tetracycline and Erythema

Topics: Arthritis, Infectious; Ceftriaxone; Drug Administration Schedule; Erythema; Humans; Lyme Disease; Nervous System Diseases; Penicillins; Skin Diseases; Tetracycline

Lyme disease is caused by the spirochete B. burgdorferi. Like its counterpart syphilis, it causes multisystem disease particularly affecting the skin, nervous system, heart and musculoskeletal system. It is endemic in several areas of the United States as well as in Europe. The prompt recognition of this disease and its diverse manifestations should lead to early treatment and resolution. Prevention is aimed at avoidance of the tick vector.

Topics: Animals; Arachnid Vectors; Arthritis; Borrelia; Diagnosis, Differential; Erythema; Humans; Lyme Disease; Neuritis; Penicillins; Rheumatic Fever; Tetracycline; Ticks

Lyme disease has protean manifestations. The causative agent is Borrelia burgdorferi, a recently discovered spirochete. The disease has been found on three continents. The initial major clinical feature is a characteristic skin eruption known as erythema chronicum migrans. Subsequent main clinical manifestations are meningopolyneuritis and arthritis. However, clinical expressions of the disease vary widely. Some patients have very mild disease and others develop severe and prolonged illness. Specific laboratory tests for the detection of antibody to the organism are now available. The sensitivity of these tests approaches 100% when the sera are collected from patients having the later clinical manifestations. Penicillin and tetracycline are the therapeutic drugs of choice.

Topics: Adolescent; Adult; Aged; Arachnid Vectors; Arthritis; Aspartate Aminotransferases; Australia; Blood Sedimentation; Borrelia; Borrelia Infections; Child; Child, Preschool; Culture Media; Diagnosis, Differential; Disease Reservoirs; Erythema; Europe; Female; Humans; Immunoglobulin M; Lyme Disease; Lymphopenia; Male; Middle Aged; Nervous System Diseases; Penicillins; Tetracycline; Ticks; United States

During 1980 and 1981, we compared antibiotic regimens in 108 adult patients with early Lyme disease. Erythema chronicum migrans and its associated symptoms resolved faster in penicillin- or tetracycline-treated patients than in those given erythromycin (mean duration, 5.4 and 5.7 versus 9.2 days, F = 3.38, p less than 0.05). None of 39 patients given tetracycline developed major late complications (meningoencephalitis, myocarditis, or recurrent attacks of arthritis) compared with 3 of 40 penicillin-treated patients and 4 of 29 given erythromycin (chi square with 2 degrees of freedom = 5.33, p = 0.07). In 1982, all 49 adult patients were given tetracycline; again, none of them developed major complications. However, with all three antibiotic agents nearly half of the patients had minor late symptoms such as headache, musculoskeletal pain, and lethargy. These complications correlated significantly with the initial severity of illness. For patients with early Lyme disease, tetracycline appears to be the most effective drug, then penicillin, and finally erythromycin.

Topics: Adolescent; Adult; Age Factors; Arthritis, Infectious; Child; Child, Preschool; Erythema; Erythromycin; Female; Humans; Male; Penicillin V; Prospective Studies; Random Allocation; Risk; Tetracycline; Time Factors

Ultraviolet (UV) exposure is the predominant cause of skin aging. A systematic evaluation of drug skin permeation via photoaged skin is lacking.. The aim of this work was to investigate whether UVA and UVB affect absorption by the skin of drugs and sunscreens, including tetracycline, quercetin, and oxybenzone.. The dorsal skin of nude mice was subjected to UVA (24 and 39 J/cm(2)) or UVB (150, 200, and 250 mJ/cm(2)) irradiation. Levels of skin water loss, erythema, and sebum were evaluated, and histological examinations of COX-2 and claudin-1 expressions were carried out. Permeation of the permeants into and through the skin was determined in vitro using a Franz cell. In vivo skin uptake was also evaluated. Senescent skin (24 weeks old) was used for comparison.. Wrinkling and scaling were significant signs of skin treated with UVA and UVB, respectively. The level of claudin-1, an indicator of tight junctions (TJs), was reduced by UVA and UVB irradiation. UVA enhanced tetracycline and quercetin skin deposition by 11- and 2-fold, respectively. A similar enhancement was shown for flux profiles. Surprisingly, a lower UVA dose revealed greater enhancement compared to the higher dose. The skin deposition and flux of tetracycline both decreased with UVB exposure. UVB also significantly reduced quercetin flux. The skin absorption behavior of chronologically aged skin approximated that of the UVA group, with photoaged skin showing higher enhancement. UV generally exhibited a negligible effect on modulating oxybenzone permeation.. Skin disruption produced by UV does not necessarily result in enhanced skin absorption. It depends on the UV wavelength, irradiated energy, and physicochemical properties of the permeant. To the best of our knowledge, this is the first report establishing drug permeation profiles for UV-irradiated skin.

