tetracycline and Celiac-Disease

Topics: Celiac Disease; Glutens; Humans; Sprue, Tropical; Tetracycline

Topics: Adult; Aged; Celiac Disease; Demeclocycline; Feces; Female; Humans; Male; Middle Aged; Tetracycline

The clinical course is described of a 69-year-old patient with a malabsorption syndrome since her stay in Indonesia. Besides chronic diarrhoea and weight loss she suffered from malnutrition and had partial villous atrophy. Coeliac disease was considered in the differential diagnosis but considering the endemic appearance of postinfectious tropical sprue (PTS) in Indonesia and the extreme vitamin B12 deficiency our patient experienced, PTS appeared more likely. A good response to the therapy prescribed for PTS confirmed the diagnosis.

Topics: Aged; Celiac Disease; Diagnosis, Differential; Female; Folic Acid; Humans; Jejunum; Sprue, Tropical; Tetracycline; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Celiac Disease; Humans; Tetracycline

Fifteen of sixteen Caucasians with acute tropical sprue were founc to have numerous aerobic bacteria closely associated with the mucosal layer of the proximal jejunum. Four species of Enterobacteria were grown in eleven patients, and concentrations were higher in the mucosal patients than in the jejunal fluid. Only one of eight control cases with similar tropical exposure but without mucosal morphological abnormalities had any similar bacteria in the mucosal biopsy. In no case were Bacteroides isolated. Since clinical and biochemical improvement only occurred on treatment with tetracycline when enterobacteria were eliminated from the mucosa, it is suggested that these organisms may be responsible for persisting jejunal abnormalities in tropical sprue.

Topics: Biopsy, Needle; Body Fluids; Celiac Disease; Culture Media; Drug Resistance, Microbial; Enterobacteriaceae; Feces; Female; Humans; Intestinal Mucosa; Jejunum; Lipids; Male; Sprue, Tropical; Streptococcus; Tetracycline; Vitamin B 12; Xylose

Idiopathic late-onset immunoglobulin deficiency in a young man was associated with achlorhydria and a severe intestinal malabsorption syndrome that did not respond to conventional therapy. Combined therapy with high doses of prednisone and tetracycline hydrochloride resulted in weight gain, cessation of diarrhea, improved absorption of water, fat, and vitamin B12, and production of gastric acid after stimulation with histamine. Serum immunoglobulin levels, however, did not increase.

Topics: Achlorhydria; Adult; Age Factors; Body Weight; Celiac Disease; Cholecystokinin; Diarrhea; Drug Therapy, Combination; Humans; Immunoglobulin M; Immunologic Deficiency Syndromes; Malabsorption Syndromes; Male; Prednisone; Tetracycline; Vitamin B 12

Clinical, immunological, and histological recovery in a patient with alpha-chain disease is described. The patient, a 27-year-old Greek man, presented with severe steatorrhoea, abdominal pain, oedema, and hypogammaglobulinaemia. Treatment with tetracycline produced only temporary remission. Intermittent therapy with prednisone and cyclophosphamide together with antibiotics was followed by clinical recovery, return of histological appearances of the small intestine to normal, and disappearance of free alpha-chain protein from the serum. The patient remained well one year later without treatment.

Topics: Adult; Beta-Globulins; Biopsy; Celiac Disease; Cyclophosphamide; Diet Therapy; Fluorescent Antibody Technique; Glucose Tolerance Test; Glutens; Heavy Chain Disease; Humans; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Prednisone; T-Lymphocytes; Tetracycline; Xylose

Topics: Adult; Celiac Disease; Female; Folic Acid; Galactose; Glucose; Hexoses; Humans; Intestinal Absorption; Male; Middle Aged; Osmolar Concentration; Perfusion; Sodium; Sodium Chloride; Sprue, Tropical; Stimulation, Chemical; Tetracycline; Tritium; Water

Topics: Achlorhydria; Anemia, Megaloblastic; Anorexia Nervosa; Body Weight; Bone Marrow Cells; Celiac Disease; Diarrhea; Gastritis; Hemoglobinometry; Humans; Jejunum; Malabsorption Syndromes; Sprue, Tropical; Tetracycline; Vitamin B 12; Zimbabwe

