tetracycline and Hypertension--Renal

Following the induction of three different forms of experimental hypertension, deposits of amyloid were found in the spleens of 5-20 per cent of the mice late in the course of the hypertension, Amyloidosis was found in nude (with genetical aplasia of the thymus) as well as in haired (normal) mice. The highest frequency of amyloidosis was observed in mice with hypertension due to partial infarction of one kidney and contralateral nephrectomy. The hypertensive vascular disease, involving lesion of the vessels and of the organs supplied by the affected vessels, is believed, to represent a stimulus for the reticulo endothelial system (RES) with development of amyloidosis as a secondary event.

Topics: Amyloidosis; Animals; Blood Pressure; Desoxycorticosterone; Female; Hypertension, Renal; Male; Mice; Mice, Inbred Strains; Mice, Nude; Nephrectomy; Sodium Chloride; Spleen; Splenic Diseases; Tetracycline

Topics: Animals; Blood Pressure; Body Weight; Female; Hypertension, Renal; Kidney Transplantation; Male; Rats; Rats, Inbred Strains; Tetracycline; Transplantation, Homologous; Urea

Oxytetracycline given to two patients with impaired renal function produced clinical deterioration and increasing azotaemia. Both patients improved when oxytetracycline was stopped. In general tetracycline should not be used in patients with poor renal function, but if it is necessary the blood urea level should be checked frequently.

Topics: Acute Kidney Injury; Aged; Bronchopneumonia; Diuresis; Haemophilus Infections; Humans; Hypertension, Renal; Male; Middle Aged; Natriuresis; Tetracycline; Uremia

Topics: Ankle; Biopsy; Blood Chemical Analysis; Bone Diseases; Fluorescence; Genetics, Medical; Hand Deformities; Hypertension; Hypertension, Renal; Joint Diseases; Kidney Diseases; Kidney Function Tests; Osteolysis; Pathology; Radiography; Surgical Procedures, Operative; Tetracycline; Urine; Wrist