Kidney Diseases; Lithium; Methoxyflurane; Peptide Biosynthesis; Protein Biosynthesis; Rats; Rodent Diseases; Tetracycline; Vasopressins; Vermont

Topics: Anaphylaxis; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Fetal Diseases; Gastrointestinal Diseases; Hearing Disorders; Hematologic Diseases; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney Diseases; Neomycin; Nervous System Diseases; Neuromuscular Diseases; Novobiocin; Penicillins; Pregnancy; Psychoses, Substance-Induced; Serum Sickness; Streptomycin; Tetracycline; Vision Disorders

Topics: Amphotericin B; Anti-Bacterial Agents; Cephalosporins; Gentamicins; Humans; Kanamycin; Kidney; Kidney Diseases; Neomycin; Penicillins; Polymyxins; Regional Blood Flow; Streptomycin; Sulfonamides; Tetracycline; Vancomycin

Topics: Amphotericin B; Analgesics; Anesthetics; Anti-Bacterial Agents; Bacitracin; Cephaloridine; Cephalothin; Drug Hypersensitivity; Humans; Kidney Diseases; Penicillins; Polymyxins; Sulfonamides; Tetracycline

Topics: Aminoglycosides; Ampicillin; Anemia, Hemolytic, Autoimmune; Anti-Bacterial Agents; Carbenicillin; Central Nervous System Diseases; Cephalosporins; Chloramphenicol; Clindamycin; Dermatitis; Drug Hypersensitivity; Gentamicins; Humans; Kanamycin; Kidney Diseases; Lincomycin; Neomycin; Penicillins; Polymyxins; Streptomycin; Tetracycline; Vancomycin

Topics: Amphotericin B; Anti-Bacterial Agents; Glycosides; Humans; Iatrogenic Disease; Kidney Diseases; Methoxyflurane; Penicillins; Peptides; Sulfonamides; Tetracycline

Topics: Adolescent; Adult; Aged; Animals; Anti-Bacterial Agents; Cephalosporins; Child; Child, Preschool; Chloramphenicol; Drug Hypersensitivity; Female; Gentamicins; Humans; Infant; Intestines; Kidney Diseases; Labyrinth Diseases; Male; Middle Aged; Optic Neuritis; Penicillins; Rabbits; Seizures; Tetracycline

Topics: Absorption; Acne Vulgaris; Bacteria; Bacteriuria; Bronchial Diseases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlortetracycline; Demeclocycline; Drug Eruptions; Humans; Infections; Kidney Diseases; Methacycline; Oxytetracycline; Protein Binding; Tetracycline; Tooth Discoloration

Topics: Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Colistin; Drug Hypersensitivity; Enterobacteriaceae Infections; Erythromycin; Female; Gonorrhea; Humans; Kidney Diseases; Mycoplasma Infections; Pelvic Inflammatory Disease; Salpingitis; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Tetracycline; Thrombophlebitis; Tuberculosis, Female Genital; Wound Infection

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Gastrointestinal Diseases; Hepatitis; Humans; Kidney Diseases; Metabolic Diseases; Pharmacology; Photosensitivity Disorders; Pigmentation Disorders; Proteins; Tetracycline; Tooth Discoloration; Toxicology

Topics: Aged; Aminosalicylic Acids; Anti-Bacterial Agents; Berlin; Clinical Trials as Topic; Cycloserine; Drug Resistance, Microbial; Ethambutol; Humans; Hypocalcemia; Hypokalemia; Kidney Diseases; Middle Aged; Rifampin; Tetracycline; Tuberculosis, Pulmonary; Urea; Vision Disorders

Topics: Chloramphenicol; Clinical Trials as Topic; Hematopoietic System; Humans; Kidney Diseases; Liver Diseases; Tetracycline

The study reports the phenolic composition of propolis from Bangladesh and its ameliorative effects against tetracycline-induced hepatonephrotoxicity in rats. Male Wistar Albino rats (n = 18) were randomly divided into three following groups: (1) normal control, (2) tetracycline-treatment (200 mg kg

