tetracycline and Colonic-Diseases

Topics: Adult; Ampicillin; Anti-Bacterial Agents; Clindamycin; Colitis; Colonic Diseases; Diarrhea; Enterocolitis, Pseudomembranous; Female; Humans; Lincomycin; Male; Middle Aged; Tetracycline

A prospective randomized trial was performed to determine the value of tetracycline lavage in addition to systemic antibiotic prophylaxis in 159 patients undergoing elective and emergency intestinal operations. Tetracycline lavage was associated with a significant overall reduction in postoperative infection rates in 25 of 74 patients (34 percent) receiving saline lavage compared with 15 of 85 patients (18 percent) having tetracycline lavage (P less than 0.05). Tetracycline lavage was associated with a significant reduction in the counts of aerobic and anaerobic bacteria in the peritoneal fluid at the end of the operation (P less than 0.05 and P less than 0.01, respectively) and with a significant reduction of aerobes 24 hours postoperatively (P less than 0.02). Tetracycline lavage would appear to confer clinical benefit in preventing postoperative infection.

Topics: Adolescent; Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Colonic Diseases; Female; Humans; Intestinal Diseases; Male; Middle Aged; Prospective Studies; Random Allocation; Sodium Chloride; Surgical Wound Infection; Tetracycline; Therapeutic Irrigation

Transmissible murine colonic hyperplasia was diagnosed in 6-month-old A/J mice kept under standard laboratory conditions. Bacterial cultures revealed the presence of Citrobacter freundii (4280). Clinical signs included rough coats, feces adhering to the anus, slight dehydration and rectal prolapses. A nonclotting sanquinous intestinal fluid and gross colonic thickening were frequently seen at necropsy. Morbidity was approximately 50%; mortality approximately 25%. Tetracycline appeared to be effective in controlling the disease.

Topics: Animals; Colonic Diseases; Enterobacteriaceae Infections; Female; Male; Mice; Mice, Inbred Strains; Rodent Diseases; Tetracycline

Topics: Adult; Amebiasis; Amebicides; Child, Preschool; Colonic Diseases; Entamoeba histolytica; Granuloma; Humans; Infant; Intestinal Perforation; Intussusception; Male; Metronidazole; Peritonitis; Skin Diseases, Infectious; Tetracycline

Topics: Chronic Disease; Colonic Diseases; Drug Synergism; Drug Therapy, Combination; Dysentery, Amebic; Humans; Metronidazole; Tetracycline

Topics: Aged; Bacitracin; Colectomy; Colon; Colonic Diseases; Colonic Neoplasms; Colostomy; Drug Therapy, Combination; Humans; Neomycin; Peritonitis; Postoperative Complications; Premedication; Rectal Diseases; Rectal Neoplasms; Rectum; Sepsis; Surgical Wound Infection; Tetracycline

Topics: Adult; Colon; Colonic Diseases; Dysentery, Amebic; Female; Humans; Intestinal Perforation; Metronidazole; Tetracycline

Topics: Anti-Bacterial Agents; Chloramphenicol; Colonic Diseases; Enterocolitis, Pseudomembranous; Humans; Infections; Neomycin; Penicillins; Postoperative Care; Preoperative Care; Retrospective Studies; Staphylococcus; Sulfathiazoles; Sulfonamides; Surgical Wound Infection; Tetracycline

Topics: Celiac Disease; Colic; Colonic Diseases; Gastric Fistula; Humans; Intestinal Fistula; Sprue, Tropical; Steatorrhea; Surgical Procedures, Operative; Tetracycline