tetracycline and Dyspnea

We report the case of a 60 year female patient suffering from rheumatoid arthritis for the last 25 years, under TNF-blocker and leflunomide, affected by a recurrent pneumothorax with several subpleural nodules, basal bronchiectasis and apical bullous emphysema. The patient was administered several treatments: aspiration, talc pleurodesis, surgical pleurodesis, pleurodesis induced by tetracycline and autologous blood. To allow the pleural inflammatory reaction necessary to the success of the pleurodesis, we had to interrupt the treatment by TNF-blocker and leflunomide. We then witnessed a partial pleurodesis with persistence of a pneumothorax. The medical situation is improving with disappearance of dyspnea.

Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiectasis; Dyspnea; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Diseases; Middle Aged; Pleural Diseases; Pleurodesis; Pneumothorax; Pulmonary Emphysema; Radiography, Thoracic; Recurrence; Tetracycline; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. It is caused by chronic inflammation of the airways and the lung parenchyma. Symptomatic treatment is based on bronchodilatation, which leads to a reduction of hyperinflation and relief of dyspnea. Smoking cessation is the only known causative treatment option. Inhaled corticosteroids (ICS) reduce exacerbations and, potentially, mortality. Future therapies should ameliorate chronic inflammation and thus stop the annual decline of lung function. In face of increasing mortality and morbidity more research is needed.

Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Dyspnea; Expectorants; Forced Expiratory Volume; Forecasting; Humans; Inflammation; Infliximab; Lung; Macrolides; Nitriles; Phosphodiesterase Inhibitors; Pilot Projects; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Research; Respiratory Function Tests; Simvastatin; Smoking Cessation; Tetracycline; Theophylline; Tumor Necrosis Factor-alpha

Topics: Ampicillin; Anti-Bacterial Agents; Bronchitis; Child; Chloramphenicol; Clinical Trials as Topic; Dyspnea; Female; Glycine; Humans; Infant; Infant, Newborn; Injections, Intramuscular; Male; Pneumonia; Respiratory Tract Infections; Tetracycline

Topics: Aerosols; Aged; Antifungal Agents; Bronchiectasis; Bronchitis; Cough; Dyspnea; Female; Humans; Male; Middle Aged; Sputum; Tetracycline

Topics: Bronchoscopy; Catheterization; Dyspnea; Equipment Design; Humans; Lung; Male; Middle Aged; Pleurodesis; Pneumothorax; Prostheses and Implants; Tetracycline

Rhinoscleroma is a rare, chronic granulomatous disease of infective causation. It usually begins in the nose and may progress to involve the larynx and trachea and cause dysphonia, stridor, and airway obstruction. Early rhinoscleroma is usually successfully treated with oral tetracycline, yet laryngotracheal disease may require operative intervention. The disease is rare in the United States, but with an increase in immigration from endemic areas, otolaryngologists should be familiar with the management of this rare disease. Current literature contains only a few reports describing the manifestations of this disease, mostly in the form of case studies. This study is a retrospective review of our institutional experience with the management of 22 patients with rhinoscleroma, 13 of whom had laryngotracheal involvement. The focus of this report is on the clinical manifestations of laryngotracheal scleroma. All of the patients were treated with long-term antibiotics. Nine patients underwent endoscopy with or without dilation and laser excision. Three patients required emergency tracheostomy, all of whom were ultimately decannulated without any sequelae. A rational approach to management of this unusual disease is provided.

Topics: Adult; Aged; Ampicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Dyspnea; Female; Humans; Klebsiella pneumoniae; Larynx; Male; Middle Aged; Retrospective Studies; Rhinoscleroma; Steroids; Tetracycline; Trachea; Tracheostomy; Voice Disorders

Topics: Abdominal Muscles; Adult; Aged; Asthma; Dyspnea; Female; Hematoma; Humans; Male; Pulmonary Emphysema; Radiography; Respiratory Tract Infections; Tetracycline; Thrombophlebitis

Topics: Acute Disease; Adolescent; Child; Child, Preschool; Dexamethasone; Dyspnea; Erythromycin; Humans; Klebsiella pneumoniae; Male; Penicillins; Respiratory Tract Infections; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Tetracycline; Tracheotomy

Topics: Acetylcholine; Airway Obstruction; Airway Resistance; Atropine; Blood Pressure; Bronchitis; Bronchodilator Agents; Chronic Disease; Coal Mining; Drug Combinations; Dyspnea; Humans; Metaproterenol; Pneumoconiosis; Prednisolone; Pulmonary Artery; Tetracycline

Topics: Adult; Aged; Aniline Compounds; Antitussive Agents; Bronchitis; Dyspnea; Expectorants; Female; Humans; Male; Middle Aged; Respiratory Tract Diseases; Tetracycline; Toluene

Topics: Adolescent; Adrenal Cortex Hormones; Aminopyrine; Blood; Blood Cell Count; Blood Transfusion; Capillaries; Child; Child, Preschool; Cyanosis; Dyspnea; Female; Humans; Lanatosides; Leukemia; Male; Methotrexate; Methylprednisolone; Nystatin; Penicillins; Plasma Cells; Prednisone; Pulmonary Circulation; Pulmonary Fibrosis; Purines; Tetracycline

Topics: Drug Hypersensitivity; Dyspnea; Eosinophilia; Fever; Humans; Lung Diseases; Nitrofurantoin; Pleural Effusion; Radiography, Thoracic; Tetracycline; Toxicology; Urinary Tract Infections