tetracycline and Empyema

Models of pleural injury were established with intrapleural tetracycline, intrapleural carrageenan, and empyema in New Zealand White rabbits to evaluate histologically the pleural inflammatory response from 3 to 90 days. Both tetracycline and empyema models produced increases in the pleural connective tissue layers both above and below the fibroelastic membrane associated with angiogenesis and lymphangiogenesis. The influx of fibroblasts from the pleural surface into acellular fibrin strands formed adhesions between the visceral and the parietal pleurae. Injury to the mesothelial cell ranged from a cuboidal transition to total desquamation with the degree of mesothelial injury associated with the amount of fibrin adherence and the propensity toward fibrosis at 90 days. Intervention to promote the resolution of pleural inflammation without fibrosis should be directed toward preservation of the mesothelial surface, removal of pleural fibrin, and inhibition of fibroblast growth and chemotaxis.

Topics: Animals; Carrageenan; Connective Tissue; Empyema; Macrophages; Neovascularization, Pathologic; Pleurisy; Rabbits; Tetracycline; Time Factors; Tissue Adhesions

Fifty patients who had pneumonia, lung abscess, or empyema, and whose specimens had a fetid odor, were presumed to be suffering from anerobic lung infection and were treated with clindamycin either orally (33 patients) or parenterally (17). Forty-six patients showed marked improvement or recovered; two also underwent lung resection, and thoracotomy was performed in 10. There were three outright treatment failures, and superinfection occurred in one patient. A review of the literature suggests that clindamycin and penicillin (in substantial dosage) are equally effective in treatment of anaerobic lung infection. Transtracheal aspiration is not deemed necessary if the patient is expectorating fetid sputum.

Topics: Adolescent; Adult; Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Child; Child, Preschool; Chloramphenicol; Clindamycin; Diagnosis, Differential; Drug Evaluation; Empyema; Female; Humans; Lung Abscess; Male; Middle Aged; Penicillins; Pneumonia; Suction; Tetracycline

Salmonella empyema in an immunologically compromised patient with malignant pleural effusion is described. Antimicrobial treatment was ineffective when given parenterally. Intrapleural administration of antibiotics resulted in a rapid rise of the antibacterial activity of the pleural fluid, leading to rapid clinical improvement and eradication of the infections.

Topics: Adenocarcinoma; Empyema; Humans; Lung Neoplasms; Male; Microbial Sensitivity Tests; Middle Aged; Neoplasm Metastasis; Pleural Effusion; Salmonella; Salmonella Infections; Tetracycline; Thyroid Neoplasms

A high incidence of thoracotomy wound infection and empyema in 1972 was associated with inadequate and irregular administration of prophylactic antibiotics. Beginning with 1973, a strict regimen was adopted that combined systemic cephalosporins and two topical antibiotics (cephalothin and kanamycin). Emphasis was placed on preoperative administration of the systemic agent and on use of the topical drugs before the operative field was contaminated. The patient groups for 1972 and 1973 were similar in most respects, but the wound complication rate was 18.4% in 1972 and 4.8% in 1973.

Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Ampicillin; Anti-Bacterial Agents; Carbenicillin; Cephalexin; Cephalothin; Empyema; Female; Gentamicins; Humans; Injections, Intramuscular; Injections, Intravenous; Kanamycin; Male; Methicillin; Middle Aged; Penicillins; Postoperative Complications; Surgical Wound Infection; Tetracycline; Thoracic Diseases; Thoracic Neoplasms

Topics: Actinobacillus Infections; Ampicillin; Bacteria; Child; Child, Preschool; Chloramphenicol; Empyema; Female; Haemophilus Infections; Humans; Infant; Male; Meningitis, Haemophilus; Microbial Sensitivity Tests; Osteomyelitis; Penicillin Resistance; Peritonitis; Tetracycline

Topics: Adult; Aged; Ampicillin; Bacteroides; Bacteroides Infections; Cephalothin; Chloramphenicol; Drug Evaluation; Empyema; Erythromycin; Female; Gentamicins; Humans; Kanamycin; Lincomycin; Male; Microbial Sensitivity Tests; Penicillin G; Peptococcus; Peptostreptococcus; Pneumonia; Sepsis; Tetracycline

Topics: Ampicillin; Anti-Bacterial Agents; Empyema; Erysipelas; Erythromycin; Humans; Lymphadenitis; Osteomyelitis; Oxacillin; Penicillin G; Penicillin V; Salivary Gland Diseases; Streptomycin; Tetracycline

Topics: Adolescent; Adult; Age Factors; Aged; Bronchi; Child; Chloramphenicol; Drainage; Empyema; Erythromycin; Female; Hospitalization; Humans; Lung Diseases; Male; Middle Aged; Missouri; Penicillins; Pleural Effusion; Sepsis; Sputum; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Burns; Cephalosporins; Chloramphenicol; Dihydrostreptomycin Sulfate; Empyema; Gentamicins; Humans; Infections; Osteomyelitis; Penicillin Resistance; Penicillins; Sepsis; Streptomycin; Surgical Wound Infection; Tetracycline

Topics: Adult; Aged; Bronchitis; Empyema; Female; Humans; Male; Middle Aged; Pleurisy; Pneumonia; Tetracycline; Urinary Tract Infections

Topics: Aged; Clostridium Infections; Clostridium perfringens; Empyema; Escherichia coli; Humans; Male; Methods; Middle Aged; Penicillin G; Pleura; Punctures; Radiography; Tetracycline

Topics: Cephalosporins; Colistin; Drainage; Empyema; Enterobacter; Humans; Lung Abscess; Male; Middle Aged; Penicillins; Pseudomonas aeruginosa; Radiography, Thoracic; Streptodornase and Streptokinase; Tetracycline

