tetracycline and Brain-Abscess

Anaerobic bacteria were isolated from the subdural space in all four cases of subdural empyema encountered over a 2 and a half year period. Only one aerobe was isolated in these cases. The bacteriology of subdural empyema was further analyzed from a review of 327 cases reported in the English literature. Anaerobes accounted for 12 per cent of 234 cases; In addition, 27 per cent of cases were reportedly "sterile." These data support our finding that anaerobic bacteria may play a far more important role in subdural empyema than was previously appreciated.

Topics: Adolescent; Ampicillin; Anaerobiosis; Bacteroides; Bacteroides Infections; Brain Abscess; Child; Chloramphenicol; Clindamycin; Dexamethasone; Drainage; Female; Humans; Male; Meninges; Methicillin; Middle Aged; Penicillins; Peptostreptococcus; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus; Streptococcal Infections; Streptococcus; Streptococcus pneumoniae; Subdural Space; Tetracycline

Topics: Abortion, Septic; Abscess; Aminoglycosides; Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Brain Abscess; Cephalosporins; Chloramphenicol; Clindamycin; Endocarditis, Bacterial; Erythromycin; Female; Humans; Lincomycin; Lung Abscess; Penicillins; Pregnancy; Sepsis; Tetracycline

This study retrospectively analyzed 12 patients with brain abscesses. Half of the patients were diagnosed inaccurately in the initial stage, and 7.2 days were required to achieve the final diagnosis of brain abscess. The patients presented only with a moderately elevated leukocyte count, serum CRP levels, or body temperatures during the initial stage. These markers changed, first with an increase in the leukocyte count, followed by the CRP and body temperature. The degree of elevation tended to be less prominent, and the time for each inflammatory index to reach its maximum value tended to be longer in the patients without ventriculitis than in those with it. The causative organisms of a brain abscess were detected in 10 cases. The primary causative organisms from dental caries were Streptococcus viridians or milleri, and Fusobacterium nucleatum. Nocardia sp. or farcinica were common when the abscess was found in other regions. The primary causative organisms of unrecognized sources of infection were Streptococcus milleri and Prolionibacterium sp. Nocardia is resistant to many antibiotics. However, carbapenem, tetracycline and quinolone were effective for Nocardia as well as many other kinds of bacteria. In summary, the brain abscesses presented with only mildly elevated inflammatory markers of body temperature, leukocyte and CRP. These inflammatory markers were less obvious in the patients without ventriculitis and/or meningitis. The source of infection tended to suggest some specific primary causative organism. It was reasonable to initiate therapy with carbapenem.

Topics: Adult; Aged; Brain Abscess; Carbapenems; Female; Fusobacterium nucleatum; Humans; Male; Middle Aged; Nocardia; Quinolones; Retrospective Studies; Streptococcus milleri Group; Tetracycline; Viridans Streptococci

Topics: Adult; Anti-Bacterial Agents; Brain Abscess; Humans; Male; Mycoplasma hominis; Mycoplasma Infections; Tetracycline; Tomography, X-Ray Computed

In this study pus samples obtained during operation from 28 patients with brain abscess have been examined microbiologically. In three of the 28 patients the cultures were negative (10%) obligate anaerobic bacteria from 20 (80%) patients, microaerophilic bacteria from 2 (4%) patients, aerobic bacteria from 11 (44%) patients have been isolated. Among the 15 obligate bacteria and 2 microaerophilic bacteria, the highest resistance has been shown against tetracycline, among the 11 aerobic bacteria the highest resistance has been shown against Gentamicin and Tetracycline.

