tetracycline and Arthritis--Reactive

In the pathogenesis of reactive arthritis, infection through the mucosal route and genetic susceptibility (HLA-B27) are the most important contributing factors. With regard to non-specific urethritis, most probably caused by Chlamydia trachomatis infection, the use of early antimicrobial therapy has been shown to be effective in preventing arthritic recurrences. When the arthritis has been initiated, short-term conventional antimicrobial therapy seems unable to modify the course of the ongoing disease. In patients with acute reactive arthritis, a prolonged (3-month) treatment with tetracycline shortens the duration of arthritis when triggered by Chlamydia trachomatis, while such treatment has not proved effective in enteroarthritis. In patients with chronic reactive enteroarthritis, a prolonged course of quinolones, such as ciprofloxacin, might be of benefit. Sulfasalazine, which has an effect in the acute exacerbations of ankylosing spondylitis, is probably also effective in chronic reactive arthritis. An antimicrobial effect can be one of the mechanisms by which sulfasalazine exerts its therapeutic effect. Follow-up studies are necessary to assess the influence of antibiotic therapy on the late prognosis of patients with reactive arthritis.

Topics: Anti-Bacterial Agents; Arthritis, Reactive; Chlamydia Infections; Ciprofloxacin; Humans; Sulfasalazine; Tetracycline

Topics: Administration, Oral; Arthritis, Reactive; Candida; Chlamydia; Coitus; Culture Media; Epididymitis; Female; Gonorrhea; Humans; Male; Mycoplasma; Neisseria gonorrhoeae; Prostatitis; Recurrence; Tetracycline; Urethral Stricture; Urethritis; Urine

Postvenereal reactive arthritis is an inflammatory form of arthritis that commonly develops after urogenital infection, predominantly in human leucocyte antigen-B27-positive men in the third decade of life. In our hospital, patients underwent synovectomy before a 4-month course of antibiotics (ciprofloxacin, tetracycline and roxithromicin). The clinical remission was achieved in approximately 70% patients. At molecular level, the remission was associated with the negative polymerase chain reaction findings of bacteria.

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Arthritis, Reactive; Chlamydia Infections; Chlamydia trachomatis; Ciprofloxacin; DNA, Bacterial; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Polymerase Chain Reaction; Roxithromycin; Synovial Membrane; Tetracycline; Treatment Outcome

Reactive arthritis is a well-defined clinical syndrome occurring after various infections, although most cases are usually associated with Chlamydiae and gastrointestinal pathogens. Its immunologic background has been extensively studied, as has its relationship with HLA-B27. We describe two cases of reactive arthritis arising after infections with two pathogens not so far related to the occurrence of reactive arthritis: one patient exhibited migratory oligoarthritis shortly after the course of acute Q fever, and another patient developed monoarthritis during recovery from leptospirosis. Arthritis was transient and did not exhibit a chronic course in either patient. We further discuss the context of pathophysiology of the arthritis in these patients, with an emphasis on the immunomodulatory properties of these two pathogens.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Reactive; Coxiella burnetii; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Leptospira; Leptospirosis; Middle Aged; Pain Measurement; Q Fever; Range of Motion, Articular; Risk Assessment; Severity of Illness Index; Tetracycline; Treatment Outcome

The basic mechanisms underlying reactive arthritis and specifically the joint injury that follows intra-articular Chlamydia trachomatis infection have not been defined. The present study addresses this question through the development of an experimental model. Stable cell lines were generated from synoviocytes harvested from the knee joints of Lewis rats. The synoviocytes were cocultivated with C. trachomatis to allow invasion by the microbe and were then transferred by intra-articular injection into the knee joints of Lewis rats. The ensuing arthritis could be subdivided into an early phase (

Topics: Animals; Arthritis, Reactive; Bacterial Outer Membrane Proteins; Blotting, Western; Chlamydia Infections; Chlamydia trachomatis; Chronic Disease; Ciprofloxacin; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Injections, Intra-Articular; Injections, Intramuscular; Injections, Subcutaneous; Lipopolysaccharides; Male; Microscopy, Fluorescence; Rats; Rats, Inbred Lew; Spleen; Synovial Membrane; Tetracycline; Time Factors

To assess the effects of antibiotic treatment of urethritis or cervicitis on the incidence of recurrences of articular symptoms in Reiter's syndrome patients.. Retrospective evaluation of the medical charts of 109 patients living in Greenland.. Thirty-seven percent of the episodes of genitourinary tract inflammation that were not treated or were treated with penicillin were followed by arthritis, compared with 10% of those treated with tetracycline or erythromycin.. Antibiotics active against Chlamydia trachomatis reduced the risk of postvenereal arthritis in the population studied.

Topics: Adult; Arthritis; Arthritis, Reactive; Erythromycin; Female; Greenland; Humans; Incidence; Inuit; Male; Penicillins; Recurrence; Retrospective Studies; Sexually Transmitted Diseases; Tetracycline; Urethritis; Uterine Cervicitis

We report a 30-year-old patient who suffered from an acute exacerbation of chronic parotitis followed by manifestation of Reiter's syndrome one month later. Clinical course of both symptoms were in favour of a connection between them.

Topics: Adult; Arthritis, Reactive; Humans; Male; Parotitis; Recurrence; Tetracycline

The Authors report the case of a young man with urethritis, conjunctivitis and oligoarticular arthritis. These symptoms are characteristic of Reiter's syndrome. Our patient also presented an inversion of CD4/CD8 ratio but the number and the activity of natural killer cells were normal and the research for HIV was negative. On the contrary the research for Chlamydiae by fluorescein-binding antibodies in urethral fluid was positive while the human leukocyte antigen HLA B27 was absent. The patient has been successfully treated by tetracycline and steroids. The Authors discuss the diagnostic, etiopathogenetic and therapeutical problems of this case, matching their findings to the up-to-date knowledge of Reiter's syndrome.

