tetracycline and Acute-Disease

Eravacycline is the newest member of the broad-spectrum class of tetracycline antimicrobials. Pancreatitis has been previously associated with the tetracycline class of antibiotics, but, to our knowledge, we believe that this is the first reported case of eravacycline-induced pancreatitis. We describe a 46-year-old male who received eravacycline for treatment of a perirectal abscess. While the patient had slightly elevated lipase levels at baseline post-cardiopulmonary arrest, he developed abdominal pain and a further increase in lipase levels following 10 days of eravacycline, consistent with pancreatitis. Based on the Naranjo adverse drug reaction probability scale, eravacycline was the probable etiology of acute pancreatitis given improvement immediately after discontinuation. Clinicians should be aware of this potential adverse effect of eravacycline and should not initiate eravacycline in those with risk factors for acute pancreatic injury. However, acute pancreatitis should be suspected in all patients complaining of symptoms followed by immediate discontinuation of eravacycline.

Topics: Acute Disease; Anti-Bacterial Agents; Humans; Lipase; Male; Middle Aged; Pancreatitis; Tetracycline; Tetracyclines

The diagnosis of drug-induced acute pancreatitis often is difficult to establish. Although some medications have been shown to cause acute pancreatitis with a large body of evidence, including rechallenge, some medications have been attributed as a cause of acute pancreatitis merely by a single published case report in which the investigators found no other cause. In addition, some medications reported to have caused acute pancreatitis have obvious patterns of presentation, including the time from initiation to the development of disease (latency). There also appear to be patterns in the severity of disease. After reviewing the literature, we have classified drugs that have been reported to cause acute pancreatitis based on the published weight of evidence for each agent and the pattern of clinical presentation. Based on our analysis of the level of evidence, 4 classes of drugs could be identified. Class I drugs include medications in which at least 1 case report described a recurrence of acute pancreatitis with a rechallenge with the drug. Class II drugs include drugs in which there is a consistent latency in 75% or more of the reported cases. Class III drugs include drugs that had 2 or more case reports published, but neither a rechallenge nor a consistent latency period. Class IV drugs were similar to class III drugs, but only 1 case report had been published. Our analysis allows an evidence-based approach when suspecting a drug as causing acute pancreatitis.

Topics: Acute Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pancreatitis; Tetracycline

ANTIBIOTIC EFFICACY: According to early studies, antibiotics have moderate efficacy in acute exacerbation of chronic bronchitis. The lack of efficacy is particularly clear for patent exacerbation with marked alteration of respiratory function. Recent studies have shown that newer compounds exhibit an efficacy similar (no proven superiority) to comparison compounds (75 to 95% favorable outcome with treatment). The recommendations of the IVth Consensus Conference on Anti-infectious Therapy thus propose first line antibiotic therapy for patients with a forced expiratory volume in 1 second (FEV1) between 80 and 35% and broader spectrum and new antibiotics in case of failure of the first line treatment for patients with severe obstruction or frequently recurrent exacerbation.. Using exacerbation-free interval, reduction in the number of exacerbations, duration of treatment and/or hospital stay as evaluation criteria, interesting results are obtained with amoxicillin/clavulanic acid, azithromycin, and ciprofloxacin. Independent factors predictive of therapeutic failure are, according to one study, FEV1 less than 35%, ambulatory administration of oxygen, more than 4 acute exacerbations within 24 months, history of pneumonia or sinusitis, and requirement for long-term corticosteroid therapy. Factors predictive of recurrence are, according to another study, dependence on oxygen therapy, prolonged corticosteroid therapy, smoking, and/or heart disease. Cost effectiveness is particularly interesting with ciprofloxacin, especially in more severe patients.. It is important to target antibiotic therapy for acute exacerbation of chronic bronchitis specifically for patients who will truly benefit, adapting the prescribed compound to the bacterial target.

Topics: Acute Disease; Adrenal Cortex Hormones; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Bronchitis, Chronic; Ciprofloxacin; Clavulanic Acid; Clinical Trials as Topic; Cost-Benefit Analysis; Double-Blind Method; Drug Therapy, Combination; Erythromycin; Humans; Maximal Expiratory Flow-Volume Curves; Multicenter Studies as Topic; Penicillins; Placebos; Practice Guidelines as Topic; Prognosis; Recurrence; Respiratory Function Tests; Tetracycline; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination

Prostatitis remains a challenging condition. The clinical features are often nonspecific while the aetiology and pathogenesis can be diverse and includes inflammatory, obstructive, and/or chemical causes and may also be related to calculi. Four categories are recognized: acute bacterial prostatitis, chronic bacterial prostatitis, non-bacterial prostatitis and prostatodynia. The diagnosis of prostatitis was advanced substantially by the introduction of sequential sampling of urine aliquots following prostatic massage. Bacterial prostatitis is largely associated with the Enterobacteriaceae although Pseudomonas spp., enterococci and Staphylococcus aureus may also be isolated. In chronic bacterial prostatitis a variety of streptococci and anaerobic bacteria may be isolated. Treatment is difficult largely owing to the limited range of agents able to achieve therapeutic concentrations within prostatic fluid, which has a pH lower than that of plasma. Trimethroprim, co-trimoxazole and the tetracyclines have been widely used. The quinolones have recently been shown to diffuse readily into the prostate; ofloxacin and temafloxacin have produced the highest concentrations in prostatic fluid. Antibiotic treatment requires prolonged high dosage and careful monitoring to ensure that bacterial eradication has occurred. Other forms of management have included the judicious use of anti-inflammatory agents and analgesics. In some patients zinc sulphate has proved to be of symptomatic benefit.

