tetracycline and Anaphylaxis

Topics: Anaphylaxis; Angioedema; Anti-Bacterial Agents; Anti-Infective Agents; Carrier Proteins; Dose-Response Relationship, Drug; Drug Hypersensitivity; Exanthema; Humans; Hydrocortisone; Mast Cells; Peptides; Proteins; Serum Sickness; Skin Tests; Tetracycline; Urticaria

Topics: Anaphylaxis; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Fetal Diseases; Gastrointestinal Diseases; Hearing Disorders; Hematologic Diseases; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney Diseases; Neomycin; Nervous System Diseases; Neuromuscular Diseases; Novobiocin; Penicillins; Pregnancy; Psychoses, Substance-Induced; Serum Sickness; Streptomycin; Tetracycline; Vision Disorders

Topics: Anaphylaxis; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Cycloserine; Drug Hypersensitivity; Kanamycin; Neomycin; Penicillins; Polymyxins; Protein Synthesis Inhibitors; Streptomycin; Tetracycline; Toxicology

Inappropriate antibiotics prescription in dental healthcare delivery that may result in the emergence of antibiotic-resistant bacteria, is a worldwide concern. The objective of the study was to determine the antibiotics knowledge and prescription patterns among dentists in Nigeria.. A total of 160 questionnaires were distributed to dentists attending continuing education courses organized by two organizations in Southern and Northern parts of Nigeria. Data analysis was done using SPSS version 17.0.. A total of 146 questionnaires were returned, properly filled, out of 160 questionnaires, giving an overall response rate 91.3%. The clinical factors predominantly influenced the choice of therapeutic antibiotics among the respondents. In this study, the most commonly prescribed antibiotics among the respondents was a combination of amoxicillin and metronidazole. Of the respondents, 136 (93.2%) of them considered antibiotic resistance as a major problem in Nigeria and 102 (69.9%) have experienced antibiotics resistance in dental practice. The major reported conditions for prophylactic antibiotics among the respondents were diabetic mellitus, HIV/AIDS, history of rheumatic fever, other heart anomalies presenting with heart murmur and presence of prosthetic hip. The knowledge of adverse effects of antibiotics was greatest for tooth discoloration which is related to tetracycline.. Data from this study revealed the most commonly prescribed antibiotics as a combination of amoxicillin and metronidazole. There existed gaps in prophylactic antibiotic prescription, consideration in the choice of therapeutic antibiotics and knowledge of adverse effects of antibiotics among the studied dentists.

Topics: Acquired Immunodeficiency Syndrome; Amoxicillin; Anaphylaxis; Anti-Bacterial Agents; Antibiotic Prophylaxis; Attitude of Health Personnel; Dental Care; Dentists; Diabetes Mellitus; Drug Combinations; Drug Prescriptions; Drug Resistance, Bacterial; Education, Dental; Female; Heart Diseases; Hip Prosthesis; HIV Infections; Humans; Male; Metronidazole; Nigeria; Practice Patterns, Dentists'; Rheumatic Fever; Tetracycline; Tooth Discoloration

A 17-year-old Japanese woman showed anaphylaxis after taking tetracycline hydrochloride, pyridoxal phosphate, flavin adenine dinucleotide sodium and ascorbic acid. Prick tests were performed for these suspicious drugs and anaphylaxis due to tetracycline hydrochloride was diagnosed.