Topics: Animals; Bangladesh; Bees; Bilirubin; Humans; Kidney Diseases; Lipids; Liver; Liver Diseases; Liver Function Tests; Male; Oxidative Stress; Propolis; Rats; Rats, Wistar; Tetracycline

Coding variants in the

Topics: Apolipoprotein L1; Autophagy; Calcium; Cell Membrane; Gene Expression; Genetic Variation; Genotype; HEK293 Cells; Humans; Ion Channels; Kidney Diseases; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Phosphorylation; Potassium; Sodium; Tetracycline

The aim of the present investigation was to determine whether tetracycline accelerated the hepatic toxicity of portacaval anastomosis and whether this could be reflected by changes in pharmacokinetics of the drug. Side-to-side portacaval shunts were constructed and converted to end-to-side by ligating the hepatic side of the portal vein in dogs. The results of this study showed that the i.v. infusion of tetracycline (50 mg/kg) to shunted animals caused rapid deterioration in hepatic and renal functions followed by the eventual transition of these animals from stage I to stage II liver disease. This was reflected by a 3- to 6-fold increase in the serum level of bilirubin, alkaline phosphatase, serum glutamic-oxalacetic transaminase, blood urea nitrogen and creatinine as compared with the levels of those produced in serum of dogs before and after the construction of the shunt before the administration of tetracycline. Kinetic analysis revealed a significant prolongation in the elimination half-life (38.2 +/- 4.2 hr) of the shunted dogs as compared with controls (14.5 +/- 1.5 hr) after the i.v. administration of tetracycline. This was accompanied by an appreciable reduction of elimination rate constant. In contrast to shunted animals, control animals exhibited no behavioral side effects after the administration of tetracycline.

Topics: Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Dogs; Kidney Diseases; Kinetics; Male; Portacaval Shunt, Surgical; Tetracycline; Time Factors

Six of 14 patients with renal abscess had prior history of urinary tract infection; initial symptoms included fever and flank pain in 12. A drip-infusion intravenous pyelogram was the most sensitive radiologic test, but selective renal arteriography was most specific. Urine cultures were positive in all 14 patients; blood cultures were positive in nine. Six patients were treated with antibiotics alone and eight required surgery. Of the eight, five had pus-filled cavities, one had multiple stones, one had a renal infarct, and one had a resolving abscess. Of six treated with antibiotics alone, one died of unrelated complications and five have demonstrated no pathological renal condition after three to six years.

Topics: Abscess; Adolescent; Adult; Ampicillin; Escherichia coli Infections; Female; Gentamicins; Humans; Kidney Diseases; Klebsiella Infections; Male; Middle Aged; Nephrectomy; Tetracycline

Topics: Adolescent; Adult; Child; Child, Preschool; Female; Fetus; Humans; Iowa; Kidney Diseases; Male; Medication Systems, Hospital; Middle Aged; Odontogenesis; Pharmacy and Therapeutics Committee; Pregnancy; Pregnancy Complications; Tetracycline

A 54-year-old man developed mild renal insufficiency after treatment with gentamicin and cephalothin. He then received tetracycline for eight days, 500 mg orally four times daily, for a total dose of 15 gm. Twelve days after discontinuation of the drug, a severe but reversible aplastic anemia developed. We propose that bone-marrow-toxic concentrations of tetracycline resulted from the preexisting renal insufficiency. Because of the temporal relationship between tetracycline administration and aplastic anemia, and the lack of any other explanation, we conclude that this case illustrates a rare but potentially fatal complication of this drug.

