tetracycline has been researched along with Asthma* in 37 studies
1 review(s) available for tetracycline and Asthma
1 trial(s) available for tetracycline and Asthma
36 other study(ies) available for tetracycline and Asthma
Article | Year |
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Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness.
Individuals with asthma have increased levels of nitric oxide in their exhaled air. To explore its role, we have developed a regulatable transgenic mouse capable of overexpressing inducible nitric oxide synthase in a lung-specific fashion. The CC10-rtTA-NOS-2 mouse contains two transgenes, a reverse tetracycline transactivator under the control of the Clara cell protein promoter and the mouse nitric oxide synthase-2 (NOS-2) coding region under control of a tetracycline operator. Addition of doxycycline to the drinking water of CC10-rtTA-NOS-2 mice causes an increase in nitric oxide synthase-2 that is largely confined to the airway epithelium. The fraction of expired nitric oxide increases over the first 24 h from approximately 10 parts per billion to a plateau of approximately 20 parts per billion. There were no obvious differences between CC10-rtTA-NOS-2 mice, with or without doxycycline, and wild-type mice in lung histology, bronchoalveolar protein, total cell count, or count differentials. However, airway resistance was lower in CC10-rtTA-NOS-2 mice with doxycycline than in CC10-rtTA-NOS-2 mice without doxycycline or wild-type mice with doxycycline. Moreover, doxycycline-treated CC10-rtTA-NOS-2 mice were hyporesponsive to methacholine compared with other groups. These data suggest that increased nitric oxide in the airways has no proinflammatory effects per se and may have beneficial effects on pulmonary function. Topics: Airway Resistance; Animals; Asthma; Blotting, Northern; Blotting, Western; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; DNA, Complementary; Doxycycline; Immunohistochemistry; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Respiratory Mechanics; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; Tetracycline; Trans-Activators; Transgenes; Uteroglobin | 2004 |
Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.
Noninflammatory structural alterations, variously referred to as airway remodeling, are well documented in the asthmatic airway. However, the pathogenesis of these alterations, the importance of airway remodeling in generating the asthma phenotype, and the natural history of airway remodeling responses have not been adequately defined. Because exaggerated cytokine production is a characteristic feature of the asthmatic airway, we used constitutive and inducible overexpression transgenic systems to investigate the contributions that interleukin 11 (IL-11) and IL-13 might make to airway remodeling responses. These studies demonstrated that both cytokines produce responses in the murine airway with features similar to those in human asthmatic tissues. IL-11 caused airway fibrosis with the enhanced accumulation of interstitial collagens, myocytes, and myofibroblasts. IL-13 caused mucous metaplasia, enhanced mucin gene expression, enhanced tissue hyaluronic acid accumulation, and subepithelial fibrosis. Importantly, IL-11 was detected most readily in tissues from asthmatic subjects with severe airway remodeling that was similar to that seen in the IL-11 transgenic mice. In addition, IL-11 was shown to inhibit asthma-like inflammation while stimulating airway fibrosis. This suggests that IL-11 elaboration is, in part, an attempt at airway healing. Last, a novel triple transgenic system is described that allows transgene expression to be regulated in a true "on/off" manner. This system may be useful in defining the reversibility of transgene-induced airway remodeling responses. Topics: Animals; Anti-Bacterial Agents; Asthma; Chronic Disease; Disease Models, Animal; Gene Expression; Humans; Inflammation; Interleukin-11; Interleukin-13; Lung; Mice; Mice, Transgenic; Phenotype; RNA, Messenger; Tetracycline; Transcription, Genetic | 2001 |
Mupirocin-resistant Staphylococcus aureus in a specialist school population.
Staphylococcus aureus strains resistant to mupirocin (MIC > 4000 mg l-1) were recovered from children and staff at a school for children with eczema and/or asthma or cystic fibrosis after mupirocin had been used to treat eczematous lesions. At least three distinct strains of S. aureus were involved and resistance was shown to be due in most isolates to a transmissible plasmid. The need for monitoring the extended use of this valuable antibiotic is emphasized. Topics: Adolescent; Asthma; Bacteriophage Typing; Carrier State; Child; Cystic Fibrosis; Drug Resistance, Microbial; Eczema; Female; Humans; Male; Mupirocin; Plasmids; Schools; Staphylococcal Infections; Staphylococcus aureus; Tetracycline | 1994 |
The treatment of the asthmatic mother during pregnancy and lactation.
