tetracycline and Enterocolitis--Pseudomembranous

Topics: Administration, Topical; Animals; Clindamycin; Cricetinae; Diarrhea; Drug Eruptions; Enterocolitis, Pseudomembranous; Erythromycin; Humans; Ointments; Skin Pigmentation; Tetracycline

Topics: Cholestyramine Resin; Clindamycin; Clostridium Infections; Enterocolitis, Pseudomembranous; Gastrointestinal Diseases; Humans; Ischemia; Lincomycin; Metals; Staphylococcal Infections; Tetracycline; Vancomycin

Topics: Adult; Ampicillin; Anti-Bacterial Agents; Clindamycin; Colitis; Colonic Diseases; Diarrhea; Enterocolitis, Pseudomembranous; Female; Humans; Lincomycin; Male; Middle Aged; Tetracycline

Topics: Ampicillin; Ascariasis; Clostridium perfringens; Enterocolitis, Pseudomembranous; Germany; Humans; Immunoglobulins; India; Intestines; Laparoscopy; Metronidazole; New Guinea; Tetracycline

Topics: Anti-Bacterial Agents; Carbenicillin; Clindamycin; Diarrhea; Enterocolitis, Pseudomembranous; Erythromycin; Humans; Legionnaires' Disease; Lung Diseases; Male; Methicillin; Penicillin Resistance; Prostatitis; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Tetracycline; Urethritis; Vancomycin

In this study, the tet(W) gene region of a human clinical isolate of Clostridium difficile resistant to tetracycline was characterized. This gene was a new allele showing 99% sequence identity to the gene found in the human strain Bifidobacterium longum F8, and it is not transferable by "in vitro" mating experiments.

Topics: Anti-Bacterial Agents; Bacterial Proteins; Child, Preschool; Clostridioides difficile; DNA, Bacterial; Enterocolitis, Pseudomembranous; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Sequence Analysis, DNA; Tetracycline; Tetracycline Resistance

An adult Bangladeshi woman had persistent bloody diarrhea. Repeated stool cultures yielded Plesiomonas shigelloides in pure growth. Tissue specimens of the colon were consistent with pseudomembranous colitis. Treatment with tetracycline, to which the isolate was susceptible, brought prompt recovery; the stool cultures became negative and the serum antibody titer against P. shigelloides lipopolysaccharide, as measured by hemagglutination inhibition with P. shigelloides lipopolysaccharide-sensitized sheep erythrocytes, declined from 1:160 to 1:40.

Topics: Adult; Bacterial Infections; Colon; Colonoscopy; Dysentery; Enterocolitis, Pseudomembranous; Female; Humans; Tetracycline; Vibrionaceae

Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Anti-Bacterial Agents; Clindamycin; Enterocolitis, Pseudomembranous; Humans; Pharmaceutical Vehicles; Tetracycline

Tetracyclines were implicated in the 1950s in induction of protracted diarrhea and pseudomembranous colitis. Because the pathogenetic mechanism of these illnesses has been questioned recently, we studied tetracycline in hamster models of antibiotic-associated colitis. Orogastric administration of tetracycline caused diarrhea and death, with evidence of hemorrhagic typhlitis. Filtrates of cecal contents were toxic when inoculated into normal hamsters and cell culture monolayers, and toxicity was neutralized with Clostridium sordellii antitoxin. Tetracycline-resistant C. difficile was cultured from stools of these hamsters, but Staphylococcus aureus was not isolated. The value of tetracycline for treatment or prevention of clindamycin-induced colitis in hamsters was also studied, and it was found that daily orogastric administration of tetracycline was poorly protective against clindamycin-induced colitis.

Topics: Animals; Bacterial Toxins; Clindamycin; Clostridium Infections; Cricetinae; Enterocolitis, Pseudomembranous; Feces; Male; Mesocricetus; Tetracycline

The hamster model of clindamycin-induced enterocolitis was studied to determine the natural course of the disease and the response to five therapeutic regimens. Tissue culture assays of stools from untreated animals showed that colitis toxin is present at low titers within 24--36 hr after challenge with clindamycin; titers of toxin in subsequent specimens of stool increased progressively until the animals died on days 2--4 after challenge. Therapeutic regimens tested in this model were initiated 24 hr after clindamycin challenge when the majority of the animals had evidence of colitis toxin. Methylprednisilone, an anion exchange resin, and gas gangrene polyvalent antitoxin had a minimal effect on toxin titers in stool and failed to delay substantially death due to enterocolitis. Vancomycin and tetracycline eliminated toxin in stools and delayed death. However, the salutary effects of these antibiotics were noted only during the course of their administration since all animals died of enterocolitis and had high titers of toxin when treatment was discontinued.

