tetracycline and Agranulocytosis

Topics: Agranulocytosis; Bacterial Infections; Carbenicillin; Cross Infection; Gentamicins; Humans; Immunity, Cellular; Leukocyte Count; Mycoses; Neutropenia; Patient Isolators; Phagocytosis; Phosphatidylethanolamines; Tetracycline

Topics: Adult; Agranulocytosis; Drug Interactions; Gingivitis, Necrotizing Ulcerative; Humans; Male; Methotrexate; Pneumonia, Mycoplasma; Psoriasis; Tetracycline

Report about cyclic agranulocytosis in a 10 1/2 years old girls, having stomatitis, sore throat and fever up to 39 degrees C in the interval of approximately 3 weeks since the age of 6 months. By the prophylactic treatment with pulverized tetracyclin, which is already given 2 days prior to the expected decrease of the neutrophils, the patient stays clinically asymptomatic since 7 months.

Topics: Agranulocytosis; Bone Marrow Cells; Child; Child, Preschool; Female; Fever; Humans; Infant; Leukocytes; Neutrophils; Periodicity; Pharyngitis; Powders; Punctures; Stomatitis; Tetracycline

Topics: Agranulocytosis; Anemia, Aplastic; Anti-Bacterial Agents; Bronchial Spasm; Cephalosporins; Chloramphenicol; Drug Eruptions; Exanthema; Fatty Liver; Fever; Gentamicins; Hearing Disorders; Humans; Nalidixic Acid; Nitrofurantoin; Penicillins; Sulfanilamides; Tetracycline; Urticaria

Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia; Bacitracin; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chloramphenicol; Deafness; Gastrointestinal Diseases; Gentamicins; Humans; Kanamycin; Kidney Diseases; Leukopenia; Lung Diseases; Neomycin; Neuromuscular Diseases; Nitrofurantoin; Optic Neuritis; Peripheral Nervous System Diseases; Skin Diseases; Streptomycin; Sulfonamides; Tetracycline; Thrombocytopenia; Vertigo

Topics: Adult; Agranulocytosis; Aminopyrine; Aspirin; Chloramphenicol; Drug-Related Side Effects and Adverse Reactions; Esophagus; Female; Humans; Intestines; Male; Meprobamate; Middle Aged; Penicillins; Phenylbutazone; Sulfanilamides; Tetracycline

Topics: Agranulocytosis; Amidines; Bone Marrow Examination; Dysgammaglobulinemia; Eosinophilia; gamma-Globulins; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologic Deficiency Syndromes; Immunotherapy; Infant; Leukocyte Count; Lymphocyte Activation; Male; Neutropenia; Pedigree; Pharynx; Phenyl Ethers; Pneumonia, Pneumocystis; Streptococcus; Tetracycline

Topics: Adult; Aged; Agranulocytosis; Aminopyrine; Antineoplastic Agents; Candidiasis, Oral; Dentin; Drug Hypersensitivity; Female; Gingival Hyperplasia; Humans; Hydantoins; Mouth; Mouth Diseases; Mouth Mucosa; Necrosis; Palate; Penicillins; Phenylbutazone; Tetracycline; Thrombocytopenia

Topics: Adolescent; Agranulocytosis; Humans; Male; Salmonella Infections; Tetracycline

1. Lymphocytes and polymorphonuclear leucocytes were separated from normal human blood by the method of Rabinowitz (1964).2. The oxygen uptake, lactic acid production and glucose uptake of suspensions of these cells in vitro were measured. The values obtained agree with published data using comparable techniques.3. Amidopyrine, chloramphenicol, chlorpromazine, phenylbutazone and thiouracil, in high concentrations, depressed the oxygen uptake of polymorphs, but not that of lymphocytes. With amidopyrine, chlorpromazine and thiouracil significant inhibition was produced by concentrations equal to therapeutic plasma levels. High concentrations of the drugs, except chlorpromazine, stimulated the glucose uptake of lymphocytes but not that of polymorphs. Tetracycline and sulphisoxazole were without effect on either parameter of leucocyte metabolism.4. Because of erythrocyte contamination the lactic acid production of lymphocytes could not be determined. Lactate production by polymorphs was not affected by any of the drugs studied.5. The significance of these results is discussed. It is suggested that there is a relationship between ability to induce agranulocytosis and effect on leucocyte metabolism in vitro.

Topics: Agranulocytosis; Aminopyrine; Chloramphenicol; Chlorpromazine; Depression, Chemical; Glucose; Humans; In Vitro Techniques; Lactates; Leukocytes; Lymphocytes; Oxygen Consumption; Phenylbutazone; Stimulation, Chemical; Sulfisoxazole; Tetracycline; Thiouracil

Topics: Agranulocytosis; Eosinophilia; Humans; Leukopenia; Male; Middle Aged; Tetracycline

Topics: Adult; Agranulocytosis; Humans; Male; Tetracycline

Topics: Aged; Agranulocytosis; Anti-Bacterial Agents; Bacteroides; Brucella; Chloramphenicol; Complement System Proteins; Endotoxins; Erythromycin; Hodgkin Disease; Humans; Leukemia; Leukopenia; Lymphadenitis; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms; Penicillins; Primary Myelofibrosis; Properdin; Research; Sarcoma; Streptomycin; Tetracycline

Topics: Adrenal Cortex Hormones; Agranulocytosis; Anti-Bacterial Agents; Oxytetracycline; Penicillins; Schizophrenia; Streptomycin; Tetracycline; Thioridazine; Thrombocytopenia; Toxicology

Topics: Adrenal Cortex Hormones; Agranulocytosis; Arthritis; Arthritis, Rheumatoid; Bone Marrow Examination; Complement Fixation Tests; Escherichia coli Infections; Geriatrics; Humans; Leukocyte Count; Penicillamine; Pharmacology; Prednisolone; Tetracycline; Toxicology

Topics: Agranulocytosis; Ecchymosis; Gingivitis; Gingivitis, Necrotizing Ulcerative; Humans; Isoniazid; Lymphadenitis; Neutropenia; Periodicity; Periodontal Diseases; Prednisone; Splenectomy; Splenomegaly; Tetracycline