tetracycline and Hepatitis

Topics: Abortion, Spontaneous; Antibodies; Bacteriuria; Chickenpox; Chromosome Aberrations; Chromosome Disorders; Congenital Abnormalities; Coxsackievirus Infections; Cytomegalovirus; Female; Fetal Death; Fetal Diseases; Hepatitis; Herpesviridae Infections; Hormones; Humans; Influenza, Human; Maternal-Fetal Exchange; Measles; Mumps; Obstetric Labor, Premature; Pneumonia; Poliomyelitis; Pregnancy; Pregnancy Complications, Infectious; Rubella; Smallpox; Smallpox Vaccine; Syphilis; Tetracycline; Toxoplasmosis; Toxoplasmosis, Congenital

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Gastrointestinal Diseases; Hepatitis; Humans; Kidney Diseases; Metabolic Diseases; Pharmacology; Photosensitivity Disorders; Pigmentation Disorders; Proteins; Tetracycline; Tooth Discoloration; Toxicology

A series of novel fluorine-containing lupane triterpenoid acid derivatives with fluoroaromatic amide moieties at the C-28 position (1-8) or with 2-(fluoroacyl)cyclopentane-1,3-dione fragments at the C-3 position (9-18) of lupane skeleton was synthesized. A simple synthesis of novel lupane triterpenoid hybrids with 2-(fluoroacyl)-2-cyclopenten-1-one moieties was developed. An interaction of 2-acyl-3-chlorocyclopent-2-en-1-ones, obtained from corresponding cyclic β-triketones, with methyl 3-amino-3-deoxybetulinate gave 3β-isomers (9-13) and 3α-isomers (14-18) of target hybrids, which were isolated as individual compounds. Anti-inflammatory properties of selected synthesized compounds were studied in vivo using the histamine-, concanavalin A- and sheep erythrocytes immunization-induced mouse paw edema models. The antioxidant activity was investigated in vivo on the model of tetracycline-induced hepatitis. Majority of synthesized fluorine-containing lupane triterpenoid acid derivatives exhibited significant anti-inflammatory and antioxidant effects. Among studied compounds, 3β-hybrid 11 with 2-perfluorobutanoyl-2-cyclopenten-1-one moiety was the most potent bioactive compound.

Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Betulinic Acid; Concanavalin A; Disease Models, Animal; Drug Design; Edema; Female; Fluorine; Hepatitis; Histamine; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Pentacyclic Triterpenes; Tetracycline; Triterpenes

Although liver involvement is frequently seen in brucellosis, acute hepatitis is a rare clinical entity. In its progress, haematological findings are non-specific and vary in respect to severity. In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia. A 19-year-old man presented with a 2-week history of fever, sweating, low back and leg pain, lassitude, loss appetite, nausea and vomiting. He gave a history of raw milk ingestion and animal contact. Physical examination showed signs of icteric skin and sclera, tenderness in the right hypochondriac region and hepatosplenomegaly. On admission to hospital, laboratory tests showed WBC 3500/mmc (polymorphs 63% and lymphocytes 33%), haemoglobin 13.8 g/dL, platelet 89000/mmc, erythrocyte sedimentation rate 19 mm/h, and C-reactive protein 21.7 mg/dL (N<0.8 mg/dL). Biochemical tests were as follows: AST 771 U/L, ALT 471 U/L, ALP 355 U/L, GGT 432 U/L, total bilirubin 2.61 mg/dL, direct bilirubin 1.45 mg/dL and albumin 3.7 g/dL. Viral hepatitis markers were found to be negative (HBsAg, anti-HBc total, anti-HBc IgM, anti-HAV IgM, and anti-HCV). Blood culture grew Brucella melitensis. Leukopenia and thrombocytopenia returned to normal levels at the 7th and 14th day of his admission, respectively. Liver function tests improved at the 28th day. Treatment of the brucellosis was performed with antibiotics (tetracycline 500 mg orally four times daily for 6 weeks and streptomycin 1 g IM once daily for 21 days). Finally, a case of brucellosis with acute hepatitis and bicytopenia was treated with a successful outcome. In conclusion, we suggest that due consideration be taken of bicytopenia/pancytopenia and acute hepatitis in brucellosis cases in Turkey, an endemic region.