Topics: Adolescent; Anaphylaxis; Female; Humans; Tetracycline; Urticaria

Although the platelets of the mouse are refractory to the direct effects of platelet-activating-factor (PAF), tail vein injection of 10-150 micrograms/kg PAF produces lethal anaphylactic shock. Sensitivity varies with strain and source: Swiss Webster mice show a range of sensitivity and DBA/2 (complement C5-deficient) mice are very resistant. At lethal doses of PAF, animals show labored respiration and general depression; death occurs within 15-45 min. Dexamethasone administered at least 1.5 hr prior consistently protects, whereas the cyclooxygenase inhibitors do not. Antihistamines, adrenergic antagonists, and methysergide have no effect, but cyproheptadine is partially protective at near lethal doses. Calcium entry blockers and calcium chelators, tetracycline and chlortetracycline are partially protective at very high doses consistent with non-specific effects on calcium dependent processes. The arachidonic acid lipoxygenase inhibitors BW755c, phenidone, nordihydroguaiaretic acid and diphenyldisulfide provide nearly complete protection after oral administration of 50-200 mg/kg. Phosphodiesterase inhibitors and dapsone are also effective orally. The leukotriene antagonist FPL55712 administered intraperitoneally (10 mg/kg) 5 min. prior to PAF challenge provides almost complete protection. PAF-induced mortality in the mouse represents a small animal model of systemic anaphylaxis particularly useful for the systemic testing of arachidonic acid lipoxygenase inhibitors and leukotriene antagonists.

Topics: Anaphylaxis; Animals; Chloroquine; Chlortetracycline; Dexamethasone; Dose-Response Relationship, Drug; Female; Indomethacin; Injections, Intravenous; Male; Mice; Mice, Inbred DBA; Naproxen; Nicardipine; Nifedipine; Platelet Activating Factor; Pyrazoles; Quinacrine; Tetracycline; Verapamil

Topics: Anaphylaxis; Animals; Dog Diseases; Dogs; Injections, Intravenous; Male; Tetracycline

Topics: Aged; Anaphylaxis; Humans; Hypersensitivity, Immediate; Male; Tablets; Tetracycline

Topics: Anaphylaxis; Gentamicins; Humans; Shock, Septic; Tetracycline

A case of anaphylactic reaction in the form of acute cyanosis, hypotension with sudden and unexpected death of a patient in the post-operative period following the administration of tetracycline is described. There was no history of previous exposure to the drug.

Topics: Adult; Anaphylaxis; Appendectomy; Drug Hypersensitivity; Heart Arrest; Humans; Male; Postoperative Complications; Tetracycline

Analysis of 302 side effects of antibiotic theraphy is presented. The side effects were studied comparatively as dependent on the antibiotic group. Dependence of the toxic and toxicoallergic reactions to the antibiotics on the antibiotic blood levels were noted. Previous sensitization resulted in more frequent and earlier side effects. The analysis and clinical observations showed that antibiotic therapy should take into account the results of the laboratory tests, i.e. examination of the kidney functional state, antibiotic levels in the blood and urine, tolerance of the drug by the patient.

Topics: Acute Disease; Adolescent; Adult; Aged; Aminoglycosides; Anaphylaxis; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Erythromycin; Female; Humans; Hypersensitivity, Delayed; Kidney; Leukocytes; Male; Middle Aged; Myocarditis; Oleandomycin; Penicillins; Skin; Streptomycin; Tetracycline; Urinary Tract

Topics: Allergens; Anaphylaxis; Animals; Guinea Pigs; Hemagglutination Tests; Hypersensitivity; Passive Cutaneous Anaphylaxis; Skin Tests; Tetracycline

Topics: Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Tetracycline

Topics: Administration, Oral; Anaphylaxis; Drug Hypersensitivity; Erysipelas; Female; Humans; Hydrocortisone; Middle Aged; Penicillins; Tetracycline

Topics: Anaphylaxis; Anti-Bacterial Agents; Cephalosporins; Chloramphenicol; Drug Hypersensitivity; Enterocolitis, Pseudomembranous; Malabsorption Syndromes; Penicillin Resistance; Penicillins; Shock; Streptomycin; Tetracycline

Topics: Anaphylaxis; Antigen-Antibody Reactions; Arthus Reaction; Barbiturates; Drug Hypersensitivity; gamma-Globulins; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Macromolecular Substances; Penicillins; Phenothiazines; Streptomycin; Sulfonamides; Tetracycline; Tranquilizing Agents

Topics: Adult; Anaphylaxis; Bronchitis; Humans; Male; Tetracycline; Tracheitis

Topics: Adrenal Cortex Hormones; Anaphylaxis; Drug Hypersensitivity; Endocarditis, Bacterial; Erythromycin; Histamine H1 Antagonists; Humans; Penicillins; Skin Tests; Streptococcal Infections; Streptomycin; Tetracycline; Vancomycin

