tetracycline and Colitis

Topics: Adult; Ampicillin; Anti-Bacterial Agents; Clindamycin; Colitis; Colonic Diseases; Diarrhea; Enterocolitis, Pseudomembranous; Female; Humans; Lincomycin; Male; Middle Aged; Tetracycline

Recent evidence suggests that antibiotic-induced changes in the composition of intestinal microflora, as well as the systemic immunoendocrine effects that result from them, can modulate myocardial tolerance to ischemia-reperfusion injury. The aim of this study was to investigate the effects of tetracycline (TTC) on myocardial infarct size in the isolated hearts obtained from obese rats with chemically-induced colitis (CIC). The association between TTC-induced changes in infarct size and intestinal microbiome composition as well as plasma levels of cytokines and short-chain fatty acids (SCFAs) was also studied.. Obesity was induced in Wistar rats by feeding them a high-fat, high-carbohydrate diet for five weeks. A single rectal administration of 3% acetic acid (2 mL) to the rats resulted in CIC. Healthy rats as well as obese rats with CIC received TTC (15 mg daily for 3 days) via gavage. The rats were euthanized, after which isolated heart perfusion with simulated global ischemia and reperfusion was performed. Infarct size was determined histochemically. Lipopolysaccharide (LPS) and cytokine levels in plasma were measured by enzyme-linked immunosorbent assay, whereas SCFA levels in plasma were measured by gas chromatography/mass spectrometry. The intestinal microbiome was analyzed using reverse transcription polymerase chain reaction.. The treatment with TTC resulted in significant infarct size limitation (50 ± 7 vs. 62 ± 4% for the control mice, p < 0.05) in the hearts from intact animals. However, infarct size was not different between the control rats and the obese rats with CIC. Furthermore, infarct size was significantly larger in TTC-treated obese rats with CIC than it was in the control animals (77 ± 5%, p < 0.05). The concentrations of proinflammatory cytokines and LPS in serum were elevated in the obese rats with CIC. Compared to the control rats, the rats with both obesity and CIC had lower counts of Lactobacillus and Bifidobacterium spp. but higher counts of Escherichia coli. The effects of TTC on infarct size were not associated with specific changes in SCFA levels.. TTC reduced infarct size in the healthy rats. However, this effect was reversed in the obese animals with CIC. Additionally, it was associated with specific changes in gut microbiota and significantly elevated levels of cytokines and LPS.

Topics: Animals; Biomarkers; Body Weight; Colitis; Disease Models, Animal; Fatty Acids, Volatile; Gastrointestinal Microbiome; Heart Function Tests; Male; Myocardial Infarction; Obesity; Rats; Tetracycline

Exposure of a group of horses to tetracycline-contaminated feed resulted in acute colitis and subsequent death in one horse and milder diarrhea in 3 others. The most severely affected animal demonstrated clinical and pathological findings typical of colitis X. The other herdmates responded well to administration of zinc bacitracin.

Topics: Acute Disease; Animal Feed; Animals; Anti-Bacterial Agents; Colitis; Diarrhea; Fatal Outcome; Food Contamination; Horse Diseases; Horses; Male; Tetracycline

A 46-year-old man with Behçet syndrome and a long history of recurrent bouts of colitis was studied by sigmoidoscopy, barium enema x-ray film, and colon biopsy. A nonspecific colitis characterized by shallow mucosal ulcerations and submucosal mononuclear infiltration in the absence of meaningful roentgenolographic changes was seen. A histopathological comparison was made between the oral and colonic lesions. The aphthous colitis appears, therefore, to be a colonic manifestation of Behçet syndrome, differing from typical chronic nonspecific ulcerative colitis in terms of clinical course, severity, and histologic appearance. The simultaneous occurrence of Behçet syndrome and inflammatory disease of the colon was discussed in terms of the differential diagnosis of colitis.

Topics: Adult; Behcet Syndrome; Colitis; Colitis, Ulcerative; Colon; Diagnosis, Differential; Humans; Male; Mouth Mucosa; Radiography; Tetracycline

Topics: Acne Vulgaris; Administration, Oral; Candidiasis, Vulvovaginal; Clindamycin; Colitis; Demeclocycline; Drug Evaluation; Erythromycin; Female; Humans; Minocycline; Photosensitivity Disorders; Tetracycline; Time Factors

Clindamycin, a semi-synthetic antibiotic of the lincomycin family, at a dose of 450 mg eight-hourly for three days in adults cured five out of 10 patients moderately ill with chloroquine-resistant falciparum malaria. Combination therapy with full-dose quinine and clindamycin for three days cured all four patients so treated who were followed up, and with half dosage three out of five patients were cured. Both combinations, however, caused upper gastrointestinal toxicity and appeared to potentiate both toxicity and possibly antimalarial efficacy. Colitis due to clindamycin was not observed. Sequential therapy was not toxic and could be useful in patients who have relapsed after more conventional treatment.

