tetracycline and Growth-Disorders

Topics: Adrenocorticotropic Hormone; Adult; Age Factors; Animals; Birth Weight; Body Height; Body Weight; Brain; Child Development; Child, Preschool; Cytomegalovirus Infections; DNA; DNA Replication; Embryonic and Fetal Development; Female; Gestational Age; Growth; Growth Disorders; Growth Hormone; Humans; Hypoxia; Infant; Infant, Newborn; Maternal-Fetal Exchange; Nutrition Disorders; Pregnancy; Rats; RNA; Rubella; Tetracycline

Topics: Adolescent; Age Factors; Animals; Bone Development; Cartilage; Child; Child, Preschool; Epiphyses; Femoral Fractures; Femur; Growth Disorders; Humans; Humeral Fractures; Humerus; Infant; Joint Dislocations; Osteogenesis; Osteotomy; Rabbits; Radius; Tetracycline; Tibia

We have previously demonstrated that excessive mitochondrial reactive oxygen species caused by mutations in the SDHC subunit of Complex II resulted in premature death in C. elegans and Drosophila, tumors in mouse cells and infertility in transgenic mice. We now report the generation and initial characterization of conditional transgenic mice (Tet-mev-1) using our uniquely developed Tet-On/Off system, which equilibrates transgene expression to endogenous levels. The mice experienced mitochondrial respiratory chain dysfunction that induced reactive oxygen species overproduction. The mitochondrial oxidative stress resulted in excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice.

Topics: Animals; Animals, Newborn; Disease Models, Animal; Gene Expression Regulation; Growth Disorders; Humans; Infant, Low Birth Weight; Infant, Newborn; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Mutation; NIH 3T3 Cells; Reactive Oxygen Species; Succinate Dehydrogenase; Tetracycline; Transgenes

A brother and sister with multifocal recurrent periostitis are presented. Their disease started at an early age and manifested itself as an episodic migrating arthropathy. At roentgenography, reversible solid periosteal reactions were visible along large tubular bones. Scintigraphic and histological investigations revealed a sterile osteitis and thickened periosteum, but there was no indication of a viral infection. The girl experienced spontaneous amelioration after puberty; the boy improved markedly on colchicine.

Topics: Adrenal Cortex Hormones; Child, Preschool; Colchicine; Female; Growth Disorders; Humans; Infant; Male; Periostitis; Prednisone; Tetracycline; Tibia

Topics: Animals; Bone Resorption; Epiphyses; Femur Head; Growth Disorders; Rabbits; Swine; Tetracycline