tetracycline and Anemia--Aplastic

Topics: Amphotericin B; Anemia, Aplastic; Animals; Anti-Bacterial Agents; Antitubercular Agents; Bone Marrow; Bone Marrow Diseases; Chloramphenicol; Humans; In Vitro Techniques; Mice; Rabbits; Ristocetin; RNA; Tetracycline

Allogeneic BMT for severe aplastic anemia is associated with a significant rate of graft rejection, especially in patients who have been previously transfused. We report a child with aplastic anemia who rejected donor marrow twice despite adequate immunosuppression as part of the conditioning therapy but engrafted successfully following combined administration of three modalities of immunosuppression: antithymocyte globulin, total lymphoid irradiation and the monoclonal antibody Campath-1G. Restriction fragment length polymorphism studies > 1 year after BMT show full donor hematopoiesis with no evidence of autologous recovery.

Topics: Alemtuzumab; Anemia, Aplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antigens, CD; Antigens, Neoplasm; Antilymphocyte Serum; Bone Marrow Transplantation; CD52 Antigen; Child, Preschool; Glycoproteins; Graft Rejection; Humans; Immunosuppression Therapy; Lymphoid Tissue; Male; Reoperation; Tetracycline

Topics: Anemia, Aplastic; Chloramphenicol; Developing Countries; Drug Compounding; Humans; Tetracycline

A 54-year-old man developed mild renal insufficiency after treatment with gentamicin and cephalothin. He then received tetracycline for eight days, 500 mg orally four times daily, for a total dose of 15 gm. Twelve days after discontinuation of the drug, a severe but reversible aplastic anemia developed. We propose that bone-marrow-toxic concentrations of tetracycline resulted from the preexisting renal insufficiency. Because of the temporal relationship between tetracycline administration and aplastic anemia, and the lack of any other explanation, we conclude that this case illustrates a rare but potentially fatal complication of this drug.

Topics: Anemia, Aplastic; Cephalothin; Gentamicins; Humans; Kidney Diseases; Male; Middle Aged; Proteus Infections; Tetracycline

Topics: Anemia, Aplastic; Animals; Antibodies, Bacterial; Blood Cell Count; Blood Sedimentation; Chronic Disease; Dog Diseases; Dogs; Ehrlichia; gamma-Globulins; Recurrence; Rickettsiaceae Infections; Sepsis; Tetracycline

Topics: Agranulocytosis; Anemia, Aplastic; Anti-Bacterial Agents; Bronchial Spasm; Cephalosporins; Chloramphenicol; Drug Eruptions; Exanthema; Fatty Liver; Fever; Gentamicins; Hearing Disorders; Humans; Nalidixic Acid; Nitrofurantoin; Penicillins; Sulfanilamides; Tetracycline; Urticaria

Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia; Bacitracin; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chloramphenicol; Deafness; Gastrointestinal Diseases; Gentamicins; Humans; Kanamycin; Kidney Diseases; Leukopenia; Lung Diseases; Neomycin; Neuromuscular Diseases; Nitrofurantoin; Optic Neuritis; Peripheral Nervous System Diseases; Skin Diseases; Streptomycin; Sulfonamides; Tetracycline; Thrombocytopenia; Vertigo

Topics: Anabolic Agents; Anemia, Aplastic; Blood Cell Count; Blood Transfusion; Chloramphenicol; Erythrocytes; Female; Follow-Up Studies; Germany, West; Glucocorticoids; Hemostatics; Hepatitis; Humans; Male; Mumps; Phenylbutazone; Plasma; Sulfonamides; Tetracycline; Time Factors; Tuberculosis

Topics: Adolescent; Adult; Anemia, Aplastic; Chloramphenicol; Female; Humans; Male; Middle Aged; Sulfonamides; Tetracycline

Topics: Ampicillin; Anemia, Aplastic; Anti-Bacterial Agents; Bone Marrow; Chloramphenicol; Dermatitis, Contact; Drug Eruptions; Drug Hypersensitivity; Drug Tolerance; Exanthema; Humans; Immune Tolerance; Neomycin; Penicillins; Photosensitivity Disorders; Tetracycline; Tooth Discoloration

Topics: Anemia, Aplastic; Animals; Bacteria; Bacterial Infections; Blood Cell Count; Blood Sedimentation; Body Temperature; Dog Diseases; Dogs; Female; Hematocrit; Hemorrhage; Male; Tetracycline; Tropical Climate

Topics: Ampicillin; Anemia, Aplastic; Child, Preschool; Chloramphenicol; Chronic Disease; Drug Hypersensitivity; Fanconi Syndrome; Female; Haemophilus influenzae; Humans; Infant; Infant, Newborn; Lung Diseases; Penicillin Resistance; Pregnancy; Seizures; Streptococcus pneumoniae; Tetracycline; Tooth Discoloration

Topics: Alkaline Phosphatase; Anemia, Aplastic; Animals; Aspartate Aminotransferases; Bilirubin; Blood Proteins; Dexamethasone; Disease Outbreaks; Dog Diseases; Dogs; Epinephrine; Epistaxis; Erythrocyte Count; Insect Control; Leukocyte Count; Tetracycline; Ticks; Vietnam; Vitamin B Complex

Topics: Adult; Anemia, Aplastic; Aspirin; Bone Marrow Examination; Chloramphenicol; Chlorpheniramine; Chlorpromazine; Gold; Hemoglobins; Humans; Hydantoins; Middle Aged; Penicillins; Phenacetin; Prognosis; Sulfisoxazole; Switzerland; Tetracycline; Tolbutamide

Topics: Anemia, Aplastic; Animals; Anti-Bacterial Agents; Dog Diseases; Dogs; Kidney; Tetracycline; Tropical Medicine; Urinary Bladder

Topics: Anemia, Aplastic; Child; Coombs Test; Hepatitis A; Humans; Male; Penicillins; Tetracycline

Topics: Anemia; Anemia, Aplastic; Blood Cell Count; Bone Marrow Examination; Colistin; Erythromycin; Female; Humans; Neomycin; Prednisone; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Pseudomonas Infections; Sepsis; Streptomycin; Testosterone; Tetracycline

Topics: Anemia; Anemia, Aplastic; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacitracin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Chlortetracycline; Erythromycin; Hearing Disorders; Hepatitis; Kidney Diseases; Neomycin; Oleandomycin; Streptomycin; Tetracycline; Toxicology