Topics: Adult; Bacteria, Aerobic; Bacteria, Anaerobic; Brain Abscess; Drug Resistance, Microbial; Gentamicins; Humans; Middle Aged; Tetracycline

Topics: Adult; Aged; Ampicillin; Brain Abscess; Child; Chloramphenicol; Diagnosis, Differential; Erythromycin; Female; Humans; L-Lactate Dehydrogenase; Male; Meningitis; Meningitis, Haemophilus; Meningitis, Listeria; Meningitis, Meningococcal; Meningitis, Pneumococcal; Meningitis, Viral; Middle Aged; Penicillin G; Penicillin Resistance; Phlebitis; Prognosis; Sinus Thrombosis, Intracranial; Staphylococcus; Tetracycline; Tuberculosis, Meningeal; Urinary Tract Infections

Topics: Adult; Aged; Brain Abscess; Cephalothin; Cerebral Angiography; Echoencephalography; Electroencephalography; Facial Paralysis; Female; Headache; Hemianopsia; Humans; Injections, Intravenous; Male; Middle Aged; Penicillin G; Radionuclide Imaging; Tetracycline

Topics: Adolescent; Adult; Brain Abscess; Female; Humans; Male; Mastoiditis; Middle Aged; Otitis Media; Penicillins; Tetracycline; Tuberculosis, Meningeal

Topics: Adult; Amphotericin B; Bacteriological Techniques; Biopsy; Brain Abscess; Cerebrospinal Fluid Proteins; Hemiplegia; Humans; Isoniazid; Joint Diseases; Lung Diseases; Male; Meningitis; Nocardia Infections; Polymyxins; Prednisone; Pseudomonas Infections; Sarcoidosis; Skin Diseases; Sporotrichosis; Tetracycline

Topics: Brain Abscess; Cerebral Ventricles; Clostridium perfringens; Cognition Disorders; Gas Gangrene; Hemiplegia; Humans; Injections; Male; Middle Aged; Otitis Media; Penicillins; Radiography; Reflex, Stretch; Streptomycin; Tetracycline

Topics: Abscess; Adolescent; Agammaglobulinemia; Arthritis, Infectious; Bacteroides Infections; Brain Abscess; Child; Child, Preschool; Chloramphenicol; Female; Humans; Infant; Infant, Newborn; Male; Penicillins; Tetracycline

Topics: Abscess; Anti-Bacterial Agents; Bacteroides; Bacteroides Infections; Brain; Brain Abscess; Cerebral Angiography; Child; Chlortetracycline; Drainage; Hemiplegia; Humans; Hydrocephalus; Oxytetracycline; Radiography; Tetracycline

The available world literature (since Friedman's and Levy's comprehensive report in 1937) regarding actinomycosis of the central nervous system is reviewed. Only cases proved by culture were included in this analysis. A total of 17 cases was collected and an additional patient with this entity is described.The important differences between actinomycosis and nocardiosis are discussed. A definite diagnosis of actinomycosis was possible only when anaerobic cultures of cerebrospinal fluid or material obtained from a brain abscess yielded colonies of typical Actinomyces organisms. The characteristic result of infection of the brain by this fungus was abscess formation, and this occurred in all except one of the cases reviewed. Penicillin appears to be the drug of choice in treatment and, where possible, surgical excision of the cerebral abscess should be undertaken.

Topics: Abscess; Actinomyces; Actinomycosis; Adolescent; Anti-Bacterial Agents; Brain; Brain Abscess; Brain Diseases; Cerebral Angiography; Chloramphenicol; Electroencephalography; Humans; Meninges; Neurosurgery; Penicillin G; Penicillin G Procaine; Penicillins; Procaine; Sulfadiazine; Tetracycline

Topics: Adolescent; Anti-Bacterial Agents; Brain Abscess; Drug Therapy; Geriatrics; Herpes Simplex; Humans; Meningitis; Meningitis, Bacterial; Meningitis, Pneumococcal; Prednisone; Sulfonamides; Tetracycline

Topics: Adolescent; Anti-Bacterial Agents; Brain Abscess; Child; Chloramphenicol; Geriatrics; Meningitis; Meningitis, Meningococcal; Meningitis, Pneumococcal; Penicillins; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Tetracycline