tetracycline and Hearing-Loss--Sensorineural

In persons suffering from occupational pathology due to antibiotics, the clinical picture of neurosensory hypoacusis is described and the pathogenetic mechanisms of the illness are unraveled. Perceptive bradyacusia occurs in the presence of organic pathology of the nervous system, internal organs and skin. In addition to the toxic action, antibiotics exert an allergenic action. As a result there develops allergic cerebral vasculitis. The latter one is an additional pathological factor giving rise to neurosensory hypoacusis in occupational pathology induced by antibiotics. The data obtained can be used in administration of pathogenetic therapy and in expert medical evaluation of the working capacity.

Topics: Adult; Air Pollutants, Occupational; Anti-Bacterial Agents; Drug Industry; Female; Hearing Loss, Sensorineural; Humans; Male; Middle Aged; Nursing Staff, Hospital; Occupational Diseases; Penicillins; Russia; Streptomycin; Tetracycline

This article describes a patient with documented sudden, severe, unilateral, sensorineural hearing loss occurring four days after audiometric evaluation for nonspecific complaints. He was hospitalized immediately; treatment included I.V. histamine and oral steroid therapy. He noted improvement within two days, and serial audiometry has documented recovery to the initial audiometric levels. We believe that this documentation of recovery to pre-illness levels is unique.

Topics: Adult; Audiometry; Bed Rest; Dexamethasone; Drug Combinations; Hearing Loss, Sensorineural; Hearing Loss, Sudden; Histamine; Humans; Hydrochlorothiazide; Male; Tetracycline; Triamterene