tetracycline and Fetal-Death

Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcoholic Beverages; Animals; Anticonvulsants; Antineoplastic Agents; Diethylstilbestrol; Estrogens; Female; Fetal Death; Fetus; Humans; Hydantoins; Iodides; Organomercury Compounds; Pregnancy; Smoking; Teratogens; Tetracycline; Thalidomide; Thiourea; Warfarin

Topics: Abortion, Spontaneous; Antibodies; Bacteriuria; Chickenpox; Chromosome Aberrations; Chromosome Disorders; Congenital Abnormalities; Coxsackievirus Infections; Cytomegalovirus; Female; Fetal Death; Fetal Diseases; Hepatitis; Herpesviridae Infections; Hormones; Humans; Influenza, Human; Maternal-Fetal Exchange; Measles; Mumps; Obstetric Labor, Premature; Pneumonia; Poliomyelitis; Pregnancy; Pregnancy Complications, Infectious; Rubella; Smallpox; Smallpox Vaccine; Syphilis; Tetracycline; Toxoplasmosis; Toxoplasmosis, Congenital

Topics: Bacteriuria; Chloramphenicol; Enterobacteriaceae Infections; Escherichia coli Infections; Female; Fetal Death; Humans; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Klebsiella Infections; Nitrofurantoin; Placebos; Pregnancy; Pregnancy Complications, Infectious; Proteus Infections; Pyelonephritis; Sulfonamides; Tetracycline

During the course of a study aiming to obtain a tetracycline (Tet)-inducible transgene expression restricted to the placenta, we have observed a toxicity of doxycycline (dox) given in the food at doses of 2.5-10 mg/g to pregnant mice from two different inbred strains. During the second half of gestation, dox-fed non-transgenic mice presented placental anomalies and impaired fetal development proportional to the dose of antibiotic. Thus, dox administered in commonly used food doses can have an adverse effect on pregnancy. These observations are important for studies of placental or fetal development using inducible gene promoters.

Topics: Animals; Dose-Response Relationship, Drug; Doxycycline; Embryonic and Fetal Development; Female; Fetal Death; Gene Expression Regulation; Gene Transfer Techniques; Mice; Mice, Inbred Strains; Placenta; Pregnancy; Tetracycline

Morphocycline was administered intravenously to rats of Wistar line in doses of 100, 50 and 20 mg/kg at various periods of pregnancy. It was found that a single administration of morphocycline in the above doses to the rats on the 9th day of their pregnancy resulted in abortus in some female rats. Death and resorption of the fetus were more frequent after the antibiotic use in doses of 20 and 50 mg/kg. Repeated administrations of morphocycline in doses of 20 mg/kg resulted in abortus and postimplantation death of the fetus most pronounced in the animal groups treated with the antibiotic during the periods of the 7th to the 10th and from the 11th to the 14th days of pregnancy. The teratogenic activity of morphocycline was slightly pronounced. It was observed in some fetus after both single and repeated administrations of the antibiotic.

Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Anophthalmos; Corpus Luteum; Dose-Response Relationship, Drug; Embryo Implantation; Female; Fetal Death; Fetus; Injections, Intravenous; Microphthalmos; Morpholines; Pregnancy; Pregnancy, Animal; Rats; Tetracycline; Tetracyclines; Time Factors

The general toxic and embryotropic effect of tetracycline was studied on unbred pregnant albino rats. The antibiotic was used in concentrations of 1 and 0.1 mg/m3, the maximum permissible concentration (MPC). The animals were exposed to tetracycline inhalation for 20 days of their pregnancy. On the basis of the results it was concluded that tetracycline in the concentration at the level of the MPC, i.e. 0.1 mg/m3 had under the experimental conditions a negative effect on the pregnant animals. In concentrations of 1 and 0.1 mg/m3 it had in addition an embryotropic effect. It was also shown that the pregnant animals were more sensitive to the antibiotic than the non-pregnant ones.

Topics: Animals; Corpus Luteum; Dose-Response Relationship, Drug; Embryo Implantation; Embryo, Mammalian; Environmental Exposure; Female; Fetal Death; Fetus; Organ Size; Placenta; Pregnancy; Rats; Tetracycline; Time Factors

Topics: Abortion, Spontaneous; Administration, Oral; Blood Cell Count; Diagnosis, Differential; Drug Therapy, Combination; Female; Fetal Death; Hemagglutination Tests; Humans; Listeria monocytogenes; Listeriosis; Penicillins; Pregnancy; Pregnancy Complications, Infectious; Tetracycline

Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Ascorbic Acid; Body Weight; Corpus Luteum; Depression, Chemical; Embryo, Mammalian; Female; Fertility; Fetal Death; Gestational Age; Glycogen; Histocytochemistry; Nucleic Acids; Organ Size; Placenta; Placenta Diseases; Pregnancy; Rats; Tetracycline

Topics: Abortion, Therapeutic; Adult; Cholelithiasis; Female; Fetal Death; Hepatitis A; Humans; Infant, Newborn; Jaundice; Maternal Mortality; Obstetric Labor, Premature; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Retrospective Studies; Tetracycline

Topics: Adult; Amnion; Birth Weight; Chloramphenicol; Female; Fetal Death; Hospitalization; Humans; Infant Mortality; Infant, Newborn; Inflammation; Injections, Intravenous; Labor Presentation; Maternal Mortality; Obstetric Labor, Premature; Penicillins; Pregnancy; Pregnancy Complications; Shock, Septic; Streptomycin; Tetracycline

Topics: Acute Kidney Injury; Adult; Female; Fetal Death; Humans; In Vitro Techniques; Kidney; Liver Diseases; Pregnancy; Pregnancy Complications, Infectious; Proteinuria; Pyelonephritis; Tetracycline; Urine; Water-Electrolyte Balance

Topics: Abnormalities, Drug-Induced; Anesthesia, Dental; Anesthetics; Dental Caries; Dentistry; Female; Fetal Death; Fetal Diseases; Fluorides; Gingivitis; Humans; Hyperemesis Gravidarum; Hypotension; Periodontal Diseases; Pregnancy; Pregnancy Complications; Radiography, Dental; Stress, Physiological; Tetracycline