Topics: Anemia, Aplastic; Cephalothin; Gentamicins; Humans; Kidney Diseases; Male; Middle Aged; Proteus Infections; Tetracycline

Topics: Acute Kidney Injury; Drug Therapy, Combination; Humans; Kidney Diseases; Kidney Failure, Chronic; Nephritis; Nephrotic Syndrome; Phenacetin; Tetracycline; Uremia; Water-Electrolyte Imbalance

Topics: Animals; Humans; Kidney Diseases; Radionuclide Imaging; Rats; Technetium; Tetracycline

Topics: Adult; Aged; Humans; Injections, Intravenous; Kidney; Kidney Diseases; Male; Middle Aged; Nephrectomy; Prostate; Prostatectomy; Prostatic Diseases; Prostatic Hyperplasia; Regional Blood Flow; Tetracycline; Urinary Tract Infections

Topics: Age Factors; Aminoglycosides; Ampicillin; Anti-Infective Agents; Antifungal Agents; Body Weight; Carbenicillin; Cephalosporins; Cloxacillin; Creatinine; Dicloxacillin; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Kinetics; Male; Nafcillin; Oxacillin; Penicillin G; Penicillins; Polymyxins; Sex Factors; Tetracycline

Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia; Bacitracin; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chloramphenicol; Deafness; Gastrointestinal Diseases; Gentamicins; Humans; Kanamycin; Kidney Diseases; Leukopenia; Lung Diseases; Neomycin; Neuromuscular Diseases; Nitrofurantoin; Optic Neuritis; Peripheral Nervous System Diseases; Skin Diseases; Streptomycin; Sulfonamides; Tetracycline; Thrombocytopenia; Vertigo

Topics: Bronchitis; Chronic Disease; Humans; Kidney Diseases; Tetracycline; Urea

Topics: Ampicillin; Child, Preschool; Chloramphenicol; Colistin; Diagnosis, Differential; Drug Eruptions; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Electroencephalography; Erythromycin; Female; Fever; Humans; Hydrocortisone; Infections; Kanamycin; Kidney Diseases; Male; Middle Aged; Penicillins; Pericarditis; Pertussis Vaccine; Pleural Diseases; Recurrence; Salicylates; Tetracycline; Tonsillectomy

Topics: Adipose Tissue; Brain Diseases; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Hepatitis; Humans; Infant; Kidney Diseases; Liver; Tetracycline; Virus Diseases

Topics: Adult; Drug Stability; Humans; Hypokalemia; Kidney Diseases; Male; Polyuria; Tetracycline

Topics: Ampicillin; Anti-Bacterial Agents; Carbenicillin; Cephalosporins; Chloramphenicol; Erythromycin; Gentamicins; Humans; Kanamycin; Kidney Diseases; Oxacillin; Penicillins; Streptomycin; Tetracycline; Vancomycin

Topics: Anti-Bacterial Agents; Anuria; Colistin; Gentamicins; Glomerular Filtration Rate; Half-Life; Humans; Kidney; Kidney Diseases; Rolitetracycline; Streptomycin; Tetracycline; Vancomycin

Topics: Adult; Ampicillin; Bacteria; Chloramphenicol; Chronic Disease; Female; Glomerulonephritis; Humans; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Penicillin Resistance; Pyelonephritis; Renal Dialysis; Streptomycin; Tetracycline; Time Factors; Transplantation, Homologous

Topics: Ampicillin; Anti-Bacterial Agents; Cephaloridine; Cephalothin; Creatinine; Erythromycin; Gentamicins; Glomerular Filtration Rate; Humans; Kanamycin; Kidney Diseases; Kidney Function Tests; Lincomycin; Oxacillin; Penicillin G; Streptomycin; Tetracycline; Vancomycin

Topics: Aged; Blood Urea Nitrogen; Humans; Kidney Diseases; Respiratory Tract Infections; Tetracycline

Topics: Adult; Ampicillin; Bacteriuria; Chloramphenicol; Humans; Kidney Diseases; Lymphoma, Non-Hodgkin; Male; Salmonella Infections; Salmonella typhimurium; Tetracycline