Topics: Administration, Topical; Aging; Animals; Benzophenones; Body Water; Claudin-1; Erythema; Fatty Acids, Nonesterified; Male; Mice; Mice, Nude; Permeability; Proteins; Quercetin; Sebum; Skin; Skin Aging; Sunscreening Agents; Tetracycline; Ultraviolet Rays

The common preventive therapy in our department for newborns' eyes is tetracycline ophthalmic ointment. Due to temporary shortage of tetracycline ophthalmic ointment for one week in December 1991, the preventive therapy given to seventy-one newborns was gentamicin sulfate ophthalmic ointment. Five babies (7 percent of all newborns) experienced marked edema of the eyelids, foci of erythema, and serous exudate within the first days of life. The lesions regressed gradually and disappeared entirely within two to three weeks without any complications. These lesions represent the first description of orbital irritant contact dermatitis in newborns, most probably caused by topical gentamicin preparation. However, one cannot exclude sensitivity to paraben, which is the preservative used in gentamicin ointment, or a synergistic action of both agent and preservative.

Topics: Anti-Bacterial Agents; Dermatitis, Irritant; Drug Eruptions; Edema; Erythema; Exudates and Transudates; Eyelid Diseases; Follow-Up Studies; Gentamicins; Humans; Infant, Newborn; Ointments; Ophthalmic Solutions; Orbital Diseases; Parabens; Preservatives, Pharmaceutical; Tetracycline

Topics: Erythema; Humans; Lyme Disease; Tetracycline

The Jarisch-Herxheimer reaction includes the accentuation of symptoms during antibiotic therapy. More commonly associated with the treatment of syphilis, it can also occur in patients treated for Lyme disease caused by the spirochete Borrelia burgdorferi.

Topics: Adult; Erythema; Humans; Lyme Disease; Male; Tetracycline

Between December 1978 and July 1985, we used various antibiotics for the treatment of 97 adult patients with early erythema migrans disease (EMD). Six patients with borrelial lymphocytoma (BL) and 20 with acrodermatitis chronica atrophicans (ACA) were treated similarly. Follow-up was for a median of 20, 14, and 12 months, respectively. The erythema migrans and all associated symptoms resolved within a median of 3 weeks (0.5-18.4), BL within 7 weeks (4-16), and ACA partly or completely within several months. A Jarisch-Herxheimer (-like) reaction was observed in 8 patients with EMD. Fourteen patients with EMD and one with ACA developed an exacerbation of symptoms or new manifestations between the 2nd and 20th day, and 28 patients with EMD and one with ACA continued to have or acquired various symptoms greater than or equal to 3 weeks after initiation of therapy. Arthralgia, neurologic and constitutional symptoms, and in one instance a slight pulmonary interstitial edema developed in EMD. More severe initial illness was a risk factor for the development of later symptoms in EMD. Retreatment was more often necessary in ACA than in EMD. A patient with ACA had a recurrence after 5 1/2 years. IgG antibody titers rose at least fourfold in 5 patients with ACA and in 1 with EMD despite therapy. We tentatively recommend minocycline or high doses of parenteral penicillin for the treatment of these disorders.

Topics: Acrodermatitis; Adult; Anti-Bacterial Agents; Borrelia Infections; Erythema; Erythromycin; Female; Follow-Up Studies; Humans; Male; Middle Aged; Minocycline; Penicillins; Tetracycline

Topics: Erythema; Humans; Male; Middle Aged; Niacinamide; Tetracycline

A 60-year-old woman with recurrent papular and vesiculobullous lesions of erythema elevatum diutinum responded to treatment with 100 mg of oral niacinamide three times a day and 250 mg of tetracycline hydrochloride four times a day. Prior therapy with 2.5 mg of dexamethasone daily and 1.0 g of erythromycin daily had been unsuccessful. After four weeks, tetracycline therapy was discontinued, and niacinamide alone sufficed to suppress the disorder. Recurrent lesions developed whenever niacinamide therapy was stopped.

Topics: Drug Therapy, Combination; Erythema; Female; Humans; Middle Aged; Niacinamide; Recurrence; Tetracycline

We studied antibiotic efficacy in 113 patients with erythema chronicum migrans, the first manifestation of Lyme disease. Erythema chronicum migrans and its associated symptoms resolved faster in patients given penicillin or tetracycline (median duration, 4 and 2 days, respectively) than in untreated patients (10 days; P less than 0.001 and P = 0.005, respectively). Erythromycin had no significant effect. Although the frequency of subsequent neurologic and cardiac abnormalities was similar in all four groups, significantly fewer patients given penicillin developed arthritis than did untreated patients (P = 0.001). Among 15 patients with arthritis who were followed for at least 29 months, the total duration of joint involvement was shorter in penicillin-treated patients (median, 4 weeks) than in untreated patients (17 weeks; P = 0.019). Although the clinical manifestations of the disease may fluctuate in frequency from year to year and influence apparent antibiotic effect, we conclude that penicillin therapy shortens the duration of erythema chronicum migrans and may prevent or attenuate subsequent arthritis.