Topics: Adult; Arthritis, Reactive; Betamethasone; Diagnosis, Differential; HLA Antigens; Humans; Lymphocytes; Male; Tetracycline

Chlamydiae are obligate intracellular parasites, bacteria with a peculiar biology. They belong to the genus Chlamydia which includes two species: C. psittaci and C. trachomatis. A wide range of hosts, including birds, mammals and man can be infected by chlamydiae. The diseases chlamydiae can produce include psittacosis, lymphogranuloma venereum, trachoma, inclusion conjunctivitis, urethritis, cervicitis, pelvic inflammatory disease, and neonatal pneumonia. The diagnosis of chlamydial infection may be made by visualization of the organism in direct smears, isolation of the agent in cell culture, or by demonstrating a significant rise in antibody titer. Chlamydial infection may be treated with tetracycline, erythromycin, or sulfonamides.

Topics: Adult; Arthritis, Reactive; Child; Chlamydia Infections; Conjunctivitis, Inclusion; Epididymitis; Erythromycin; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lymphogranuloma Venereum; Male; Pelvic Inflammatory Disease; Pneumonia; Sexually Transmitted Diseases; Tetracycline; Trachoma; Urethritis; Uterine Cervicitis

Topics: Anti-Bacterial Agents; Arthritis, Reactive; Chlamydia Infections; Drug Resistance, Microbial; Erythromycin; Humans; Tetracycline; Ureaplasma

Topics: Arthritis, Reactive; Humans; Male; Prostatitis; Tetracycline

Topics: Adolescent; Adult; Arthritis, Reactive; Female; Humans; Male; Middle Aged; Tetracycline

Three cases of Reiter's disease occurring in boys under the age of 16 are reported. One of these presented with a Salmonella enteritidis diarrhoea. This conforms to the 'dysenteric' form of Reiter's disease usually seen in Europe and rarely reported in England. Another presented with a monarticular arthritis of the knee, and the third has developed a chronic relapsing erosive arthritis as a result of sexually acquired Reiter's disease--an occurrence not previously reported in this age group. We draw attention to the frequency of diarrhoea in these children and the sex incidence of 1 female to 4--5 males, which agrees more with Reiter's disease of dysenteric origin than that acquired venereally.

Topics: Adolescent; Arthritis; Arthritis, Reactive; Diarrhea; Humans; Indomethacin; Male; Phenylbutazone; Salmonella enteritidis; Tetracycline

Topics: Adult; Animals; Arthritis, Reactive; Complement Fixation Tests; Culture Techniques; Cytopathogenic Effect, Viral; Female; Haplorhini; Humans; Immunodiffusion; Kidney; Male; Mice; Phenylbutazone; Simian virus 40; Synovial Fluid; Tetracycline; Viruses

Topics: Arthritis; Arthritis, Reactive; Female; Haemophilus Infections; Humans; Hypersensitivity; Inclusion Bodies; Male; Mycoplasma Infections; Mycoses; Oxytetracycline; Tetracycline; Trichomonas vaginalis; Urethritis; Uveitis

Topics: Adult; Arthritis, Reactive; Aspirin; Humans; Male; Methotrexate; Phenylbutazone; Remission, Spontaneous; Tetracycline

Topics: Adrenal Cortex Hormones; Adult; Arthritis, Reactive; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Male; Methotrexate; Middle Aged; Phenylbutazone; Tetracycline

Topics: Adolescent; Adult; Ampicillin; Anemia; Arthritis, Infectious; Arthritis, Reactive; Endocarditis, Bacterial; Female; Gonorrhea; Hepatitis; Humans; Male; Meningitis; Menstruation; Myocarditis; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin V; Pericarditis; Pregnancy; Pregnancy Complications, Infectious; Pyuria; Sepsis; Skin Diseases; Tetracycline

Topics: Acute Disease; Adult; Arthritis, Reactive; Gonorrhea; Humans; Injections, Intramuscular; Male; Rolitetracycline; Tetracycline

Topics: Arthritis, Reactive; Female; Humans; Hydrocortisone; Indomethacin; Male; Phenylbutazone; Tetracycline

Topics: Adult; Arthritis, Reactive; Culture Media; Erythromycin; Female; Humans; Male; Mycoplasma; Mycoplasma Infections; Prostatitis; Tetracycline; Urethritis; Urinary Tract Infections

Topics: Arthritis, Reactive; Chlamydia; Chlamydia Infections; Conjunctivitis, Inclusion; Female; Humans; Male; Sulfonamides; Tetracycline; Trachoma; United Kingdom; Urethritis; Uterine Cervicitis

Topics: Adolescent; Adult; Arthritis; Arthritis, Infectious; Arthritis, Reactive; Female; Gonorrhea; Humans; Male; Middle Aged; Neisseria gonorrhoeae; Penicillins; Pregnancy; Synovial Fluid; Tenosynovitis; Tetracycline

Topics: Analgesics; Anti-Bacterial Agents; Arthritis, Reactive; Aspirin; Dextropropoxyphene; Female; Hematuria; Humans; Knee; Protein Synthesis Inhibitors; Sulfisoxazole; Tetracycline; Urography; Women

Topics: Anti-Bacterial Agents; Arthritis, Reactive; Child; Drug Therapy; Humans; Leukocytosis; Mouth Diseases; Mycoplasma; Oral Manifestations; Pathology; Penicillins; Tetracycline