tetracycline and Candidiasis--Vulvovaginal

Topics: Antifungal Agents; Candidiasis, Vulvovaginal; Female; Glucocorticoids; Gonorrhea; Haemophilus Infections; Herpes Simplex; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metronidazole; Mycoplasma Infections; Ophthalmia Neonatorum; Penicillin G Procaine; Pregnancy; Pregnancy Complications, Infectious; Pregnancy in Diabetics; Syphilis; Syphilis Serodiagnosis; Syphilis, Congenital; Tetracycline; Trichomonas Vaginitis; Vaginal Diseases

A double-blind, random distribution study showed that a lower than recommended dose of minocycline--50 mg twice daily--was as effective as a dose of 250 mg twice daily of tetracycline for treatment of acne vulgaris in comparable patient groups, and that minocycline produced no vestibular side effects at the lower dosage. Like tetracycline, minocycline did not produce the phototoxicity associated with demeclocycline or the life-threatening colitis associated with clindamycin. Patients in this study did not develop a resistance either to minocycline or to tetracycline. Studies of the use of minocycline in patients who have developed tetracycline resistance and long-range studies of patients on the new lower dose of minocycline are now underway.

Topics: Acne Vulgaris; Adolescent; Adult; Candidiasis, Vulvovaginal; Clinical Trials as Topic; Female; Humans; Male; Minocycline; Tetracycline; Tetracyclines; Time Factors

Two groups of women with non-specific genital infection were treated for two weeks with tetracycline 250 mg six-hourly and minocycline 100 mg twice daily respectively. Cultures for yeasts were performed before treatment and at the end of the first and second weeks. Before treatment yeasts, mostly Candida albicans, were recovered from 13% of the women. After one and two weeks' treatment yeasts were isolated from 22 and 29% of women treated with tetracycline, and from 19 and 29% of women treated with minocycline. It is concluded that despite inhibition of the growth of yeasts shown by minocycline in vitro, there is no evidence of any significant difference between the actions of tetracycline and minocycline on the vaginal yeast flora.

Topics: Candida albicans; Candidiasis, Vulvovaginal; Clinical Trials as Topic; Female; Humans; Minocycline; Tetracycline; Tetracyclines; Vagina; Vaginal Smears; Vulvovaginitis; Yeasts

A proctocol to be administered by nurses for the management of dysuria, frequent urination, and vaginal discharge was validated. In a randomized, controlled trial, 146 women were seen by both nurse and physician and then assigned to either the nurse-proctocol treatment plan or the physician treatment plan. The clinical data collected by the nurse showed no important differences from the physicians' data. The protocol recommended that 89 percent of the patients be sent home without seeing the physician. The physicians agreed with the protocol-recommended disposition in all but two cases. All patients with complications were appropriately referred to the physician. In follow-up, more than 95 percent of both groups reported symptomatic improvement, and repeat urine cultures were negative. We conclude that the protocol can be accurately administered, makes sound recommendations, is safe, and efficiently saves physician time.

Topics: Adolescent; Adult; Ampicillin; Candidiasis, Vulvovaginal; Female; Humans; Nurses; Physicians; Sulfisoxazole; Syndrome; Tetracycline; Trichomonas Infections; Urethral Diseases; Urethritis; Urinary Tract Infections; Urination Disorders; Vagina; Vaginal Diseases; Vaginitis

Topics: Amphotericin B; Candida; Candidiasis, Vulvovaginal; Drug Synergism; Female; Humans; Metronidazole; Tetracycline; Trichomonas Vaginitis

Topics: Adolescent; Adult; Amphotericin B; Bacterial Infections; Candidiasis, Vulvovaginal; Drug Combinations; Female; Genital Diseases, Female; Humans; Middle Aged; Pelvic Inflammatory Disease; Suppositories; Tetracycline; Vaginitis

We have briefly presented practical approaches to the management of the most common disorders caused by sexually transmitted pathogens, including pelvic inflammatory disease, urethritis in men, genital lesions, vaginal discharge, and syphilis. Guidelines for the management of gonorrhea may change if penicillin-resistant strains become more prevalent. Areas which require further research include the treatment of genital herpes and the prevention of recurrences, the treatment of nonspecific vaginitis, and definition of the importance of metronidazole toxicity.

Topics: Anti-Bacterial Agents; Candidiasis, Vulvovaginal; Female; Genital Diseases, Female; Genital Diseases, Male; Gonorrhea; Herpesviridae Infections; Humans; Male; Pelvic Inflammatory Disease; Penicillin G; Pharyngeal Diseases; Pregnancy; Sexually Transmitted Diseases; Syphilis; Tetracycline; Urethritis; Vaginitis

The minimal inhibition concentration of Tetracycline was tested in 177 strains of gram positive and gram negative species of bacteria from the vagina which were found to be resistant to Tetracycline in the Agardiffusion Test. 170 of the 177 strains (96%) were inhibited with a Tetracycline concentration of 512 microgram/ml. Six Klebsiella-enterobacter strains and one proteus morgaini strain needed a minimal inhibition concentration of 1024 microgram/ml. For a successful local treatment of vaginitis by Tetracycline against species highly resistant to Tetracycline local Tetracycline levels of 1000 microgram/ml or better have to be obtained. Concomitant preventive treatment of fungi for instance, with amphotericin containing drugs such as mysteclin is indicated.