Topics: Animals; Antitoxins; Clindamycin; Clostridium perfringens; Colestipol; Cricetinae; Drug Evaluation; Enterocolitis, Pseudomembranous; Enterotoxins; Male; Mesocricetus; Methylprednisolone; Polyamines; Tetracycline; Vancomycin

Two cases of pseudomembranous colitis are presented. The first patient had been treated with novobiocin-tetracycline and penicillin, and two weeks later developed severe fulminating diarrhea with ascites and bilateral pleural effusions which did not respond to intravenous ACTH. Subsequently she underwent subtotal colectomy and made a rapid and complete recovery. The second patient developed severe diarrhea two weeks after a 10-day course of clindamycin. She was treated with intravenous ACTH, oral Lactobacillus and a fecal enema and made a complete recovery.These cases reconfirm the importance of antibiotics as etiologic agents in this disease. They also stress the classic sigmoidoscopic and histologic findings that should facilitate prompt and rapid diagnosis.

Topics: Adolescent; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Ascites; Biological Products; Clindamycin; Colon; Diarrhea; Enema; Enterocolitis, Pseudomembranous; Female; Humans; Lactobacillus; Middle Aged; Novobiocin; Penicillins; Pleural Effusion; Rectum; Tetracycline

Topics: Ampicillin; Arthritis; Enterocolitis, Pseudomembranous; Feces; Female; Humans; Male; Pasteurella; Pasteurella Infections; Sacroiliac Joint; Tetracycline

Topics: Enterocolitis, Pseudomembranous; Escherichia coli; Humans; Male; Tetracycline

Topics: Adult; Ampicillin; Anti-Bacterial Agents; Barium Sulfate; Diarrhea; Enema; Enterocolitis, Pseudomembranous; Female; Humans; Lincomycin; Male; Middle Aged; Radiography; Sigmoidoscopy; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Antibody Formation; Chloramphenicol; Enterocolitis, Pseudomembranous; Humans; Infections; Intestines; L Forms; Pharyngitis; Rickettsia Infections; Salmonella Infections; Staphylococcus; Streptococcus; Streptomycin; Tetracycline; Time Factors

Topics: Anaphylaxis; Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Drug Hypersensitivity; Enterocolitis, Pseudomembranous; Malabsorption Syndromes; Penicillin Resistance; Penicillins; Shock; Streptomycin; Tetracycline

Topics: Adult; Aged; Anti-Bacterial Agents; Chloramphenicol; Dysentery, Bacillary; Enterocolitis, Pseudomembranous; Erythromycin; Humans; Intestines; Male; Middle Aged; Nalidixic Acid; Nystatin; Penicillins; Pneumonia; Proteus Infections; Rheumatic Heart Disease; Staphylococcal Infections; Streptomycin; Tetracycline

Topics: Adolescent; Adult; Child; Child, Preschool; Dysentery, Bacillary; Enterocolitis, Pseudomembranous; Humans; Infant; Male; Middle Aged; Respiratory Tract Infections; Tetracycline; Typhus, Epidemic Louse-Borne

Topics: Anti-Bacterial Agents; Chloramphenicol; Colonic Diseases; Enterocolitis, Pseudomembranous; Humans; Infections; Neomycin; Penicillins; Postoperative Care; Preoperative Care; Retrospective Studies; Staphylococcus; Sulfathiazoles; Sulfonamides; Surgical Wound Infection; Tetracycline

Topics: Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Colitis, Ulcerative; Colon; Dehydration; Diagnosis, Differential; Enterocolitis, Pseudomembranous; Female; Furazolidone; Humans; Intubation, Gastrointestinal; Middle Aged; Novobiocin; Otitis; Radiography; Sigmoidoscopy; Tetracycline; Water-Electrolyte Balance

Topics: Acute Disease; Acute Kidney Injury; Adult; Enterocolitis, Pseudomembranous; Erythromycin; Humans; Isotonic Solutions; Male; Nephrosis; Pneumonia; Tetracycline; Ultrasonics

Topics: Enterocolitis, Pseudomembranous; Female; Humans; Male; Tetracycline

Topics: Adult; Anti-Bacterial Agents; Chloramphenicol; Cholecystectomy; Enterocolitis, Pseudomembranous; Erythromycin; Female; Gastritis; Humans; Kanamycin; Male; Middle Aged; Penicillins; Postoperative Complications; Staphylococcal Infections; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Enterocolitis; Enterocolitis, Pseudomembranous; Oxytetracycline; Penicillins; Protein Synthesis Inhibitors; Staphylococcal Infections; Streptomycin; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Autopsy; Chloramphenicol; Colitis; Demeclocycline; Enterocolitis, Pseudomembranous; Geriatrics; Humans; Neomycin; Pathology; Penicillins; Postoperative Complications; Streptomycin; Tetracycline

Topics: Enteritis; Enterocolitis, Pseudomembranous; Femoral Neck Fractures; Femur Neck; Fractures, Bone; Protein Synthesis Inhibitors; Tetracycline