tetracycline and Appendicitis

Eighty-four cases of non-perforated appendicitis in children were randomly allocated to receive either oxytetracycline lavage alone or oxytetracycline lavage plus peroperative intravenous metronidazole and cefuroxime. The wound infection rate with the oxytetracycline lavage alone was 4.4% compared with 7.7% when metronidazole and cefuroxime were added. These rates were not significantly different. This study supports the use of oxytetracycline lavage alone as effective prophylaxis against wound infection in non-perforated appendicitis of childhood.

Topics: Adolescent; Anti-Bacterial Agents; Appendicitis; Cefuroxime; Child; Child, Preschool; Female; Humans; Male; Metronidazole; Surgical Wound Infection; Tetracycline; Therapeutic Irrigation

Since 1967, 2480 appendectomies have been performed at the St. Lucas Hospital (Amsterdam) and the St. Annadal Hospital (Maastricht), of which 250 were for perforated appendicitis. A so-called 'combined method' of treatment was used in all these cases: during the operation saline was used to lavage the peritoneal cavity with the patients in the reverse-Trendelenburg position. Antibiotics were left in the peritoneal cavity. No intraperitoneal drainage was performed, but the wound was drained for 5 days. Postoperative treatment consisted of nasogastric suction and parenteral antibiotics for 5 days in combination with anticoagulation. With thus combined approach one death was seen in 250 cases. There were 20 cases of wound infection (8%), 7 pelvic abscesses (2.8%), and 2 retroperitoneal abscesses. No thromboembolic complications were seen because of the use of routine anticoagulation. For 191 patients (77%), total hospitalization was less than 14 days. This method of treatment is compared with recent reports in literature.

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendicitis; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Penicillins; Peritoneal Cavity; Postoperative Period; Tetracycline; Therapeutic Irrigation

Topics: Acute Disease; Amoxicillin; Appendicitis; Escherichia coli; Female; Humans; Male; Sudan; Tetracycline

Topics: Adult; Appendectomy; Appendicitis; Child; Humans; Intestinal Perforation; Sepsis; Surgical Wound Infection; Tetracycline; Therapeutic Irrigation

Peritoneal lavage resulted in a significant reduction in the duration of hospital stay in a retrospective series of 189 children with peritonitis secondary to perforation of the appendix. Antibiotic peritoneal lavage also resulted in a significant reduction in the number of children with septic and adhesive complications compared with antiseptic lavage and no lavage, mainly as a result of fewer wound infections. The overall incidence of residual intraperitoneal infection was low, and although differences in this respect were not significant, none of the children treated with antibiotic peritoneal lavage required reoperation for intraperitoneal sepsis.

Topics: Appendicitis; Child; Humans; Length of Stay; Noxythiolin; Peritonitis; Tetracycline; Therapeutic Irrigation; Thiourea

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Appendectomy; Appendicitis; Humans; Surgical Wound Infection; Tetracycline

Topics: Acute Disease; Appendectomy; Appendicitis; Humans; Postoperative Care; Surgical Wound Infection; Tetracycline

Topics: Ampicillin; Appendicitis; Drug Evaluation; Humans; Penicillin Resistance; Povidone; Surgical Wound Infection; Tetracycline

Topics: Administration, Topical; Ampicillin; Anti-Inflammatory Agents; Appendicitis; Humans; Penicillin Resistance; Povidone; Povidone-Iodine; Surgical Wound Infection; Tetracycline

Topics: Acute Disease; Ampicillin; Appendectomy; Appendicitis; Cross Infection; Humans; Povidone; Povidone-Iodine; Surgical Wound Infection; Tetracycline

Topics: Abscess; Adolescent; Adult; Aged; Ampicillin; Appendectomy; Appendicitis; Child; Child, Preschool; Drainage; Humans; Surgical Wound Infection; Tetracycline

Topics: Adolescent; Adult; Appendicitis; Arthritis; Child; Child, Preschool; Chloramphenicol; Diagnosis, Differential; Drug Resistance, Microbial; Erythema Nodosum; Female; Humans; Intestinal Diseases; Male; Pasteurella; Pasteurella Infections; Sepsis; Serologic Tests; Tetracycline

Topics: Adult; Ampicillin; Anti-Bacterial Agents; Antifungal Agents; Appendicitis; Escherichia coli Infections; Humans; Kanamycin; Male; Methicillin; Nystatin; Peritonitis; Polymyxins; Staphylococcal Infections; Sulfadimethoxine; Tetracycline