Topics: Amphotericin B; Candidiasis, Vulvovaginal; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; Tetracycline; Vaginitis

A positive microbiological evidence could be obtained 54 times from the smear of the exterior genitals of 80 women suffering from complaints that were caused by urethritis, criteria of the examinations being sterile catheter specimen, negative cystoscopical findings, and missing indications to anatomical changes in the urethral region. Cytological examinations of these cases with regard to the vaginal epithelium had the following results:Group I:6 times; group II: 37 times; group IIW:8 times; group IIId: once; group IVa:twice. The cytological tests were carried out according to the method of papanicolaou as modified by Soost. Furthermore, we could state the following degrees of purity: Degree I: 8 times; degree II:16 times; degree III: 30 times. The cytological examinations of the urethral epithelium demonstrated, in 52 cases, an increased appearance of "nude" completely exposed epithelial cell nuclei--a fact corresponding to a degenerative autolysis (according to Wied). In the 26 women with missing atypical germ flora within the region of the exterior genitals, exclusively groups I (according to Papanicolaou and Soost) and degrees of purity I were stated. These persons also demonstrated remarkably grave psychical disturbances, especially in the intimate regions. In the cases of positive microbiological evidence, the following measures have proved satisfactory: Vaginal hygienization combined with a directly aimed antibacterial therapy, and the prescription of preparations containing lactic acid. A transitory discontinuation of contraceptives is being discussed. Our examination results are emphasizing the necessity of an analysis of the germ flora in cases of complaints arising from urethritis. Also psychical disturbances must be taken into consideration in cases of missing urological and gynaecological criteria of evidence.

Topics: Candidiasis, Vulvovaginal; Cervix Uteri; Chronic Disease; Female; Humans; Male; Metronidazole; Mycoplasma Infections; Nystatin; Psychophysiologic Disorders; Tetracycline; Trichomonas Vaginitis; Urethra; Urethritis; Vagina; Vaginal Diseases

Topics: Acne Vulgaris; Administration, Oral; Candidiasis, Vulvovaginal; Clindamycin; Colitis; Demeclocycline; Drug Evaluation; Erythromycin; Female; Humans; Minocycline; Photosensitivity Disorders; Tetracycline; Time Factors

Topics: Candidiasis, Vulvovaginal; Drug Combinations; Female; Humans; Natamycin; Pregnancy; Pregnancy Complications, Infectious; Suspensions; Tetracycline; Trichomonas Vaginitis

Topics: Adult; Candidiasis, Vulvovaginal; Chlortetracycline; Dermatitis; Female; Humans; Nystatin; Tetracycline

Topics: Acne Vulgaris; Adolescent; Candidiasis, Vulvovaginal; Female; Humans; Tetracycline; Vaginitis

Topics: Adolescent; Adult; Candidiasis, Vulvovaginal; Drug Resistance, Microbial; Female; Gonorrhea; Humans; Intrauterine Devices; Metronidazole; Neisseria gonorrhoeae; Nigeria; Nystatin; Penicillin Resistance; Sexually Transmitted Diseases; Tetracycline; Trichomonas Vaginitis

Topics: Candidiasis, Vulvovaginal; Female; Gonorrhea; Humans; Male; Pelvic Inflammatory Disease; Penicillin G Procaine; Pharyngitis; Proctitis; Syphilis; Tetracycline; Urogenital System; Vulvovaginitis

Topics: Adult; Amphotericin B; Candidiasis; Candidiasis, Oral; Candidiasis, Vulvovaginal; Female; Humans; Tetracycline; Trichomonas Vaginitis

Topics: Candida; Candidiasis, Vulvovaginal; Chloramphenicol; Female; Humans; Tetracycline

Topics: Amphotericin B; Anti-Bacterial Agents; Candidiasis; Candidiasis, Vulvovaginal; Female; Humans; Tetracycline; Toxicology; Triamcinolone Acetonide

Topics: Amphotericin B; Anti-Bacterial Agents; Candidiasis, Vulvovaginal; Drug Therapy; Female; Humans; Tetracycline; Toxicology

Topics: Amphotericin B; Candidiasis, Vulvovaginal; Female; Humans; Protein Synthesis Inhibitors; Tetracycline; Trichomonas Vaginitis; Vaginitis; Vulvovaginitis