tetracycline and Carcinoma--Bronchogenic

Thirty-three unselected patients with cardiac tamponade secondary to malignant pericardial effusion were treated by intrapericardial instillation of tetracycline hydrochloride. Complete control of the initial signs and symptoms of tamponade was obtained in 30 patients without concomitant chemotherapy or radiotherapy. The procedure did not result in clinically significant complications. Failure of the technique was related to premature removal of the catheter by the patient (one patient) or the inability to totally remove hemorrhagic, clot-filled pericardial fluid (two patients). Survival ranged between 28-704 days and extended survival was related to the performance status and/or chemoradiosensitivity of the primary cancer. No patient successfully treated subsequently developed recurrent cardiac tamponade or alternatively, constrictive pericarditis. Tetracycline pericardial instillation remains a safe, simple, and efficacious treatment of tamponade secondary to malignant disease.

Topics: Adult; Aged; Carcinoma, Bronchogenic; Cardiac Tamponade; Electrocardiography; Female; Heart Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Pericardial Effusion; Radiography; Sclerosing Solutions; Tetracycline

Tumor-seeking radiopharmaceuticals have been employed in the diagnosis of primary neoplasms, in the detection of distant disease, particularly in the localization of tumor foci to facilitate biopsies and the planning of radiation portals, and in assessing the response to tumor therapy. At the present, there is no ideal tumor-scanning agent. However, several approaches appear to be useful and offer promise for further study. The greatest experience has been with Gallium-67, which has major utility in the staging of Hodgkin's disease, in the diagnosis of bronchogenic carcinoma, in the detection of certain metastatic brain tumors, in the identification of recurrent disease, and in the noninvasive diagnosis of leukemic complications. A number of radiolabeled antibiotic and chemotherapeutic agents have shown promise, including tetracycline and bleomycin. A major drawback, however, of these agents which is shared with Gallium-67 is that they appear to be sequestered by inflammatory as well as neoplastic tissue. A most intriguing approach is the use of radiolabeled antibodies to tumor-associated antigens. Animal and clinical experiments have employed antifibrin, antifibrinogen, anticarcinoembryonic antigen, and antiferritin. Theoretically, agents such as these should allow for greater tumor specificity.

Topics: Antibodies, Neoplasm; Bleomycin; Brain Neoplasms; Carcinoembryonic Antigen; Carcinoma, Bronchogenic; Gallium Radioisotopes; Hodgkin Disease; Humans; Indium; Leukemia; Lung Neoplasms; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Radiography; Radioisotopes; Radionuclide Imaging; Technetium; Tetracycline

Topics: Adenocarcinoma; Animals; Carcinoma, Bronchogenic; Carcinoma, Hepatocellular; Gallium; Glioblastoma; Hodgkin Disease; Humans; L-Lactate Dehydrogenase; Liver Neoplasms; Lung Neoplasms; Mediastinal Neoplasms; Methane; Mice; Muscular Diseases; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Osteosarcoma; Rabbits; Radioisotopes; Radionuclide Imaging; Rats; Sarcoma; Sarcoma, Experimental; Technetium; Tetracycline; Transplantation, Homologous

Topics: Carcinoma, Bronchogenic; Carcinoma, Small Cell; Cyclophosphamide; Humans; Lung Neoplasms; Neoplasm Metastasis; Tetracycline; Time Factors

Topics: Adult; Aged; Carcinoma, Bronchogenic; Female; Fluorescence; Humans; Lung Neoplasms; Male; Middle Aged; Tetracycline

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Cytodiagnosis; Humans; Lung Diseases; Lung Neoplasms; Microscopy, Fluorescence; Pleural Effusion; Tetracycline

Topics: Carcinoma; Carcinoma, Bronchogenic; Clinical Laboratory Techniques; Fluorescence; Humans; Lung Diseases; Microscopy; Microscopy, Fluorescence; Neoplasms; Sputum; Tetracycline; Ultraviolet Rays

Topics: Anti-Bacterial Agents; Bronchial Neoplasms; Carcinoma, Bronchogenic; Early Diagnosis; Fluorescence; Humans; Neoplasms; Sputum; Tetracycline

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide; Geriatrics; Leukopenia; Lung Neoplasms; Nitrogen Mustard Compounds; Prednisolone; Tetracycline; Toxicology; Urethane

Topics: Bronchiectasis; Bronchitis; Carcinoma, Bronchogenic; Fluorescence; Humans; Lung Diseases; Neoplasms; Oxytetracycline; Pulmonary Emphysema; Tetracycline