Topics: Acute Disease; Adult; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Drug Therapy, Combination; Hepatitis; Humans; Leukopenia; Male; Streptomycin; Tetracycline; Thrombocytopenia; Treatment Outcome; Turkey

The clinical information of acute Q fever in Taiwan was limited. A clinical study of 109 adults with serologically documented acute Q fever in the past decade (1994-2005) at 3 referral hospitals in southern Taiwan was reported. Their clinical manifestations, laboratory findings, and clinical outcomes were analyzed. Males predominated (98, 90%). There is a significant correlation between monthly average temperature and case numbers of acute Q fever (r = 0.74, P = 0.006). Fever (99%), chills (69%), and headache (45%) were the common symptoms, and relative bradycardia (44/60, 73 %) was often noted. Acute hepatitis, defined as either serum aspartate aminotransferase >or=60 IU/L or alanine aminotransferase >or=78 IU/L, was found in 88 (85%) cases, and more than one-third (31/87, 36%) had hyperbilirubinemia (serum total bilirubin >or=1.4 mg/dL) at initial presentation. The intervals between initiation of appropriate therapy to defervescence were longer in patients with hyperbilirubinemia than those without hyperbilirubinemia, irrespective of tetracycline or fluoroquinolone therapy. Of note, 8 (7.3%) cases experienced a prolonged period of fever (>28 days). In southern Taiwan, the predominant presentation of acute Q fever is acute febrile illness with hepatitis with or without jaundice. Acute Q fever should be added to the list of differential diagnoses of patients with fever, headache, relative bradycardia, elevated serum aminotransferase levels, or prolongation of activated partial thromboplastin time, irrespective of jaundice.

Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Anti-Bacterial Agents; Aspartate Aminotransferases; Female; Fluoroquinolones; Hepatitis; Hospitals; Humans; Hyperbilirubinemia; Male; Middle Aged; Q Fever; Taiwan; Tetracycline

Numerous diseases can lead to multilocular lesions of the liver. The authors report a rare pediatric case of hepatic granulomas due to Pasteurella multocida: a 7-year-old girl with chronic fever was investigated by sonography and CT scan, demonstrating mesenteric lymph node enlargement and numerous small hepatic lesions. After surgical biopsy, histopathology of the liver specimens showed pyogenic granuloma, with serologic testing positive for Pasteurella multocida. Treatment with a tetracycline and corticosteroids was successful. Pasteurella multocida infection, despite its habitual benign course, should be suspected among differential diagnoses of lymphogranulomatous affections with hepatic involvement. No case of liver and lymph node foci in a child has been previously described.

Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Child; Diagnosis, Differential; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Granuloma; Hepatitis; Humans; Lymphatic Diseases; Pasteurella Infections; Pasteurella multocida; Tetracycline; Tomography, X-Ray Computed

Topics: Adult; Anti-Bacterial Agents; Anticoagulants; Autoantibodies; Cryoglobulins; Erythema Nodosum; Granuloma; Hepatitis; Humans; Immunoglobulin G; Immunoglobulin M; Male; Q Fever; Tetracycline

Four cases of the Curtis-Fitz-Hugh syndrome diagnosed laparoscopically and with microbiological or serological evidence of chlamydial pelvic infection are reviewed. The case histories emphasize the part played by renal angle and left upper quadrant symptoms. In one patient the surface of the spleen was affected by the same classical inflammation normally seen on the surface of the liver. In 3 patients bilateral or left-sided renal angle pain and tenderness constituted the presenting features, or a major manifestation, and in all patients renal tract investigations were entirely normal. The patient with laparoscopic perisplenitis also had perihepatitis and pelvic inflammation, the latter being florid in all cases. Perisplenitis and perinephritis are proposed as possible additional manifestations of this syndrome.

Topics: Adolescent; Adult; Chlamydia Infections; Chlamydia trachomatis; Female; Hepatitis; Humans; Pelvic Inflammatory Disease; Perinephritis; Peritonitis; Splenic Diseases; Syndrome; Tetracycline

A case of Fitz-Hugh Curtis syndrome caused by chlamydia is described in which the perihepatic and abdominal swelling also extended to the right perirenal tissue. The case was diagnosed on the basis of the clinical picture, the behaviour of anti-chlamydia serum antibodies, abdominal echography and laparoscopy. The infection was quickly cured by the administration of tetracycline.

Topics: Adult; Chlamydia Infections; Condylomata Acuminata; Female; Hepatitis; Hepatitis, Chronic; Heroin Dependence; Humans; Salpingitis; Syndrome; Syphilis; Tetracycline; Vaginal Neoplasms

The worldwide increase in the incidence of sexually transmitted diseases confronts the physician to an increasing extent with this group of infections. The high morbidity and the change in the clinical picture of gonorrhea, especially its asymptomatic form, give rise to extragenital complications which frequently lead the patient to the internal specialist in the first instance. Non-gonorrheal urethritis, in particular the infectious form, is undergoing intensive research. A number of organisms may be responsible, but a non-infectious origin must also be kept in mind. Syphilis is still important. The late stages of the disease have become rare thanks to highly effective therapy with antibiotics. The early stages of the infection, however, must always be considered in the differential diagnosis of any genital or anal affection, and also in generalized exanthemas of unknown origin. Homosexual transmission presents diagnostic problems of its own. Serological mass screening is essential. Interpretation of the results must take into account the different specificity of the various serological tests and their indication.

