tetracycline and Drug-Hypersensitivity

Bismuth triple therapy was the first effective Helicobacter pylori eradication therapy. The addition of a proton pump inhibitor helped overcome metronidazole resistance. Its primary indication is penicillin allergy or when clarithromycin and metronidazole resistance are both common. Resistance to the primary first-line therapy have centered on complexity and difficulties with compliance. Understanding regional differences in effectiveness remains unexplained because of the lack of studies including susceptibility testing and adherence data. We discuss regimen variations including substitutions of doxycycline, amoxicillin, and twice a day therapy and provide suggestions regarding what is needed to rationally and effectively use bismuth quadruple therapy.

Topics: Antacids; Anti-Bacterial Agents; Bismuth; Drug Administration Schedule; Drug Hypersensitivity; Drug Resistance, Bacterial; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Humans; Medication Adherence; Metronidazole; Proton Pump Inhibitors; Tetracycline

Because minocycline can cause serious adverse events including hypersensitivity syndrome reaction (HSR), serum sicknesslike reaction (SSLR), and drug-induced lupus, a follow-up study based on a retrospective review of our Drug Safety Clinic and the Health Protection Branch databases and a literature review was conducted to determine if similar rare events are associated with tetracycline and doxycycline. Cases of isolated single organ dysfunction (SOD) attributable to the use of these antibiotics also were identified.. Nineteen cases of HSR due to minocycline, 2 due to tetracycline, and 1 due to doxycycline were identified. Eleven cases of SSLR due to minocycline, 3 due to tetracycline, and 2 due to doxycycline were identified. All 33 cases of drug-induced lupus were attributable to minocycline. Forty cases of SOD from minocycline, 37 cases from tetracycline, and 6 from doxycycline were detected. Hypersensitivity syndrome reaction, SSLR, and SOD occur on average within 4 weeks of therapy, whereas minocycline-induced lupus occurs on average 2 years after the initiation of therapy.. Early serious events occurring during the course of tetracycline antibiotic treatment include HSR, SSLR, and SOD. Drug-induced lupus, which occurs late in the course of therapy, is reported only with minocycline. We theorize that minocycline metabolism may account for the increased frequency of serious adverse events with this drug.

Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Anti-Bacterial Agents; Arthralgia; Canada; Databases as Topic; Doxycycline; Drug Eruptions; Drug Hypersensitivity; Drug Prescriptions; Female; Fever; Follow-Up Studies; Humans; Liver; Lupus Erythematosus, Systemic; Male; Middle Aged; Minocycline; Retrospective Studies; Safety; Serum Sickness; Syndrome; Tetracycline; Time Factors

The high incidence of allergic reactions to some common dental antibiotics, primarily topical penicillins, has led to general concerns about all topical antibiotics. The development of resistant bacterial strains and efforts to reserve key antibiotics for life-threatening infections have also limited topical use of antibiotics. Delivery technologies providing for site-specific drug delivery have renewed interest in the use of topical antimicrobials to treat adult periodontitis. Topical tetracycline has an extremely low sensitizing potential and is not one of the antibiotics reserved by the medical community for use in life-threatening situations. Despite tetracycline's widespread dermatologic use and increasing use in adjunctive treatment of adult periodontitis, the incidence of allergic response to topical tetracycline is very low. Also, it is unlikely to cause resistance when used locally for short durations--particularly at the high per-site concentrations achieved with tetracycline periodontal fiber. Studies with tetracycline fiber showed no significant change in the tetracycline susceptibility of gram-negative periodontal microorganisms.

Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Drug Hypersensitivity; Gram-Negative Bacteria; Humans; Periodontitis; Tetracycline; Tetracycline Resistance

Topics: Anaphylaxis; Angioedema; Anti-Bacterial Agents; Anti-Infective Agents; Carrier Proteins; Dose-Response Relationship, Drug; Drug Hypersensitivity; Exanthema; Humans; Hydrocortisone; Mast Cells; Peptides; Proteins; Serum Sickness; Skin Tests; Tetracycline; Urticaria

Penicillin remains the treatment of choice for syphilis, with sustained low blood levels curing virtually all patients having early syphilis and halting disease progression in most patients with symptomatic syphilis. Tetracycline, erythromycin or cephalothin yields similar cure rates for patients with early syphilis who are allergic to penicillin. The efficacy of non-penicillin regimens for the treatment of late syphilis is uncertain. Results of Venereal Disease Research Laboratory (VDRL) or other reagin tests should become negative or remain at very low titer following adequate therapy, although results of Treponema pallidum immobilization (TPI) and fluorescent treponemal antibody-absorbed (FTA-ABS) tests often remain positive.

Topics: Cephalexin; Cephaloridine; Cephalosporins; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Female; Fever; Fluorescent Antibody Technique; Follow-Up Studies; Humans; Neurosyphilis; Penicillin G Benzathine; Penicillins; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, First; Syphilis; Syphilis Serodiagnosis; Syphilis, Cardiovascular; Syphilis, Congenital; Syphilis, Latent; Tetracycline; Treponema pallidum; United States

Topics: Age Factors; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Blood Coagulation; Cerebral Hemorrhage; Child; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Female; Fetus; Fusidic Acid; Humans; Kidney; Lincomycin; Liver; Maternal-Fetal Exchange; Penicillins; Polymyxins; Pregnancy; Tetracycline

Topics: Anaphylaxis; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Fetal Diseases; Gastrointestinal Diseases; Hearing Disorders; Hematologic Diseases; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney Diseases; Neomycin; Nervous System Diseases; Neuromuscular Diseases; Novobiocin; Penicillins; Pregnancy; Psychoses, Substance-Induced; Serum Sickness; Streptomycin; Tetracycline; Vision Disorders

Topics: Amphotericin B; Analgesics; Anesthetics; Anti-Bacterial Agents; Bacitracin; Cephaloridine; Cephalothin; Drug Hypersensitivity; Humans; Kidney Diseases; Penicillins; Polymyxins; Sulfonamides; Tetracycline

Topics: Aminoglycosides; Ampicillin; Anemia, Hemolytic, Autoimmune; Anti-Bacterial Agents; Carbenicillin; Central Nervous System Diseases; Cephalosporins; Chloramphenicol; Clindamycin; Dermatitis; Drug Hypersensitivity; Gentamicins; Humans; Kanamycin; Kidney Diseases; Lincomycin; Neomycin; Penicillins; Polymyxins; Streptomycin; Tetracycline; Vancomycin

Topics: Adolescent; Adult; Aged; Animals; Anti-Bacterial Agents; Cephalosporins; Child; Child, Preschool; Chloramphenicol; Drug Hypersensitivity; Female; Gentamicins; Humans; Infant; Intestines; Kidney Diseases; Labyrinth Diseases; Male; Middle Aged; Optic Neuritis; Penicillins; Rabbits; Seizures; Tetracycline

Topics: Administration, Oral; Anti-Bacterial Agents; Bacteria; Cephalosporins; Chemical Phenomena; Chemistry; Drug Compounding; Drug Hypersensitivity; Eye Diseases; Humans; Injections, Intramuscular; Injections, Intravenous; Nitrofurans; Penicillin Resistance; Penicillins; Sulfonamides; Tetracycline