Topics: Anaphylaxis; Anemia; Anemia, Hemolytic; Anti-Bacterial Agents; Drug Eruptions; Drug Hypersensitivity; Humans; Penicillins; Serum Sickness; Skin Manifestations; Tetracycline; Toxicology; Urticaria

Topics: Anaphylaxis; Anti-Bacterial Agents; Humans; Tetracycline

Topics: Anaphylaxis; Anti-Bacterial Agents; Antigen-Antibody Reactions; Hemagglutination Inhibition Tests; Penicillins; Tetracycline; Toxicology

Topics: Adult; Anaphylaxis; Antigen-Antibody Reactions; Drug Hypersensitivity; Humans; Lymphocytes; Male; Penicillins; Serum Sickness; Skin Tests; Tetracycline

Topics: Anaphylaxis; Anti-Bacterial Agents; Child; Debridement; Humans; Ireland; Penicillins; Protein Synthesis Inhibitors; Serum Sickness; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline; Toxicology

Topics: Anaphylaxis; Anti-Bacterial Agents; Aspirin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Colistin; Drug Eruptions; Drug Hypersensitivity; Hepatitis; Nitrofurantoin; Novobiocin; Penicillins; Polymyxins; Protein Synthesis Inhibitors; Serum Sickness; Streptomycin; Tetracycline; Toxicology

Topics: Anaphylaxis; Anti-Bacterial Agents; Chloramphenicol; Colistin; Diagnosis; Drug Hypersensitivity; Humans; Hypersensitivity; Nystatin; Penicillins; Statistics as Topic; Streptomycin; Tetracycline; Toxicology

Topics: Anaphylaxis; Animals; Fluorescence; Histological Techniques; In Vitro Techniques; Kidney Diseases; Kidney Tubules; Necrosis; Pituitary Hormones, Posterior; Rats; Tetracycline

Topics: Anaphylaxis; Anti-Bacterial Agents; Eye Injuries; Humans; Hypersensitivity; Immunization Schedule; Ophthalmology; Penicillins; Serum Sickness; Tetanus; Tetanus Antitoxin; Tetanus Toxoid; Tetracycline

Topics: Adrenocorticotropic Hormone; Aminosalicylic Acid; Aminosalicylic Acids; Anaphylaxis; Anti-Bacterial Agents; Aspirin; Body Constitution; Chloramphenicol; Cortisone; Drug Hypersensitivity; Otolaryngology; Penicillins; Physiology; Procaine; Shock; Shock, Septic; Skin Tests; Streptomycin; Surgical Procedures, Operative; Tetracycline; Toxicology

Cleansing and debridement is paramount in dealing with tetanus-prone wounds (severe crushing injuries, piercing wounds, blisters and burns are outstanding examples, particularly if contaminated with dirt, grass or other debris). Prophylaxis then is relatively easy in persons who have been actively immunized by toxoid injections. For them, a "booster" injection is indicated. Use of antitoxin, however, is hazardous, whether for prophylaxis or for treatment of the disease. Since it may in itself cause severe disease, including anaphylactic reaction and serum sickness, decision to use it must be weighed against the possibility of the development of tetanus in each case. To prepare for use of it, careful history should be taken, with particular reference to sensitivity to horse dander. Dermal tests, and perhaps ophthalmic tests, for sensitivity to the serum should be carried out. Even the tests may be hazardous and precautions should be taken accordingly. If it is decided that the use of antitoxin is necessary even though the patient is sensitive to the material, desensitization must be carried out promptly, with adequate preparation for severe reaction. There is experimental evidence that antibiotics of the tetracycline group, given soon after injury, may have prophylactic effect against tetanus.

Topics: Anaphylaxis; Anti-Bacterial Agents; Antitoxins; Burns; Debridement; Humans; Immunization; Serum Sickness; Tetanus; Tetanus Toxoid; Tetracycline; Vaccination

Topics: Anaphylaxis; Anti-Bacterial Agents; Hypersensitivity; Immune System Diseases; Protein Synthesis Inhibitors; Tetracycline