Topics: Erythromycin; Family Practice; Female; Gonorrhea; Hepatitis; Humans; Male; Neisseria gonorrhoeae; Penicillins; Proctitis; Sepsis; Sexually Transmitted Diseases; Syphilis; Tetracycline; Urethritis

Topics: Adult; Alcoholism; Ampicillin; Cephalothin; Chloramphenicol; Escherichia coli Infections; Fatty Liver; Female; Hepatitis; Humans; Klebsiella Infections; Liver Cirrhosis; Male; Methicillin; Middle Aged; Penicillins; Peritonitis; Pneumococcal Infections; Streptomycin; Syndrome; Tetracycline

Topics: Adipose Tissue; Brain Diseases; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Hepatitis; Humans; Infant; Kidney Diseases; Liver; Tetracycline; Virus Diseases

Topics: Anabolic Agents; Anemia, Aplastic; Blood Cell Count; Blood Transfusion; Chloramphenicol; Erythrocytes; Female; Follow-Up Studies; Germany, West; Glucocorticoids; Hemostatics; Hepatitis; Humans; Male; Mumps; Phenylbutazone; Plasma; Sulfonamides; Tetracycline; Time Factors; Tuberculosis

Topics: Adult; Aged; Bronchitis; Cholangitis; Chronic Disease; Drug Combinations; Female; Hepatitis; Humans; Male; Middle Aged; Oleandomycin; Pneumonia; Pyelonephritis; Tetracycline

Topics: Cholestasis; Fatty Liver; Female; Halothane; Hepatitis; Hepatitis A; Hepatitis B; Hepatitis B Antigens; Humans; Hysterectomy; Liver Diseases; Liver Function Tests; Liver Regeneration; Maternal Mortality; Methoxyflurane; Middle Aged; Postoperative Complications; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Tetracycline; Transfusion Reaction

Topics: Adolescent; Adult; Ampicillin; Anemia; Arthritis, Infectious; Arthritis, Reactive; Endocarditis, Bacterial; Female; Gonorrhea; Hepatitis; Humans; Male; Meningitis; Menstruation; Myocarditis; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin V; Pericarditis; Pregnancy; Pregnancy Complications, Infectious; Pyuria; Sepsis; Skin Diseases; Tetracycline

Topics: Anti-Bacterial Agents; Bile Duct Neoplasms; Bile Ducts; Biopsy; Cholangitis; Cholestasis; Colectomy; Colitis, Ulcerative; Fatty Liver; Follow-Up Studies; Hepatitis; Humans; Inflammation; Liver; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Diseases; Liver Function Tests; Portal System; Prednisolone; Sepsis; Tetracycline

Topics: Animals; Bile Ducts; Body Weight; Cecum; Cholangitis; Culture Media; Diet; Epididymis; Food Microbiology; Guinea Pigs; Hepatitis; Hyperplasia; Liver; Male; Mycotoxins; Necrosis; Penicillium; Plant Poisoning; Rats; Scrotum; Stomach Diseases; Tetracycline; Zea mays

Topics: Adult; Animals; Child; Female; Hepatitis; Humans; Male; Meningoencephalitis; Middle Aged; Myocarditis; Psittaciformes; Psittacosis; Respiratory Tract Infections; Tetracycline; Zoonoses

Topics: Adult; Cholestasis; Female; Hepatitis; Humans; Postoperative Complications; Pruritus; Tetracycline; Transaminases

Topics: Chemical and Drug Induced Liver Injury; Drug Therapy; Fatty Liver; Female; Hepatitis; Hepatitis A; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Tetracycline; Toxicology

Topics: Chemical and Drug Induced Liver Injury; Electrons; Hepatitis; Intestinal Obstruction; Microscopy; Microscopy, Electron; Pathology; Tetracycline; Toxicology

Topics: Amides; Calcium; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Edetic Acid; Fluorescence; Formates; Hepatitis; Hepatitis A; Metabolism; Necrosis; Pathology; Pharmacology; Promethazine; Rats; Research; Sulfhydryl Compounds; Tetracycline; Toxicology

Topics: Adult; Child; Chlamydia Infections; Communicable Diseases; Cortisone; Hepatitis; Hepatitis A; Humans; Prednisone; Tetracycline

