tetracycline and Dermatitis--Atopic

To assess the efficacy of tetracycline in triamcinolone acetonide ointment compared with triamcinolone acetonide ointment in patients with moderate to severe atopic dermatitis.. Randomised, double-blind parallel group study of 8 weeks' duration.. Outpatient clinic in a university hospital.. Forty-four adult patients with moderate to severe atopic dermatitis (objective SCORAD > 25).. Initial phase (2 weeks): 3% tetracycline 0.1% triamcinolone acetonide vs. 0.1% triamcinolone acetonide twice daily all over the body. MAINTENANCE PHASE: (6 weeks) 0.1% triamcinolone acetonide once daily for 2 weeks, followed by every other day for 2 weeks. In the last 2 weeks, two applications a week were done. An emollient was used additionally once daily.. Primary outcomes were the disease severity scores assessed by objective SCORAD and SASSAD at week 2. Secondary outcomes were the objective SCORAD and SASSAD at weeks 4 and 8, and Staphylococcus aureus colonization at weeks 0 and 2.. No significant differences in disease severity outcomes were found between the two groups. Both groups showed clinically relevant improvements in disease severity compared with baseline at weeks 2 and 4. At week 8, there was some worsening in disease severity in both groups, but the disease severity was still significantly lower than at the beginning of the study. Improvement of bacterial colonization was seen in 14 (63.6%) out of the 22 patients in the 3% tetracycline 0.1% triamcinolone acetonide group and in 5 (22.7%) out of the 22 patients in the 0.1% triamcinolone acetonide group.. The addition of tetracycline was effective on skin colonization by S. aureus but did in our patients with atopic dermatitis not result in a significantly different improvement compared with the group treated without tetracycline.

Topics: Adolescent; Adult; Aged; Dermatitis, Atopic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Severity of Illness Index; Tetracycline; Treatment Outcome; Triamcinolone Acetonide

Topical tacrolimus has been observed to induce granulomatous rosacea (GR) in prior case reports and series. In most cases, patients recover fully after withdrawing tacrolimus and initiating doxycycline or minocycline. Herein, we describe a case of severe GR, which required further therapy. Clinicians should be aware of this rare complication because of the frequent use of topical tacrolimus.

Topics: Anti-Bacterial Agents; Dermatitis, Atopic; Female; Humans; Rosacea; Tacrolimus; Tetracycline; Young Adult

Acne fulminans is an ulcerative form of acne with an acute onset and systemic symptoms. It most commonly affects adolescent boys.. Clinical and laboratory findings and treatment results of patients with acne fulminans were reviewed to obtain a better understanding of the clinical course and outcome of the disease.. Data of patients with severe acne were collected from the Dermatology Departments of Finnish hospitals during the years 1970 to 1991.. Twenty-four patients with acne fulminans are described. All patients had ulcerative acne with acute onset. In 22 patients acne was associated with high fever for at least 1 week. All patients had musculoskeletal pain. Increased uptake in bone scan or radiographic findings compatible with an infectious origin were detected in 17 patients. Eight patients were treated with antibiotics alone, but the response was poor; three patients had a relapse of musculoskeletal symptoms. Ten patients were given systemic steroids in addition to antibiotics. In this group the response was rapid, but acne and musculoskeletal symptoms tended to relapse when the steroid dosage was reduced. Four patients were treated with a combination of antibiotics, systemic steroids, and isotretinoin; all responded well, but one of these patients also had a relapse.. Musculoskeletal symptoms are common in patients with acne fulminans. Systemic steroid treatment rapidly controls the skin lesions and systemic symptoms. The duration of steroid treatment should be 2 to 4 months to avoid relapses. Therapy with isotretinoin, antibiotics, or both was often combined with steroids, but the role of these agents is still uncertain.

Topics: Acne Vulgaris; Adolescent; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Sedimentation; Dermatitis, Atopic; Female; Fever; Glucocorticoids; Humans; Isotretinoin; Joints; Leukocytosis; Male; Muscles; Osteolysis; Pain; Retrospective Studies; Tetracycline; Ulcer

Topics: Adult; Aged; Angioedema; Child; Dermatitis, Atopic; Diet; Eczema; Emotions; Female; Humans; Immune Sera; Infant; Male; Penicillins; Psychophysiologic Disorders; Psychotherapy; Skin Tests; Steroids; Sulfonamides; Tetracycline; Urticaria; Vaccines

Topics: Adrenocorticotropic Hormone; Asthma; Conjunctivitis; Dermatitis; Dermatitis, Atopic; Drug Hypersensitivity; Drug Therapy; Female; Headache; Humans; Hypersensitivity; Influenza Vaccines; Nasal Polyps; Pregnancy; Pregnancy Complications; Rhinitis, Allergic, Seasonal; Smallpox Vaccine; Tetracycline; Toxicology; Urticaria; Vertigo