Topics: Adult; Aged; Bile Acids and Salts; Celiac Disease; Chemical Phenomena; Chemistry; Cholesterol; Cholestyramine Resin; Cholic Acids; Diarrhea; Feces; Female; Gastrointestinal Motility; Glycocholic Acid; Humans; Intestinal Obstruction; Intestine, Small; Lipid Metabolism; Liver; Malabsorption Syndromes; Male; Middle Aged; Taurocholic Acid; Tetracycline

Thirty-four cases of malabsorption are described in young adults after brief periods of overland travel to India. Symptoms included diarrhoea, abdominal distension, and weight loss. Investigation revealed fat, xylose, and vitamin B(12) malabsorption with marked morphological changes in the mucosa. Lower levels of serum folate and vitamin B(12) were observed in those with protracted diarrhoea, but no anaemia developed. Malabsorption may persist for many months after return to the U.K. Most patients responded initially to antibiotics, but some subsequently relapsed. The reasons why these patients developed tropical sprue are discussed.

Topics: Adult; Asia, Western; Biopsy; Body Weight; Celiac Disease; Diarrhea; Fats; Female; Folic Acid; Humans; India; Intestinal Absorption; Jejunum; Malabsorption Syndromes; Male; Tetracycline; Travel; Vitamin B 12; Xylose

Topics: Biopsy, Needle; Body Weight; Celiac Disease; Female; Humans; Hypersensitivity, Delayed; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Lymphopenia; Middle Aged; Penicillins; Pericarditis; Pleurisy; Tetracycline; Whipple Disease

Topics: Autopsy; Biopsy; Celiac Disease; Chlorambucil; Gastrointestinal Neoplasms; Humans; Intestinal Polyps; Israel; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prednisone; Tetracycline

Topics: Amino Acids; Ampicillin; Bacteria; Bacterial Infections; Barium Sulfate; Body Weight; Celiac Disease; Chloramphenicol; Colon; Dietary Fats; Esophagoscopy; Fats; Feces; Female; Gastroesophageal Reflux; Humans; Lipids; Malabsorption Syndromes; Manometry; Middle Aged; Postoperative Complications; Radiography; Tetracycline; Transplantation, Autologous; Vomiting

Topics: Aged; Ampicillin; Bacteroides; Bacteroides Infections; Blind Loop Syndrome; Candida; Celiac Disease; Enterobacteriaceae; Enterobacteriaceae Infections; Feces; Female; Humans; Intestinal Absorption; Intestine, Small; Male; Middle Aged; Staphylococcus; Tetracycline; Vitamin B 12

Topics: Adult; Celiac Disease; Diagnosis, Differential; Folic Acid; Glutens; Humans; Male; Sprue, Tropical; Tetracycline

Topics: Achlorhydria; Adult; Aged; Alkalies; Bacterial Infections; Celiac Disease; Diabetes Complications; Diabetic Neuropathies; Diarrhea; Drug Synergism; Female; Humans; Male; Middle Aged; Parasympatholytics; Potassium; Salts; Solutions; Tetracycline

Topics: Adolescent; Adult; Celiac Disease; Folic Acid; Hookworm Infections; Humans; Male; South Africa; Tetracycline

Topics: Adult; Agammaglobulinemia; Celiac Disease; Diet Therapy; gamma-Globulins; Humans; Immunoglobulins; Intestinal Mucosa; Male; Tetracycline

Topics: Adult; Celiac Disease; Chronic Disease; Diet Therapy; Duodenum; Escherichia coli; Fats; Female; Folic Acid; Humans; Ileum; Intestinal Absorption; Jejunum; Male; Middle Aged; Neomycin; Nutrition Disorders; Protein Deficiency; Stomach; Tetracycline; Vitamin B 12; Xylose

Topics: Adaptation, Physiological; Animals; Body Weight; Celiac Disease; Dogs; Fats; Feces; Gastrointestinal Motility; Ileum; Intestine, Small; Jejunum; Methods; Nutritional Physiological Phenomena; Postoperative Complications; Tetracycline

