tetracycline and Diabetes-Insipidus

Topics: Animals; Arginine; Carbamazepine; Chlorpropamide; Clofibrate; Cyclic AMP; Diabetes Insipidus; Hypothalamus; Kidney Diseases; Lithium; Methoxyflurane; Peptide Biosynthesis; Protein Biosynthesis; Rats; Rodent Diseases; Tetracycline; Vasopressins; Vermont

Manifestations of lithium carbonate toxicity include acneform eruptions, sinus node dysfunction, hyperparathyroidism, hypothyroidism, thyrotoxicosis, extrapyramidal side effects, and renal toxicity, which may present as nephrogenous diabetes insipidus. This report concerns a patient with a toxic reaction to lithium carbonate. The patient initially had acneform lesions, hypoglycemia, hypothyroidism, and nephrogenous diabetes insipidus. Features of lithium carbonate-induced acneform eruptions are emphasized. Renal toxicity from a lithium carbonate overdose is common, and the hazards of prescribing potentially nephrotoxic drugs to such a patient are stressed.

Topics: Acne Vulgaris; Adult; Diabetes Insipidus; Drug Interactions; Humans; Hypoglycemia; Hypothyroidism; Kidney Tubules; Lithium; Lithium Carbonate; Male; Tetracycline

Topics: Adenylyl Cyclase Inhibitors; Chlortetracycline; Cyclic AMP; Cytosol; Demeclocycline; Diabetes Insipidus; Humans; In Vitro Techniques; Kidney; Kidney Medulla; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Tetracycline; Vasopressins

Topics: Adult; Aged; Diabetes Insipidus; Drug Resistance, Microbial; Escherichia coli; Female; Humans; Kidney Diseases; Male; Microbial Sensitivity Tests; Middle Aged; Staphylococcus; Tetracycline; Urinary Tract Infections