tetracycline and Immunologic-Deficiency-Syndromes

Topics: Adolescent; Bone Diseases, Developmental; Child; Diagnosis, Differential; Fanconi Syndrome; Female; Gigantism; Humans; Immunologic Deficiency Syndromes; Infant; Male; Tetracycline

A murine model of severe combined immunodeficiency syndrome (scid mice) affords an opportunity to study the interaction of Candida albicans with a host lacking functional B- and T-cell mechanisms. We have previously reported no significant difference in yeast recovery after intravenous challenge of BALB/c mice and scid mice with C. albicans (S. Mahanty, R.A. Greenfield, W.A. Joyce, and P.W. Kincade, Infect. Immun. 56:3162-3166, 1988). In this study, we evaluate the course of gastrointestinal candidiasis after a single oral challenge with C. albicans. BALB/c and scid mice received H2O containing 10(6) C. albicans per ml for 16 h. Half the mice of each strain continuously received H2O containing 1 mg of tetracycline per ml. Stool samples were cultured for yeast twice weekly until they were negative three consecutive times or positive for 8 weeks. Mice were then sacrificed for quantitative cultures of liver, spleen, and kidneys. At eight weeks postinoculation, 2 of 13 BALB/c mice, 0 of 14 BALB/c mice receiving tetracycline, 6 of 12 scid mice, and 8 of 13 scid mice receiving tetracycline had positive stool cultures (P less than 0.05, likelihood ratio chi-square). Quantitative recovery of yeasts from stools was also higher in the scid mice. Cultures of liver, spleen, and kidneys wer negative in all BALB/c mice and essentially all negative in scid mice; a single colony was isolated from the kidney of one scid mouse and the liver of another scid mouse. We conclude that B cells and/or T cells and their products are important in gastrointestinal colonization with C. albicans but that even in their absence, dissemination of infection from the gastrointestinal tract does not consistently occur. Thus, other aspects of host defense must be critical in containing gastrointestinal Candida colonization.

Topics: Administration, Oral; Animals; Candida albicans; Candidiasis; Colony Count, Microbial; Disease Models, Animal; Disease Susceptibility; Female; Gastrointestinal Diseases; Immunologic Deficiency Syndromes; Mice; Mice, Inbred BALB C; Random Allocation; Tetracycline

Structure of the thymus in Wistar rats has been studied during antenatal and early postnatal periods of ontogenesis by means of histological, morphometric and electron microscopic methods. Theraputic doses of tetracycline hydrochloride have been administered during fetogenesis (15-20 days of pregnancy). An accelerated formation of the thymic structures, cellular blasttransformation in the thymic cortex and movement of lymphocytes from the cortex into medulla and increased secretory activity of epithelioreticulocytes have been revealed. The data obtained are considered as a display of the organ's immune response to tetracycline administration.

Topics: Animals; Female; Immunologic Deficiency Syndromes; Lymphatic Diseases; Maternal-Fetal Exchange; Pregnancy; Rats; Tetracycline; Thymus Gland

Idiopathic late-onset immunoglobulin deficiency in a young man was associated with achlorhydria and a severe intestinal malabsorption syndrome that did not respond to conventional therapy. Combined therapy with high doses of prednisone and tetracycline hydrochloride resulted in weight gain, cessation of diarrhea, improved absorption of water, fat, and vitamin B12, and production of gastric acid after stimulation with histamine. Serum immunoglobulin levels, however, did not increase.

Topics: Achlorhydria; Adult; Age Factors; Body Weight; Celiac Disease; Cholecystokinin; Diarrhea; Drug Therapy, Combination; Humans; Immunoglobulin M; Immunologic Deficiency Syndromes; Malabsorption Syndromes; Male; Prednisone; Tetracycline; Vitamin B 12

Topics: Acne Vulgaris; Adolescent; Carcinoma, Squamous Cell; Female; Humans; Immunologic Deficiency Syndromes; Palatal Neoplasms; Tetracycline

Topics: Adolescent; Adult; Child; Diagnosis, Differential; Erythromycin; Humans; Immunologic Deficiency Syndromes; Male; Mycoplasma; Mycoplasma Infections; Pharynx; Pneumonia; Radiography; Tetracycline

Topics: Agranulocytosis; Amidines; Bone Marrow Examination; Dysgammaglobulinemia; Eosinophilia; gamma-Globulins; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologic Deficiency Syndromes; Immunotherapy; Infant; Leukocyte Count; Lymphocyte Activation; Male; Neutropenia; Pedigree; Pharynx; Phenyl Ethers; Pneumonia, Pneumocystis; Streptococcus; Tetracycline