tetracycline and Anemia--Hypochromic

Topics: Anemia, Hypochromic; Animals; Anti-Bacterial Agents; Biological Transport; Chloramphenicol; Cholestyramine Resin; Cycloheximide; Hematocrit; Hemoglobins; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Iron; Iron Isotopes; Liver; Penicillins; Rats; Spleen; Sulfates; Tetracycline

Topics: Anemia, Hypochromic; Back Pain; Brain Diseases; Cerebral Ventriculography; Cerebrovascular Disorders; Child; Craniocerebral Trauma; Craniotomy; Endocrine System Diseases; Female; Genital Diseases, Female; Humans; Intracranial Pressure; Nalidixic Acid; Postoperative Complications; Pseudotumor Cerebri; Seizures; Spinal Puncture; Tetracycline; Vitamin A; Wiskott-Aldrich Syndrome

Topics: Anemia, Hypochromic; Anemia, Pernicious; Anti-Infective Agents; Cystic Fibrosis; Diabetes Complications; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid Deficiency; Glucosephosphate Dehydrogenase Deficiency; Hemoglobinopathies; Humans; Hypersensitivity; Isoniazid; Male; Nervous System Diseases; Penicillins; Pharmacogenetics; Pregnancy; Tetracycline

In comparison with normal rats, those with iron deficiency anaemia showed no significant difference in susceptibility to experimental infection with Candida albicans although anaemic rats had a significantly greater incidence of persistent infection. These findings support the suggestion that patients with chronic candidosis should be investigated for iron deficiency.

Topics: Anemia, Hypochromic; Animals; Candidiasis, Oral; Disease Susceptibility; Male; Rats; Rats, Inbred Strains; Tetracycline; Time Factors

The role of iron deficiency in the development of oral candidosis was investigated using the mouse mutant sex-linked anaemia (sla). Susceptibility was assessed in terms of the recovery of organisms, particularly from oral swabs, and histological evidence of infection approximately 10 days after the last exposure to Candida albicans. The influence of three factors was studied in mixed groups of normal and anaemic mice: mode of inoculation, treatment with tetracycline and treatment with hydrocortisone. The most susceptible group had received drinking water containing tetracycline (1 mg/ml), hydrocortisone (0.1 mg/ml) and candida (5 X 10(4) c.f.u./ml for 6 days). Anaemic mice showed a rather higher rate of recovery of organisms and more frequent histological evidence of infection than normal mice in certain groups. Neither of these tendencies was statistically significant alone but, taken together, they suggest that some small difference of susceptibility may exist between normal mice and mice with sla. The mouse model could be of value in studying the influence of several other inherited disorders on susceptibility to candidosis.

Topics: Anemia, Hypochromic; Animals; Candidiasis; Disease Models, Animal; Hydrocortisone; Male; Mice; Mice, Mutant Strains; Tetracycline

Topics: Anemia, Hypochromic; Breast Feeding; Deglutition Disorders; Female; Ferritins; Gastrointestinal Hemorrhage; Hemorrhage; Hemosiderin; Humans; Intestinal Absorption; Iron; Male; Pregnancy; Sex Factors; Syndrome; Tetracycline

Topics: Anemia, Hypochromic; Drug Incompatibility; Humans; Intestinal Absorption; Iron; Iron Chelating Agents; Tetracycline; Time Factors

Topics: Adult; Anemia, Hypochromic; Female; Hormones; Humans; Male; Nalidixic Acid; Pseudotumor Cerebri; Sex Factors; Tetracycline; Vitamin A

Topics: Anemia; Anemia, Hypochromic; Anti-Bacterial Agents; Bephenium Compounds; Child; Humans; Iron; Prednisolone; Quinacrine; Sepsis; Sulfates; Tetracycline