tetracycline and Infertility--Female

Recurrent endometriomas after medical or surgical treatment is a difficult clinical problem for those patients who wish to perform ovulation induction. Therefore we tried to investigate the efficacy of sclerotherapy as an adjuvant management before ovulation induction to preserve more ovarian tissue for folliculogenesis in ART program.. Thirty-two patients with persistent or recurrent endometrioma after surgical or medical treatment were included in this study. Transvaginal ultrasound needle guided aspiration of the cyst followed by tetracycline instillation was performed before ovulation induction.. There is an encouraging clinical pregnancy rate of 34.37%. Also, there is a disappointing recurrent rate of 46.87% in 12 months follow-up course.. The increased interest in cost-effective outpatient therapy and the expected difficulty in surgical treatment of recurrent endometriomas made aspiration and sclerotherapy of endometrioma an attractive option before ovulation induction.

Topics: Adult; Anti-Bacterial Agents; Endometriosis; Female; Humans; Infertility, Female; Ovulation Induction; Pregnancy; Prospective Studies; Recurrence; Sclerotherapy; Tetracycline; Treatment Outcome

To explore the effects of mycoplasma and chlamydia infections on tubal infertilityand to assess the antibiotic susceptibility and resistance of female urogenital, and consequently to guide clinical rational drug use.. 327 tubal infertility women as infertility group and 286 healthy pregnant women as control group were randomly selected, detected chlamydia trachomatis (CT), ureaplasma urealyticum (UU) and mycoplasma hominis (MH) in cervical secretions and drug resistance of UU and MH.. CT infection rates (14.99%), UU infection rates (23.24%), UU + MH infection rates (29.05%),CT + UU + MH infection rates (9.17%) and total infection rates (88.99%) in infertility group is higher than those (order: 2.80%, 6.99%, 8.39%, 4.55%, 29.02%) in the control group, comparisons of two groups are statistically significant differences (P < 0.05), the susceptibility of UU to roxithromycin (sensitivity is 96.05%), josamycin (sensitivity is 96.05%), tetracycline (sensitivity is 82.89%), vibramycin( sensitivity is 92.11%) and clarithromycin (sensitivity is 96.05%) were relatively high and low to ciprofloxacin and acetyl spiramycin. The susceptibility of MH to josamycin (sensitivity is 95.83%), vibramycin (sensitivity is 91.67%), minocin (sensitivity is 83.33%) and actinospectacin (sensitivity is 75.00%) were relatively high and low to erythromycin, azithromycin, roxithromycin and clarithromycin. UU + MH was only sensitive to josamycin (sensitivity is 90.52%), high resistance (77.89% -91.58%) to erythromycin, azithromycin, acetyl spiramycin, ciprofloxacin, ofloxacin, azithromycin and clarithromycin.. Infection of CT, UU, MH and tubal infertility have certain relevance,the rates of CT, UU and MH infection in tubal infertility patients higher than fertile people. For many commonantibacterial drugs, UU, MH and UU + MH has strong resistance, the etiology detection and using adapted antibios should be taken seriously in clinical treatment.

Topics: Adult; Anti-Bacterial Agents; Azithromycin; Chlamydia; Chlamydia Infections; Clarithromycin; Doxycycline; Erythromycin; Female; Humans; Infertility, Female; Josamycin; Microbial Sensitivity Tests; Minocycline; Mycoplasma; Mycoplasma Infections; Roxithromycin; Spectinomycin; Tetracycline; Ureaplasma urealyticum; Urogenital System; Young Adult

The Sterile Insect Technique is a species-specific and environmentally friendly method of pest control involving mass release of sterilized insects that reduce the wild population through infertile matings. Insects carrying a female-specific autocidal genetic system offer an attractive alternative to conventional sterilization methods while also eliminating females from the release population. We exploited sex-specific alternative splicing in insects to engineer female-specific autocidal genetic systems in the Mediterranean fruit fly, Ceratitis capitata. These rely on the insertion of cassette exons from the C. capitata transformer gene into a heterologous tetracycline-repressible transactivator such that the transactivator transcript is disrupted in male splice variants but not in the female-specific one. As the key components of these systems function across a broad phylogenetic range, this strategy addresses the paucity of sex-specific expression systems (e.g., early-acting, female-specific promoters) in insects other than Drosophila melanogaster. The approach may have wide applicability for regulating gene expression in other organisms, particularly for combinatorial control with appropriate promoters.

