tetracycline and Granuloma

Actinomycosis is a chronic, specific inflammation which is characterized by suppuration, abscess formation, tissue fibrosis and granuloma formation. Actinomycosis has three main forms (cervicofacial, which is the most frequent, approximately 60%, pulmonary and abdominal), but other regions of the body can be involved, too (e.g. neck, ovaries, bones), that is why its differential diagnosis becomes more and more relevant. Regarding its treatment, the majority of authors recommends the combination of surgical and antibiotic treatment. The authors of this article present a typical case of cervicofacial actinomycosis, in which the authors used the combination of surgical and antibiotic treatment. As a result of the treatment the healing process was completed successfully and without complications.

Topics: Actinomycosis; Actinomycosis, Cervicofacial; Aged; Anti-Bacterial Agents; Chloramphenicol; Clindamycin; Cutaneous Fistula; Diagnosis, Differential; Granuloma; Humans; Male; Penicillin G; Penicillin V; Tetracycline; Treatment Outcome

Granulomatous periorificial dermatitis (GPD) is a distinct facial eruption in prepubertal children that should be distinguished from granulomatous rosacea, perioral dermatitis, and cutaneous sarcoidosis. We describe a case of GPD and review the key distinguishing features of this condition.

Topics: Anti-Bacterial Agents; Child; Dermatitis, Perioral; Diagnosis, Differential; Granuloma; Humans; Male; Steroids; Tetracycline

Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Granuloma; Hemorrhagic Disorders; Humans; Liver; Liver Diseases; Pharmaceutical Preparations; Tetracycline

Osteomyelitis due to Coxiella burnetii infection is a rare condition in adults. We report the case of a healthy young man presenting with subacute osteomyelitis of the left cheek bone, evolving gradually after an episode of acute febrile illness. Histological evaluation confirmed subacute granulomatous inflammation. Despite antibody titres not reaching the standard cut-off for chronic Q fever (phase I IgG 1/160, phase II IgG 1/2560), osteomyelitis was radiologically and histologically confirmed. A 6-month course of doxycycline/hydroxychloroquine brought clinical and radiological cure while various conventional antibiotic treatments had failed to improve the clinical condition. Currently, at 6-month follow-up, no relapse has occurred and antibody titres have declined. A shorter course of doxycycline/hydroxychloroquine than that used for chronic Q fever osteomyelitis may be sufficient to treat subacute Q fever osteomyelitis in some cases.

Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Doxycycline; Granuloma; Humans; Hydroxychloroquine; Magnetic Resonance Imaging; Male; Osteomyelitis; Q Fever; Tetracycline; Young Adult; Zygoma

Topics: Child; Dermatitis, Perioral; Diagnosis, Differential; Facial Dermatoses; Female; Granuloma; Humans; Isotretinoin; Metronidazole; Skin Diseases, Papulosquamous; Tetracycline

A 60-year-old man with common variable immunodeficiency presented with a 7-year history of violaceous plaques and papules on the thighs, arms and trunk. In the preceding 2 years he had developed new lesions on both hands. He had been previously diagnosed with sarcoidosis on the basis of skin and visceral histology, but subsequent opinion was that these were sarcoid-like granulomas rather than being representative of true sarcoidosis. Biopsy of the hand lesions showed necrotizing granulomas, and a single acid-fast bacillus (AFB) was identified on Wade-Fite stain. Subsequent repeat tissue biopsies for histology, culture and polymerase chain reaction testing failed to confirm the presence of mycobacterial organisms and it was felt that the organism was a contaminant introduced during tissue processing. The hand lesions responded well to intralesional injections of triamcinolone acetonide 10 mg/mL and oral tetracycline 500 mg b.d. was later introduced with a good clinical response. The diagnostic dilemma of finding granulomatous inflammation in a patient with common variable immunodeficiency, and the significance of a single AFB on histology are discussed. The treatment of sarcoid-like granulomas with tetracycline therapy is also commented on.

