tetracycline and Genital-Diseases--Male

The role of Chlamydia trachomatis in infections of the male genital tract is reviewed. The organism is an important cause of non-gonococcal urethritis, post-gonococcal urethritis and epididymitis, but does not appear to play a major part in the pathogenesis of chronic abacterial prostatitis or in proctitis in anoreceptive homosexual men.

Topics: Chlamydia Infections; Chlamydia trachomatis; Epididymitis; Genital Diseases, Male; Humans; Male; Tetracycline; Urethritis

Topics: Arthritis; Drug Resistance, Microbial; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Mycoplasma; Mycoplasma Infections; Pregnancy; Pregnancy Complications, Infectious; Respiratory Tract Infections; Sepsis; Tetracycline; Urinary Tract Infections

Topics: Acute Disease; Adult; Age Factors; Analgesics; Epididymitis; Genital Diseases, Male; Gonorrhea; Humans; Male; Radionuclide Imaging; Scrotum; Sodium Pertechnetate Tc 99m; Spermatic Cord Torsion; Technetium; Testicular Neoplasms; Testis; Tetracycline; Trachoma; Ultrasonography

The trachoma and LGV organisms, the human pathogens of the species C. trachomatis, cause oculogenital infections and disease syndromes of the eye and genital tract. The incidence of the most prominent disease, endemic trachoma with eye-to-eye transmission, is decreasing all over the world. At the same time there is increasing recognition of high-frequency venereal infections with trachoma organisms and of the genital disease and occasional ocular disease that they cause. Laboratory techniques for diagnosis and investigation are improving, but work with these interesting intermediate agents remains more difficult than that with many other microorganisms. Proper recognition of the diseases is important because specific therapy is available.

Topics: Adolescent; Adult; Animals; Antigens, Bacterial; Child; Child, Preschool; Chlamydia; Chlamydia Infections; Disease Models, Animal; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Infant; Infant, Newborn; Lymphogranuloma Venereum; Male; Middle Aged; Sulfonamides; Tetracycline; Trachoma; United States

To study the treatment efficacy of tetracyclines and azithromycin in Mycoplasma genitalium positive patients attending an STD clinic.. All M genitalium positive patients (34 men and 26 women) attending an STD clinic during a 6 month period were treated with antibiotics. All patients known to be partners of M genitalium positive patients and those who were M genitalium positive, but not initially treated, were treated with azithromycin. Patients with urethritis and/or cervicitis were treated with tetracyclines before their M genitalium status was known.. 10 of 14 women (71%) and 10 of 16 men (63%) treated with tetracyclines were M genitalium positive at follow up, whereas all patients treated with azithromycin (16 men and 20 women) were M genitalium negative, at the 4 week follow up visit.. These results suggest that tetracyclines are not sufficient to eradicate M genitalium. Randomised controlled treatment trials are urgently needed.

Topics: Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Mycoplasma; Mycoplasma Infections; Polymerase Chain Reaction; Tetracycline

Topics: Anti-Bacterial Agents; Chlamydia trachomatis; Doxycycline; Erythromycin; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Lymphogranuloma Venereum; Male; Pregnancy; Pregnancy Complications, Infectious; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination; Ulcer

We report a male patient with severe penicillin-resistant gonococcal urethritis, coinfected with a tetracycline resistant strain of ureaplasma urealyticum. Ureaplasmas are frequently involved in gonococcal urethritis and commonly this organism may persist after the penicillin therapy causing a "post-gonoccal-urethritis" (PGU). Additional treatment with tetracyclines prove to be successful in most of these patients except in cases of tetracycline resistance in ureaplasma urealyticum. In a case like this erythromycin may be useful, a drug to which these isolates are sensitive. The microbiological and genetic feature of a tetracycline resistant strain of ureaplasma urealyticum is presented in detail. The clinical and epidemiological importance of these results are discussed and compared with the literature.

Topics: Adult; Genital Diseases, Male; Gonorrhea; Humans; Male; Mycoplasma Infections; Neisseria gonorrhoeae; Penicillin Resistance; R Factors; Tetracycline; Ureaplasma

Objectives criteria of semen quality were evaluated in 243 men treated for Ureaplasma urealyticum genital tract infection with 1 of 4 different antibiotic regimens. Significant improvement was observed in motility, quantity, quality, and percentages of oval and small forms. Doxycycline, whether used for 2 or 4 weeks, at a dosage of 100 mg, twice daily resulted in the same cure rate (79 and 81 per cent, respectively). Tetracycline regimens of 500 mg. 3 times daily for 2 or 4 weeks had significantly inferior cure rates (17 and 55 per cent, respectively). These findings suggest that antibiotic therapy could be valuable in improving semen quality when Ureaplasma is isolated, and that followup culture for the organism should decide the endpoint in therapy, since resistant strains for doxycycline and tetracycline are emerging.

Topics: Bacterial Infections; Doxycycline; Genital Diseases, Male; Humans; Male; Sperm Motility; Spermatozoa; Tetracycline; Ureaplasma

Of 97 patients with genital ulcers attending a special treatment clinic in Nairobi, Kenya, 60 harboured Haemophilus ducreyi, four herpes simplex virus, and five Neisseria gonorrhoeae. Eleven patients had serological evidence of syphilis; of these one case was confirmed by darkfield microscopy. In the remaining cases no aetiological agent was identified. An enriched chocolate agar with vancomycin and serum was a useful medium for primary isolation of H ducreyi. Tetracycline was generally ineffective in the treatment of ulcers, but sulfadimidine was successful in almost 80% of cases.