Topics: Alternative Splicing; Animals; Animals, Genetically Modified; Ceratitis capitata; Drosophila Proteins; Female; Gene Expression Regulation; Infertility, Female; Insect Control; Nuclear Proteins; Population Dynamics; Sex Factors; Tetracycline; Transcription, Genetic

Haemophilus somnus was consistently isolated from vaginal discharges of dairy cows submitted from field cases of vaginitis, cervicitis and/or metritis in the KwaZulu-Natal Midlands during the period July 1995 - December 2000 and from the East Griqualand area in November/December 2000. The purulent vaginal discharges, red granular vaginitis and cervicitis, and pain on palpation described in these cases was very similar to that reported in outbreaks of H.somnus endometritis syndrome in Australia, Europe and North America. In all the herds involved in these outbreaks, natural breeding with bulls was employed. Although there was a good cure rate in clinically-affected animals treated with tetracyclines, culling rates for chronic infertility were unacceptably high. Employment of artificial insemination in these herds improved pregnancy rates in cows that had calved previously, but many cows that had formerly been infected failed to conceive.

Topics: Animals; Breeding; Cattle; Cattle Diseases; Disease Outbreaks; Endometritis; Female; Haemophilus; Haemophilus Infections; Infertility, Female; Insemination, Artificial; Male; Pregnancy; Pregnancy Rate; South Africa; Syndrome; Tetracycline; Uterine Cervicitis; Vaginitis

To study the prevalence of Chlamydia trachomatis (CT) and Ureaplasma urealyticum (Uu) cervical infection in infertility women, and therapeutic effectiveness of tetracycline and qianglimycin.. CT in cervical swab specimen was detected by cell culture, polymerase chain reaction(PCR) and immunofluorescent assay(IFA), Uu in cervical swab specimen was detected by culture, in a group of 145 infertility women, before and after treatment, and 45 women at productive age who attended obstetric and gynecologic clinic.. The positive rate of CT by cell culture, PCR, IFA(shell) and IFA(direct smear) was 62.7%, 66.8%, 64.8% and 36.5%, respectively, which was obviously higher than that of the control (P < 0.01). The positive rate of Uu was 33.1%, that of CT and Uu co-infection was 18.6%. Both were obviously higher than those of the control (P < 0.01).. This study indicates that the prevalence of CT and Uu cervical infection in infertility women is high. CT and Uu cervical infection is closely related to female infertility. The therapeutic effectiveness of tetracycline and qianglimycin is not ideal.

Topics: Adult; Anti-Bacterial Agents; China; Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Infertility, Female; Prevalence; Tetracycline; Ureaplasma Infections; Ureaplasma urealyticum; Uterine Cervicitis

Topics: Adult; Cysts; Endometriosis; Endometrium; Female; Humans; Infertility, Female; Recurrence; Sclerotherapy; Suction; Tetracycline; Uterine Diseases

Three treatment regimens are currently recommended for penicillin-susceptible Neisseria gonorrhoeae infection of the cervix: ampicillin, tetracycline, and a combination of ampicillin and tetracycline. To evaluate the cost-effectiveness of these options, we developed a decision analysis model and analyzed the efficacy of each treatment in curing gonorrhea, as well as coexisting Chlamydia trachomatis infection, and in preventing subsequent pelvic inflammatory disease, ectopic pregnancy, and infertility. We included direct costs of medication and expenditures for management of unresolved infections and associated complications. Combination treatment is more than twice as cost-effective as tetracycline and seven times as cost-effective as ampicillin when the medical cost of managing pelvic inflammatory disease is considered. When the costs of ectopic pregnancies and infertility are included, the cost-effectiveness of combination treatment increases further.