In summary, the management of asthma in the pregnant patient does not differ much from the management of asthma in a patient who is not pregnant. An awareness of how asthma medications affect the fetus is important since it is rare to reach the ideal management where no medication at all is given. The benefit to risk ratio must be considered for both mother and her fetus should be medication be required. Since hypoxemia is the greatest single danger to both the mother and fetus important medications should not be withheld and the physician should not wait too long. The mother should be counseled about avoiding medications that include tetracycline, iodine products, aspirin or non-steroidal anti-inflammatory agents, tartrazine, sedatives, and beta-adrenergic blocking agents. It is just as important to remember that alcohol and cigarettes are potent drugs or interact with other medications. Inapropriate exercise, irritants or allergens might also require counseling so that the pregnant mother can avoid them. A good common sense and caring approach of a physician to a well informed patient represents the most appropriate management of asthma in the pregnant patient and nursing mother. Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Caffeine; Cromolyn Sodium; Ethanol; Female; Fetus; Humans; Hypnotics and Sedatives; Lactation; Maternal-Fetal Exchange; Milk, Human; Pregnancy; Pregnancy Complications; Smoking; Tetracycline; Tranquilizing Agents | 1983 |
Tetracycline asthma--a case report.
A mechanic working in the antibiotic capsuling section of a pharmaceutical company developed asthmatic attacks 1 year after starting work. His occupation involved exposure to a variety of chemical agents including tetracycline. He developed immediate weal and flare reaction to the intradermal test and an immediate (type 1) asthmatic response to intradermal, inhalation and oral challenge tests with tetracycline. On leaving the tetracycline plant he became symptom free. Topics: Adult; Asthma; Drug Hypersensitivity; Drug Industry; Dust; Environmental Exposure; Humans; Intradermal Tests; Lung Volume Measurements; Male; Occupational Diseases; Tetracycline | 1977 |
Letter: Minocycline: possible vestibular side-effects.
Topics: Asthma; Bronchitis; Drug Tolerance; Female; Humans; Minocycline; Tetracycline; Vertigo; Vestibule, Labyrinth | 1974 |
[Long-term treatment of bronchial asthma (author's transl)].
Topics: Adult; Airway Obstruction; Asthma; Cromolyn Sodium; Female; Glucocorticoids; Humans; Long-Term Care; Male; Parasympatholytics; Tetracycline | 1974 |
[Long-term or intermittent treatment of chronic bronchitis?].
Topics: Aerosols; Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Glucocorticoids; Humans; Hypersensitivity; Long-Term Care; Tetracycline | 1974 |
[Experimental studies on minocycline intravenous infusion (author's transl)].
Topics: Adult; Asthma; Bronchitis; Chronic Disease; Dose-Response Relationship, Drug; Haemophilus influenzae; Humans; Infusions, Parenteral; Kidney; Liver; Male; Microbial Sensitivity Tests; Middle Aged; Minocycline; Sputum; Staphylococcus; Tetracycline; Tetracyclines | 1974 |
Trimethoprim--sulphamethoxazole in intestinal and lung infections.
Topics: Anti-Infective Agents; Asthma; Bronchiectasis; Bronchitis; Bronchopneumonia; Chloramphenicol; Drug Combinations; Enteritis; Folic Acid Antagonists; Humans; Intestinal Diseases; Lung Diseases; Microbial Sensitivity Tests; Pneumonia; Pyrimidines; Respiratory Tract Infections; Sulfamethoxazole; Tetracycline; Trimethoprim | 1973 |
Rectus sheath hematoma.
Topics: Abdominal Muscles; Adult; Aged; Asthma; Dyspnea; Female; Hematoma; Humans; Male; Pulmonary Emphysema; Radiography; Respiratory Tract Infections; Tetracycline; Thrombophlebitis | 1972 |
[Experience with minocycline in the treatment of respiratory infections].
Topics: Administration, Oral; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Asthma; Bronchiectasis; Bronchitis; Female; Humans; Lung Abscess; Male; Middle Aged; Pneumonia, Staphylococcal; Respiratory Tract Infections; Tetracycline; Tuberculosis, Pulmonary | 1972 |
[Treatment of acute bronchopulmonary infections with intra-muscular tetracycline laurylsulfate. Apropos of 25 cases].
Topics: Acute Disease; Aged; Asthma; Bronchiectasis; Bronchitis; Bronchopneumonia; Chronic Disease; Humans; Injections, Intramuscular; Male; Middle Aged; Pulmonary Emphysema; Respiratory Tract Infections; Tetracycline | 1972 |
Assessment and management of severe asthma.