Topics: Acute Kidney Injury; Humans; Kidney Diseases; Tetracycline; Urea

Topics: Humans; Kidney Diseases; Renal Dialysis; Tetracycline

Topics: Aged; Humans; Kidney Diseases; Male; Nitrogen; Tetracycline; Uremia

Topics: Age Factors; Anti-Bacterial Agents; Biliary Tract Diseases; Chloramphenicol; Drug Hypersensitivity; Female; Genotype; Glucosephosphate Dehydrogenase; Humans; Kanamycin; Kidney Diseases; Liver; Liver Diseases; Metabolism, Inborn Errors; Nervous System Diseases; Pregnancy; Pregnancy Complications; Streptomycin; Sulfonamides; Tetracycline

Topics: Acidosis, Renal Tubular; Aged; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Hemorrhagic Disorders; Humans; Hypoproteinemia; Jaundice; Kidney Diseases; Male; Middle Aged; Tetracycline; Uremia

Topics: Humans; Kidney Diseases; Peritoneal Dialysis; Renal Dialysis; Tetracycline; Time Factors

Topics: Humans; Kidney Diseases; Peritoneal Dialysis; Renal Dialysis; Tetracycline; Time Factors

Topics: Ampicillin; Anti-Bacterial Agents; Cephaloridine; Cephalothin; Chloramphenicol; Creatinine; Dicloxacillin; Gentamicins; Humans; Kanamycin; Kidney Diseases; Methicillin; Novobiocin; Oxacillin; Penicillin G; Penicillins; Polymyxins; Streptomycin; Sulfonamides; Tetracycline; Vancomycin

Topics: Amphotericin B; Anti-Bacterial Agents; Cephalosporins; Humans; Kidney Diseases; Kidney Function Tests; Penicillins; Polymyxins; Tetracycline

Topics: Adult; Aged; Diabetes Insipidus; Drug Resistance, Microbial; Escherichia coli; Female; Humans; Kidney Diseases; Male; Microbial Sensitivity Tests; Middle Aged; Staphylococcus; Tetracycline; Urinary Tract Infections

Topics: Abdomen, Acute; Aged; Blood Urea Nitrogen; Humans; Kidney Calculi; Kidney Diseases; Male; Middle Aged; Tetracycline; Uremia; Urinary Bladder Neoplasms

Topics: Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Demeclocycline; Dogs; Female; Humans; Kidney Diseases; Male; Methacycline; Oxytetracycline; Photosensitivity Disorders; Pregnancy; Tetracycline; Tooth Calcification; Tooth Discoloration

Topics: Animals; Anti-Bacterial Agents; Contrast Media; Dogs; Fanconi Syndrome; Humans; Kidney Diseases; Metals; Phenacetin; Rats; Tetracycline

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Antitubercular Agents; Child; Child, Preschool; Chloramphenicol; Drug Hypersensitivity; Female; Gastrointestinal Diseases; Glossitis; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Diseases; Pregnancy; Stomatitis; Sulfonamides; Tetracycline

Topics: Adult; Aged; Ampicillin; Bacteriuria; Cephaloridine; Chloramphenicol; Female; Furans; Humans; Kidney Diseases; Leucomycins; Male; Middle Aged; Novobiocin; Proteus Infections; Pseudomonas Infections; Streptomycin; Tetracycline; Urinary Tract Infections

Topics: Acute Kidney Injury; Adult; Anemia; Arthritis, Rheumatoid; Dextrans; Drug-Related Side Effects and Adverse Reactions; Fanconi Syndrome; Female; Glomerulonephritis; Hepatolenticular Degeneration; Humans; Hydralazine; Kidney Diseases; Kidney Failure, Chronic; Male; Methysergide; Middle Aged; Nephrotic Syndrome; Penicillamine; Phenacetin; Potassium Deficiency; Retroperitoneal Fibrosis; Sulfonamides; Tetracycline

Topics: Administration, Oral; Adult; Ampicillin; Anti-Bacterial Agents; Bacteriuria; Candida; Cell Membrane Permeability; Enterococcus faecalis; Female; Humans; Hydrogen-Ion Concentration; Injections, Intramuscular; Kidney; Kidney Diseases; Kidney Transplantation; Nitrofurantoin; Postoperative Complications; Pregnancy; Pregnancy Complications, Infectious; Proteus; Pseudomonas aeruginosa; Sulfonamides; Tetracycline; Time Factors; Transplantation, Homologous