Topics: Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Colistin; Drug Hypersensitivity; Enterobacteriaceae Infections; Erythromycin; Female; Gonorrhea; Humans; Kidney Diseases; Mycoplasma Infections; Pelvic Inflammatory Disease; Salpingitis; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Tetracycline; Thrombophlebitis; Tuberculosis, Female Genital; Wound Infection

Topics: Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Colistin; Drug Hypersensitivity; Erythromycin; Gentamicins; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Infections; Intestinal Absorption; Kanamycin; Neomycin; Odontogenesis; Oleandomycin; Penicillin Resistance; Penicillins; Polymyxins; Staphylococcal Infections; Streptomycin; Tetracycline

Topics: Animals; Arsenicals; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; Contraceptives, Oral; Drug Hypersensitivity; Humans; Isoniazid; Liver Diseases; Steroids; Tannins; Tetracycline

Topics: Anti-Bacterial Agents; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Kanamycin; Neomycin; Penicillins; Pharmacology; Streptomycin; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Anticonvulsants; Chlorothiazide; Coloring Agents; Coumarins; Drug Hypersensitivity; Gold; Histamine H1 Antagonists; Hypoglycemic Agents; Phenothiazines; Photosensitivity Disorders; Plant Poisoning; Porphyrins; Silver; Sulfonamides; Tars; Tetracycline; Toxicology

Topics: Anaphylaxis; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Cycloserine; Drug Hypersensitivity; Kanamycin; Neomycin; Penicillins; Polymyxins; Protein Synthesis Inhibitors; Streptomycin; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Penicillins; Streptomycin; Tetracycline; Toxicology

H. pylori eradication is a challenge in patients allergic to penicillin, both first-line and failures of prior therapy. We aimed to assess the eradication rate of H. pylori in patients allergic to penicillin, first-line and failures of prior therapy, the efficacy of healing of active duodenal ulcer disease (DUD) and erosive gastritis, and the safety and tolerability of the combination. Twenty patients with documented allergy to penicillin, DUD, and H. pylori infection, 17 (85%) for first-line treatment and 3 (15%) prior therapy failures, were given a 10-day regimen of esomeprazole, 40 mg qid, tetracycline, 500 mg qid, and metronidazole, 500 mg qid. Baseline and follow-up panendoscopy > or =30 days after end of treatment was performed for rapid urease test (Clotest), and four site biopsies for H. pylori, and to document endoscopic peptic ulcer disease. All adverse events during treatment were documented. Eradication rates by intention to treat (ITT) were 85% for first-line treatment and 100% for failures. Seventy percent of all cases had a normal endoscopy at follow-up, and 85 and 100% of patients had healed erosive gastritis and DUD, respectively, from baseline. There were histological improvements in most patients. A high eradication rate was obtained even in patients who had a shorter duration of treatment. The combination was well tolerated. A combination of esomeprazole, tetracycline, and metronidazole is effective for eradication of H. pylori in patients allergic to penicillin, for both first-line treatment and failures of prior treatment.

Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Drug Hypersensitivity; Drug Therapy, Combination; Duodenal Ulcer; Esomeprazole; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metronidazole; Middle Aged; Penicillins; Tetracycline; Treatment Outcome

One hundred and eighty-four male patients with uncomplicated gonorrhea were treated in a randomized double-blind trial using two drug regimens. The combinations used were co-trimoxazole (trimethoprim, 80 mg and sulfamethoxazole, 400 mg) and TMP-SDZ (sulfadiazine, 400 mg and trimethoprim, 80 mg). In 43 patients who received eight tablets of co-trimoxazole in a single dose the cure rate was 88%. In the 46 patients who received a second dose of eight tablets 24 hours later the cure rate was 100%. When TMP-SDZ was used according to the same schedule the respective cure rates were 85% (41 patients) and 86% (35 patients). It is suggested that the two-dose regimen with co-trimoxazole is very effective in the treatment of uncomplicated urethral gonorrhea in the male and that the single-dose regimen, although less effective, may well prove adequate in patients defaulting after the initial treatment. At the present time, and with our local conditions, this form of treatment should be reserved for patients sensitive to penicillin or whose infections are resistant to this agent. The attack rate for patients having an episode of gonorrhea in the 12-month period immediately preceding the trial bore a direct relation to the outcome of therapy. It was highest (26%) in the group with an unsatisfactory outcome and lowest(4.3%) in the group with the highest cure rate. No adverse toxic reactions to the drug were recorded.

Topics: Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Drug Hypersensitivity; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Patient Dropouts; Penicillin Resistance; Penicillins; Sulfadiazine; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Ampicillin; Costs and Cost Analysis; Drug Hypersensitivity; Drug Synergism; Female; Genetics, Microbial; Gonorrhea; Humans; Male; Molecular Biology; Neisseria gonorrhoeae; Penicillin G Benzathine; Penicillin G Procaine; Penicillin Resistance; Penicillins; Placebos; Probenecid; Spectinomycin; Syphilis; Tetracycline; United States

Topics: Administration, Oral; Adolescent; Adult; Demeclocycline; Doxycycline; Drug Hypersensitivity; Gonorrhea; Humans; Injections, Intramuscular; Male; Middle Aged; Neisseria gonorrhoeae; Oxytetracycline; Penicillin G Procaine; Penicillin Resistance; Tetracycline

In a comparative investigation incised skin abscesses were treated by either introducing sterile fusidic acid gel into the cavity on one occasion only or applying daily superficial dressings impregnated with sodium fusidate ointment. In comparison with the dressing group, the intracavity use of fusidic acid gel reduced the mean healing time of incised abscesses by approximately one-half. When abscesses were analysed according to site and size, the reduction in mean healing time was equally striking. No hypersentisivity or irritation to fusidic acid or its sodium salt applied by either method was observed.The procedure of introducing fusidic acid gel into an incised abscess cavity is a promising alternative to superficial antibiotic dressings or wicks in the treatment of incised abscesses.

Topics: Abscess; Bandages; Drug Hypersensitivity; Fusidic Acid; Gels; Humans; Ointments; Penicillins; Skin Diseases; Tetracycline; Time Factors; Wound Healing

Topics: Clinical Trials as Topic; Drug Hypersensitivity; Fever; Humans; Infant; Penicillin V; Respiratory Tract Infections; Tetracycline

Experience in Helicobacter pylori eradication treatment of patients allergic to penicillin is very scarce. A triple combination with a PPI, clarithromycin (C), and metronidazole (M) is often prescribed as the first option, although more recently the use of a quadruple therapy with PPI, bismuth (B), tetracycline (T), and M has been recommended.. To evaluate the efficacy and safety of first-line and rescue treatments in patients allergic to penicillin in the "European Registry of H pylori management" (Hp-EuReg).. A systematic prospective registry of the clinical practice of European gastroenterologists (27 countries, 300 investigators) on the management of H pylori infection. An e-CRF was created on AEG-REDCap. Patients with penicillin allergy were analyzed until June 2019.. One-thousand eighty-four patients allergic to penicillin were analyzed. The most frequently prescribed first-line treatments were as follows: PPI + C + M (n = 285) and PPI + B + T + M (classic or Pylera. In patients allergic to penicillin, a triple combination with PPI + C + M should not be generally recommended as a first-line treatment, while a quadruple regimen with PPI + B + T + M seems to be a better option. As a rescue treatment, this quadruple regimen (if not previously prescribed) or a triple regimen with PPI + C + L could be used but achieved suboptimal (<80%) results.