Topics: Adolescent; Adult; Age Factors; Aged; Amebiasis; Child; Colitis; Colitis, Ulcerative; Dysentery, Amebic; Emetine; Empyema; Female; Hemagglutination Tests; Humans; Hypokalemia; Indians, North American; Liver Abscess, Amebic; Male; Middle Aged; Saskatchewan; Serum Albumin; Sex Factors; Sigmoidoscopy; Tetracycline

Topics: Bronchitis; Cephalothin; Child; Child, Preschool; Chloramphenicol; Empyema; Epiglottis; Erythromycin; Escherichia coli; Haemophilus Infections; Haemophilus influenzae; Histoplasma; Humans; Infant; Klebsiella; Laryngeal Diseases; Methicillin; Mycobacterium tuberculosis; Otitis Media; Penicillins; Pneumonia; Pseudomonas; Respiratory Tract Infections; Sinusitis; Staphylococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline

Topics: Adolescent; Adult; Aged; Cardiac Surgical Procedures; Child; Empyema; Esophageal Diseases; Extracorporeal Circulation; Female; Humans; Hypothermia, Induced; Inflammation; Infusions, Parenteral; Injections, Intravenous; Injections, Spinal; Lung Diseases; Male; Middle Aged; Pleura; Pleural Diseases; Postoperative Care; Suppuration; Tetracycline; Troleandomycin

Topics: Catheterization; Child; Child, Preschool; Chloramphenicol; Empyema; Erythromycin; Humans; Infant; Infant, Newborn; Kanamycin; Mortality; Novobiocin; Penicillin Resistance; Penicillins; Pneumonia; Pneumothorax; Radiography, Thoracic; Staphylococcal Infections; Streptomycin; Tetracycline

Topics: Adult; Anti-Bacterial Agents; Bacteroides; Bronchography; Empyema; Humans; Male; Middle Aged; Pleural Diseases; Tetracycline

Topics: Adult; Blood Sedimentation; Empyema; Humans; Lung Abscess; Male; Methacycline; Middle Aged; Radiography, Thoracic; Tetracycline

Topics: Drainage; Empyema; Female; Humans; Infant; Lung Abscess; Male; Penicillins; Pleuropneumonia; Pneumonia, Staphylococcal; Pneumothorax; Tetracycline

Topics: Anti-Bacterial Agents; Bacitracin; Child; Chloramphenicol; Chlortetracycline; Drainage; Empyema; Erythromycin; Escherichia coli Infections; Haemophilus influenzae; Humans; Infant; Infant, Newborn; Kanamycin; Novobiocin; Oleandomycin; Pediatrics; Penicillins; Pneumococcal Infections; Pneumothorax; Staphylococcal Infections; Streptococcal Infections; Sulfonamides; Surgical Procedures, Operative; Tetracycline; Vancomycin

Topics: Abscess; Anti-Bacterial Agents; Bacitracin; Bronchial Fistula; Chloramphenicol; Empyema; Erythromycin; Humans; Kanamycin; Novobiocin; Penicillins; Pleural Effusion; Pneumonia; Pneumonia, Staphylococcal; Pneumothorax; Sepsis; Staphylococcal Infections; Tetracycline; Vancomycin

Topics: Abscess; Air Microbiology; Antisepsis; Bacteriological Techniques; Bacteriophage Typing; Burns; Chloramphenicol; Drug Resistance; Drug Resistance, Microbial; Empyema; Enteritis; Epidemiology; Osteomyelitis; Penicillins; Pneumonia; Postoperative Complications; Pressure Ulcer; Pyelonephritis; Sepsis; Staphylococcal Infections; Staphylococcus; Staphylococcus Phages; Tetracycline; Toxicology; Wound Infection

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bronchial Fistula; Bronchopneumonia; Cross Infection; Empyema; Humans; Influenza, Human; Lung Abscess; Pneumonectomy; Postoperative Complications; Sputum; Staphylococcal Infections; Surgical Wound Infection; Tetracycline; Thoracic Diseases; Thoracoplasty; Tuberculosis; Tuberculosis, Pulmonary

Topics: Anti-Bacterial Agents; Bronchial Fistula; Chloramphenicol; Chlortetracycline; Collapse Therapy; Drug Therapy; Empyema; Escherichia coli Infections; Humans; Klebsiella; Penicillins; Pneumonectomy; Polymyxins; Postoperative Complications; Staphylococcal Infections; Streptomycin; Tetracycline; Thoracic Surgery

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Child; Chloramphenicol; Empyema; Empyema, Pleural; Erythromycin; Humans; Kanamycin; Penicillins; Staphylococcal Infections; Streptomycin; Tetracycline

Topics: Abscess; Anti-Bacterial Agents; Appendicitis; Bursitis; Carbuncle; Cellulitis; Empyema; Geriatrics; Humans; Infant; Lymphadenitis; Lymphangitis; Oleandomycin; Osteomyelitis; Paronychia; Parotitis; Peritonitis; Suppuration; Surgical Wound Infection; Tetracycline

Topics: Anti-Bacterial Agents; Bronchiectasis; Cholangitis; Coombs Test; Drug Hypersensitivity; Empyema; Endocarditis; Endocarditis, Bacterial; Hemagglutination; Humans; Osteomyelitis; Penicillins; Precipitin Tests; Pyelonephritis; Sepsis; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Empyema; Humans; Oleandomycin; Tetracycline; Tuberculosis; Tuberculosis, Pulmonary

Topics: Abscess; Anti-Bacterial Agents; Empyema; Empyema, Pleural; Humans; Lung; Lung Abscess; Pleura; Protein Synthesis Inhibitors; Tetracycline