Topics: Adolescent; Adult; Ampicillin; Appendicitis; Appendix; Autopsy; Child; Chloramphenicol; Diarrhea, Infantile; Dysentery; Feces; Female; Humans; Ileum; Infant; Infant, Newborn; Japan; Kanamycin; Male; Microbial Sensitivity Tests; Middle Aged; Pasteurella; Pasteurella Infections; Serotyping; Streptomycin; Tetracycline

Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Drainage; Humans; Surgical Wound Infection; Tetracycline; Wound Healing

Topics: Acute Disease; Appendectomy; Appendicitis; Appendix; Bacitracin; Humans; Methods; Neomycin; Penicillins; Polymyxins; Streptomycin; Surgical Wound Infection; Tetracycline

Topics: Acute Disease; Adolescent; Ampicillin; Appendicitis; Ascitic Fluid; Child; Child, Preschool; Depression, Chemical; Drug Synergism; Escherichia coli; Female; Humans; Kanamycin; Methicillin; Oleandomycin; Oxacillin; Penicillin Resistance; Penicillins; Peritonitis; Staphylococcus; Tetracycline

Topics: Abdomen; Anti-Bacterial Agents; Appendicitis; Chloramphenicol; Chronic Disease; Erythromycin; Erythromycin Ethylsuccinate; Escherichia coli; Exudates and Transudates; Herniorrhaphy; Humans; Neomycin; Penicillin Resistance; Penicillins; Pneumonia; Postoperative Complications; Staphylococcal Infections; Staphylococcus; Streptomycin; Surgical Wound Infection; Tetracycline

Topics: Adolescent; Adult; Age Factors; Aged; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ascitic Fluid; Australia; Child; Drainage; Humans; Middle Aged; Seasons; Surgical Wound Infection; Tetracycline

Topics: Adolescent; Adult; Aged; Appendicitis; Brucellosis; Child; Child, Preschool; Chloramphenicol; Cholangitis; Escherichia coli Infections; Female; Gastroenteritis; Humans; Infant; Male; Meningitis; Middle Aged; Respiratory Tract Infections; Tetracycline; Typhoid Fever

Topics: Acute Disease; Adult; Appendectomy; Appendicitis; Gangrene; Hernia; Herniorrhaphy; Humans; Male; Pelvis; Tetracycline

Topics: Adolescent; Aged; Appendicitis; Chloramphenicol; Drug Synergism; Female; Humans; Infections; Male; Middle Aged; Peritonitis; Respiratory Tract Infections; Skin Diseases; Tetracycline

Topics: Appendectomy; Appendicitis; Child; Diagnosis, Differential; Hemagglutination Tests; Humans; Lymph Node Excision; Male; Mesenteric Lymphadenitis; Tetracycline

Topics: Abscess; Adolescent; Anti-Bacterial Agents; Appendicitis; Diagnosis, Differential; Drug Therapy; Humans; Lymphography; Protein Synthesis Inhibitors; Radiography; Sigmoidoscopy; Tetracycline

Topics: Anti-Bacterial Agents; Appendicitis; Bacteroides; Chloramphenicol; Erythromycin; Humans; Infections; Leucomycins; Oleandomycin; Oxytetracycline; Tetracycline

Topics: Abscess; Animals; Anti-Bacterial Agents; Appendectomy; Appendicitis; Child; Humans; Lymph Nodes; Lymphadenitis; Mice; Pasteurella Infections; Penicillins; Skin Tests; Streptomycin; Surgical Procedures, Operative; Tetracycline; Zoonoses

Topics: Abscess; Anti-Bacterial Agents; Antibiotics, Antitubercular; Appendectomy; Appendicitis; Chloramphenicol; Gangrene; Humans; Intestinal Perforation; Penicillins; Peritonitis; Postoperative Complications; Streptomycin; Suppuration; Surgical Wound Infection; Tetracycline

Topics: Actinomycosis; Adolescent; Anti-Bacterial Agents; Appendicitis; Duodenal Ulcer; Gastrectomy; Humans; Intraabdominal Infections; Penicillins; Peptic Ulcer Perforation; Tetracycline

Topics: Abscess; Adolescent; Anti-Bacterial Agents; Antibiotics, Antitubercular; Appendectomy; Appendicitis; Child; Dermatologic Agents; Drainage; Geriatrics; Humans; Infant; Postoperative Care; Tetracycline; Wound Infection

Topics: Abscess; Anti-Bacterial Agents; Appendicitis; Bursitis; Carbuncle; Cellulitis; Empyema; Geriatrics; Humans; Infant; Lymphadenitis; Lymphangitis; Oleandomycin; Osteomyelitis; Paronychia; Parotitis; Peritonitis; Suppuration; Surgical Wound Infection; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Appendicitis; Humans; Streptomycin; Tetracycline; Tetracyclines