Topics: Analgesics; Anti-Bacterial Agents; Cathartics; Chloroquine; Creatinine; Diuretics; Drug-Related Side Effects and Adverse Reactions; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Labyrinth Diseases; Metabolic Clearance Rate; Metals; Streptomycin; Tetracycline; Uremia; Vestibule, Labyrinth

Topics: Adult; Aged; Anabolic Agents; Blood Urea Nitrogen; Chloramphenicol; Creatinine; Female; Humans; Kidney Diseases; Kidney Failure, Chronic; Male; Middle Aged; Tetracycline; Urea

Topics: Animals; Anti-Bacterial Agents; Cephaloridine; Chloramphenicol; Cricetinae; Dihydrostreptomycin Sulfate; Erythromycin; Fusidic Acid; Kanamycin; Kidney Diseases; Leptospirosis; Lincomycin; Penicillins; Spectinomycin; Tetracycline

Topics: Animals; Female; Hemoglobinuria; Kidney; Kidney Diseases; Rats; Tetracycline

Seven patients with acute or chronic renal failure who were receiving intermittent peritoneal dialysis and who required parenteral oxacillin, ampicillin or tetracycline were studied to determine the disposition of these antibiotics in severe renal disease and the effects of peritoneal dialysis. While severe renal impairment markedly prolongs persistence in the serum of ampicillin and tetracycline, there is little effect on oxacillin. Whereas required doses of ampicillin and tetracycline are lower in the presence of severe renal disease, oxacillin should be given in doses equivalent to those used for patients with normal renal function. Peritoneal dialysis does not alter these dosage requirements.Four patients receiving ampicillin or tetracycline in the infusing solution during peritoneal dialysis were studied to determine the amount of systemic absorption. Local prophylaxis alone is not achieved with this method of administration, since small amounts of both antibiotics are absorbed systemically from the infusing solution. The serum concentration of tetracycline attained is inadequate for treatment of systemic infections but is probably significant, with repeated use in intermittent dialysis, in causing adverse effects. Tetracycline should be abandoned in the local prophylaxis of peritonitis during peritoneal dialysis.

Topics: Acute Kidney Injury; Ampicillin; Humans; Kidney Diseases; Oxacillin; Peritoneal Dialysis; Tetracycline

Topics: Animals; Cytoplasm; Histocytochemistry; In Vitro Techniques; Injections, Intraperitoneal; Kidney; Kidney Diseases; Kidney Tubules; Male; Oxidoreductases; Rats; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Biological Transport; Blood Chemical Analysis; Dialysis; Drug Therapy; Humans; Kidney Diseases; Methicillin; Peritoneal Cavity; Peritoneal Dialysis; Peritoneum; Renal Dialysis; Tetracycline

Topics: Anti-Bacterial Agents; Bacitracin; Bone Marrow Diseases; Drug Eruptions; Gastrointestinal Diseases; Kanamycin; Kidney Diseases; Liver Diseases; Necrosis; Neomycin; Neurologic Manifestations; Penicillins; Pharmacology; Polymyxins; Ristocetin; Streptomycin; Tetracycline; Toxicology; Vancomycin; Vestibule, Labyrinth

Topics: Anti-Bacterial Agents; Blood Urea Nitrogen; Drug Therapy; Humans; Kidney; Kidney Diseases; Metabolism; Tetracycline; Toxicology; Uremia

Topics: Anti-Bacterial Agents; Brain Diseases; Drug Therapy; Fatty Liver; Female; Kidney Diseases; Pancreatitis; Pregnancy; Pregnancy Complications; Pyelonephritis; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Blood Chemical Analysis; Hypokalemia; Kidney Diseases; Pathology; Potassium; Potassium Deficiency; Syndrome; Tetracycline; Toxicology

Topics: Castration; Estrogens; Geriatrics; Humans; Kidney; Kidney Diseases; Liver Diseases; Male; Orchiectomy; Tetracycline; Toxicology

