tetracycline and Granuloma-Inguinale

Topics: Anti-Bacterial Agents; Chancroid; Female; Gonorrhea; Granuloma Inguinale; Humans; Infant; Infant, Newborn; Lymphogranuloma Venereum; Male; Penicillins; Pregnancy; Sexually Transmitted Diseases; Syphilis; Syphilis, Congenital; Tetracycline

An unusual American epidemic consisting of twenty cases of granuloma inguinale is chronicled. Evidence from this series supports the venereal transmission of the disorder. Trimethoprim/sulfamethoxazole proved to be a safe and effective therapy.

Topics: Administration, Oral; Adult; Balanitis; Clinical Trials as Topic; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Granuloma Inguinale; Homosexuality; Humans; Male; Middle Aged; Sex Work; Sulfamethoxazole; Tetracycline; Texas; Time Factors; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

A 23-year-old male presented with oral ulcers. Tissue smear showed Donovan bodies. The patient was treated with oral tetracycline.

Topics: Adult; Anti-Bacterial Agents; Eunuchism; Granuloma Inguinale; Humans; Male; Mouth Diseases; Tetracycline

A case of extragenital donovanosis in a patient with AIDS is reported from Zimbabwe. Despite the rarity of donovanosis in Zimbabwe it is important that health workers are familiar with this disease since donovanosis increases the risk of HIV transmission and appropriate treatment is often successful even in patients with severe immunodeficiency.

Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Antifungal Agents; Facial Dermatoses; Granuloma Inguinale; Humans; Ketoconazole; Male; Tetracycline

Topics: Adult; Combined Modality Therapy; Female; Granuloma Inguinale; Humans; Tetracycline; Vulva; Vulvar Diseases

Topics: Drug Combinations; Granuloma Inguinale; Humans; Sulfamethoxazole; Tetracycline; Texas; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

A case of granuloma inguinale of the oral cavity clinically resembling actinomycosis is reported. This condition should be considered in the differential diagnosis of chronic ulcerative lesions of the mouth, especially in patients with associated genital ulcers.

Topics: Actinomycosis; Adult; Diagnosis, Differential; Drug Combinations; Female; Granuloma Inguinale; Humans; Mouth Diseases; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Vulvar Diseases

Granuloma inguinale, considered to be a venereal disease, has a world-wide distribution but is more prevalent in tropical and subtropical regions. A number of patients presenting with typical features of this disease, characterized in particular by a beefy-red exuberant appearance of the lesions, have been treated at Shongwe Hospital in Kangwane in the Eastern Transvaal. In 43 of these patients (27 male and 16 female), nearly all in the sexually active age group of 18-41 years, the diagnosis was confirmed by demonstration of typical Donovan bodies. These patients responded well to treatment with tetracycline, but in some the lesions recurred and required further treatment. The chronicity of the lesions should alert the clinician to the possibility of granuloma inguinale, a condition which appears to be more prevalent in this region than previously recognized.

Topics: Adolescent; Adult; Female; Granuloma Inguinale; Humans; Male; South Africa; Tetracycline

A case of Hemophilus ducreyi infection clinically resembling granuloma inguinale is reported. Culture of the causative organism permitted a definitive diagnosis to be made. Combined treatment with tetracycline and sulphamethizole/trimethoprim rapidly cleared the infection.

Topics: Adult; Chancroid; Diagnosis, Differential; Drug Combinations; Drug Therapy, Combination; Granuloma Inguinale; Humans; Male; Skin Ulcer; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Diagnosis, Differential; Female; Gentamicins; Granuloma Inguinale; Humans; Male; Tetracycline

Thirteen cases of granuloma inguinale were diagnosed in just over a twelve-month period at the Australian Government Health Laboratory and the General Hospital, Townsville. Seven patients were males, four of whom were immates of Her Majesty's Prison, Townsville. Two of the patients were married, and two were sisters. All the female patients were pregnant at the time of diagnosis. The provisional diagnosis was confirmed by the presence of intracytoplasmic Donovan bodies in crushed tissue smears stained with Wright's stain and pinacyanole. The diagnosis of granuloma inguinale could not be reliably made from sections of formalin-fixed tissue alone. The clinical findings, methods of laboratory diagnosis, management and treatment of this disease are also described with an added emphasis on treatment during pregnancy.

