tetracycline and Emphysema

tetracycline has been researched along with Emphysema* in 6 studies

Reviews

1 review(s) available for tetracycline and Emphysema

ArticleYear
Role of infection in the cause and course of chronic bronchitis and emphysema.
    The Journal of infectious diseases, 1975, Volume: 131, Issue:6

    Topics: Age Factors; Air Pollution; Ampicillin; Bronchitis; Cephalothin; Chloramphenicol; Chronic Disease; Drug Therapy, Combination; Emphysema; Environmental Exposure; Maximal Expiratory Flow-Volume Curves; Mycoplasma; Respiratory Syncytial Viruses; Respiratory Tract Infections; Rhinovirus; Smoking; Sulfamethoxazole; Tetracycline; Trimethoprim; Urban Population

1975

Other Studies

5 other study(ies) available for tetracycline and Emphysema

ArticleYear
Expression of the reverse tetracycline-transactivator gene causes emphysema-like changes in mice.
    American journal of respiratory cell and molecular biology, 2006, Volume: 34, Issue:5

    The doxycycline-inducible, gene regulatory system allows tight control of transgene expression for the study of organ development and disease pathogenesis. Multiple recent reports have employed this model to investigate various lung diseases including emphysema. For our study, we used this transgenic system to test whether prolonged, lung-specific, overexpression of the serine protease urokinase plasminogen activator (uPA) would result in alveolar wall destruction. Double transgenic mice were generated that possessed: (1) the rat Clara cell secretory protein promoter controlling the reverse tetracycline transactivator gene (CCSP:rtTA) and (2) the tetracycline operator controlling the murine uPA cDNA (tet[O]:muPA). Mice were treated with doxycycline beginning at age 6 wk to initiate uPA overexpression. Single transgenic and wild-type animals served as controls. A second group of double transgenic and control animals were maintained off of doxycycline. At ages 10, 18, and 30 wk, the mice underwent measurements of alveolar size, lung compliance, and total lung capacity. We found that, although the uPA overexpressing mice demonstrated an emphysema phenotype, similar abnormalities occurred in the CCSP-rtTA control animals. These CCSP-rtTA-related alterations occurred even without doxycycline exposure. Evaluation of a second transgenic line possessing the human surfactant protein C promoter controlling rtTA expression also exhibited lung abnormalities consistent with emphysema. These findings indicate that pulmonary epithelial expression of rtTA alone causes an emphysema phenotype in mice. Therefore, when using this system to study emphysema pathogenesis, the inclusion of proper controls is essential for accurate data interpretation.

    Topics: Animals; Body Weight; Doxycycline; Emphysema; Gene Expression; Genotype; Kinetics; Lung Compliance; Mice; Mice, Inbred C57BL; Mice, Transgenic; Promoter Regions, Genetic; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein C; Tetracycline; Total Lung Capacity; Trans-Activators; Urokinase-Type Plasminogen Activator; Uteroglobin

2006
Emphysematous cholecystitis.
    The American surgeon, 1971, Volume: 37, Issue:7

    Topics: Adult; Cholangitis; Cholecystectomy; Cholecystitis; Emphysema; Gallbladder Diseases; Humans; Male; Middle Aged; Radiography; Tetracycline

1971
Mediastinal and subcutaneous emphysema complicating acute bronchial asthma.
    Chest, 1970, Volume: 57, Issue:6

    Topics: Asthma; Child; Emphysema; Epinephrine; Head; Humans; Male; Mediastinal Emphysema; Neck; Oxygen Inhalation Therapy; Tetracycline

1970
ACUTE EMPHYSEMATOUS CHOLECYSTITIS.
    The Journal of the International College of Surgeons, 1965, Volume: 43

    Topics: Anti-Bacterial Agents; Bacteriology; Chloramphenicol; Cholecystectomy; Cholecystitis; Cholecystography; Emphysema; Emphysematous Cholecystitis; Gastrectomy; Geriatrics; Humans; Pathology; Preoperative Care; Prognosis; Stomach Neoplasms; Tetracycline

1965
Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. I. Chemoprophylaxis with intermittent tetracycline.
    The American journal of medicine, 1961, Volume: 31

    Topics: Anti-Bacterial Agents; Bacterial Infections; Chemoprevention; Emphysema; Humans; Pulmonary Emphysema; Tetracycline

1961