tetracycline and Kidney-Diseases--Cystic

Symptomatic simple renal cysts can be treated by combination of percutaneous aspiration and sclerotherapy. A number of sclerosing agents including glucose, phenol, iophendylate, polidocanol, minocycline and pantopaque have been used in the past to prevent reformation of cyst. In this study, tetracycline HCL solution is evaluated as a sclerosant for treatment of simple renal cysts.. Our study treated 76 cysts in 70 patients with symptomatic renal cysts. Aspiration and sclerotherapy was performed on 56 cysts, and 20 cysts aspirated without sclerotherapy as a control group. Treatment was performed under local anesthesia and punctured under ultrasound guidances with an 18-gauge needle. Tetracycline HCL (20%) was injected into the cystic cavity according to cyst diameter. All patients were followed up with an ultrasound examination at 3 months, 6 months, and then at yearly intervals. The reduction rate was estimated by a comparison of the volume of the cyst before and after treatment. A cyst reduction of 50% or greater in diamater was considered as a successful treatment.. The average follow-up period was 9.8 months in the sclerotherapy group and 9.9 months in the control group. The success rate was 85.7% in the sclerotherapy group. There was a significant difference in the reduction rate of tetracycline HCL sclerotherapy group and control group. No major complications were encountered.

Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chi-Square Distribution; Female; Humans; Injections; Kidney Diseases, Cystic; Male; Middle Aged; Recurrence; Sclerosing Solutions; Sclerotherapy; Tetracycline; Treatment Outcome; Ultrasonography

To evaluate the efficacy of alcohol in combination with tetracycline for the treatment of symptomatic renal cysts.. Twenty-four patients age 45 to 77 years (mean 66 years) with a large (5-13-cm; mean 7.5-cm) symptomatic renal cyst associated with flank pain were treated by aspiration under ultrasound guidance and injection of alcohol and tetracycline. Patients were followed with ultrasonography at 1, 6, and 12 months and once a year thereafter.. The aspirated volume ranged from 65 to 1500 mL (mean 360.5 mL). Two patients experienced mild pain during alcohol injection, but the procedure was completed successfully. One patient reported severe pain after tetracycline injection. The tetracycline was immediately aspirated, and the procedure was then aborted. The remaining patients were relieved of their symptoms after treatment, and they remained symptom free during a mean follow-up of 20 months (range 7-36 months).. The combination of alcohol and tetracycline is safe and effective and offers a very favorable minimally invasive therapeutic alternative for the treatment of symptomatic renal cysts.

Topics: Aged; Diagnosis, Differential; Drug Therapy, Combination; Ethanol; Female; Humans; Injections, Intralesional; Kidney Diseases, Cystic; Male; Middle Aged; Outpatients; Suction; Tetracycline; Treatment Outcome

Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant, Newborn; Kidney Diseases, Cystic; Male; Sclerotherapy; Tetracycline; Ultrasonography

Seven patients with a large symptomatic renal cyst were treated by aspiration under US guidance and injection of a tetracycline solution (5-8 ml; 1%). All patients were relieved of complaints directly after treatment and US follow-up revealed complete remission or only small residual cysts after one week to twenty-one months. The combination of a strong sclerosing action with a long-acting local antibiotic prophylaxis gives tetracycline an advantage over other sclerosing agents, especially in patients with impaired renal function.

Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Female; Humans; Kidney Diseases, Cystic; Male; Middle Aged; Sclerosing Solutions; Suction; Tetracycline

Topics: Adenocarcinoma; Adult; Aged; Ampicillin; Breast Neoplasms; Carcinoma; Cross Infection; Cysts; Disease Outbreaks; Erythromycin; Female; Foot; Gentamicins; Hallux Valgus; Herniorrhaphy; Humans; Kidney Diseases, Cystic; Leg; Male; Middle Aged; Ovarian Diseases; Penicillins; Peptic Ulcer; Quebec; Streptococcal Infections; Surgical Wound Infection; Tetracycline