Topics: Anti-Bacterial Agents; Bismuth; Clarithromycin; Drug Hypersensitivity; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Metronidazole; Penicillins; Prospective Studies; Proton Pump Inhibitors; Registries; Tetracycline

Helicobacter pylori eradication is a challenge in penicillin allergy.. To assess the efficacy and safety of first-line and rescue treatments in patients allergic to penicillin.. Prospective multicenter study. Patients allergic to penicillin were given a first-line treatment comprising (a) 7-day omeprazole-clarithromycin-metronidazole and (b) 10-day omeprazole-bismuth-tetracycline-metronidazole. Rescue treatments were as follows: (a) bismuth quadruple therapy; (b) 10-day PPI-clarithromycin-levofloxacin; and (c) 10-day PPI-clarithromycin-rifabutin. Eradication was confirmed by (13)C-urea breath test. Compliance was determined through questioning and recovery of empty medication envelopes. Adverse effects were evaluated by questionnaires.. In total, 267 consecutive treatments were included. (1) First-line treatment: Per-protocol and intention-to-treat eradication rates with omeprazole-clarithromycin-metronidazole were 59 % (62/105; 95 % CI 49-62 %) and 57 % (64/112; 95 % CI 47-67 %). Respective figures for PPI-bismuth-tetracycline-metronidazole were 75 % (37/49; 95 % CI 62-89 %) and 74 % (37/50; 95 % CI (61-87 %) (p < 0.05). Compliance with treatment was 94 and 98 %, respectively. Adverse events were reported in 14 % with both regimens (all mild). (2) Second-line treatment: Intention-to-treat eradication rate with omeprazole-clarithromycin-levofloxacin was 64 % both after triple and quadruple failure; compliance was 88-100 %, with 23-29 % adverse effects (all mild). (3) Third-/fourth-line treatment: Intention-to-treat eradication rate with PPI-clarithromycin-rifabutin was 22 %.. In allergic to penicillin patients, a first-line treatment with a bismuth-containing quadruple therapy (PPI-bismuth-tetracycline-metronidazole) seems to be a better option than the triple PPI-clarithromycin-metronidazole regimen. A levofloxacin-based regimen (together with a PPI and clarithromycin) represents a second-line rescue option in the presence of penicillin allergy.

Topics: Antacids; Anti-Bacterial Agents; Bismuth; Breath Tests; Clarithromycin; Drug Administration Schedule; Drug Hypersensitivity; Drug Therapy, Combination; Female; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Male; Medication Adherence; Metronidazole; Middle Aged; Omeprazole; Penicillins; Predictive Value of Tests; Prospective Studies; Proton Pump Inhibitors; Rifabutin; Salvage Therapy; Spain; Tetracycline; Time Factors; Treatment Outcome

Topics: Adult; Anti-Bacterial Agents; Drug Hypersensitivity; Female; Fingers; Humans; Lymecycline; Onycholysis; Photosensitivity Disorders; Tetracycline; Toes

Antibiotic selection is challenging in patients with severe β-lactam allergy due to declining reliability of alternate antibiotics. Organisms isolated from these patients may exhibit unique resistance phenotypes. The objective of this study was to determine which alternate antibiotics or combinations provide adequate empirical therapy for patients with β-lactam allergy who develop Gram-negative infections at our institution. We further sought to determine the effects of risk factors for drug resistance on empirical adequacy. A retrospective analysis was conducted for adult patients hospitalized from September 2009 to May 2010 who had a severe β-lactam allergy and a urine, blood, or respiratory culture positive for a Gram-negative organism and who met predefined criteria for infection. Patient characteristics, culture and susceptibility data, and predefined risk factors for antibiotic resistance were collected. Adequacies of β-lactam and alternate antibiotics were compared for all infections and selected subsets. The primary outcome was adequacy of each alternate antibiotic or combination for all infections. One hundred sixteen infections (40 pneumonias, 67 urinary tract infections, and 9 bacteremias) were identified. Single alternate agents were adequate less frequently than β-lactams and combination regimens. Only in cases without risk factors for resistance did single-agent regimens demonstrate acceptable adequacy rates; each factor conferred a doubling of risk for resistance. Resistance risk factors should be considered in selecting empirical antibiotics for Gram-negative pathogens in patients unable to take β-lactams due to severe allergy.

Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; beta-Lactams; Drug Hypersensitivity; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Empirical Research; Female; Fluoroquinolones; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Middle Aged; Pneumonia, Bacterial; Retrospective Studies; Risk; Tetracycline; Urinary Tract Infections

(1) Photosensitivity reactions are cutaneous disorders due to exposure to ultraviolet (UV) radiation of natural or artificial origin. They occur or are more prevalent on unprotected skin. The main clinical manifestations are burns, eczema-like rash, urticaria, pigmentation, or onycholysis; (2) Many drugs increase cutaneous sensitivity to UV, sometimes for therapeutic purposes, but it is generally an unwanted effect.

Topics: Aminolevulinic Acid; Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Agents; Dermatitis, Photoallergic; Dermatitis, Phototoxic; Dihematoporphyrin Ether; Diuretics; Doxycycline; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Eczema; Furocoumarins; Hematoporphyrin Photoradiation; Humans; Methotrexate; Onycholysis; Photochemotherapy; Photosensitivity Disorders; Photosensitizing Agents; Porphyrins; Psychotropic Drugs; Quinolines; Skin; Skin Aging; Skin Diseases; Skin Neoplasms; Skin Pigmentation; Sulfonamides; Sunscreening Agents; Tetracycline; Ultraviolet Rays; Urticaria; Verteporfin

Topics: Acne Vulgaris; Adolescent; Anti-Bacterial Agents; Drug Hypersensitivity; Fever; Humans; Male; Tetracycline

The current data suggest that local delivery of antimicrobials into the periodontal pocket can improve periodontal health. However, they do not provide a superior result to scaling and root planing. In conjunction with scaling and root planing, the adjunctive use of local drug delivery devices may enhance the results in sites which do not respond to conventional therapy.

Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Chlorhexidine; Doxycycline; Drug Hypersensitivity; Drug Resistance, Microbial; Humans; Minocycline; Periodontal Pocket; Periodontitis; Tetracycline

The author revealed an increase of dienic conjugates in 391 patients under the effect of drugs in patients with drug intolerance and a study is also presented in 46 patients with good tolerance to drugs. It is shown that the dienic test has an information value as to intolerance of penicillin, streptomycin, tetraolean, analgin, novocaine and vitamin B1.

