tetracycline has been researched along with Chondrosarcoma* in 2 studies
2 other study(ies) available for tetracycline and Chondrosarcoma
| Article | Year |
|---|---|
Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases.
Among other non-antibiotic properties, tetracyclines inhibit matrix metalloproteinases and are currently under study for the treatment of osteoarthritis. Quaternary ammonium conjugates of tetracyclines were synthesized by direct alkylation of the amine function at the 4-position with methyl iodide. When tested in vitro, they inhibited cytokine-induced MMP expression to a lesser extent than parent tetracyclines. This was compensated by an improved inhibition of MMP catalytic activity. Since inhibition of collagen degradation was maintained these derivatives could be potent drug candidates for cartilage-targeted chondroprotective treatment. Topics: Animals; Cartilage, Articular; Chondrosarcoma; Collagen; Humans; In Vitro Techniques; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Protease Inhibitors; Proteoglycans; Rabbits; Tetracyclines | 2007 |
[Distribution of tetracycline in bones].
Topics: Adult; Animals; Bone and Bones; Bone Neoplasms; Chondrosarcoma; Fluorescence; Humans; Infection Control; L Forms; Male; Mice; Pancreatitis; Pericarditis; Pneumonia; Postoperative Complications; Rabbits; Tetracycline | 1967 |