Topics: Adolescent; Adult; Arthritis, Infectious; B-Lymphocytes; Child; Child, Preschool; Erythema; Erythromycin; Female; Humans; Isoantigens; Male; Middle Aged; Penicillin G; Tetracycline

Topics: Ascorbic Acid; Erythema; Humans; Male; Middle Aged; Riboflavin; Tetracycline; Thiamine; Tick Toxicoses

Topics: Atrophy; Cortisone; Cosmetics; Dermatitis, Contact; Drug Eruptions; Erythema; Facial Dermatoses; Female; Humans; Male; Tea; Telangiectasis; Tetracycline

Topics: Adolescent; Adult; Age Factors; Aged; Arthritis; Child; Child, Preschool; Diarrhea; Diet Therapy; Enteritis; Erythema; Erythema Nodosum; Feces; Female; Gastroenteritis; Humans; Infant; Infant, Newborn; Male; Middle Aged; Myocarditis; Pasteurella; Pasteurella Infections; Prognosis; Sex Factors; Sulfonamides; Sweden; Tetracycline

Topics: Adult; Bronchitis; Drug Hypersensitivity; Erythema; Female; Humans; Pulmonary Emphysema; Tetracycline

Topics: Administration, Oral; Drug Hypersensitivity; Erythema; Humans; Pruritus; Skin Diseases; Tetracycline

Fourteen patients suffering from rosacea treated by prolonged topical applications of fluorinated steroids showed adverse effects. Aggravation and extension of telangiectasia occurred in all, and in most cessation of the treatment was followed by severe rebound inflammatory oedema and acute pustular eruption. The telangiectasia cleared or was much improved within three months of cessation of the use of fluorinated steroids. Hydrocortisone did not produce the same effect, and hence it was used, together with oral tetracycline, for treatment.

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Betamethasone; Erythema; Facial Dermatoses; Female; Fluocinolone Acetonide; Humans; Hydrocortisone; Male; Middle Aged; Rosacea; Substance Withdrawal Syndrome; Telangiectasis; Tetracycline

Topics: Adult; Drug Eruptions; Drug Hypersensitivity; Erythema; Humans; Male; Tetracycline

Topics: Animals; Benzene; Cyclophosphamide; Dermatitis, Contact; Dinitrophenols; Edema; Erythema; Guinea Pigs; Immunodiffusion; Leukopenia; Lymphocytes; Promethazine; Proteins; Skin; Tetracycline; Tissue Extracts

Topics: Adult; Chlorpromazine; Chlortetracycline; Demeclocycline; Erythema; Filtration; Humans; Injections, Intradermal; Light; Male; Methods; Photosensitivity Disorders; Tetracycline; Ultraviolet Rays

Topics: Carbohydrates; Child; Child, Preschool; Clubfoot; Dental Caries; Erythema; Extremities; Female; Humans; Male; Periodontitis; Tetracycline; Tooth Discoloration

Topics: Adult; Cells, Cultured; Complement Fixation Tests; Disease Outbreaks; Erythema; Humans; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; Seasons; Student Health Services; Tetracycline; Time Factors; Universities; Wisconsin

Boric acid poisoning in 11 infants, occurring in the newborn nursery as a result of the accidental and inadvertent use of 2.5% boric acid in the preparation of the formulae, is reported. Five of the infants died. All except two exhibited the classical symptomatology of acute boric acid poisoning, namely, diarrhea, vomiting, erythema, exfoliation, desquamation of the skin, and marked central nervous system irritation. Early manifestations of poisoning were nonspecific, and one patient died before skin manifestations were noted. Peritoneal dialysis, instituted in nine cases, was found to be the most effective method of treatment. It is recommended that boric acid, which is of doubtful therapeutic value, should be completely removed from hospitals, dispensaries and pharmacopoeias.

Topics: Acidosis; Anti-Bacterial Agents; Borates; Boric Acids; Color Perception Tests; Dehydration; Diarrhea; Diarrhea, Infantile; Erythema; Exchange Transfusion, Whole Blood; Gastric Lavage; Hypernatremia; Infant; Infant, Newborn; Peritoneal Dialysis; Phenobarbital; Seizures; Tetracycline; Toxicology; Vomiting

Topics: Anti-Bacterial Agents; Erythema; Erythema Chronicum Migrans; Humans; Protein Synthesis Inhibitors; Rickettsia Infections; Tetracycline

Topics: Anti-Bacterial Agents; Brucellosis; Erythema; Humans; Medical Records; Protein Synthesis Inhibitors; Tetracycline