tetracycline and Gas-Gangrene

Gas gangrene caused by Clostridium perfringens is associated with significant mortality and morbidity in spite of penicillin treatment. Although prompt surgical debridement has been established as the primary therapeutic objective, additional studies are needed for determination of the optimal antimicrobial therapy. In a mouse model of gas gangrene caused by Clostridium perfringens, clindamycin, metronidazole, rifampin, and tetracycline were all more efficacious than penicillin (P less than .05). Survival of penicillin-treated mice was not significantly better than that of untreated controls in spite of serum levels that ranged up to 77-1,800 micrograms/ml. Responses to metronidazole were highly dose dependent. For example, 60% of mice survived after 75 mg of metronidazole/kg, but only 10% survived after 19 mg/kg. In contrast, clindamycin was highly effective over a broad dosing range (8.6-86 mg/kg). The efficacy of all antibiotics was reduced if treatment was delayed or larger inocula of bacteria were used.

Topics: Animals; Anti-Bacterial Agents; Clindamycin; Clostridium perfringens; Female; Gas Gangrene; Male; Metronidazole; Mice; Penicillin G; Rifampin; Tetracycline

The effect of potassium benzylpenicillin, streptomycin sulfate and chlortetracycline on experimental gangrenous intoxication was studied. When the antibiotics were injected before intoxication, the albino mice resistance did not significantly change. When the antibiotics were injected immediately after the toxin administration, the resistance of the test animals markedly decreased.

Topics: Animals; Anti-Bacterial Agents; Clostridium perfringens; Drug Interactions; Drug Resistance; Gas Gangrene; Mice; Penicillins; Streptomycin; Tetracycline; Time Factors; Toxins, Biological

Topics: Animals; Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Clostridium perfringens; Disease Models, Animal; Dogs; Gas Gangrene; Hyperbaric Oxygenation; Penicillins; Prognosis; Tetracycline

Topics: Administration, Oral; Ampicillin; Animals; Anti-Bacterial Agents; Gas Gangrene; Mice; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Cephaloridine; Clostridium; Clostridium Infections; Gas Gangrene; Injections, Intravenous; Lincomycin; Mice; Microbial Sensitivity Tests; Penicillin G; Tetracycline

Topics: Animals; Clostridium; Clostridium Infections; Clostridium perfringens; Drug Synergism; Erythromycin; Gas Gangrene; Mice; Stimulation, Chemical; Tetracycline; Time Factors

Topics: Amputation, Surgical; Cellulitis; Clostridium; Clostridium Infections; Debridement; Diagnosis, Differential; Gas Gangrene; Humans; Injections, Intravenous; Male; Middle Aged; Penicillin G; Radiography; Tetracycline; Time Factors

Topics: Adolescent; Adult; Aged; Child; Female; Gas Gangrene; Germany, West; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Penicillins; Retrospective Studies; Tetracycline

Topics: Adult; Antitoxins; Clostridium perfringens; Gas Gangrene; Humans; Hydrogen Peroxide; Leucomycins; Male; Penicillins; Proteus; Surgical Wound Infection; Tetracycline; Ureter

Topics: Administration, Oral; Animals; Clostridium; Clostridium perfringens; Depression, Chemical; Gas Gangrene; Immunodiffusion; Mice; Muscles; Oxytetracycline; Tetracycline; Time Factors

Topics: Adolescent; Adult; Amputation, Surgical; Clostridium Infections; Clostridium perfringens; Extremities; Gas Gangrene; Humans; Hyperbaric Oxygenation; Leg Injuries; Methods; Middle Aged; Penicillins; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Clostridium Infections; Disease Models, Animal; Drug Synergism; Escherichia coli Infections; Gas Gangrene; Liver Extracts; Penicillin G Procaine; Proteus Infections; Rats; Staphylococcal Infections; Tetracycline

Topics: Abortion, Septic; Adult; Anti-Bacterial Agents; Clostridium Infections; Curettage; Drug Synergism; Female; Gas Gangrene; Humans; Kanamycin; Penicillins; Pregnancy; Sepsis; Tetracycline

Topics: Anti-Bacterial Agents; Cephaloridine; Cephalothin; Clostridium perfringens; Drug Hypersensitivity; Gas Gangrene; Humans; Penicillin G; Penicillin Resistance; Penicillins; Tetracycline

Topics: Brain Abscess; Cerebral Ventricles; Clostridium perfringens; Cognition Disorders; Gas Gangrene; Hemiplegia; Humans; Injections; Male; Middle Aged; Otitis Media; Penicillins; Radiography; Reflex, Stretch; Streptomycin; Tetracycline

Topics: Animals; Clostridium; Clostridium perfringens; Clostridium tetani; Gas Gangrene; Metronidazole; Mice; Penicillin G; Tetanus; Tetracycline

Topics: Animals; Antitoxins; Clostridium Infections; Gas Gangrene; Penicillins; Sheep; Tetracycline; Wounds, Gunshot

Topics: Animals; Bacteria; Gas Gangrene; Humans; Immunization, Passive; Liver Extracts; Male; Neomycin; Penicillin G Procaine; Rats; Tetracycline; Time Factors; Wounds and Injuries

Topics: Adult; Asthma; Blood Transfusion; Clostridium perfringens; Epinephrine; Gas Gangrene; Humans; Hydrocortisone; Immunization, Passive; Infusions, Parenteral; Injections, Intramuscular; Male; Metaraminol; Oils; Tetracycline; Thigh

Topics: Abortion, Spontaneous; Adult; Chloramphenicol; Exchange Transfusion, Whole Blood; Female; Gas Gangrene; Humans; Hysterectomy; Penicillins; Pregnancy; Renal Dialysis; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Bacitracin; Chemotherapy, Cancer, Regional Perfusion; Chloramphenicol; Clostridium perfringens; Dogs; Drug Therapy; Erythromycin; Gas Gangrene; Hyperbaric Oxygenation; Leg; Novobiocin; Research; Streptococcal Infections; Tetracycline

Topics: Abdomen; Aged; Anti-Bacterial Agents; Antitoxins; Cellulitis; Chloramphenicol; Clostridium; Debridement; Diagnosis; Drug Therapy; Gas Gangrene; Geriatrics; Humans; Hyperbaric Oxygenation; Hypothermia; Hypothermia, Induced; Penicillins; Postoperative Complications; Steroids; Streptomycin; Surgical Procedures, Operative; Tetracycline; Toxins, Biological

Topics: Anti-Bacterial Agents; Gas Gangrene; Humans; Immunization, Passive; Penicillins; Protein Synthesis Inhibitors; Tetracycline

Topics: Abortion, Criminal; Abortion, Septic; Acute Kidney Injury; Adrenal Cortex Hormones; Anti-Bacterial Agents; Bacillus; Chloramphenicol; Clostridium perfringens; Criminals; Female; Gas Gangrene; Hemoglobinuria; Hemolysis; Humans; Kidneys, Artificial; Oleandomycin; Pigmentation Disorders; Pregnancy; Renal Insufficiency; Sepsis; Tetracycline

Topics: Animals; Anti-Bacterial Agents; Blood Proteins; Gas Gangrene; Guinea Pigs; Humans; Liver Extracts; Penicillin G Procaine; Penicillins; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Gas Gangrene; Humans; Protein Synthesis Inhibitors; Tetracycline