Topics: Adolescent; Adult; Bicarbonates; Biological Transport; Biopsy; Celiac Disease; Chlorides; Electrolytes; Female; Humans; Ileum; Intestinal Secretions; Intestine, Small; Jejunum; Male; Middle Aged; Nutrition Disorders; Potassium; Sodium; Tetracycline; Water-Electrolyte Balance

Topics: Anemia, Macrocytic; Celiac Disease; Diverticulum; Duodenum; Humans; Intestinal Diseases; Jejunum; Male; Middle Aged; Spinal Cord Diseases; Tetracycline; Vitamin B 12

Microbial populations of the small bowel and bile salt metabolism were studied in 15 patients with lesions of the stomach and small intestine. These types of microorganism could be correlated with the site and extent of stasis in the small bowel and the presence of a normally functioning stomach. The presence of obligate anaerobes (bacteroides) and free bile acids could be correlated with areas of stagnation. When these abnormalities were detected throughout the small bowel, steatorrhoea was also noted. However, bacteroides and free bile acids in localized regions of either proximal or distal small bowel were generally associated with normal faecal fat excretion. Vitamin B(12) malabsorption appeared to be related to the total number of bacteria colonizing the small bowel rather than to any specific type of microorganisms. The effect of antibiotics on intestinal function and bacteriology was studied in three patients. In one patient, the broad-spectrum antibiotic tetracycline was effective in eradicating an abnormal bacterial flora. In the other two, lincomycin, which is specifically effective in eradicating the anaerobic flora, restored intestinal function to normal.

Topics: Adult; Aged; Bacteria; Bacteroides; Bile Acids and Salts; Celiac Disease; Diverticulum; Fats; Feces; Female; Gastrectomy; Humans; Intestinal Absorption; Intestinal Diseases; Intestine, Small; Lincomycin; Lipids; Male; Middle Aged; Stomach Diseases; Tetracycline; Vitamin B 12

Topics: Adult; Aged; Bile Acids and Salts; Biopsy; Celiac Disease; Child; Duodenum; Fatty Acids; Female; Humans; Ileum; Intestinal Diseases; Intestinal Mucosa; Jejunum; Male; Microscopy, Electron; Middle Aged; Tetracycline

Topics: Aged; Anemia, Macrocytic; Celiac Disease; Diverticulum; Erythrocyte Count; Female; Hematocrit; Hemoglobinometry; Humans; Intestinal Absorption; Intestine, Small; Jejunum; Leukocyte Count; Malabsorption Syndromes; Male; Neomycin; Radiography; Reticulocytes; Tetracycline; Vitamin B 12

Topics: Animals; Celiac Disease; Digestive System; Humans; Neomycin; Tetracycline; Triparanol

Topics: Adult; Celiac Disease; Chloramphenicol; Female; Humans; Intestinal Diseases; Intestinal Obstruction; Intestine, Small; Jejunum; Malabsorption Syndromes; Middle Aged; Pneumatosis Cystoides Intestinalis; Pneumoperitoneum; Radiography; Scleroderma, Systemic; Tetracycline; Vitamin B 12; Xylose

Several aspects of the metabolism of hydroxy fatty acids were studied in dogs with steatorrhea resulting from an experimentally produced jejunal blind loop. In these animals hydroxy acids were present in the stool in amounts far above normal. These acids disappeared from the feces during tetracycline administration and after exclusion of the blind loop-both procedures that corrected the steatorrhea apparently by reducing bacterial overgrowth. Hydroxy acids persisted in higher than normal amounts, however, after administration of taurocholic acid, which also corrected the steatorrhea, but by a different mechanism. Both in normal dogs and in those with blind loops, hydroxy acid constituted a higher percentage of total fatty acids in the jejunum. A possible conclusion is that hydroxy fatty acids have an enterohepatic circulation via the portal system. When hydroxy acids were fed to normal dogs, steatorrhea was not produced and absorption in amounts similar to that of unsubstituted stearic acid was observed. Isotopic oleic and linoleic acids were converted to hydroxy acids both in vivo and during in vitro incubation with feces; stearic acid was not. These findings support the idea that hydroxy acids arise by the addition of water across double bonds, this addition being catalyzed by enzymes of intestinal bacteria.

