tetracycline and Intracranial-Hypertension

A 14-year-old girl presented with a history of left-sided headache and acute bilateral blurred vision. She had a remote history of oral tetracycline use for the treatment of acne vulgaris, which had been discontinued for 1 month. The patient was diagnosed with drug-induced intracranial hypertension (IH) and treated with oral acetazolamide with subsequent resolution of symptoms. IH, a known rare complication of the tetracycline class of antibiotics, can also have a delayed presentation after discontinuation of the medication.

Topics: Acetazolamide; Acne Vulgaris; Adolescent; Anti-Bacterial Agents; Carbonic Anhydrase Inhibitors; Female; Humans; Intracranial Hypertension; Tetracycline; Vision Disorders; Visual Acuity; Visual Field Tests; Visual Fields; Withholding Treatment

Topics: Acetazolamide; Anti-Bacterial Agents; Antidepressive Agents; Body Mass Index; Cerebrospinal Fluid Shunts; Diet, Sodium-Restricted; Diuretics; Female; Humans; Intracranial Hypertension; Lithium Compounds; Magnetic Resonance Angiography; Male; Obesity; Sex Distribution; Sex Factors; Steroids; Tetracycline; Tinnitus; Vision Disorders; Vitamin A; Vitamins; Weight Loss

A young, non-obese woman aged 24 years with normal blood pressure developed intracranial hypertension after the oral use of tetracycline. Neuro-ophthalmologic examination revealed severely reduced acuity, papilledema, and concentric impaired visual fields. She was treated with acetazolamide and recurrent lumbar punctures and recovered, but without improvement in either acuity or visual fields. Intracranial hypertension is a fairly rare disease characterised by increased intracranial pressure without structural abnormalities in the brain or hydrocephalus, and is termed idiopathic in the absence of an underlying cause. Tetracycline should be considered as a cause of intracranial hypertension if a patient complains of previously unknown headache a few days after its ingestion. Headache and the presence of bilateral papilledema, decreased visual acuity and visual-field defects are indications for urgent referral to a neurologist. Therapy consists of a combination of repetitive lumbar punctures and medication. Surgical interventions include lumboperitoneal shunting and optic nerve fenestration. Intracranial hypertension may lead to irreversible decreased visual acuity and visual-field defects resulting in disability.

Topics: Acetazolamide; Administration, Oral; Adult; Diuretics; Female; Humans; Intracranial Hypertension; Intracranial Pressure; Papilledema; Recurrence; Spinal Puncture; Tetracycline; Treatment Outcome; Visual Acuity; Visual Fields

Topics: Anti-Bacterial Agents; Humans; Intracranial Hypertension; Tetracycline; Time Factors; Visual Acuity

We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.

Topics: Acne Vulgaris; Adolescent; Anti-Bacterial Agents; Female; Humans; Intracranial Hypertension; Tetracycline

Topics: Adolescent; Anti-Bacterial Agents; Female; Humans; Intracranial Hypertension; Tetracycline

Topics: Adrenal Cortex Hormones; Bartholin's Glands; Chelating Agents; Combined Modality Therapy; Fatal Outcome; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Intracranial Hypertension; Lead Poisoning; Lead Poisoning, Nervous System, Childhood; Ointment Bases; Peritoneal Dialysis; Pregnancy; Pregnancy Complications, Infectious; Prenatal Exposure Delayed Effects; Tetracycline; Vulvovaginitis

Topics: Anti-Bacterial Agents; Humans; Intracranial Hypertension; Protein Synthesis Inhibitors; Tetracycline