Topics: Adult; Diagnostic Errors; Dipyrone; Drug Hypersensitivity; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Male; Methods; Middle Aged; Oleandomycin; Penicillins; Procaine; Streptomycin; Sulfanilamides; Tetracycline; Thiamine

In 1985 dentists in the Lothian Region of Scotland were questioned about their use of prophylactic antibiotics for patients at risk of developing infective endocarditis. Replies were compared with those obtained from a similar survey in 1981. The results showed a marked change in practice with widespread adoption of the single-dose oral amoxycillin regimen; this was the regimen of choice for 63% of general dental practitioners. For patients allergic to penicillin 76% of practitioners used erythromycin and there was a decline in the use of tetracycline and clindamycin. The adoption of amoxycillin reflects the ease of compliance with a simple single-dose regimen. This change has produced a striking improvement in the timing of prophylactic antibiotic therapy.

Topics: Amoxicillin; Anti-Bacterial Agents; Clindamycin; Dentistry; Drug Administration Schedule; Drug Hypersensitivity; Endocarditis, Bacterial; Erythromycin; Heart Diseases; Humans; Penicillins; Risk Factors; Surveys and Questionnaires; Tetracycline

Topics: Cephalosporins; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Humans; Penicillins; Spectinomycin; Syphilis; Tetracycline

Twenty nine patients with genital fixed drug eruptions were studied during one year. In 15 the genitalia were exclusively affected, whereas the other 14 had cutaneous lesions in addition. It was striking that those whose lesions were exclusively genital reported for consultation much earlier. Drug history was the mainstay of diagnosis. Provocation tests with graded doses of the suspected drug(s) were undertaken in all cases. Tetracycline was the commonest causative drug, followed by oxyphenbutazone and acetylsalicylic acid.

Topics: Adolescent; Adult; Child; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Penile Diseases; Skin Tests; Skin Ulcer; Tetracycline; Vaginal Diseases; Vulvar Diseases

Topics: Antitubercular Agents; Bone Marrow; Chloramphenicol; Drug Hypersensitivity; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Hematopoiesis; Humans; Neutropenia; Nitrofurantoin; Pancytopenia; Penicillins; Phenylbutazone; Phenytoin; Red-Cell Aplasia, Pure; Tetracycline; Thrombocytopenia

Topics: Adult; Anemia, Hemolytic, Autoimmune; Drug Hypersensitivity; Humans; Male; Prostatitis; Tetracycline

Topics: Adolescent; Ampicillin; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Liver; Male; Middle Aged; Oleandomycin; Tetracycline

Topics: Antibodies, Bacterial; Drug Hypersensitivity; Erythromycin; Humans; Penicillins; Syphilis; Syphilis Serodiagnosis; Tetracycline; Treponema Immobilization Test; Treponema pallidum

The effects of numerous drugs and drug metabolites on the liver cleansing system are reviewed. Topics covered include metabolite-related drug toxicity, drug hypersensitivity, chronic liver disease, and hepatic tumors and oral contraceptives (OCs). Currently available evidence implicating OCs in the pathogenesis of hepatic tumors is large but inconclusive. However, both benign and malignant hepatic tumors have been encountered in women taking OCs, inviting further speculation that in some patients malignant transformation may occur. In a study covering 1937-1976, only 400 cases of hepatic cell adenoma and focal nodular hyperplasia were reported in patients, not taking OCs, but more than 200 cases have been reported in women taking OCs in the past 3 years. This may, however, present a biased view in favor of reporting contraceptive-associated tumors. An 8-year prospective study in Great Britain has so far not revealed tumors either in women receiving these agents or in any of their control groups. Studies with animals have been inconclusive so far; norethynodrel with mestranol (Enovid) failed to increase the incidence of hepatic tumors in susceptible mice, though a number of C17 alpha alkyl derivatives of testosterone will increase the expected frequency of hepatic tumors in susceptible mice. The reported regression of benign hepatic tumors on withdrawal of therapy and recurrences of tumors after primary resection in patients who continued to use such agents support the etiological role of OCs. However, more accurate statistics, which can only be obtained by large regional or national registries of hepatic tumors, are essential before this problem can be adequately evaluated.

Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptives, Oral; Drug Hypersensitivity; Female; Halothane; Humans; Isoniazid; Liver; Liver Neoplasms; Methotrexate; Pharmaceutical Preparations; Tetracycline

Photo-onycholysis is a rare complication of tetracycline therapy. Its occurrence is probably greater than the few reported cases indicate. It is hoped that this case report will alert physicians to its occurrence.

Topics: Adolescent; Drug Hypersensitivity; Female; Humans; Nail Diseases; Photosensitivity Disorders; Tetracycline

A case of an 18-year-old woman with postoperative infectious complications and multiple antibiotic allergies is discussed. The case poses several problems: the selection of an appropriate antibiotic to combat the infection, the persistence of the infection, and the treatment of multiple allergic responses to each of the antibiotic agents chosen.

Topics: Adolescent; Anti-Bacterial Agents; Cephalexin; Drug Hypersensitivity; Erythromycin; Female; Humans; Lincomycin; Tetracycline

Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Drug Hypersensitivity; Erythromycin; Humans; Hydrocortisone; Injections, Intravenous; Male; Middle Aged; Penicillin G; Relapsing Fever; Syndrome; Tetracycline

A case of anaphylactic reaction in the form of acute cyanosis, hypotension with sudden and unexpected death of a patient in the post-operative period following the administration of tetracycline is described. There was no history of previous exposure to the drug.

Topics: Adult; Anaphylaxis; Appendectomy; Drug Hypersensitivity; Heart Arrest; Humans; Male; Postoperative Complications; Tetracycline

A mechanic working in the antibiotic capsuling section of a pharmaceutical company developed asthmatic attacks 1 year after starting work. His occupation involved exposure to a variety of chemical agents including tetracycline. He developed immediate weal and flare reaction to the intradermal test and an immediate (type 1) asthmatic response to intradermal, inhalation and oral challenge tests with tetracycline. On leaving the tetracycline plant he became symptom free.

Topics: Adult; Asthma; Drug Hypersensitivity; Drug Industry; Dust; Environmental Exposure; Humans; Intradermal Tests; Lung Volume Measurements; Male; Occupational Diseases; Tetracycline

An original method for diagnosis of drug allergy, i.e. a scarification-film test (SFT) in 2 variants has been worked out for the first itme on the basis of examination of 241 persons and is recommended for use. 10 mm parallel scarifications with intervals of 3-4 mm between them were made on the epidermis of the antibrachial flexor and the following agents were applied to them: 1) a film-forming aerosol composition with medicines (tetracycline)--the 1st variant of SFT. (2) powder or solutions of medicines (antibiotics, sulfanylamides, vitamins, etc.) covered with a film-forming ocmposition without any medicine--the 2nd variant of SFT, 3) film-forming aerosol composition without any medicine-control of both variants out of 46 patients with professional dermatosis and in 10 (7.8 per cent) out of 127 practically healthy persons with latent sensitization (workers of pharmaceutical factories) being in contact with tetracycline. Hypersensitivity of the delay type to benzylpenicillin, streptomycin, sulfanylamides and other medicines was found in 54 79.4 per cent) out of 68 patients with drug allergy of professional and non-professional etiology. The method was shown to be highly sensitive, handy, simple and safe, which provided its recommendation for the use in wide clinical practice for diagnosis of drug allergy of the retarded type which developed because of drug use or professional contact.