Topics: Ampicillin; Chlamydia Infections; Chlamydia trachomatis; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Gonorrhea; Humans; Infertility, Female; Pelvic Inflammatory Disease; Pregnancy; Pregnancy, Ectopic; Tetracycline; Uterine Cervicitis

Two hundred consecutive infertility patients and sixty-seven controls subjects were studied for the incidence of infection with Ureaplasma urealyticum (T-mycoplasma). On the basis of a complete infertility investigation, the infertility patients were subdivided into those with explained infertility and those with unexplained infertility. Of the patients with unexplained infertility, 55% had a positive culture for T-mycoplasma as compared with a 32% incidence of positive cultures in the control population. The differences were statistically significant. The 6-month pregnancy rate following successful antibiotic treatment in patients with unexplained infertility was 42%. The 6-month pregnancy rate in a comparable group of patients with unexplained infertility, seen during a 3-year period prior to mycoplasma culture and treatment, was 32%. The difference in pregnancy rates between the two groups was not statistically significant. No correlation was found between a poor postcoital test and the presence of T-mycoplasma infection nor between T-mycoplasma infection and poor cervical mucus. The role of T-mycoplasma infection in infertility was neither proven nor disproven by this study.

Topics: Cervix Uteri; Female; Infertility, Female; Mycoplasma Infections; Tetracycline; Ureaplasma

Ureaplasma urealyticum (T-mycoplasma) was isolated more frequently and in heavier growth from cervical mucus (49%) than from vaginal fluid (34%). It was isolated in 24% of vaginal fluid samples and in 35% of cervical mucus samples from fertile women, and in 29% of vaginal fluid samples and in 47% of cervical mucus samples from infertile women. The incidence of infection was high following abortion or total hysterectomy and during pregnancy or oral contraceptive use. T-mycoplasma was also isolated from the vaginal fluid and cervical mucus of a woman with tubo-ovarian abscess, but was not present in women with Trichomonas vaginalis infection. U. urealyticum did not alter the physiophysiologic characteristics of vaginal fluid and cervical mucus or the sperm penetration and sperm viability in cervical mucus. Treatment with tetracycline eradicated the organism in 88% of the infected women. Pregnancies were recorded during a 6-month follow-up in 1 of 19 infertile women who were treated with tetracycline.

Topics: Cell Survival; Cervix Mucus; Female; Humans; Infertility, Female; Male; Mycoplasma Infections; Sperm Motility; Spermatozoa; Tetracycline; Ureaplasma; Vagina

Topics: Cervix Uteri; Female; Humans; Infertility; Infertility, Female; Infertility, Male; Male; Mycoplasma; Pregnancy; Spermatozoa; Tetracycline

Topics: Cervix Uteri; Female; Fertilization; Humans; Infertility; Infertility, Female; Infertility, Male; Male; Mycoplasma; Pregnancy; Semen; Tetracycline

Topics: Adult; Dexamethasone; Electrolytes; Fallopian Tubes; Female; Genital Neoplasms, Female; Humans; Infertility, Female; Middle Aged; Postoperative Care; Preoperative Care; Sulfamethoxypyridazine; Tetracycline; Tissue Adhesions; Uterus

Topics: Dexamethasone; Female; Glucocorticoids; Humans; Infertility, Female; Postoperative Care; Pregnancy; Preoperative Care; Tetracycline

Topics: Adolescent; Adult; Drug Synergism; Female; Follow-Up Studies; Humans; Infertility, Female; Middle Aged; Oleandomycin; Oophoritis; Prednisolone; Salpingitis; Tetracycline