tetracycline and Infertility--Male

This systematic review assesses effects of paternal exposure to dermatologic medications by using the former US Food and Drug Administration (FDA) pregnancy categories as a benchmark.. To assess whether systemic dermatologic medications can cause infertility and teratogenicity when taken by men.. Categories D and X dermatologic medications were identified; a systematic review of the literature and reviews of the FDA Adverse Events Reporting System and prescribing information were performed to identify the effects of these medications on male fertility and teratogenicity. A secondary search was performed to assess for other systemic dermatologic medications causing teratogenicity or infertility following paternal exposure.. A total of 13 medications met the inclusion criteria. Of 1,032 studies identified, 19 were included after a systematic review of the literature. Studies evaluating medication effects with paternal exposure were identified for 10 of the 13 evaluated medications, and evidence of a negative effect was identified for 6 medications.. We did not encounter any studies for 3 medications that met the inclusion criteria. Information submitted to the FDA Adverse Events Reporting System may not reflect the incidence of side effects.. Many former pregnancy category D and X systemic dermatologic medications also have effects on male fertility. More research and better-quality studies are required in this area, particularly studies assessing potential teratogenicity.

Topics: Acitretin; Adrenal Cortex Hormones; Colchicine; Cyclophosphamide; Dermatologic Agents; Doxycycline; Finasteride; Humans; Infertility, Male; Isotretinoin; Male; Methotrexate; Paternal Exposure; Teratogenesis; Tetracycline; Thalidomide

The effect of low dose immunosuppression with methylprednisolone during the first 4 days after oocyte retrieval on potential immune cell invasion of partially zona dissected embryos in utero was investigated in alternate in vitro fertilization patients (n = 32). The incidence of pregnancy was significantly higher in patients receiving methylprednisolone (7 of 18, 39%) than in control patients (1 of 14, 7%). Twenty-eight percent (11 of 39) of the embryos replaced in the corticosteroid treated patients implanted, whereas only 7% (2 of 31) of embryos in control patients had a fetal heart beat. There were no side effects reported in any of the patients receiving corticosteroids. It can be concluded that methylprednisolone supports implantation of embryos with small holes in their zonae. However, the actual mechanisms of corticosteroid support on the interaction between immune cells and micromanipulated embryos are not well understood.

Topics: Clinical Trials as Topic; Embryo Implantation; Embryo Transfer; Female; Fertilization in Vitro; Humans; Immunosuppression Therapy; Infertility, Male; Male; Prednisolone; Pregnancy; Tetracycline; Zona Pellucida

The current study focused on the pro-fertility potential of. A total of 36 male and 36 female adult SD rats were used for this investigation. The male rats randomly assigned to Group A (controls) were given normal saline 2ml/kg. Rats in Groups B, C, D, E, and F were respectively administered [30 mg/kg of body weight (bwt) of tetracycline], [30 mg/kg bwt of tetracycline + 50 mg/kg of vitamin C], [30 mg/kg bwt of tetracycline + 500 mg/kg bwt of Sb], [30 mg/kg bwt of tetracycline + 50 mg/kg of vitamin C + 500 mg/kg bwt of Sb], and [30 mg/kg bwt of tetracycline reversal] daily for 28 days via gastric gavage. Tested parameters included sperm parameters, hormonal profile, histology, and fertility test.. Significant (

Topics: Animals; Body Weight; Female; Follicle Stimulating Hormone; Infertility, Male; Luteinizing Hormone; Male; Plant Extracts; Rats, Sprague-Dawley; Semen Analysis; Senecio; Sperm Count; Sperm Motility; Testis; Testosterone; Tetracycline

The ability of sterile males to survive, disperse, find, and mate with wild females is key to the success of sterile insect technique (SIT). The Release of Insects carrying a Dominant Lethal (RIDL) system is a genetics-based SIT strategy for Aedes aegypti. We examine two aspects of insect performance, flight potential (dispersal ability) and teneral energy reserves, by comparing wild-type (WT) males with genetically-modified lines carrying the tetracycline-repressible constructs OX513A and OX3604C. Our results show significant differences in the flight capacity of the modified lines. OX513A males bred with tetracycline covered 38% less distance, while OX3604C males reared without tetracycline spent 21% less time in flight than their WT counterparts. Such differences in flight performance should be considered when designing release programs (e.g., by placing release sites sufficiently close together to achieve adequate coverage). All mosquito lines had similar teneral carbohydrate contents, though males of the OX3604C line contained more lipids. The addition of tetracycline to the larval diet did not influence the flight potential of the males; however, it did change the teneral sugar reserves of the WT and the lipid reserves of both the WT and the OX3604C lines.

Topics: Aedes; Animal Distribution; Animals; Animals, Genetically Modified; Body Constitution; Carbohydrate Metabolism; Carbohydrates; Energy Metabolism; Female; Flight, Animal; Genes, Dominant; Genes, Lethal; Glycogen; Infertility, Male; Insect Vectors; Lipid Metabolism; Lipids; Male; Mosquito Control; Mutation; Tetracycline; Wings, Animal; Yellow Fever

Topics: Animals; Animals, Genetically Modified; Ceratitis capitata; Ecology; Genes, Dominant; Genes, Insect; Genes, Lethal; Genetic Engineering; Genetic Markers; Infertility, Male; Insect Control; Male; Models, Biological; Mutation; Tetracycline; Trans-Activators; Transgenes

The Australian sheep blowfly Lucilia cuprina is the most important pest species involved in cutaneous myiasis (flystrike) of sheep in Australia and New Zealand. In New Zealand L. cuprina is primarily controlled through the application of insecticides. However, there is an increased interest in biological methods of control of this species. We have proposed to develop a genetically modified strain of L. cuprina that would be ideal for a male-only sterile release program. To that end we have developed a method for making transgenic L. cuprina using a piggyBac vector and an EGFP marker gene. We have also developed in Drosophila melanogaster a 2-component genetic system for controlling female viability. Females carrying both components of the system die unless fed a diet that contains tetracycline. We anticipate that the female-killing system will need to be optimised for L. cuprina in order to make a strain with the properties required for a male-only release program.