Topics: Blood; Child; Chloroquine; Clindamycin; Colitis; Digestive System; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Male; Plasmodium falciparum; Quinine; Tetracycline

Topics: Acne Vulgaris; Biological Availability; Clindamycin; Colitis; Drug Resistance, Microbial; Humans; Lincomycin; Staphylococcal Infections; Tetracycline

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Chronic Disease; Colitis; Dysentery; Enteritis; Erythromycin Ethylsuccinate; Escherichia coli Infections; Feces; Humans; Infant; Lactobacillaceae; Mice; Salmonella Infections; Seasons; Staphylococcal Infections; Tetracycline

Topics: Anti-Bacterial Agents; Bacteriophage Typing; Chloramphenicol; Chlortetracycline; Colitis; Enteritis; Erythromycin; Erythromycin Ethylsuccinate; Furazolidone; Neomycin; Penicillin Resistance; Penicillins; Respiratory Tract Infections; Staphylococcal Infections; Staphylococcus; Staphylococcus Phages; Streptomycin; Surgical Wound Infection; Temperature; Tetracycline; Time Factors

Topics: Adult; Amoeba; Autopsy; Black People; Blood Protein Electrophoresis; Clone Cells; Colitis; Dysentery, Amebic; Erythrocytes; Erythrocytes, Abnormal; Female; Glucosephosphate Dehydrogenase; Hemoglobinuria, Paroxysmal; Heterozygote; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Mosaicism; Mutation; Penicillins; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Complications, Infectious; Sex Chromosomes; Streptomycin; Tetracycline

Topics: Adult; Aged; Animals; Bile; Brain; Colitis; Dogs; Feces; Female; Humans; Intestinal Mucosa; Kidney; Liver; Lung; Male; Mice; Microbial Sensitivity Tests; Middle Aged; Pyelitis; Respiratory Tract Infections; Spleen; Staphylococcal Infections; Staphylococcus; Tetracycline

Topics: Adolescent; Adult; Age Factors; Aged; Amebiasis; Child; Colitis; Colitis, Ulcerative; Dysentery, Amebic; Emetine; Empyema; Female; Hemagglutination Tests; Humans; Hypokalemia; Indians, North American; Liver Abscess, Amebic; Male; Middle Aged; Saskatchewan; Serum Albumin; Sex Factors; Sigmoidoscopy; Tetracycline

Topics: Adolescent; Adult; Ascorbic Acid; Child; Colitis; Female; Humans; Male; Middle Aged; Neurologic Manifestations; Niacinamide; Pantothenic Acid; Pyridoxine; Skin Manifestations; Tetracycline; Vitamin B 12

Topics: Clostridium perfringens; Colectomy; Colitis; Digitalis Glycosides; Female; Humans; Hydrocortisone; Ileostomy; Middle Aged; Necrosis; Tetracycline

Topics: Abscess; Anti-Bacterial Agents; Asthma; Bronchitis; Bronchopneumonia; Chloramphenicol; Cholecystitis; Colitis; Communicable Diseases; Erythromycin; Humans; Tetracycline

Topics: Adrenocorticotropic Hormone; Anti-Bacterial Agents; Chloramphenicol; Colitis; Diet; Diet Therapy; Guanidines; Hydrocortisone; Hypnotics and Sedatives; Meprobamate; Phenothiazines; Proctocolitis; Surgical Procedures, Operative; Tetracycline; Vitamin A

Topics: Anti-Bacterial Agents; Autopsy; Chloramphenicol; Colitis; Demeclocycline; Enterocolitis, Pseudomembranous; Geriatrics; Humans; Neomycin; Pathology; Penicillins; Postoperative Complications; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Colitis; Humans; Novobiocin; Tetracycline

Topics: Amebiasis; Anti-Bacterial Agents; Colitis; Dysentery, Amebic; Entamoebiasis; Oleandomycin; Oxytetracycline; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Cholangitis; Colitis; Colitis, Ulcerative; Humans; Liver; Tetracycline

Topics: Anti-Bacterial Agents; Colitis; Enteritis; Enterocolitis; Infections; Micrococcus; Staphylococcus aureus; Tetracycline

Topics: Anti-Bacterial Agents; Child; Colitis; Fermentation; Humans; Infant; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Child; Colitis; Cortisone; Enteritis; Humans; Infant; Protein Synthesis Inhibitors; Tetracycline