Topics: Ammonium Compounds; Chlorides; Fluorescence; Heparin Antagonists; Ischemia; Kidney; Kidney Diseases; Kidney Tubules; Mercury; Necrosis; Pathology; Potassium; Quaternary Ammonium Compounds; Rats; Research; Serine; Tetracycline; Toxicology

Topics: Blood Chemical Analysis; Dialysis; Drug Therapy; Fluid Therapy; Kidney Diseases; Peritoneal Dialysis; Preventive Medicine; Renal Dialysis; Tetracycline; Uremia

Topics: Acidosis; Acidosis, Renal Tubular; Ataxia; Biopsy; Blood; Chemistry, Pharmaceutical; Glycosuria; Glycosuria, Renal; Humans; Hypokalemia; Kidney Diseases; Neurologic Manifestations; Nystagmus, Pathologic; Pathology; Proteinuria; Renal Aminoacidurias; Tetracycline; Toxicology; Uric Acid; Urine

Topics: Colic; Contrast Media; Drug Therapy; Humans; Kidney Diseases; Renal Colic; Retroperitoneal Space; Tetracycline; Ureteral Calculi; Ureterolithiasis; Urine; Urography

Topics: Animals; Ascorbic Acid; Blood Urea Nitrogen; Body Fluids; Histocytochemistry; In Vitro Techniques; Kidney; Kidney Diseases; Mercury Poisoning; Organ Size; Rats; Succinate Dehydrogenase; Tetracycline

Topics: Ankle; Biopsy; Blood Chemical Analysis; Bone Diseases; Fluorescence; Genetics, Medical; Hand Deformities; Hypertension; Hypertension, Renal; Joint Diseases; Kidney Diseases; Kidney Function Tests; Osteolysis; Pathology; Radiography; Surgical Procedures, Operative; Tetracycline; Urine; Wrist

Topics: Amyloidosis; Anti-Bacterial Agents; Boston; Hydrocortisone; Kidney Diseases; Massachusetts; New England; Pathology; Penicillins; Pigmentation; Sodium Chloride; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Candidiasis; Chemical and Drug Induced Liver Injury; Chloramphenicol; Diagnosis, Differential; Erythromycin; Halothane; Hepatitis; Hydrocortisone; Hypertension; Kidney Diseases; Metaraminol; Novobiocin; Pathology; Pyelonephritis; Surgical Procedures, Operative; Surgical Wound Infection; Tetracycline; Toxicology; Tracheotomy; Urinary Bladder Neoplasms; Urinary Diversion

Topics: Absorption; Anilides; Antineoplastic Agents; Biomedical Research; Blood; Dogs; Kidney Diseases; Kidney Neoplasms; Kidney Tubules; Lymphoma; Lymphoma, Non-Hodgkin; Metabolic Diseases; Metabolism; Tetracycline; Toxicology; Urine

Topics: Anti-Bacterial Agents; Black People; Chemical and Drug Induced Liver Injury; Chlortetracycline; Demeclocycline; Female; Hepatitis; Hepatitis A; Humans; Kidney Diseases; Liver; Maternal-Fetal Exchange; Oxytetracycline; Pharmacology; Pregnancy; Pregnancy Complications; Tetracycline; Tetracyclines; Tooth; Toxicology; Urine

Topics: Abortion, Criminal; Abortion, Septic; Anti-Bacterial Agents; Anuria; Biopsy; Criminals; Curettage; Diuresis; Eclampsia; Female; Fever; Hemoglobinuria; Hemolysis; Humans; Jaundice; Kidney Cortex Necrosis; Kidney Diseases; Nephritis; Nephritis, Interstitial; Penicillins; Pregnancy; Sepsis; Tetracycline

Topics: Acidosis; Acidosis, Renal Tubular; Anti-Bacterial Agents; Blood; Kidney Diseases; Kidney Tubules; Metabolism; Tetracycline; Toxicology; Urine