Topics: Anti-Bacterial Agents; Common Variable Immunodeficiency; Diagnosis, Differential; Glucocorticoids; Granuloma; Humans; Male; Middle Aged; Sarcoidosis; Skin; Skin Diseases; Tetracycline; Tuberculosis, Cutaneous

Topics: Anti-Infective Agents; Drug Therapy, Combination; Granuloma; Humans; Leprostatic Agents; Leprosy; Minocycline; Ofloxacin; Rifampin; Tetracycline

Numerous diseases can lead to multilocular lesions of the liver. The authors report a rare pediatric case of hepatic granulomas due to Pasteurella multocida: a 7-year-old girl with chronic fever was investigated by sonography and CT scan, demonstrating mesenteric lymph node enlargement and numerous small hepatic lesions. After surgical biopsy, histopathology of the liver specimens showed pyogenic granuloma, with serologic testing positive for Pasteurella multocida. Treatment with a tetracycline and corticosteroids was successful. Pasteurella multocida infection, despite its habitual benign course, should be suspected among differential diagnoses of lymphogranulomatous affections with hepatic involvement. No case of liver and lymph node foci in a child has been previously described.

Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Child; Diagnosis, Differential; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Granuloma; Hepatitis; Humans; Lymphatic Diseases; Pasteurella Infections; Pasteurella multocida; Tetracycline; Tomography, X-Ray Computed

Topics: Adult; Anti-Bacterial Agents; Anticoagulants; Autoantibodies; Cryoglobulins; Erythema Nodosum; Granuloma; Hepatitis; Humans; Immunoglobulin G; Immunoglobulin M; Male; Q Fever; Tetracycline

We describe the clinicopathologic features of the papular form of granulomatous acne rosacea of the eyelids. This unusual cutaneous disorder is typified by painless eruptions of reddish to yellowish brown, occasionally ulcerative papules symmetrically distributed around the eyelids, lower part of the forehead, nasolabial folds, and upper lip. Histopathologically, the lesions display caseating and noncaseating dermal granulomas that mimic those seen in tuberculosis, tuberculoid leprosy, sarcoidosis, and other diseases. The disorder responds well to systemic tetracycline therapy but may involute spontaneously during a period of months to years. The distinction of this disorder from other dermal granulomatous diseases, such as tuberculosis, leprosy, syphilis, and foreign bodies, is important because of the different therapeutic implications.

Topics: Aged; Eyelid Diseases; Female; Granuloma; Humans; Rosacea; Tetracycline

A persistent periocular dermatitis resulting from the prolonged use of topical fluorinated corticosteroids that resembled the perioral variety was observed in three patients. All topical therapy was ineffective until systemic tetracycline was administered.

Topics: Drug Eruptions; Eyelid Diseases; Facial Dermatoses; Female; Granuloma; Humans; Male; Skin; Steroids, Fluorinated; Tetracycline

Two cases of periocular micropapular dermatitis with sarcoid-like granulomatous histology are reported. After 8-12 weeks treatment with tetracycline the cutaneous eruptions of both patients cleared. The condition is equivalent to perioral dermatitis.

Topics: Adult; Biopsy; Facial Dermatoses; Female; Granuloma; Humans; Male; Skin; Tetracycline

Multiple granulomata pyogenica are usually satellites of a primary lesion recently treated unsuccessfully. Disseminated pyogenic granulomas are very uncommon. In our case report, we describe a young man with six granulomata pyogenica over the chest, after treating his acne with tetracycline and vitamin A acid. In the discussion, we include infection, trauma and vitamin A acid as factors which can induce the vascular tumor in the region of a vascular dysplasia.

Topics: Acne Vulgaris; Adult; Granuloma; Humans; Male; Tetracycline; Tretinoin; Vitamin A

Topics: Animals; Antibodies; Child; Granuloma; Humans; Male; Ointments; Skin Diseases; Tetracycline

Topics: Bacterial Infections; Calymmatobacterium; Diagnosis, Differential; Female; Granuloma; Humans; Middle Aged; Neoplasms; Prognosis; Tetracycline

Topics: Adult; Amebiasis; Amebicides; Child, Preschool; Colonic Diseases; Entamoeba histolytica; Granuloma; Humans; Infant; Intestinal Perforation; Intussusception; Male; Metronidazole; Peritonitis; Skin Diseases, Infectious; Tetracycline

Five cases of Mycobacterium marinum skin infections were successfully treated with 2 gm of tetracycline hydrochloride daily for periods from four to 12 weeks. In each case, the isolated M marinum was sensitive in vitro to tetracycline at levels from 25 to 50 microgram/ml. Tetracycline is recommended as treatment for extensive or sporotrichoid M marinum infections.

