tetracycline and Disseminated-Intravascular-Coagulation

A 65-year-old man was admitted because of high grade fever and cough after 3 days of gathering edible wild plants. Although ceftriaxone was given to him, his symptoms did not improve. His high grade fever escalated after changing the antibiotics (imipenem with erythromycin). His situation further declined with disseminated intravascular coagulation (DIC) and acute respiratory distress syndrome (ARDS). As a result, he was transferred to the Department of Respiratory Medicine 7 days after admission. He was intubated and placed on mechanical ventilation and treated by polymyxin-direct hemoperfusion. The eschar on his chest wall caused us to suspect Tsutsugamushi disease and a blood test confirmed our suspicion. Since the antibodies for Tsutsugamushi were elevated we arrived at the diagnosis of Tsutsugamushi disease with DIC and ARDS. The administration of tetracycline was sufficient to significantly improve his condition. Because its complications are life threatening, when we see a patient with fever and eruptions, it is necessary to keep in mind the possibility of Tsutsugamushi disease. Careful anamnesis and physical examinations are most important for the diagnosis of Tsutsugamushi disease.

Topics: Aged; Anti-Bacterial Agents; Antibodies, Bacterial; Biomarkers; Disseminated Intravascular Coagulation; Hemoperfusion; Humans; Male; Orientia tsutsugamushi; Polymyxins; Respiratory Distress Syndrome; Scrub Typhus; Serologic Tests; Severity of Illness Index; Tetracycline; Treatment Outcome

Brucellosis, being eradicated among domestic animals in some countries, is still prevalent in some others where it poses a potential threat to the consumers of milk and cheese and those working with animals and meat. The patient presented below had contracted a severe and long-standing Brucella abortus infection by ingesting raw camel milk. She had signs of endocarditis and disseminated intravascular coagulation, but recovered when treated with tetracyclin and streptomycin.

Topics: Adult; Brucellosis; Disseminated Intravascular Coagulation; Endocarditis, Bacterial; Female; Humans; Streptomycin; Tetracycline

Topics: Adult; Disseminated Intravascular Coagulation; Female; Humans; Hypoxia; Psittacosis; Tetracycline

Topics: Acute Kidney Injury; Adult; Blood Coagulation Tests; Bronchopneumonia; Cytoplasm; Diagnosis, Differential; Disseminated Intravascular Coagulation; Female; Hepatic Encephalopathy; Humans; Liver; Liver Function Tests; Necrosis; Pneumonia; Pregnancy; Respiratory Insufficiency; Seizures; Tetracycline; Time Factors; Twins; Uric Acid

Topics: Anemia, Hemolytic; Chemical and Drug Induced Liver Injury; Disseminated Intravascular Coagulation; Fatty Liver; Female; Humans; Kidney Failure, Chronic; Liver; Pregnancy; Pregnancy Complications, Hematologic; Tetracycline

Topics: Acute Kidney Injury; Disseminated Intravascular Coagulation; Fatty Liver; Female; Humans; Pregnancy; Pregnancy Complications, Hematologic; Tetracycline

Topics: Adolescent; Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Biopsy; Blood Cell Count; Blood Coagulation Tests; Child; Chloramphenicol; Disseminated Intravascular Coagulation; Electrocardiography; Female; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Plague; Skin; Streptomycin; Tetracycline; Vietnam

Topics: Adolescent; Blood Transfusion; Cephaloridine; Disseminated Intravascular Coagulation; Female; Fever; Fibrinogen; Heparin; Humans; Infectious Mononucleosis; Pharyngitis; Tetracycline; Trephining; Vomiting

Topics: Autopsy; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Ecchymosis; Epistaxis; Fibrinogen; Fibrinolysis; Hematuria; Hemorrhage; Humans; Purpura; Relapsing Fever; Retinal Hemorrhage; Tetracycline; Thrombocytopenia