Topics: Adolescent; Adult; Aged; Allergens; Child; Dermatitis, Occupational; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Male; Middle Aged; Penicillin G; Skin Tests; Streptomycin; Sulfanilamides; Tetracycline

Topics: Adolescent; Drug Hypersensitivity; Escherichia coli Infections; Female; Fingers; Hemorrhage; Humans; Nails; Photosensitivity Disorders; Pigmentation Disorders; Skin Diseases; Tetracycline

Topics: Drug Hypersensitivity; Erythromycin; Female; Humans; Infant, Newborn; Penicillin G Benzathine; Penicillin G Procaine; Penicillins; Pregnancy; Pregnancy Complications; Syphilis; Syphilis, Congenital; Tetracycline

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities.

Topics: Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Contraceptives, Oral, Hormonal; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Ethanol; Female; Humans; Liver Diseases; Mitochondria, Liver; Rifampin; Steroids; Tetracycline; Tranquilizing Agents

Topics: Age Factors; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Eruptions; Drug Hypersensitivity; Humans; Liver; Pediatrics; Societies, Medical; Tetracycline; Tooth Discoloration

Phototoxic and photoallergic reactions of the skin are certainly not very common, but, on the other hand, the complete list of medicinal substances which are accused of causing them is extremely extensive. For this reason, dispensing with many details, an attempt is made to present the basis of such reactions. After irradiation with longwave ultra-violet light, which alone would not have produced inflammation, a reaction occurred through the agency of many drugs which can proceed according to a toxic or allergic mechanism.

Topics: Anilides; Diagnosis, Differential; Drug Hypersensitivity; Humans; Light; Phenothiazines; Photosensitivity Disorders; Salicylates; Skin Diseases; Skin Tests; Sulfonamides; Tars; Tetracycline; Ultraviolet Rays

Topics: Adolescent; Ampicillin; Bacteria; Bacterial Infections; Child; Child, Preschool; Chloramphenicol; Cyclacillin; Drug Hypersensitivity; Exanthema; Humans; Infant; Infant, Newborn; Pediatrics; Penicillins; Private Practice; Staphylococcus; Tetracycline; Vomiting

In the presence of penicillin allergy early syphilis can be treated with tetracyclines, erythromycin and thiamphenicol. Treatment with semisynthetic penicillins or cephalosporins should not be attempted in view of possible cross-sensitivity. From comparison of different antibiotic treatment schedules in the literature a time-dose relationship seems evident: within therapeutic limits, treatment with a high daily dose of antibiotic requires a relatively short duration, and vice versa. Results of various treatment schedules with different antibiotics suggest that preference should be given to doxycycline by oral route, 100 mg twice daily for 12 days.

Topics: Administration, Oral; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Doxycycline; Drug Hypersensitivity; Erythromycin; Humans; Penicillins; Syphilis; Tetracycline; Thiamphenicol; Time Factors

Toxicity of tetracyclines was studied experimentally on different species of laboratory animals. It was shown that tetracycline, oxytetracycline and chlortetracycline were close by their chemical structure and physico-chemical properties, as well as by the main toxicity parameters, i.e. acute toxicity, cumulative activity, skin-irritating and sensitizing effect. Under the conditions of subacute experiments the above 3 antibiotics induced evenly pronounced one direction changes in animals. The data obtained during the experiments provided recommendation of the level of 0.1 mg/m3 as the maximum allowable concentration (MAC) of oxytetracycline and chlortetracycline, i.e. the same level as the previously recommended for tetracycline.

Topics: Administration, Oral; Animals; Chlortetracycline; Drug Hypersensitivity; Guinea Pigs; Lethal Dose 50; Maximum Allowable Concentration; Mice; Oxytetracycline; Rats; Species Specificity; Tetracycline; Tetracyclines; Time Factors

Analysis of 302 side effects of antibiotic theraphy is presented. The side effects were studied comparatively as dependent on the antibiotic group. Dependence of the toxic and toxicoallergic reactions to the antibiotics on the antibiotic blood levels were noted. Previous sensitization resulted in more frequent and earlier side effects. The analysis and clinical observations showed that antibiotic therapy should take into account the results of the laboratory tests, i.e. examination of the kidney functional state, antibiotic levels in the blood and urine, tolerance of the drug by the patient.

Topics: Acute Disease; Adolescent; Adult; Aged; Aminoglycosides; Anaphylaxis; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Erythromycin; Female; Humans; Hypersensitivity, Delayed; Kidney; Leukocytes; Male; Middle Aged; Myocarditis; Oleandomycin; Penicillins; Skin; Streptomycin; Tetracycline; Urinary Tract

Topics: Aminopyrine; Animals; Antibodies; Antigens; Drug Hypersensitivity; Humans; Hydroxyindoleacetic Acid; Immunity, Cellular; Penicillins; Rats; Ristocetin; Serotonin; Sulfathiazoles; Tetracycline

Topics: Adult; Balanitis; Drug Hypersensitivity; Humans; Laryngitis; Male; Tetracycline

Topics: Amphotericin B; Cephaloridine; Chemical Precipitation; Drug Combinations; Drug Hypersensitivity; Drug Incompatibility; Drug Stability; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Protein Binding; Sulfadiazine; Tetracycline; Time Factors

Topics: Chemical and Drug Induced Liver Injury; Chloramphenicol; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Hematuria; Humans; Nalidixic Acid; Neurologic Manifestations; Nitrofurantoin; Penicillins; Skin Manifestations; Sulfonamides; Sweden; Tetracycline

Topics: Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Bacteria; Cephalosporins; Chloramphenicol; Clindamycin; Cloxacillin; Drug Hypersensitivity; Erythromycin; Humans; Lincomycin; Penicillin G; Penicillin Resistance; Penicillins; Pneumococcal Infections; Staphylococcal Infections; Streptococcal Infections; Sulfonamides; Tetracycline; Vancomycin

Topics: Aged; Ampicillin; Contraceptives, Oral; Diuretics; Drug Hypersensitivity; Female; Food Analysis; Guanethidine; Humans; Isoniazid; Kidney Failure, Chronic; Male; Pharmaceutical Preparations; Photosensitivity Disorders; Potassium; Procaine; Rejuvenation; Sunscreening Agents; Tetracycline; Vitamin B Deficiency

Topics: Adult; Age Factors; Bilirubin; Cell Membrane; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Female; Halothane; Humans; Infant, Newborn; Liver; Liver Cirrhosis; Male; Methotrexate; Microsomes, Liver; Pharmaceutical Preparations; Pregnancy; Tetracycline