Topics: Adult; Anti-Bacterial Agents; Australia; Female; Granuloma Inguinale; Humans; Male; Pregnancy; Pregnancy Complications, Infectious; Tetracycline

Topics: Adult; Diagnosis, Differential; Doxycycline; Female; Granuloma; Granuloma Inguinale; Humans; Tetracycline

A female patient suffering from donovanosis of the oral cavity without associated lesions elsewhere is reported. The importance of remembering donovanosis in the differential diagnosis of chronic granulomatous ulceration of the mouth is emphasized.

Topics: Adult; Female; Granuloma Inguinale; Humans; Inclusion Bodies; Macrophages; Mouth Diseases; Tetracycline

Granuloma inguinale is an uncommon infectious granulomatous disease of the inguinale area that can insidiously engulf and mutilate tissue. The reported case of granuloma inguinale demonstrated the painless progression of the disease to destroy most penile, scrotal, and inguinal tissue and also showed the subsequent satisfactory therapeutic result with antibiotic treatment. Light microscopy of plastic-embedded thin-sectioned tissue specimens allowed clear demonstration of the Donovan bodies and may be valuable in diagnosis.

Topics: Granuloma Inguinale; Humans; Male; Middle Aged; Penis; Perineum; Remission, Spontaneous; Scrotum; Tetracycline

Topics: Chancroid; Drug Combinations; Erythromycin; Female; Gonorrhea; Granuloma Inguinale; Humans; Injections, Intramuscular; Kanamycin; Lymphogranuloma Venereum; Male; Metronidazole; Penicillin Resistance; Penicillins; Rifampin; Sexually Transmitted Diseases; Streptomycin; Sulfamethoxazole; Sulfonamides; Syphilis; Tetracycline; Trimethoprim; Urethritis

Topics: Diagnosis, Differential; Granuloma Inguinale; Humans; Madagascar; Male; Penile Diseases; Tetracycline

Topics: Aged; Carcinoma; Diagnosis, Differential; Female; Granuloma Inguinale; Humans; Streptomycin; Tetracycline; Uterine Cervical Neoplasms

Topics: Chlamydia Infections; Female; Granuloma Inguinale; Humans; Lymphogranuloma Venereum; Male; Mycoplasma Infections; Proctitis; Sexually Transmitted Diseases; Tetracycline; Urethritis; Uterine Cervicitis; Vaginitis

Topics: Adolescent; Adult; Bacteria; Black People; Carcinoma, Squamous Cell; Female; Granuloma Inguinale; Homosexuality; Humans; Male; Microscopy, Electron; Middle Aged; Penile Neoplasms; Staining and Labeling; Syphilis; Tetracycline

Topics: Adult; Chloramphenicol; Granuloma Inguinale; Humans; Male; Streptomycin; Tetracycline

Topics: Adult; Carcinoma, Squamous Cell; Diagnosis, Differential; Granuloma Inguinale; Humans; Male; Middle Aged; Penile Diseases; Staining and Labeling; Streptomycin; Tetracycline

Topics: Adult; Granuloma Inguinale; Humans; Male; Tetracycline

Topics: Anti-Bacterial Agents; Chancroid; Granuloma Inguinale; Humans; Lymphogranuloma Venereum; Pathology; Podophyllum; Sexually Transmitted Diseases; Tetracycline

Topics: Complement Fixation Tests; Granuloma Inguinale; Homosexuality; Homosexuality, Male; Humans; Lymphogranuloma Venereum; Male; Protein Synthesis Inhibitors; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Cervix Uteri; Female; Granuloma; Granuloma Inguinale; Humans; Medical Records; Pregnancy; Tetracycline

Topics: Anti-Bacterial Agents; Granuloma Inguinale; Humans; Protein Synthesis Inhibitors; Tetracycline; Tetracyclines

Topics: Anti-Bacterial Agents; Granuloma Inguinale; Humans; Lymphogranuloma Venereum; Protein Synthesis Inhibitors; Tetracycline