tetracycline and Granulomatous-Mastitis

Granulomatous mastitis is a rare inflammatory disease of varying etiology. Tuberculosis and cystic neutrophilic granulomatous mastitis caused by Corynebacterium are the best-established infectious examples. Despite the increasing incidence of Rickettsia-related diseases worldwide, granulomatous inflammation of breast parenchyma caused by Rickettsia has not yet been reported. We present a unique case of bilateral granulomatous mastitis documented with mammography, magnetic resonance imaging and core-needle biopsy. The rickettsial etiology of the disease was proved with specific immunohistochemistry and confirmed with DNA extraction, PCR and serology. The lesions completely resolved after a full-course tetracycline treatment. This case report widens the knowledge about the possible clinical manifestations of Rickettsia infection and adds a new bacterium to the list of etiological factors causing granulomatous mastitis.

Topics: Anti-Bacterial Agents; Bacteriological Techniques; Biopsy, Large-Core Needle; Female; Granulomatous Mastitis; Humans; Magnetic Resonance Imaging; Mammography; Middle Aged; Rickettsia; Rickettsia Infections; Tetracycline; Treatment Outcome