Topics: 4-Aminobenzoic Acid; Adult; Ethambutol; Granuloma; Humans; Isoniazid; Male; Microbial Sensitivity Tests; Middle Aged; Mycobacterium; Mycobacterium Infections; Rifampin; Skin Diseases, Infectious; Streptomycin; Tetracycline

Topics: Adult; Diagnosis, Differential; Doxycycline; Female; Granuloma; Granuloma Inguinale; Humans; Tetracycline

Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Dihydroxyphenylalanine; Enzyme Induction; Fatty Liver; Female; Granuloma; Halothane; Hepatomegaly; Humans; Male; Middle Aged; Oxyphenisatin Acetate; Pregnancy; Sulfonamides; Tetracycline

Topics: Agglutinins; Animals; Antibodies; Ciliary Body; Complement Fixation Tests; Crystallins; Eosinophils; Epithelial Cells; Freund's Adjuvant; Granuloma; Histiocytes; Hypersensitivity; Injections, Subcutaneous; Iris; Lens, Crystalline; Lymphocytes; Male; Phagocytosis; Plasma Cells; Precipitins; Rats; Tetracycline; Uveitis; Uveitis, Anterior

Topics: Adult; Aged; Arm; Female; Fingers; Foot Dermatoses; Granuloma; Hand Dermatoses; Humans; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Skin Diseases; Tetracycline; Toes

Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Bacterial Infections; Brucella abortus; Brucellosis; Diagnosis, Differential; Granuloma; Humans; Mycobacterium tuberculosis; Synovial Membrane; Tetracycline; Tuberculosis, Osteoarticular

Topics: Abscess; Acute Disease; Adolescent; Chronic Disease; Enterobacteriaceae Infections; Granuloma; Humans; Knee; Male; Methylamines; Serratia marcescens; Skin Diseases, Infectious; Suppuration; Tetracycline

Topics: Animals; Chymotrypsin; Drug Interactions; Endopeptidases; Granuloma; Injections, Intramuscular; Injections, Intraperitoneal; Kinetics; Peptide Hydrolases; Rats; Tetracycline; Time Factors

Topics: Diagnosis, Differential; Drug Eruptions; Erythema Multiforme; Granuloma; Tetracycline

Topics: Acute Disease; Child; Cholesteatoma; Cholesterol; Chronic Disease; Drug Resistance, Microbial; Ear, Middle; Granuloma; Haemophilus Infections; Hearing Disorders; Humans; Mastoiditis; Mucous Membrane; Ossification, Heterotopic; Otitis Media; Streptococcal Infections; Tetracycline

Topics: Antibodies; Bacteria; Bone Diseases; Child, Preschool; Female; Gentamicins; Granuloma; Humans; Lymphatic Diseases; Male; Necrosis; Tetracycline; Tonsillitis

Topics: Adult; Diagnosis, Differential; Female; Granuloma; Humans; Middle Aged; Ointments; Rosacea; Sarcoidosis; Tetracycline; Tuberculosis, Cutaneous

Topics: Adult; Animals; Biopsy; Blood Sedimentation; Diagnosis, Differential; Female; Fever; Granuloma; Guinea Pigs; Hodgkin Disease; Humans; Leukocytosis; Lymphadenitis; Mycobacterium tuberculosis; Pelvis; Sarcoidosis; Tetracycline; Tuberculin Test; Tuberculosis, Lymph Node

Topics: Animals; Demeclocycline; Exudates and Transudates; Granuloma; Rats; Tetracycline

Topics: Anti-Bacterial Agents; Granuloma; Protein Synthesis Inhibitors; Skin; Tetracycline

Topics: Granuloma; Granuloma, Lethal Midline; Granulomatosis with Polyangiitis; Hodgkin Disease; Humans; Rickettsia Infections; Serologic Tests; Tetracycline

Topics: Anti-Bacterial Agents; Cervix Uteri; Female; Granuloma; Granuloma Inguinale; Humans; Medical Records; Pregnancy; Tetracycline