tetracycline and Ataxia-Telangiectasia

Anatomic pathology has produced considerable knowledge about environmental teratogens and carcinogens. A special disease registry established by a pathologist provided details of the association between oral contraceptives and hepatic neoplams. Pathologists were also involved in establishing in the link between diethylstilbestrol use and clear-cell adenocarcinomas of the vagina. An area of particular interest has been gender and ethnic differences in the incidence of certain diseases. Pathologists further make use of animal studies to investigate the pathogenesis of human tumors. Finally, stored serum or tissue is often used by pathologists to help diagnose diseases retrospectively. Human skin fibroblasts grown in culture and stored have been especially valuable for laboratory research. This chapter briefly highlights some of the milestones in the detection of enviromental effects through anatomic pathology.

Topics: Adenocarcinoma; Animals; Ataxia Telangiectasia; Contraceptives, Oral; Diethylstilbestrol; Disease Models, Animal; Environment; Ethnicity; Female; Geography; Herpesvirus 4, Human; Humans; Liver Neoplasms; Lymphoproliferative Disorders; Osteosarcoma; Pathology, Clinical; Radiation, Ionizing; Sex Factors; Tetracycline; Thorium Dioxide; Tooth Discoloration; Vaginal Neoplasms; X Chromosome