tetracycline and Bronchitis--Chronic

ANTIBIOTIC EFFICACY: According to early studies, antibiotics have moderate efficacy in acute exacerbation of chronic bronchitis. The lack of efficacy is particularly clear for patent exacerbation with marked alteration of respiratory function. Recent studies have shown that newer compounds exhibit an efficacy similar (no proven superiority) to comparison compounds (75 to 95% favorable outcome with treatment). The recommendations of the IVth Consensus Conference on Anti-infectious Therapy thus propose first line antibiotic therapy for patients with a forced expiratory volume in 1 second (FEV1) between 80 and 35% and broader spectrum and new antibiotics in case of failure of the first line treatment for patients with severe obstruction or frequently recurrent exacerbation.. Using exacerbation-free interval, reduction in the number of exacerbations, duration of treatment and/or hospital stay as evaluation criteria, interesting results are obtained with amoxicillin/clavulanic acid, azithromycin, and ciprofloxacin. Independent factors predictive of therapeutic failure are, according to one study, FEV1 less than 35%, ambulatory administration of oxygen, more than 4 acute exacerbations within 24 months, history of pneumonia or sinusitis, and requirement for long-term corticosteroid therapy. Factors predictive of recurrence are, according to another study, dependence on oxygen therapy, prolonged corticosteroid therapy, smoking, and/or heart disease. Cost effectiveness is particularly interesting with ciprofloxacin, especially in more severe patients.. It is important to target antibiotic therapy for acute exacerbation of chronic bronchitis specifically for patients who will truly benefit, adapting the prescribed compound to the bacterial target.

Topics: Acute Disease; Adrenal Cortex Hormones; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Bronchitis, Chronic; Ciprofloxacin; Clavulanic Acid; Clinical Trials as Topic; Cost-Benefit Analysis; Double-Blind Method; Drug Therapy, Combination; Erythromycin; Humans; Maximal Expiratory Flow-Volume Curves; Multicenter Studies as Topic; Penicillins; Placebos; Practice Guidelines as Topic; Prognosis; Recurrence; Respiratory Function Tests; Tetracycline; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Anti-Bacterial Agents; Bacitracin; Bronchitis; Bronchitis, Chronic; Chemoprevention; Chloramphenicol; Colistin; Drug Therapy; Kanamycin; Naphthyridines; Neomycin; Oleandomycin; Penicillins; Sulfonamides; Tetracycline; Tyrothricin; Virginiamycin

Topics: Bronchitis; Bronchitis, Chronic; Disease Outbreaks; Drug Therapy; Humans; Penicillin V; Penicillins; Respiratory Tract Infections; Superinfection; Tetracycline; Tetracyclines

Topics: Agammaglobulinemia; Anti-Bacterial Agents; Bronchiectasis; Bronchitis; Bronchitis, Chronic; Drug Therapy; gamma-Globulins; Oleandomycin; Penicillins; Tetracycline

Topics: Bacteriological Techniques; Bronchitis; Bronchitis, Chronic; Enterobacter; Haemophilus influenzae; Humans; Klebsiella; Penicillins; Proteus; Pseudomonas; Specimen Handling; Sputum; Staphylococcus; Streptococcus pneumoniae; Tetracycline

Topics: Adolescent; Anti-Bacterial Agents; Bacteriological Techniques; Blood Chemical Analysis; Bronchitis; Bronchitis, Chronic; Child; Hydrochloric Acid; Protein Synthesis Inhibitors; Tartrates; Tetracycline; Urine

Topics: Biomedical Research; Blood Gas Analysis; Bronchitis; Bronchitis, Chronic; Congenital Abnormalities; Drainage; Edema; Humans; Obesity; Penicillin G; Physical Therapy Modalities; Posture; Pulmonary Heart Disease; Respiratory Function Tests; Respiratory Insufficiency; Tetracycline; Therapeutics; Tracheotomy

Topics: Anti-Bacterial Agents; Biomedical Research; Bronchiectasis; Bronchitis; Bronchitis, Chronic; Drug Tolerance; Lymecycline; Pneumonia; Pneumonia, Pneumococcal; Sputum; Statistics as Topic; Tetracycline; Toxicology

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Drug Therapy; Erythromycin; Penicillins; Sulfamethoxypyridazine; Tetracycline

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Chlortetracycline; Drug Therapy; Protein Synthesis Inhibitors; Tetracycline; Toxicology

Topics: Ampicillin; Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Dermatologic Agents; Drug Therapy; Humans; Tetracycline

Topics: Ammonium Chloride; Anti-Bacterial Agents; Bacteriological Techniques; Bronchitis; Bronchitis, Chronic; Cytodiagnosis; Drug Therapy; Electrophoresis; Humans; Potassium; Prednisone; Sodium; Sputum; Tetracycline; Viscosity

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Oleandomycin; Penicillins; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Folic Acid; Penicillins; Tetracycline; Vitamin B Complex

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Humans; Tetracycline

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bronchitis; Bronchitis, Chronic; Bronchodilator Agents; Chloramphenicol; Detergents; Oxygen Inhalation Therapy; Penicillins; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Humans; Penicillin V; Penicillins; Tetracycline; Tetracyclines

Topics: Acetylcysteine; Aerosols; Anti-Bacterial Agents; Bronchi; Bronchitis; Bronchitis, Chronic; Cysteine; Humans; Pharmacology; Tetracycline

Topics: Anti-Bacterial Agents; Bronchiectasis; Bronchitis; Bronchitis, Chronic; Haemophilus influenzae; Humans; Pneumococcal Infections; Respiratory Tract Infections; Tetracycline

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Humans; Long-Term Care; Tetracycline

Topics: Anti-Bacterial Agents; Bronchiectasis; Bronchitis; Bronchitis, Chronic; Humans; Oleandomycin; Penicillins; Protein Synthesis Inhibitors; Sputum; Tetracycline

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Costs and Cost Analysis; Penicillins; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bronchiectasis; Bronchitis; Bronchitis, Chronic; Humans; Penicillins; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Chemoprevention; Erythromycin; Humans; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Oleandomycin; Oxytetracycline; Protein Synthesis Inhibitors; Tetracycline

Topics: Anti-Bacterial Agents; Bronchiectasis; Bronchitis; Bronchitis, Chronic; Humans; Tetracycline

Topics: Anti-Bacterial Agents; Bronchitis; Bronchitis, Chronic; Humans; Prednisolone; Tetracycline