Topics: Adolescent; Adult; Aged; Airway Obstruction; Aminophylline; Asthma; Carbon Dioxide; Child; Cyanosis; Electrocardiography; Female; Humans; Hydrocortisone; Male; Metaproterenol; Middle Aged; Oxygen; Partial Pressure; Prednisone; Pulmonary Ventilation; Pulse; Radiography, Thoracic; Respiratory Dead Space; Spirometry; Sputum; Tetracycline; Vital Capacity | 1971 |
[Pathogens in lower respiratory tract diseases in children with special reference to the relationship between bacteria and viruses].
Topics: Acute Disease; Asthma; Bacteria; Bronchitis; Child; Child, Preschool; Chronic Disease; Complement Fixation Tests; Female; Hemagglutination Inhibition Tests; Humans; Infant; Infant, Newborn; Male; Penicillins; Tetracycline; Viruses | 1971 |
Sinusitis in children. Lessons from twenty-five patients.
Topics: Age Factors; Ampicillin; Asthma; Child; Female; Humans; Hypersensitivity; Male; Penicillins; Pneumonia; Radiography; Respiratory Hypersensitivity; Sex Factors; Sinusitis; Tetracycline | 1970 |
Infectious asthma.
Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Asthma; Female; Humans; Hypersensitivity; Infections; Tetracycline | 1970 |
Mediastinal and subcutaneous emphysema complicating acute bronchial asthma.
Topics: Asthma; Child; Emphysema; Epinephrine; Head; Humans; Male; Mediastinal Emphysema; Neck; Oxygen Inhalation Therapy; Tetracycline | 1970 |
[Clinical experiences with a new synthetic tetracycline in the treatment of pulmonary infection].
Topics: Adolescent; Adult; Aged; Asthma; Bronchitis; Child; Child, Preschool; Chronic Disease; Female; Humans; Male; Middle Aged; Pneumonia; Tablets; Tetracycline | 1969 |
The bacterial flora of the upper respiratory tract in children with severe asthma.
Topics: Adolescent; Ampicillin; Asthma; Bacteria; Child; Child, Preschool; Chloramphenicol; Erythromycin; Female; Haemophilus; Haemophilus influenzae; Humans; Male; Nose; Novobiocin; Penicillin Resistance; Pharynx; Staphylococcus; Streptococcus; Streptomycin; Sulfonamides; Tetracycline | 1968 |
[Clinical contribution to the use of oral antibiotic and enzyme therapy].
Topics: Abscess; Adult; Aged; Asthma; Chymotrypsin; Dermatitis; Female; Humans; Male; Middle Aged; Otitis; Respiratory Tract Infections; Tetracycline; Thrombophlebitis; Trypsin | 1968 |
Clinical significance of PaCO2 during status asthma: the cross-over point.
Topics: Acidosis, Respiratory; Adrenal Cortex Hormones; Adult; Asthma; Carbon Dioxide; Eosinophilia; Female; Humans; Hydrogen-Ion Concentration; Hyperventilation; Hypnotics and Sedatives; Hypoventilation; Male; Middle Aged; Respiratory Insufficiency; Skin Tests; Spirometry; Tetracycline | 1968 |
[Clinical trial of an association of benzydamine and tetracycline].
Topics: Asthma; Bronchitis; Child; Child, Preschool; Female; Humans; Infant; Male; Pharyngitis; Pyrazoles; Respiratory Tract Infections; Tetracycline; Tonsillitis | 1968 |
An evaluation of methacycline hydrochloride (6 methylene oxytetracycline).
Topics: Asthma; Blood Protein Disorders; Bronchiectasis; Bronchitis; Child; Child, Preschool; Dermatitis, Seborrheic; Eczema; Female; gamma-Globulins; Humans; Infant; Infant, Newborn; Malabsorption Syndromes; Male; Methacycline; Otitis Media; Pneumonia; Pyelonephritis; Respiratory Tract Infections; Tetracycline; Tonsillectomy | 1967 |
Gas gangrene following an adrenaline-in-oil injection into the left thigh with survival.
Topics: Adult; Asthma; Blood Transfusion; Clostridium perfringens; Epinephrine; Gas Gangrene; Humans; Hydrocortisone; Immunization, Passive; Infusions, Parenteral; Injections, Intramuscular; Male; Metaraminol; Oils; Tetracycline; Thigh | 1967 |
DRUGS IN THE TREATMENT OF ASTHMA.