Topics: Adult; Chancroid; Female; Genital Diseases, Male; Haemophilus ducreyi; Humans; Kenya; Male; Neisseria gonorrhoeae; Sulfamethazine; Tetracycline; Ulcer

The incidence of chlamydial organisms in early morning urine specimens obtained from 53 men and 50 women without evidence of urinary tract pathology was 2 per cent in both groups. Early morning urine specimens and/or prostatic fluid or semen was examined in 50 patients with chronic prostatitis and 39 (56 per cent) yielded this organism. Of 31 patients with epididymo-orchitis the early morning urine specimens yielded chlamydiae in 12 (39 per cent) and in those with the acute form of disease the incidence was 56 per cent. The chlamydia recovery rate was 27 per cent in 119 women with cystourethritis. Within these groups of patients approximately 50 per cent of sexual partners had urine cultures positive for chlamydia. The importance of reinfection and the need for careful treatment of patients and consort should be stressed. An appropriate transport medium is necessary for specimen collection and adequate culture facilities are required to achieve effective chlamydial recovery. Trimethoprim-sulfamethoxazole and tetracycline were used effectively in the study for primary and secondary drug therapy.

Topics: Adolescent; Adult; Aged; Child; Chlamydia; Chlamydia Infections; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Middle Aged; Semen; Sulfamethoxazole; Tetracycline; Trimethoprim; Urinary Tract Infections

Topics: Adult; Chlamydia Infections; Erythromycin; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Infant, Newborn; Male; Tetracycline; Urethritis; Urinary Tract Infections

Topics: Actinomycosis; Administration, Oral; Genital Diseases, Male; Humans; Injections, Intravenous; Male; Middle Aged; Penicillins; Scrotum; Tetracycline

Semen characteristics were evaluated in 64 men visiting our infertility clinic before and after the eradication of genital infection with Ureaplasma urealyticum. Semen quality was also analyzed in 9 men who were unsuccessfully treated for genital Ureaplasma infection, 11 men who had negative cultures and received no treatment, and 11 men who had negative cultures but received empirical antibiotic therapy. A significant improvement in spermatozoal motility (both the speed of forward progession and the percentage of motile cells) was found in the group that was successfully treated for Ureaplasma infection. Improvements were not demonstrated in any of the other patient groups. A correlation was found between improved motility and a decrease in certain abnormal features of seminal cytology that appear to be associated with Ureaplasma genital infection.

Topics: Cell Count; Doxycycline; Genital Diseases, Male; Humans; Infertility, Male; Male; Semen; Sperm Motility; Spermatozoa; Tetracycline; Ureaplasma

Topics: Anti-Bacterial Agents; Cell Membrane Permeability; Chlamydia; Erythromycin; Genital Diseases, Male; Humans; Male; Mycoplasma; Prostatitis; Seminal Vesicles; Tetracycline; Tinidazole; Trichomonas Infections

We have briefly presented practical approaches to the management of the most common disorders caused by sexually transmitted pathogens, including pelvic inflammatory disease, urethritis in men, genital lesions, vaginal discharge, and syphilis. Guidelines for the management of gonorrhea may change if penicillin-resistant strains become more prevalent. Areas which require further research include the treatment of genital herpes and the prevention of recurrences, the treatment of nonspecific vaginitis, and definition of the importance of metronidazole toxicity.

Topics: Anti-Bacterial Agents; Candidiasis, Vulvovaginal; Female; Genital Diseases, Female; Genital Diseases, Male; Gonorrhea; Herpesviridae Infections; Humans; Male; Pelvic Inflammatory Disease; Penicillin G; Pharyngeal Diseases; Pregnancy; Sexually Transmitted Diseases; Syphilis; Tetracycline; Urethritis; Vaginitis

Asymptomatic gonorrhea is significantly common in both males and females. A patient with one sexually transmitted disease (STD) is more likely to have an asymptomatic gonorrheal infection. A physician seeing a patient with an STD should obtain a culture for Neisseria gonorrhoeae to check for a possible asymptomatic infection. Routine culturing of this sexually active population will help to control the increasing incidence of gonorrhea. Appropriate treatment should be initiated by the physician who makes the diagnosis of gonorrhea.

Topics: Aftercare; Ampicillin; Female; Genital Diseases, Female; Genital Diseases, Male; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin Resistance; Pharyngeal Diseases; Probenecid; Sexually Transmitted Diseases; Spectinomycin; Tetracycline

Topics: Amphotericin B; Chlamydia Infections; Chloramphenicol; Condylomata Acuminata; Female; gamma-Globulins; Genital Diseases, Female; Genital Diseases, Male; Herpes Zoster; Humans; Immunoglobulins; Lymphogranuloma Venereum; Male; Molluscum Contagiosum; Mumps; Mycoplasma Infections; Orchitis; Podophyllin; Tetracycline; Vaccination; Vaccinia; Virus Diseases

Topics: Adolescent; Antibodies, Viral; Antibody Specificity; Antigens, Viral; Child; Chlamydia; Chlamydia Infections; Cross Reactions; Epitopes; Fluorescent Antibody Technique; Genital Diseases, Male; Humans; Indians, North American; Male; Tetracycline; Trachoma; Tunisia

Topics: Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Minocycline; Sex Factors; Tetracycline; Vestibule, Labyrinth

Topics: Chlortetracycline; Condylomata Acuminata; Female; Genital Diseases, Male; Genital Neoplasms, Female; Humans; Male; Tetracycline; Vitamin A

Topics: Adult; Aged; Female; Genital Diseases, Male; Humans; Lactobacillus; Lung Diseases; Male; Middle Aged; Tetracycline; Urologic Diseases