Topics: Adolescent; Ampicillin; Chickenpox; Diagnosis, Differential; Drug Hypersensitivity; Erythromycin; Humans; Male; Mycoplasma; Mycoplasma Infections; Skin Diseases, Infectious; Stevens-Johnson Syndrome; Tetracycline

Topics: Administration, Oral; Anemia, Hemolytic; Blood-Brain Barrier; Chlortetracycline; Demeclocycline; Doxycycline; Drug Hypersensitivity; Female; Glucosephosphate Dehydrogenase Deficiency; Gonorrhea; Humans; Injections, Intramuscular; Intestinal Absorption; Male; Methacycline; Minocycline; Oxytetracycline; Penicillins; Tetracycline; Urethritis

Topics: Ampicillin; Child, Preschool; Chloramphenicol; Colistin; Diagnosis, Differential; Drug Eruptions; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Electroencephalography; Erythromycin; Female; Fever; Humans; Hydrocortisone; Infections; Kanamycin; Kidney Diseases; Male; Middle Aged; Penicillins; Pericarditis; Pertussis Vaccine; Pleural Diseases; Recurrence; Salicylates; Tetracycline; Tonsillectomy

Topics: Acute Kidney Injury; Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Female; Fever; Gentamicins; Humans; Hyperkalemia; Lincomycin; Methenamine; Nalidixic Acid; Nitrofurantoin; Penicillins; Photosensitivity Disorders; Polymyxins; Pregnancy; Seizures; Spectinomycin; Sulfonamides; Tetracycline

Topics: Administration, Oral; Aged; Dermatitis, Contact; Drug Hypersensitivity; Humans; Male; Minocycline; Skin Tests; Tetracycline; Urinary Tract Infections

Topics: Adult; Drug Hypersensitivity; Humans; Male; Muscle Rigidity; Tetracycline

Topics: Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Tetracycline

Topics: Aspirin; Child; Drug Hypersensitivity; gamma-Globulins; Humans; Male; Penicillins; Prednisone; Stevens-Johnson Syndrome; Tetracycline

Topics: Adult; Aged; Agranulocytosis; Aminopyrine; Antineoplastic Agents; Candidiasis, Oral; Dentin; Drug Hypersensitivity; Female; Gingival Hyperplasia; Humans; Hydantoins; Mouth; Mouth Diseases; Mouth Mucosa; Necrosis; Palate; Penicillins; Phenylbutazone; Tetracycline; Thrombocytopenia

Topics: Alcoholic Intoxication; Analgesics; Anticoagulants; Aspirin; Blood Coagulation Disorders; Blood Coagulation Tests; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Humans; Hypnotics and Sedatives; Iatrogenic Disease; Infections; Liver Cirrhosis; Oral Hemorrhage; Preoperative Care; Tetracycline

Topics: Adolescent; Adult; Aged; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Bacteriological Techniques; Cephaloridine; Cephalothin; Drug Hypersensitivity; Evaluation Studies as Topic; Female; Gentamicins; Hospitals, Teaching; Humans; Male; Michigan; Microbial Sensitivity Tests; Middle Aged; Streptomycin; Tetracycline

Topics: Actinomycosis, Cervicofacial; Animals; Antibodies; Desensitization, Immunologic; Drug Hypersensitivity; Female; Humans; In Vitro Techniques; Injections, Intradermal; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Mast Cells; Middle Aged; Models, Biological; Penicillin G; Penicillins; Rats; Skin Tests; Sulfadiazine; Tetracycline

Topics: Ampicillin; Anti-Infective Agents, Urinary; Australia; Chloramphenicol; Drug Hypersensitivity; Humans; Methenamine; Nalidixic Acid; Nitrofurantoin; Sulfamethoxazole; Sulfonamides; Tetracycline; Trimethoprim; Urinary Tract Infections

Topics: Animals; Blood Pressure; Cephalothin; Chloramphenicol; Contrast Media; Dogs; Drug Hypersensitivity; Ethanol; Female; Gastrointestinal Motility; Injections, Intravenous; Iothalamic Acid; Microcirculation; Nitrofurantoin; Penicillins; Photography; Regional Blood Flow; Tetracycline

Topics: Drug Hypersensitivity; Humans; Skin Diseases; Tetracycline

Topics: Adolescent; Adult; Drug Hypersensitivity; Female; Follow-Up Studies; Gonorrhea; Humans; Injections, Intramuscular; Male; Middle Aged; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Penicillin Resistance; Probenecid; Rectum; Streptomycin; Syphilis; Syphilis Serodiagnosis; Tetracycline

Topics: Ampicillin; Anemia, Aplastic; Anti-Bacterial Agents; Bone Marrow; Chloramphenicol; Dermatitis, Contact; Drug Eruptions; Drug Hypersensitivity; Drug Tolerance; Exanthema; Humans; Immune Tolerance; Neomycin; Penicillins; Photosensitivity Disorders; Tetracycline; Tooth Discoloration

Topics: Acute Disease; Adolescent; Adult; Amine Oxidase (Copper-Containing); Depression, Chemical; Desensitization, Immunologic; Drug Hypersensitivity; Dysentery, Bacillary; Feces; Female; Histamine; Histamine H1 Antagonists; Humans; Injections, Intramuscular; Male; Middle Aged; Shigella dysenteriae; Shigella sonnei; Tetracycline

Topics: Adult; Anti-Bacterial Agents; Ascorbic Acid; Brucellosis; Chronic Disease; Drug Hypersensitivity; Female; Humans; Immunotherapy; Male; Middle Aged; Muramidase; Oleandomycin; Phagocytosis; Physical Therapy Modalities; Pigments, Biological; Prodigiosin; Pyrroles; Serratia marcescens; Stimulation, Chemical; Tetracycline; Vitamins

Topics: Drug Hypersensitivity; Female; Humans; Iatrogenic Disease; Long-Term Care; Middle Aged; Nitrofurantoin; Pulmonary Fibrosis; Radiography; Steroids; Tetracycline

Topics: Anti-Bacterial Agents; Cell Aggregation; Drug Hypersensitivity; Drug Industry; Environmental Exposure; Griseofulvin; Humans; Leukocyte Count; Leukocytes; Nystatin; Occupational Diseases; Oleandomycin; Tetracycline; Time Factors

Topics: Aspirin; Chloramphenicol; Drug Hypersensitivity; Epithelial Cells; Gastrointestinal Diseases; Humans; Microscopy, Electron; Phenylbutazone; Tetracycline

Topics: Administration, Oral; Anaphylaxis; Drug Hypersensitivity; Erysipelas; Female; Humans; Hydrocortisone; Middle Aged; Penicillins; Tetracycline

Topics: Adult; Drug Hypersensitivity; Female; Humans; Myocardial Infarction; Myocarditis; Tetracycline

Topics: Adult; Bronchitis; Drug Hypersensitivity; Erythema; Female; Humans; Pulmonary Emphysema; Tetracycline

