tetracycline and Eye-Manifestations

Three consecutive cases of Whipple's disease observed by us in recent years have involved neurologic symptoms, i.e. psychoorganic syndromes, gaze palsy, nystagmus, masseteric and pharyngeal myoclonus or papilledema. In one case mononuclear cells in the cerebrospinal fluid, most probably of ependymal origin, were loaded with periodic-acid-Schiff (PAS) positive granules. On treatment with antibiotics the neurologic signs cleared considerably or completely. The findings suggest (a) that neurologic involvement Whipple's disease may not be so uncommon as appears from the literature, (b) that examination of the spinal fluid with PAS staining may be helpful in the diagnosis of such cases, and (c) that neurologic involvement in Whipple's disease may also be amenable to treatment with antibiotics.

Topics: Adult; Aged; Cerebrospinal Fluid; Chloramphenicol; Cognition Disorders; Eye Manifestations; Humans; Male; Masticatory Muscles; Myoclonus; Neurologic Manifestations; Papilledema; Penicillins; Streptomycin; Tetracycline; Whipple Disease

Topics: Administration, Topical; Bronchial Neoplasms; Eye Manifestations; Fluorescent Antibody Technique; Humans; Immunoglobulin G; Microscopy, Fluorescence; Middle Aged; Quinolines; Skin Diseases; Tetracycline

Topics: Adult; Eye Manifestations; Humans; Inflammation; Jejunum; Male; Microscopy, Electron; Middle Aged; Radiography; Tetracycline; Whipple Disease

Topics: Adult; Cortisone; Eye Manifestations; Female; Humans; Multiple Sclerosis; Pupil; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Czechoslovakia; Dermatologic Agents; Eye Manifestations; Humans; Lymphadenitis; Protein Synthesis Inhibitors; Streptomycin; Tetracycline; Tularemia