Topics: Animals; Bacteria; Bile Acids and Salts; Carbon Isotopes; Celiac Disease; Chromatography, Gas; Chromatography, Thin Layer; Dogs; Fatty Acids; Feces; Intestines; Jejunum; Linoleic Acids; Lipid Metabolism; Oleic Acids; Stearic Acids; Stimulation, Chemical; Tetracycline

Topics: Adult; Aged; Bile Acids and Salts; Celiac Disease; Child; Chromatography, Thin Layer; Diverticulum; Fats; Female; Gastrectomy; Humans; In Vitro Techniques; Intestines; Jejunum; Malabsorption Syndromes; Male; Middle Aged; Postoperative Complications; Tetracycline

Topics: Alcaligenes; Bacillus; Celiac Disease; Culture Media; Enterococcus faecalis; Escherichia coli; Fluoroscopy; Folic Acid; Haiti; Humans; Intestinal Mucosa; Proteus; Spectrophotometry; Tetracycline

Topics: Anemia, Macrocytic; Bone Marrow Examination; Celiac Disease; Dumping Syndrome; Folic Acid Deficiency; Humans; Male; Middle Aged; Radiography; Tetracycline; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Aged; Celiac Disease; Diet Therapy; Female; Glutens; Humans; Intestinal Mucosa; Middle Aged; Tetracycline

Topics: Animals; Celiac Disease; Dietary Fats; Dogs; Lipid Metabolism; Malabsorption Syndromes; Pharmacology; Postgastrectomy Syndromes; Research; Tetracycline

Topics: Aged; Animals; Bile Acids and Salts; Celiac Disease; Chromatography, Thin Layer; Escherichia coli; Feces; Humans; Intestine, Small; Lactobacillus; Malabsorption Syndromes; Male; Oleic Acids; Postoperative Complications; Rats; Tetracycline; Triolein

Topics: Celiac Disease; Colic; Colonic Diseases; Gastric Fistula; Humans; Intestinal Fistula; Sprue, Tropical; Steatorrhea; Surgical Procedures, Operative; Tetracycline

Topics: Adult; Biochemical Phenomena; Biochemistry; Celiac Disease; Dietary Proteins; Glutens; Humans; Hydroxyindoleacetic Acid; Indican; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Proteins; Tetracycline; Tryptophan; Urine; Vitamin B 6; Vitamin B 6 Deficiency; Xanthurenates

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Celiac Disease; Diverticulum; Drug Therapy; Geriatrics; Humans; Intestinal Diseases; Intestine, Small; Intestines; Pain; Steatorrhea; Tetracycline; Toxicology; Vitamin B 12

Topics: Anti-Bacterial Agents; Celiac Disease; Diagnosis, Differential; Drug Therapy; Humans; Malabsorption Syndromes; Sprue, Tropical; Tetracycline; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Anti-Bacterial Agents; Celiac Disease; Diet; Drug Therapy; Folic Acid; Hematinics; Humans; Intestinal Absorption; Jejunum; Metabolism; Sprue, Tropical; Tetracycline; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Anti-Bacterial Agents; Calcium; Celiac Disease; Drug Therapy; Folic Acid; Glutens; Humans; Iron; New York; New York City; Pathology; Puerto Rico; Serum Albumin; Sprue, Tropical; Statistics as Topic; Tetracycline

Topics: Celiac Disease; Diarrhea; Diverticulum; Duodenal Diseases; Escherichia coli Infections; Humans; Intestinal Diseases; Intestines; Sprue, Tropical; Steatorrhea; Tetracycline; Vitamin B 12

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibiotics, Antitubercular; Belgium; Celiac Disease; Chloramphenicol; Dermatologic Agents; Geriatrics; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Peptic Ulcer Perforation; Sarcoma; Sprue, Tropical; Steatorrhea; Tetracycline