tetracycline and Jaundice

Topics: Cholestasis, Intrahepatic; Enzymes; Female; Hepatitis, Viral, Human; Humans; Hyperemesis Gravidarum; Jaundice; Labor, Obstetric; Liver; Liver Cirrhosis; Liver Function Tests; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Recurrence; Tetracycline

Using prescription-event monitoring to determine whether erythromycin estolate was a more frequent cause of jaundice than erythromycin stearate or tetracycline 12 208 patients, for whom 5343 doctors had prescribed one of the three drugs, were identified by the Prescription Pricing Authority. Of the questionnaires sent to general practitioners about the possible occurrence of jaundice, 76% were returned. There were 16 reports of jaundice, of which four were attributable to gall stones, three to cancer, six to viral hepatitis, and only three were possibly related to an antibiotic. All three patients, in whom the antibiotic was a possible cause, had been treated with erythromycin stearate. No case was attributable to the estolate which had previously been suspected of being a more frequent cause of jaundice. Although the incidence is unknown, it is very unlikely to be more than one in 100.

Topics: Adolescent; Adult; Aged; Erythromycin; Erythromycin Estolate; Female; Humans; Jaundice; Male; Middle Aged; Tetracycline

The sera from 2453 patients suffering from pneumonia were investigated for antibodies against the agent causing "Legionnaires' disease". A complement-fixing antigen developed in this institute was used for the screening of these sera, and the positive results were confirmed with the IF-test developed by CDC Atlanta. Antibodies were found in 23 Swiss patients. The clinical details from one of these patients are presented.

Topics: Aged; Doxycycline; Erythromycin; Humans; Jaundice; Legionnaires' Disease; Male; Pleural Effusion; Switzerland; Tetracycline

Twenty-six patients are described who had otherwise unexplained hepatitis after halothane anaesthesia. Twenty-four (92 per cent) had multiple exposures, and 11 (42 per cent) died. In eight patients a characteristic pattern of delayed postoperative pyrexia has been found. Obesity was common, but the clinical features and complications were those of any severe hepatitis. Obesity, early onset of jaundice after anaesthesia, and low thrombotest, were associated with a fatal outcome. None of those who were followed up after recovery developed clinical or biochemical evidence of chronic liver disease. The differential diagnosis of postoperative jaundice is discussed, and it is shown that halothane patients with hepatic encephalopathy are significantly older (25.4 plus or minus 11.6 years) than those referred to this unit with viral hepatitis of equal severity (34.1 plus or minus 16.4 years). Unexplained jaundice or delayed pyrexia after a previous administration of halothane should be a contraindication to its further use.

Topics: Adult; Aged; Anesthesia, General; Bilirubin; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Glucose; Halothane; Humans; Jaundice; Male; Middle Aged; Neomycin; Penicillins; Phenothiazines; Phenytoin; Postoperative Complications; Sulfonamides; Tetracycline; Trimethoprim

Topics: Ampicillin; Candida albicans; Candidiasis; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Diagnosis, Differential; Fatty Liver; Female; Halothane; Humans; Hydronephrosis; Injections, Intravenous; Jaundice; Liver; Nitrofurantoin; Postoperative Complications; Sulfisoxazole; Tetracycline; Urinary Tract Infections; Vesico-Ureteral Reflux

Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptives, Oral; Fatty Liver; Female; Halothane; Hepatitis A; Humans; Jaundice; Jaundice, Chronic Idiopathic; Liver; Liver Cirrhosis; Liver Diseases; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Rupture, Spontaneous; Tetracycline

Topics: Cholestasis; Contraceptives, Oral; Fatty Liver; Female; Humans; Jaundice; Pregnancy; Pregnancy Complications; Pruritus; Tetracycline

Topics: Abortion, Therapeutic; Adult; Cholelithiasis; Female; Fetal Death; Hepatitis A; Humans; Infant, Newborn; Jaundice; Maternal Mortality; Obstetric Labor, Premature; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Retrospective Studies; Tetracycline