Topics: Animals; Animals, Genetically Modified; Australia; Diptera; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Female; Gene Expression; Genes, Insect; Genes, Lethal; Genetic Engineering; Infertility, Male; Male; Pest Control, Biological; Sheep; Tetracycline; Transformation, Genetic; Transgenes; X Chromosome

The case of an infertile man with oligospermia and symptoms of urethritis-prostatitis, whose spouse had a vaginal discharge, is reported. Microbiological analysis of appropriate specimens revealed a strain of tetracycline-resistant ureaplasma urealyticum in both patients. Using the transmission electron microscope, it was possible to demonstrate spermatozoal heads "infected" with microorganisms strongly resembling ureaplasma urealyticum.

Topics: Adult; Chlamydia Infections; Chlamydia trachomatis; Drug Resistance, Microbial; Female; Humans; Infertility, Male; Male; Mycoplasmatales Infections; Prostatitis; Sperm Head; Spermatozoa; Tetracycline; Ureaplasma; Urethritis; Vaginitis

Semen characteristics were evaluated in 64 men visiting our infertility clinic before and after the eradication of genital infection with Ureaplasma urealyticum. Semen quality was also analyzed in 9 men who were unsuccessfully treated for genital Ureaplasma infection, 11 men who had negative cultures and received no treatment, and 11 men who had negative cultures but received empirical antibiotic therapy. A significant improvement in spermatozoal motility (both the speed of forward progession and the percentage of motile cells) was found in the group that was successfully treated for Ureaplasma infection. Improvements were not demonstrated in any of the other patient groups. A correlation was found between improved motility and a decrease in certain abnormal features of seminal cytology that appear to be associated with Ureaplasma genital infection.

Topics: Cell Count; Doxycycline; Genital Diseases, Male; Humans; Infertility, Male; Male; Semen; Sperm Motility; Spermatozoa; Tetracycline; Ureaplasma

In view of the potential role of ureaplasma urealyticum in reproductive failure, sample of semen from 100 Nigerian males was cultured in oxoid mycoplasma broth. In 39% of the patients, Uraeplasma uraelyticum was cultured. Of those with positive culture, 92.3% were infertile patients. Five subfertile males achieved pregnancy in their partners after eradication of the ureaplasma urealyticum by a course of tetracycline.. Findings in a study of 100 Nigerian males supported the contention that ureaplasma urealyticum may have an inhibitory influence on fertility. When semen samples from 20 normal males, 17 males with sperm counts of 20-39 million/ml, and 63 males with sperm concentrations less than 20 million/ml were cultured in an oxoid mycoplasma broth, ureaplasma urealyticum was cultured in 39 of the samples. 36 of these 39 positive cultures were from males with sperm counts of less than 20 million/ml. Those patients with positive cultures and their wives were treated with tetracycline and within 6 months of treatment, conception occurred in the wives of 5 of the males with sperm concentrations of 20-35 million/ml. Apparently there is a tendency for the ureaplasma urealyticum to attach to sperm cells, and this may have an inhibitory effect on fertilization. Since positive cultures were obtained from 3 of the fertile males, it is possible that ureaplasma urealyticum is pathogenic for some individuals but not for others. This study does not prove that there is a cause and effect relationship between ureaplasma urealyticum and infertility; however, in view of the high infertility rates in many parts of Africa, tetracycline or doxycycline therapy is routinely recommended for males with ureaplasma urealyticum in their ejaculate and for their wives. Included is the formula for the oxoid mycoplasma broth and a table showing the number and distribution of positive and negative cultures by sperm concentration.

Topics: Humans; Infertility, Male; Male; Mycoplasma Infections; Tetracycline; Ureaplasma

Topics: Cervix Uteri; Female; Humans; Infertility; Infertility, Female; Infertility, Male; Male; Mycoplasma; Pregnancy; Spermatozoa; Tetracycline

Topics: Cervix Uteri; Female; Fertilization; Humans; Infertility; Infertility, Female; Infertility, Male; Male; Mycoplasma; Pregnancy; Semen; Tetracycline

Male hybrids between the Santa Marta and Mesitas strains of Drosophila paulistorum are sterile. The sterility can be partially alleviated by treatment of the Santa Marta mothers with the antimycoplasmal antibiotics tylosin tartrate and tetracycline hydrochloride. The proportions of hybrid males in which there are mature motile spermatozoa are higher in the progenies of drug-treated mothers than in the controls. Electron microscopy reveals mycoplasma-like bodies in the untreated controls, but not in the sons of the treated females. The mycoplasma-like symbionts appear to be implicated in the production of the sterility in the hybrid males.

Topics: Animals; Anti-Bacterial Agents; Drosophila; Fertility; Hybridization, Genetic; Infertility, Male; Male; Microscopy, Electron; Mycoplasma; Spermatozoa; Testis; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Female; Fertility; Humans; Infertility; Infertility, Male; Male; Pelvic Inflammatory Disease; Penicillins; Protein Synthesis Inhibitors; Spermatozoa; Streptomycin; Tetracycline; Uterine Cervicitis