tetracycline and Impetigo

Forty-nine children aged 0.2-13 years with bullous and eroded lesions, from which Staphylococcus aureus was isolated, were diagnosed with impetigo and entered into a randomized, open-labeled trial of topical oxytetracycline hydrochloride (tetracycline) compared with a combination of topical tetracycline and oral antibiotics. After one week of topical tetracycline treatment, 22 of the 28 patients were clinically cured, and the remaining six patients had improved. In the other treatment group, 14 patients of 21 were clinically cured and 7 patients improved by the combination of topical tetracycline and oral antibiotics. There were no significant differences between the two groups. Therefore, the present study suggests that topical tetracycline treatment is effective for the treatment of impetigo.

Topics: Administration, Oral; Administration, Topical; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Drug Resistance, Bacterial; Female; Humans; Impetigo; Infant; Male; Staphylococcal Infections; Tetracycline

Topics: Adolescent; Carrier State; Child, Institutionalized; Disease Outbreaks; Drug Resistance, Microbial; Humans; Impetigo; Intellectual Disability; Male; Nose; Staphylococcal Infections; Staphylococcus; Tetracycline; Virulence

A 50-year-old Japanese woman visited our clinic, complaining of generalized erythema with painful erosions and bullae. The histopathological findings of the skin lesion suggested development of impetigo. Gentamycin-resistant Staphylococcus aureus was detected by the bacterial culture examination from the impetiginous bullae. A direct immunofluorescence study of the lesion showed an intercellular deposition of IgG and C3 in the upper epidermis. We diagnosed this case as pemphigus foliaceus associated with bullous impetigo. A combined oral administration of tetracycline (200 mg/day) and nicotinamide (1200 mg/day) for 3 weeks was successful. In Japan, patients with moderate to severe symptoms of pemphigus foliaceus are usually treated with oral steroid therapy. To our knowledge, however, there is no reported pemphigus case which has been successfully treated only with tetracycline and nicotinamide.

Topics: Anti-Bacterial Agents; Drug Therapy, Combination; Female; Humans; Impetigo; Middle Aged; Niacinamide; Pemphigus; Tetracycline

Topics: Ampicillin; Anti-Bacterial Agents; Cephalexin; Chloramphenicol; Erythromycin; Furunculosis; Humans; Impetigo; Penicillin Resistance; Skin Diseases, Vesiculobullous; Staphylococcus aureus; Tetracycline

Topics: Acne Vulgaris; Bacterial Infections; Cellulitis; Child; Dermatitis, Exfoliative; Furunculosis; Humans; Impetigo; Infant; Infant, Newborn; Penicillins; Skin Diseases, Infectious; Staphylococcal Infections; Tetracycline; Wound Infection

Topics: Bacteriophage Typing; Carrier State; Child; Chloramphenicol; Germany, West; Humans; Immunodiffusion; Impetigo; Penicillin G; Penicillin Resistance; School Health Services; Staphylococcal Infections; Staphylococcus; Tetracycline

Topics: Administration, Oral; Bronchitis; Child; Child, Preschool; Dosage Forms; Female; Humans; Impetigo; Infant; Lymphadenitis; Male; Microbial Sensitivity Tests; Pneumonia; Respiratory Tract Infections; Staphylococcus; Tetracycline; Tonsillitis; Whooping Cough

Topics: Anti-Bacterial Agents; Child; Child, Preschool; Erythromycin; Furunculosis; Glycosides; Humans; Impetigo; Infant; Lincomycin; Male; Microbial Sensitivity Tests; Penicillin Resistance; Penicillins; Pneumonia, Staphylococcal; Pyrrolidines; Staphylococcal Infections; Staphylococcus; Tetracycline

Topics: Adolescent; Adult; Azoles; Child; Child, Preschool; Chloramphenicol; Erythromycin; Female; Humans; Impetigo; Infant; Infant, Newborn; Male; Penicillin Resistance; Penicillins; Phosphoric Acids; Staphylococcus; Tetracycline

Topics: Acne Vulgaris; Anti-Bacterial Agents; Antifungal Agents; Carbuncle; Chlortetracycline; Eczema; Erysipelas; Folliculitis; Furunculosis; Griseofulvin; Humans; Impetigo; Lupus Vulgaris; Paronychia; Penicillins; Scalp Dermatoses; Skin Diseases, Infectious; Tetracycline

Topics: Anti-Bacterial Agents; Child; Chloramphenicol; Clioquinol; Copper; Ecthyma; Gentian Violet; Humans; Impetigo; Infant; Infant, Newborn; Iodine; Mercury; Neomycin; Penicillin G; Penicillin G Procaine; Potassium Permanganate; Procaine; Pyoderma; Quinolines; Silver Nitrate; Sulfur; Tetracycline; Toxicology; Zinc

Topics: Animals; Anti-Bacterial Agents; Dermatology; Family; Furunculosis; Hexachlorophene; Humans; Hydrocortisone; Impetigo; Minor Surgical Procedures; Quinolines; Staphylococcal Infections; Tetracycline; Toxicology

Topics: Acetates; Alkaline Phosphatase; Cell Wall; Electrophoresis; Glycerol; Impetigo; Lipid Metabolism; Oleic Acid; Oleic Acids; Research; Streptococcus; Streptococcus pyogenes; Tetracycline