Topics: Acidosis, Renal Tubular; Aged; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Hemorrhagic Disorders; Humans; Hypoproteinemia; Jaundice; Kidney Diseases; Male; Middle Aged; Tetracycline; Uremia

Topics: Adult; Female; Humans; Jaundice; Mestranol; Norethindrone; Tetracycline

Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bacteroides; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Enterococcus faecalis; Female; Humans; Hyperbilirubinemia; Jaundice; Liver; Liver Diseases; Liver Function Tests; Male; Mercaptopurine; Postoperative Complications; Pseudomonas; Sepsis; Staphylococcus; Streptococcus; Tetracycline; Transfusion Reaction

Topics: Adult; Alkaline Phosphatase; Antibodies; Aspartate Aminotransferases; Cephalothin; Diagnosis, Differential; Fever; Hepatic Encephalopathy; Hepatitis A; Humans; Infectious Mononucleosis; Jaundice; Leukocyte Count; Liver Function Tests; Male; Prednisolone; Tetracycline

Topics: Ethionine; Fatty Liver; Female; Humans; Infant, Newborn; Jaundice; Lipid Metabolism; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Tetracycline

Topics: Adult; Aged; Fatty Liver; Female; Humans; Jaundice; Middle Aged; Neoplasms; Pancreatitis; Postoperative Complications; Pregnancy; Pregnancy Complications; Tetracycline

Topics: Abortion, Septic; Adult; Blood Urea Nitrogen; Bronchopneumonia; Female; Humans; Jaundice; Liver Diseases; Male; Middle Aged; Pregnancy; Pregnancy Complications; Pyelonephritis; Rectovaginal Fistula; Tetracycline; Urea

Topics: Anti-Bacterial Agents; Congenital Abnormalities; Cortisone; Esophageal Fistula; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Jaundice; Jaundice, Neonatal; Penicillins; Prednisone; Respiratory Tract Infections; Sclerema Neonatorum; Sepsis; Streptomycin; Tetracycline

Topics: Biopsy; Diagnosis, Differential; Hemorrhage; Humans; Iatrogenic Disease; Jaundice; Jaundice, Obstructive; Liver; Penicillins; Peritonitis; Streptomycin; Surgical Procedures, Operative; Tetracycline

Topics: Adrenocorticotropic Hormone; Anti-Bacterial Agents; Diet; Diet Therapy; Hepatitis; Hepatitis A; Humans; Jaundice; Oxytetracycline; Pathology; Prednisone; Prognosis; Tetracycline; Therapeutics; Vitamin K; Vitamins

Topics: Abortion, Criminal; Abortion, Septic; Anti-Bacterial Agents; Anuria; Biopsy; Criminals; Curettage; Diuresis; Eclampsia; Female; Fever; Hemoglobinuria; Hemolysis; Humans; Jaundice; Kidney Cortex Necrosis; Kidney Diseases; Nephritis; Nephritis, Interstitial; Penicillins; Pregnancy; Sepsis; Tetracycline

Topics: Chloramphenicol; Clinical Enzyme Tests; Escherichia coli Infections; Female; Humans; Jaundice; Jaundice, Obstructive; Liver Diseases; Liver Function Tests; Pancreas; Pancreatitis; Pregnancy; Pregnancy Complications; Pyelonephritis; Streptomycin; Tetracycline; Toxicology; Uremia

Topics: Acidosis; Cesarean Section; Fatty Liver; Female; Hematemesis; Humans; Hypoproteinemia; Hypotension; Hysterectomy; Jaundice; Liver Diseases; Melena; Oxytetracycline; Pathology; Placenta Previa; Pneumonia; Postpartum Hemorrhage; Postpartum Period; Pregnancy; Pregnancy Complications; Tetracycline; Toxicology

Topics: Bile Ducts; Cholangiography; Common Bile Duct; Cysts; Jaundice; Jaundice, Obstructive; Radiography; Surgical Procedures, Operative; Tetracycline