tetracycline and Cholestasis

Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Halothane; Humans; Imipramine; Liver; Methotrexate; Methyldopa; Nicotinic Acids; Oxacillin; Phenylbutazone; Testosterone; Tetracycline

Topics: Aminosalicylic Acids; Animals; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Female; Halothane; Humans; Phenothiazines; Steroids; Testosterone; Tetracycline

Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Granuloma; Hemorrhagic Disorders; Humans; Liver; Liver Diseases; Pharmaceutical Preparations; Tetracycline

Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred within 2 months of ingesting tetracyclines in two female patients. Serum bilirubin levels normalized 12 and 34 months after tetracycline ingestion. Liver histology revealed bile duct paucity, severe cholestasis, and minimal necrosis and inflammation. Tetracyclines may infrequently induce bile duct paucity and prolonged, severe, and reversible cholestasis.

Topics: Adult; Bile Ducts; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Liver; Middle Aged; Necrosis; Tetracycline

Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Dihydroxyphenylalanine; Enzyme Induction; Fatty Liver; Female; Granuloma; Halothane; Hepatomegaly; Humans; Male; Middle Aged; Oxyphenisatin Acetate; Pregnancy; Sulfonamides; Tetracycline

Topics: Adult; Age Factors; Bilirubin; Cell Membrane; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Female; Halothane; Humans; Infant, Newborn; Liver; Liver Cirrhosis; Male; Methotrexate; Microsomes, Liver; Pharmaceutical Preparations; Pregnancy; Tetracycline

Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptives, Oral; Fatty Liver; Female; Halothane; Hepatitis A; Humans; Jaundice; Jaundice, Chronic Idiopathic; Liver; Liver Cirrhosis; Liver Diseases; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Rupture, Spontaneous; Tetracycline

Topics: Cholestasis; Fatty Liver; Female; Halothane; Hepatitis; Hepatitis A; Hepatitis B; Hepatitis B Antigens; Humans; Hysterectomy; Liver Diseases; Liver Function Tests; Liver Regeneration; Maternal Mortality; Methoxyflurane; Middle Aged; Postoperative Complications; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Tetracycline; Transfusion Reaction

Topics: Cholestasis; Contraceptives, Oral; Fatty Liver; Female; Humans; Jaundice; Pregnancy; Pregnancy Complications; Pruritus; Tetracycline

Topics: Anti-Bacterial Agents; Bile Duct Neoplasms; Bile Ducts; Biopsy; Cholangitis; Cholestasis; Colectomy; Colitis, Ulcerative; Fatty Liver; Follow-Up Studies; Hepatitis; Humans; Inflammation; Liver; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Diseases; Liver Function Tests; Portal System; Prednisolone; Sepsis; Tetracycline

Topics: Adult; Cholestasis; Female; Hepatitis; Humans; Postoperative Complications; Pruritus; Tetracycline; Transaminases

Topics: Child, Preschool; Cholestasis; Female; Humans; Tetracycline; Tooth Calcification; Tooth Discoloration

Topics: Alkaline Phosphatase; Animals; Arginase; Aspartate Aminotransferases; Bile Ducts, Intrahepatic; Bilirubin; Cholestasis; Common Bile Duct; Erythrocytes; L-Lactate Dehydrogenase; Liver; Male; Rats; Tetracycline; Thiocyanates

Topics: Cholestasis; Humans; Tetracycline; Troleandomycin