Topics: Aspartate Aminotransferases; Dogs; Glycosuria; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Necrosis; Pathology; Proteinuria; Rats; Research; Tetracycline; Toxicology; Urine

Topics: Estradiol; Fluorescence; Ischemia; Kidney Diseases; Pathology; Pharmacology; Physiology; Pituitary Hormones; Pituitary Hormones, Posterior; Rats; Research; Tetracycline

Topics: Abnormalities, Drug-Induced; Amelogenesis; Drug Therapy; Female; Fetal Diseases; Fetus; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Diseases; Liver Diseases; Pregnancy; Pregnancy Complications; Tetracycline; Tooth Discoloration; Toxicology

Topics: Anemia; Anemia, Aplastic; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacitracin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Chlortetracycline; Erythromycin; Hearing Disorders; Hepatitis; Kidney Diseases; Neomycin; Oleandomycin; Streptomycin; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Blood; Kidney Diseases; Nitrogen; Protein Synthesis Inhibitors; Tetracycline; Toxicology; Water-Electrolyte Balance

Topics: Anaphylaxis; Animals; Fluorescence; Histological Techniques; In Vitro Techniques; Kidney Diseases; Kidney Tubules; Necrosis; Pituitary Hormones, Posterior; Rats; Tetracycline

Topics: Anti-Bacterial Agents; Humans; Kidney Diseases; Protein Synthesis Inhibitors; Tetracycline; Urinary Tract Physiological Phenomena

Topics: Anti-Bacterial Agents; Humans; Kidney Diseases; Nitrogen; Tetracycline; Uremia; Urologic Diseases

A strain of Leptospira zanoni was used to produce chronic renal infections in young white mice. A variant of this strain produced an acute disease with over 50% mortality. The responses of both forms of disease to chemotherapy were studied. When treatment of the acute disease was initiated before jaundice occurred, suitable single doses of streptomycin, chlortetracycline, tetracycline, erythromycin, oxytetracycline and oxytetracycline (in oil) prevented death and chronic renal infection in a high percentage of mice. Bicillin, a long-acting penicillin preparation, was more effective than other penicillins, but it prevented the development of chronic renal infection in only half the treated mice. Streptomycin was the only antibiotic of which a single administration regularly cured the chronic renal infections: chlortetracycline, tetracycline and oxytetracycline (in oil) were partially effective. Oxytetracycline, chloramphenicol, Bicillin, fortified penicillin, procaine penicillin and potassium penicillin had no permanent action. The suitability of mice as laboratory animals in the study of experimental leptospirosis and the need for complete cure of carriers of chronic renal infection are emphasized. The above findings indicate that streptomycin is the drug of choice for the treatment of leptospirosis in animals, and that it is worthy of further trial in man.

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Chlortetracycline; Erythromycin; Kidney Diseases; Leptospira; Leptospirosis; Mice; Oxytetracycline; Penicillin G Benzathine; Penicillins; Streptomycin; Tetracycline

Topics: Anabolic Agents; Kidney Diseases; Proteins; Riboflavin Deficiency; Steroids; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Calcification, Physiologic; Calculi; Kidney Diseases; Muscles; Myocardium; Neoplasms; Pancreatitis; Tetracycline

Topics: Anti-Bacterial Agents; Body Fluids; Child; Fluorescence; Humans; Kidney Diseases; Protein Synthesis Inhibitors; Tetracycline; Urine

Topics: Female; Fetal Diseases; Fetus; Gastrointestinal Tract; Humans; Kidney Diseases; Liver Diseases; Maternal-Fetal Exchange; Myocarditis; Pregnancy; Pregnancy, Animal; Rabbits; Research; Tetracycline; Tetracyclines; Toxicology

Topics: Anti-Bacterial Agents; Humans; Kidney; Kidney Diseases; Tetracycline; Tetracyclines

Topics: Anti-Bacterial Agents; Bronchopneumonia; Kidney Diseases; Penicillins; Pneumonia; Pneumonia, Pneumococcal; Sulfonamides; Tetracycline