Topics: Anesthesia; Atropine; Barbiturates; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Halothane; Hepatitis; Massive Hepatic Necrosis; Necrosis; Neomycin; Phenazocine; Postoperative Complications; Promethazine; Sigmoidoscopy; Surgical Procedures, Operative; Tetracycline; Toxicology

Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood Chemical Analysis; Cholecystitis; Clinical Enzyme Tests; Cystic Duct; Diagnosis, Differential; Hepatitis; Hepatitis A; Isocitrate Dehydrogenase; Liver Function Tests; Meperidine; Oxidoreductases; Tetracycline; Toxicology; Transaminases

Topics: Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Child; Chloramphenicol; Chlortetracycline; Fatty Liver; Female; Hepatitis; Oxytetracycline; Pregnancy; Pregnancy Complications; Prochlorperazine; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Candidiasis; Chemical and Drug Induced Liver Injury; Chloramphenicol; Diagnosis, Differential; Erythromycin; Halothane; Hepatitis; Hydrocortisone; Hypertension; Kidney Diseases; Metaraminol; Novobiocin; Pathology; Pyelonephritis; Surgical Procedures, Operative; Surgical Wound Infection; Tetracycline; Toxicology; Tracheotomy; Urinary Bladder Neoplasms; Urinary Diversion

Topics: Gastrointestinal Hemorrhage; Hematemesis; Hematuria; Hepatitis; Hepatitis A; Humans; Liver Diseases; Melena; Nephritis; Tetracycline

Topics: Anti-Bacterial Agents; Black People; Chemical and Drug Induced Liver Injury; Chlortetracycline; Demeclocycline; Female; Hepatitis; Hepatitis A; Humans; Kidney Diseases; Liver; Maternal-Fetal Exchange; Oxytetracycline; Pharmacology; Pregnancy; Pregnancy Complications; Tetracycline; Tetracyclines; Tooth; Toxicology; Urine

Topics: Adrenocorticotropic Hormone; Anti-Bacterial Agents; Diet; Diet Therapy; Hepatitis; Hepatitis A; Humans; Jaundice; Oxytetracycline; Pathology; Prednisone; Prognosis; Tetracycline; Therapeutics; Vitamin K; Vitamins

Topics: Anaphylaxis; Anti-Bacterial Agents; Aspirin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Colistin; Drug Eruptions; Drug Hypersensitivity; Hepatitis; Nitrofurantoin; Novobiocin; Penicillins; Polymyxins; Protein Synthesis Inhibitors; Serum Sickness; Streptomycin; Tetracycline; Toxicology

Topics: Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Hepatitis; Liver Diseases; Pathology; Pregnancy; Pregnancy Complications; Pyelonephritis; Tetracycline; Toxicology

Topics: Bilirubin; Blood Chemical Analysis; Child; Dexamethasone; Hepatitis; Hepatitis A; Humans; Hyperbilirubinemia; Liver Function Tests; Pharmacology; Spectrophotometry; Tetracycline

Topics: Anemia; Anemia, Aplastic; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacitracin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Chlortetracycline; Erythromycin; Hearing Disorders; Hepatitis; Kidney Diseases; Neomycin; Oleandomycin; Streptomycin; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Anti-Infective Agents; Candidiasis; Dermatology; Gastroenterology; Hepatitis; Hepatitis A; Humans; Nystatin; Respiratory Tract Infections; Tetracycline

Topics: Chloramphenicol; Folic Acid; Fructose; Hepatic Encephalopathy; Hepatitis; Hepatitis A; Humans; Liver Cirrhosis; Neomycin; Tetracycline; Vitamin B Complex

Topics: Carbon; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Growth; Hepatitis; Hepatitis A; Mineral Waters; Pharmacology; Rats; Research; Tetracycline; Toxicology; Water

Topics: Administration, Intravenous; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatitis; Histocytochemistry; Humans; Liver Diseases; Pathology; Pregnancy; Pregnancy Complications; Pyelonephritis; Research; Tetracycline

Topics: Biopsy; Clinical Laboratory Techniques; Hepatitis; Hepatitis A; Infectious Mononucleosis; Laboratories; Pathology; Prednisone; Splenomegaly; Tetracycline

Topics: Chemical and Drug Induced Liver Injury; Fatty Liver; Hepatitis; Insulin; Liver Glycogen; Pharmacology; Rats; Research; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Protein Synthesis Inhibitors; Tetracycline

Topics: Cholangitis; Hepatitis; Hepatitis A; Humans; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Protein Synthesis Inhibitors; Tetracycline