tetracycline and Cat-Scratch-Disease

Discovered in 1950-51 by two great parisian medical teams, inoculation lymphoreticulosis, also called cat's scratch disease, is locoregional adenitis whose aetiology is imperfectly determined. Following, often bu not always, cat's scratch, it may evolve to suppuration. Pus is always aseptic. Attributed to Bedsonia's family micro-organism, no cultivation was possible up to date. Evolution is as a rule favourable, but disease is poorly accessible to tetracycline family's antibiotics. Diagnosis is possible by intradermoreaction. The antigen used is tyndallised pus of homologous infection. The role of the cat, still healthy, has not yet been explained.

Topics: Animals; Cat-Scratch Disease; Cats; Humans; Immunologic Tests; Tetracycline

Topics: Adolescent; Adult; Aged; Animals; Cat-Scratch Disease; Child; Child, Preschool; Disease Outbreaks; Female; Fever; Gastroenteritis; Humans; Indians, North American; Insect Vectors; Leukemia; Lymphogranuloma Venereum; Male; Middle Aged; New Mexico; Phagocytosis; Plague; Rodentia; Sciuridae; Siphonaptera; Streptomycin; Syphilis; Tetracycline; Tularemia; Yersinia pestis

Systemic cat scratch disease (CSD) is often associated with prolonged fever and microabscesses in the liver and/or spleen. We report a case of systemic CSD with hepatic, splenic and renal involvement in an aboriginal child in Taiwan. A previously healthy 9-year-old girl had an intermittent fever for about 17 days, and complained of abdominal pain, headache and weight loss. Abdominal computed tomography showed multiple tiny hypodense nodular lesions in the spleen and both kidneys. Laparotomy revealed multiple soft, whitish-tan lesions on the surface of the liver and spleen. Histopathologic examination of a biopsy specimen of the spleen showed necrotizing granulomatous inflammation with central necrosis surrounded by epithelioid cells and occasional Langhans' giant cells, strongly suggestive of Bartonella henselae infection. History revealed close contact with a cat. B. henselae DNA was detected by polymerase chain reaction in the tissue specimen, and the single antibody titer against B. henselae was greater than 1:2048. These results confirmed the diagnosis of visceral CSD caused by B. henselae. The patient's symptoms resolved after treatment with rifampin and tetracycline. This case illustrates the need for inclusion of systemic CSD in patients with fever of unknown origin and abdominal pain.

Topics: Animals; Bartonella henselae; Cat-Scratch Disease; Cats; Child; Female; Fever of Unknown Origin; Humans; Polymerase Chain Reaction; Rifampin; Tetracycline

We report a patient with neuroretinitis, whose associated lymphadenopathy, exposure to cats, and strongly positive cat scratch antigen skin tests suggested the diagnosis of cat scratch disease. Cat scratch disease should be added to the list of infectious agents believed to produce the clinical picture of neuroretinitis.

Topics: Adult; Cat-Scratch Disease; Female; Fluorescein Angiography; Fundus Oculi; Humans; Optic Disk; Prednisone; Retinitis; Skin Tests; Tetracycline; Visual Acuity

Topics: Adult; Ampicillin; Cat-Scratch Disease; Drug Therapy, Combination; Female; Humans; Oleandomycin; Tetracycline; Tuberculosis, Pulmonary

Topics: Adult; Aged; Antibodies; Cat-Scratch Disease; Chlamydia; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Tetracycline

Topics: Cat-Scratch Disease; Child; Female; Humans; Male; Tetracycline

Topics: Anti-Bacterial Agents; Cat-Scratch Disease; Diagnosis; Humans; Tetracycline