Topics: Adrenocorticotropic Hormone; Aerosols; Aminophylline; Anti-Bacterial Agents; Asthma; Child; Ephedrine; Epinephrine; Hydrocortisone; Isoproterenol; Methylprednisolone; Paraldehyde; Phenobarbital; Prednisolone; Prednisone; Tetracycline; Theophylline; Toxicology; Triamcinolone | 1964 |
MANAGEMENT OF ALLERGY IN PREGNANCY.
Topics: Adrenocorticotropic Hormone; Asthma; Conjunctivitis; Dermatitis; Dermatitis, Atopic; Drug Hypersensitivity; Drug Therapy; Female; Headache; Humans; Hypersensitivity; Influenza Vaccines; Nasal Polyps; Pregnancy; Pregnancy Complications; Rhinitis, Allergic, Seasonal; Smallpox Vaccine; Tetracycline; Toxicology; Urticaria; Vertigo | 1964 |
RAPID THERAPY WITH BETAMETHASONE IN SEVERE INTERMITTENT ASTHMA.
Topics: Anti-Bacterial Agents; Asthma; Betamethasone; Child; Drug Therapy; Humans; Infant; Protein Synthesis Inhibitors; Tetracycline; Toxicology | 1964 |
[A NEW TETRACYCLINE IN THE TREATMENT OF BRONCHIAL INFECTION IN ASTHMA AND CHRONIC BRONCHOPNEUMOPATHY].
Topics: Anti-Bacterial Agents; Asthma; Bronchial Diseases; Bronchitis; Bronchopneumonia; Drug Therapy; Haemophilus influenzae; Humans; Tetracycline | 1964 |
AUTOGENOUS BACTERIAL ANTIGEN COMPLEXES USED SUCCESSFULLY IN CHRONIC LUNG DISEASE UNRESPONSIVE TO ANTIBIOTICS AND OTHER THERAPY. A CASE REPORT.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antigens; Antigens, Bacterial; Asthma; Bronchitis; Chloramphenicol; Chronic Disease; Chymotrypsin; Demeclocycline; Drug Resistance, Microbial; Enterobacter aerogenes; Erythromycin; Humans; Isoproterenol; Penicillin Resistance; Penicillins; Sputum; Staphylococcus; Streptomycin; Sulfisoxazole; Tetracycline | 1963 |
[CLINICAL EXPERIENCES WITH A NEW ANTIBIOTIC ASSOCIATION].
Topics: Abscess; Anti-Bacterial Agents; Asthma; Bronchitis; Bronchopneumonia; Chloramphenicol; Cholecystitis; Colitis; Communicable Diseases; Erythromycin; Humans; Tetracycline | 1963 |
[USE IN RESPIRATORY INFECTIOUS PATHOLOGY OF A COMBINATION OF DIHYDRONOVOBIOCIN AND ACTIVATED TETRACYCLINE].
Topics: Asthma; Bronchiectasis; Bronchitis; Humans; Novobiocin; Pneumonia; Respiratory Tract Infections; Tetracycline | 1963 |
[CURRENT THERAPEUTIC METHODS IN THE THOROUGH TREATMENT OF ASTHMA].
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Allergic Agents; Asthma; Bloodletting; Child; Climate; Cortisone; Desensitization, Immunologic; gamma-Globulins; Histamine H1 Antagonists; Humans; Hyperthermia, Induced; Immunotherapy, Active; Mineral Waters; Penicillins; Progesterone; Psychotherapy; Radiotherapy; Respiratory Therapy; Surgical Procedures, Operative; Testosterone; Tetracycline; Theobromine; Theophylline | 1963 |
TWO CASES OF MEDIASTINAL EMPHYSEMA.
Topics: Anti-Bacterial Agents; Asthma; Epinephrine; Humans; Mediastinal Emphysema; Pathology; Tetracycline | 1963 |
A controlled trial of tetracyc-line (Achromycin) therapy in asthmatic children during the winter period.
Topics: Anti-Bacterial Agents; Asthma; Child; Humans; Infant; Protein Synthesis Inhibitors; Seasons; Tetracycline | 1960 |
Prophylaxis of recurring infection in children with asthma by the use of tetracycline.
Topics: Anti-Bacterial Agents; Asthma; Child; Communicable Diseases; Humans; Infant; Protein Synthesis Inhibitors; Respiratory System; Respiratory Tract Infections; Tetracycline | 1958 |