Topics: Ampicillin; Anemia, Aplastic; Child, Preschool; Chloramphenicol; Chronic Disease; Drug Hypersensitivity; Fanconi Syndrome; Female; Haemophilus influenzae; Humans; Infant; Infant, Newborn; Lung Diseases; Penicillin Resistance; Pregnancy; Seizures; Streptococcus pneumoniae; Tetracycline; Tooth Discoloration

Topics: Adult; Drug Hypersensitivity; Humans; Male; Middle Aged; Oleandomycin; Respiratory Tract Infections; Sulfamethazine; Sulfathiazoles; Tetracycline; Tonsillitis

Topics: Administration, Oral; Drug Hypersensitivity; Erythema; Humans; Pruritus; Skin Diseases; Tetracycline

Topics: Age Factors; Anti-Bacterial Agents; Biliary Tract Diseases; Chloramphenicol; Drug Hypersensitivity; Female; Genotype; Glucosephosphate Dehydrogenase; Humans; Kanamycin; Kidney Diseases; Liver; Liver Diseases; Metabolism, Inborn Errors; Nervous System Diseases; Pregnancy; Pregnancy Complications; Streptomycin; Sulfonamides; Tetracycline

Topics: Adolescent; Adult; Aged; Animals; Antibodies; Cephalosporins; Child; Drug Hypersensitivity; Female; Guinea Pigs; Hemagglutination Inhibition Tests; Hemagglutination Tests; Humans; Immunoglobulin G; Male; Middle Aged; Penicillins; Skin Tests; Tetracycline

Topics: Bismuth; Cephalosporins; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Female; Humans; Male; Penicillins; Pregnancy; Rolitetracycline; Syphilis; Tetracycline

Topics: Ampicillin; DNA; Drug Hypersensitivity; gamma-Globulins; Humans; Lymphocyte Activation; Lymphocytes; RNA; Tetracycline

Topics: Acne Vulgaris; Contraceptives, Oral; Cosmetics; Drug Hypersensitivity; England; Humans; Tetracycline

Topics: Adult; Drug Eruptions; Drug Hypersensitivity; Erythema; Humans; Male; Tetracycline

Topics: Adult; Anti-Bacterial Agents; Colistin; Drug Hypersensitivity; Female; Humans; Immunoglobulin E; Male; Mitral Valve Stenosis; Oleandomycin; Penicillin G; Penicillins; Polymyxins; Skin Tests; Streptomycin; Tetracycline

Topics: Anaphylaxis; Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Drug Hypersensitivity; Enterocolitis, Pseudomembranous; Malabsorption Syndromes; Penicillin Resistance; Penicillins; Shock; Streptomycin; Tetracycline

Topics: Aeromonas; Agglutination Tests; Chloramphenicol; Drug Hypersensitivity; Drug Resistance, Microbial; Salmonella; Shigella; Streptomycin; Sulfonamides; Tetracycline; Vibrio

Topics: Aminosalicylic Acids; Antitubercular Agents; Cortisone; Drug Hypersensitivity; Ethambutol; Fludrocortisone; Humans; Hypotension; Isoniazid; Male; Middle Aged; Osteoporosis; Prednisone; Streptomycin; Tetracycline; Tuberculosis, Pulmonary

Topics: Adult; Anti-Bacterial Agents; Drug Hypersensitivity; Female; Humans; Penicillins; Skin Tests; Streptomycin; Tetracycline

Topics: Adolescent; Clostridium Infections; Clostridium perfringens; Drug Hypersensitivity; Erythromycin; Humans; Male; Penicillin G; Penicillin Resistance; Tetracycline

Topics: Anaphylaxis; Antigen-Antibody Reactions; Arthus Reaction; Barbiturates; Drug Hypersensitivity; gamma-Globulins; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Macromolecular Substances; Penicillins; Phenothiazines; Streptomycin; Sulfonamides; Tetracycline; Tranquilizing Agents

Topics: Animals; Antigen-Antibody Reactions; Bacitracin; Blood Platelets; Chloramphenicol; Drug Eruptions; Drug Hypersensitivity; Horses; Humans; Immune Sera; In Vitro Techniques; Penicillin G; Serotonin; Skin Tests; Tetanus Antitoxin; Tetracycline; Trichophytin

Topics: Anti-Bacterial Agents; Cyanosis; Drug Eruptions; Drug Hypersensitivity; Edema; Episiotomy; Erythromycin Ethylsuccinate; Female; Fever; Hearing Disorders; Humans; Hysterectomy; Neomycin; Nystatin; Penicillins; Postoperative Care; Pregnancy; Pregnancy, Ectopic; Streptomycin; Tetracycline

Topics: Acute Kidney Injury; Amphotericin B; Anti-Bacterial Agents; Bacitracin; Cephaloridine; Colistin; Drug Hypersensitivity; Gentamicins; Griseofulvin; Humans; Kanamycin; Kidney Function Tests; Methicillin; Penicillin G; Polymyxins; Streptomycin; Sulfonamides; Tetracycline

Topics: Anti-Bacterial Agents; Cephaloridine; Cephalothin; Clostridium perfringens; Drug Hypersensitivity; Gas Gangrene; Humans; Penicillin G; Penicillin Resistance; Penicillins; Tetracycline

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bacitracin; Cattle; Chlortetracycline; Drug Hypersensitivity; Escherichia coli; Fish Products; Food Additives; Humans; Oleandomycin; Oxytetracycline; Penicillin Resistance; Penicillins; Poultry; Preservation, Biological; Salmonella typhimurium; Swine; Tetracycline

Topics: Drug Hypersensitivity; Gonorrhea; Humans; Kanamycin; Penicillin G Benzathine; Penicillin Resistance; Penicillinase; Penicillins; Streptomycin; Tetracycline

Topics: Administration, Topical; Anti-Inflammatory Agents; Antifungal Agents; Candida; Chloramphenicol; Conjunctiva; Conjunctivitis; Culture Media; Drug Hypersensitivity; Female; Fungi; Glucocorticoids; Humans; Hydrocortisone; In Vitro Techniques; Male; Tetracycline; Trachoma

Topics: Animals; Cecum; Chlortetracycline; Colon, Sigmoid; Cricetinae; Diarrhea; Drug Hypersensitivity; Epithelium; Intestine, Large; Necrosis; Oxytetracycline; Tetracycline; Vascular Diseases

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Antitubercular Agents; Child; Child, Preschool; Chloramphenicol; Drug Hypersensitivity; Female; Gastrointestinal Diseases; Glossitis; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Diseases; Pregnancy; Stomatitis; Sulfonamides; Tetracycline

Topics: Adult; Drug Hypersensitivity; Female; Humans; Milk, Human; Pregnancy; Tetracycline

Topics: Antimalarials; Drug Hypersensitivity; Exanthema; Humans; Phenothiazines; Photosensitivity Disorders; Sulfonamides; Tetracycline

Topics: Ampicillin; Drug Hypersensitivity; Female; Humans; Tetracycline

Topics: Adult; Drug Hypersensitivity; Female; Humans; Hypothermia; Male; Middle Aged; Tetracycline

