tetracycline and Cicatrix

Topics: Adult; Anti-Bacterial Agents; Child; Cicatrix; Female; Humans; Hygiene; Male; Tetracycline; Trachoma

Topics: Adult; Anti-Bacterial Agents; Child; Cicatrix; Eyelids; Face; Female; Humans; Hygiene; Male; Tetracycline; Trachoma

Topics: Adult; Anti-Bacterial Agents; Child; Cicatrix; Eyelids; Face; Female; Humans; Hygiene; Male; Tetracycline; Trachoma

Topics: Administration, Oral; Administration, Topical; Anti-Bacterial Agents; Azithromycin; Cicatrix; Combined Modality Therapy; Drug Therapy, Combination; Eyelids; Humans; Randomized Controlled Trials as Topic; Skin Care; Tetracycline; Trachoma; Treatment Outcome

Acne vulgaris is the clinical expression of inflammation of the pilosebaceous unit. Factors known to predispose to the development of acne include increased sebum, which is acted on by Propionobacterium acnes to generate inflammatory substances, and retention hyperkeratosis, which causes obstruction of the sebaceous follicle. Therapeutic modalities for acne include topical and systemic antibiotics, comedolytic agents (such as benzoyl peroxide and topical retinoids) and systemic retinoids. Acne scars may be treated surgically using procedures such as dermabrasion and dermal injections of bovine collagen or simple scar excision, scar punch elevation, or punch grafting.

Topics: Acne Vulgaris; Adolescent; Adult; Benzoyl Peroxide; Cicatrix; Female; Humans; Male; Office Visits; Surgery, Plastic; Tetracycline; Tretinoin

Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adrenal Cortex Hormones; Anti-Bacterial Agents; Astringents; Cicatrix; Cosmetics; Cryosurgery; Dermatitis, Seborrheic; Diet Therapy; Diuretics; Estrogens; Humans; Immunotherapy; Progesterone; Tetracycline; Ultraviolet Rays; Vitamin A

Several studies of trichiasis recurrence suggest an association between surgical factors and long-term recurrence, yet data on short-term risk factors are limited. This study was conducted to evaluate risk factors for early trichiasis recurrence and other unfavorable short-term outcomes.. Trichiasis patients presenting for surgery were evaluated for presence of active trachoma and signs of cicatricial outcomes of trachoma, including number of trichiatic lashes, epilation, and entropion. Surgical factors recorded included incision length, surgery duration, and the surgeon performing the operation. Participants were followed up for 6 weeks after surgery and evaluated for eyelid closure defect and trichiasis recurrence; in addition, in two thirds of the patients, eyelid contour abnormality and granuloma formation were evaluated.. First-time trichiasis surgery was performed on 2615 eyelids. Of these, 2601 eyelids without surgical failure were followed up 6 weeks after surgery. Of the eyelids treated, 2.3% had recurrent trichiasis and 1.3% had an eyelid closure defect. Data on eyelid contour abnormalities and granuloma formation were recorded for 1881 eyes, with rates of 1.2% and 10.5%, respectively. Associated risk factors differed by outcome. Surgeon was predictive of eyelid closure defect and granuloma formation. Eyelids with short incisions were nearly four times more likely to have recurrent trichiasis (95% confidence interval, 1.7-9.3). Baseline trichiasis severity was predictive of eyelid contour abnormalities and recurrent trichiasis. Epilation was associated with granuloma formation, but was protective against eyelid closure defect.. Surgical factors are important predictors of unfavorable outcomes in the weeks immediately after surgery. Although the overall rate of serious uncorrectable unfavorable outcomes was very low, the high rate of granuloma formation, which can be treated by removal, highlights the need for follow-up of patients after trichiasis surgery. (ClinicalTrials.gov number, NCT00347776.).

Topics: Adult; Aged; Anti-Bacterial Agents; Azithromycin; Cicatrix; Ethiopia; Eyelid Diseases; Female; Granuloma, Pyogenic; Humans; Male; Middle Aged; Recurrence; Risk Factors; Tetracycline; Time Factors; Trachoma; Treatment Outcome; Trichiasis

Antimicrobial and scar preventive wound dressings were developed by coating a blend of chitosan (CS), polyethylene glycol (PEG) and polyvinyl pyrolidone (PVP) on the cotton fabric and subsequent freeze drying. The miscibility of blend systems and functional group interaction were investigated by attenuated total reflectance-infra red spectroscopy. The scanning electron microscopy of the coated fabric revealed porous structure. The porosity of the material was 54-70% and the pore size was in the range of 75-120μm depending on the blend composition. The air permeability diminished as the PVP content increased. The water vapour transmission rate was in the range of 2000-3500g/m(2)day which may offer to be proper material for the wound dressing with moderate exudate absorption. Tetracycline hydrochloride was used as model drug within the hydrogel matrix. The cumulative release of drug was found to be ∼80% of the total loading after ∼48h. The drug loaded dressings showed good antimicrobial nature against both gram positive and gram negative bacteria. In vivo wound healing and tissue compatibility studies were carried out over a period of 21 days on full-thickness skin wounds created on male Wistar rats. Fast healing was observed in drug loaded dressing treated wounds with minimum scarring, as compared to the other groups. These results suggest that drug loaded dressing could provide scar preventive wound healing.

Topics: Animals; Anti-Infective Agents; Bandages, Hydrocolloid; Chitosan; Cicatrix; Drug Liberation; Freeze Drying; Hydrogel, Polyethylene Glycol Dimethacrylate; Male; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Polyethylene Glycols; Povidone; Rats; Spectrophotometry, Infrared; Tensile Strength; Tetracycline; Wound Healing

Topics: Acne Vulgaris; Administration, Topical; Adrenal Cortex Hormones; Benzoyl Peroxide; Cicatrix; Contraceptives, Oral, Hormonal; Humans; Isotretinoin; Minocycline; Propionibacterium acnes; Tetracycline; Tretinoin

Topics: Acne Vulgaris; Administration, Topical; Adolescent; Anti-Bacterial Agents; Benzoyl Peroxide; Child; Cicatrix; Dermatologic Agents; Erythromycin; Estrogens; Humans; Sebum; Tetracycline; Tretinoin

Topics: Animal Feed; Animals; Cattle; Cattle Diseases; Cicatrix; Keratosis; Tetracycline

Topics: Acne Vulgaris; Adolescent; Adult; Aerosols; Cicatrix; Cysts; Female; Follow-Up Studies; Humans; Injections; Male; Tetracycline; Triamcinolone Acetonide

Topics: Cicatrix; Cornea; Corneal Injuries; Humans; Protein Synthesis Inhibitors; Research; Tetracycline; Wounds and Injuries