Topics: Adolescent; Adult; Ampicillin; Drug Hypersensitivity; Erythromycin; Female; Humans; Infectious Mononucleosis; Leukocyte Count; Male; Penicillins; Pharyngitis; Retrospective Studies; Tetracycline

Topics: Adrenal Cortex Hormones; Anaphylaxis; Drug Hypersensitivity; Endocarditis, Bacterial; Erythromycin; Histamine H1 Antagonists; Humans; Penicillins; Skin Tests; Streptococcal Infections; Streptomycin; Tetracycline; Vancomycin

Topics: Adrenal Cortex Hormones; Antimalarials; Drug Hypersensitivity; Griseofulvin; Histamine H1 Antagonists; Humans; Phenothiazines; Photosensitivity Disorders; Porphyrins; Sulfonamides; Tetracycline

Topics: Adult; Biological Assay; Chromatography, Thin Layer; Drug Hypersensitivity; Fluorescent Antibody Technique; Hemagglutination Tests; Humans; Male; Passive Cutaneous Anaphylaxis; Penicillins; Serum Sickness; Skin Tests; Tetracycline

Topics: Ampicillin; Blood Proteins; Cloxacillin; Demeclocycline; Drug Hypersensitivity; Humans; Kanamycin; Neomycin; Novobiocin; Penicillin G; Protein Binding; Serum Albumin; Tetracycline

Topics: Absorption; Carbutamide; Dermatitis, Photoallergic; Drug Hypersensitivity; Humans; Phenothiazines; Photosensitivity Disorders; Sulfonamides; Tetracycline; Toxicology; Ultraviolet Rays

Topics: Anaphylaxis; Anemia; Anemia, Hemolytic; Anti-Bacterial Agents; Drug Eruptions; Drug Hypersensitivity; Humans; Penicillins; Serum Sickness; Skin Manifestations; Tetracycline; Toxicology; Urticaria

Topics: Adolescent; Anti-Bacterial Agents; Child; Chloramphenicol; Drug Hypersensitivity; Drug Resistance; Drug Resistance, Microbial; Erythromycin; Humans; Novobiocin; Penicillins; Periapical Abscess; Protein Synthesis Inhibitors; Staphylococcus; Streptococcus; Streptomycin; Tetracycline

Topics: Adult; Anaphylaxis; Antigen-Antibody Reactions; Drug Hypersensitivity; Humans; Lymphocytes; Male; Penicillins; Serum Sickness; Skin Tests; Tetracycline

Topics: Adult; Chloramphenicol; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Penicillins; Pyridoxine; Streptomycin; Tetracycline; Thiamine; Vitamin B 12

Topics: Amphotericin B; Anti-Bacterial Agents; Bacitracin; Chloramphenicol; Cross Infection; Drug Hypersensitivity; Drug Resistance; Drug Resistance, Microbial; Erythromycin; Kanamycin; Methicillin; Mycoses; Penicillins; Staphylococcal Infections; Streptococcal Infections; Tetracycline; Toxicology; Vancomycin

Topics: Drug Hypersensitivity; Dyspnea; Eosinophilia; Fever; Humans; Lung Diseases; Nitrofurantoin; Pleural Effusion; Radiography, Thoracic; Tetracycline; Toxicology; Urinary Tract Infections

Topics: Aminosalicylic Acid; Aminosalicylic Acids; Chickenpox; Child; Clinical Enzyme Tests; Cortisone; Dermatomyositis; Drug Hypersensitivity; Drug Therapy; Humans; Isoniazid; Prednisolone; Streptomycin; Tetracycline; Toxicology; Tuberculosis; Tuberculosis, Miliary

Topics: Adrenocorticotropic Hormone; Anti-Bacterial Agents; Chloramphenicol; Corticosterone; Dermatitis; Dermatitis, Contact; Drug Eruptions; Drug Hypersensitivity; Griseofulvin; Neomycin; Novobiocin; Penicillins; Tetracycline; Toxicology

Topics: Anaphylaxis; Anti-Bacterial Agents; Aspirin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Colistin; Drug Eruptions; Drug Hypersensitivity; Hepatitis; Nitrofurantoin; Novobiocin; Penicillins; Polymyxins; Protein Synthesis Inhibitors; Serum Sickness; Streptomycin; Tetracycline; Toxicology

Topics: Adrenocorticotropic Hormone; Asthma; Conjunctivitis; Dermatitis; Dermatitis, Atopic; Drug Hypersensitivity; Drug Therapy; Female; Headache; Humans; Hypersensitivity; Influenza Vaccines; Nasal Polyps; Pregnancy; Pregnancy Complications; Rhinitis, Allergic, Seasonal; Smallpox Vaccine; Tetracycline; Toxicology; Urticaria; Vertigo

Topics: Anti-Bacterial Agents; Chloramphenicol; Drug Hypersensitivity; Drug Therapy; Gonorrhea; Humans; Penicillin Resistance; Tetracycline

Topics: Anti-Bacterial Agents; Diagnosis; Drug Hypersensitivity; Hypersensitivity; Penicillins; Tetracycline; Toxicology

Topics: Anaphylaxis; Anti-Bacterial Agents; Chloramphenicol; Colistin; Diagnosis; Drug Hypersensitivity; Humans; Hypersensitivity; Nystatin; Penicillins; Statistics as Topic; Streptomycin; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Child; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Humans; Infant; Kanamycin; Novobiocin; Penicillins; Ristocetin; Streptomycin; Sulfonamides; Tetracycline; Toxicology; Vancomycin

Topics: Aniline Compounds; Anti-Bacterial Agents; Dermatitis, Contact; Diagnosis, Differential; Drug Eruptions; Drug Hypersensitivity; Food Additives; Food Contamination; Humans; Hydralazine; Lupus Erythematosus, Systemic; Pesticides; Pigmentation Disorders; Syndrome; Tetracycline; Toxicology

Topics: Adrenocorticotropic Hormone; Aminosalicylic Acid; Aminosalicylic Acids; Anaphylaxis; Anti-Bacterial Agents; Aspirin; Body Constitution; Chloramphenicol; Cortisone; Drug Hypersensitivity; Otolaryngology; Penicillins; Physiology; Procaine; Shock; Shock, Septic; Skin Tests; Streptomycin; Surgical Procedures, Operative; Tetracycline; Toxicology

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Circumcision, Male; Colistin; Digitalis; Drug Hypersensitivity; Exchange Transfusion, Whole Blood; Humans; Infant, Newborn; Infusions, Parenteral; Injections, Intramuscular; Kanamycin; Male; Nalorphine; Novobiocin; Nurseries, Infant; Penicillins; Punctures; Resuscitation; Sulfonamides; Surgical Procedures, Operative; Tetracycline; Vitamin K

Topics: Anti-Bacterial Agents; Bronchiectasis; Cholangitis; Coombs Test; Drug Hypersensitivity; Empyema; Endocarditis; Endocarditis, Bacterial; Hemagglutination; Humans; Osteomyelitis; Penicillins; Precipitin Tests; Pyelonephritis; Sepsis; Streptomycin; Tetracycline