Topics: Acute Disease; Adult; Anti-Infective Agents, Urinary; Bacterial Infections; Chronic Disease; Colony Count, Microbial; Enterobacteriaceae Infections; Humans; Male; Prostatitis; Pseudomonas Infections; Staphylococcal Infections; Tetracycline; Trimethoprim

Tetracycline has long been implicated as a causative agent in acute pancreatitis. Early reports of acute pancreatitis after tetracycline administration were associated with liver dysfunction attributed to the drug's ability to induce fatty degeneration of this organ. At present, few data are available to suggest that tetracycline-induced pancreatitis may occur in the absence of overt liver failure. We report here, the third and fourth cases of acute pancreatitis after the administration of oral tetracycline in patients without evidence of liver abnormalities. A review of the relevant literature is presented.

Topics: Acute Disease; Administration, Oral; Adolescent; Humans; Male; Pancreatitis; Tetracycline

To the best of our knowledge, no case of acute pancreatitis associated with brucellosis has been reported. This report details the occurrence of acute pancreatitis in which Brucella melitensis was cultured from blood. We discuss various diagnostic tests and the recommended therapy for brucellosis.

Topics: Acute Disease; Adult; Brucellosis; Drug Therapy, Combination; Humans; Male; Pancreatitis; Streptomycin; Tetracycline

Topics: Acute Disease; Eclampsia; Fatty Liver; Female; Humans; Liver; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Tetracycline

Periodontal diseases are common oral diseases that afflict all humans to some degree. The major aetiological agent is dental plaque--the complex microflora which forms on teeth in the absence of effective oral hygiene. The interaction of the microbial flora and the periodontal tissues produces an inflammatory response and tissue breakdown. Recent information has categorized periodontal diseases on the basis of increased knowledge about the particular microorganisms associated with the different clinical conditions. In addition, the important role of host defences, in particular the phagocytic cellular elements, has allowed for a better understanding of the pathological processes. This knowledge is contributing towards the development of rational and effective therapy for all forms of periodontal diseases. Because of the widespread occurrence of periodontal diseases and their potential relationships to systemic conditions, it is important that medical practitioners should be able to recognize, and be conversant with methods of treatment of, these diseases.

Topics: Acute Disease; Adult; Child; Chronic Disease; Dental Plaque; Gingivitis; Gingivitis, Necrotizing Ulcerative; Humans; Metronidazole; Oral Hygiene; Periodontal Diseases; Periodontal Pocket; Periodontitis; Periodontium; Stomatitis, Herpetic; Tetracycline

Topics: Acute Disease; Adult; Age Factors; Analgesics; Epididymitis; Genital Diseases, Male; Gonorrhea; Humans; Male; Radionuclide Imaging; Scrotum; Sodium Pertechnetate Tc 99m; Spermatic Cord Torsion; Technetium; Testicular Neoplasms; Testis; Tetracycline; Trachoma; Ultrasonography

In acute pancreatitis the standard treatment is with antibiotics given prophylactically. Available studies indicate that the usefulness of such chemotherapy in the milder form of the disease (degree of severity I) has not yet been fully established. In the absence of contradictory results, prophylactic antibiotic treatment can, however, be recommended in severe pancreatitis (degrees II and III) and in those conditions induced by ethyl or of idiopathic origin. In all forms showing underlying biliary tract disease and in pancreatitis complicated by infection, antibiotic treatment should invariably be administered. Administration of broad-spectrum antibiotics which can be excreted via the bile duct, e.g. ampicillin or tetracycline, is preferable.

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Clinical Trials as Topic; Humans; Pancreatitis; Prospective Studies; Random Allocation; Tetracycline

Topics: Acid-Base Equilibrium; Acute Disease; Age Factors; Bicarbonates; Body Temperature; Child; Child, Preschool; Cholera; Citrates; Coma; Feces; Furazolidone; Glucose; Humans; Hypertonic Solutions; Infusions, Parenteral; Injections, Intraperitoneal; Injections, Intravenous; Potassium; Seizures; Sodium; Tetracycline; Water-Electrolyte Balance

Topics: Acute Disease; Child; Child, Preschool; Chlorpheniramine; Chronic Disease; Ear, Middle; Enterobacteriaceae Infections; Gentamicins; Haemophilus Infections; Humans; Infant; Methicillin; Otitis Media; Recurrence; Streptococcal Infections; Tetracycline; Tympanic Membrane

Topics: Acute Disease; Ampicillin; Animals; Anti-Bacterial Agents; Chloramphenicol; Chronic Disease; Corynebacterium; Disease Models, Animal; Dogs; Escherichia coli Infections; Gentamicins; Haplorhini; Kidney; Ligation; Mice; Nalidixic Acid; Nitrofurantoin; Penicillin G; Proteus Infections; Pseudomonas Infections; Pyelonephritis; Rabbits; Rats; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Sulfonamides; Tetracycline; Ureter

Topics: Acute Disease; Anti-Bacterial Agents; Bacitracin; Bronchitis; Chloramphenicol; Chronic Disease; Ear Diseases; Humans; Labyrinth Diseases; Laryngitis; Neomycin; Novobiocin; Otitis Externa; Otitis Media; Penicillins; Pneumococcal Infections; Polymyxins; Respiratory Tract Infections; Staphylococcal Infections; Streptococcal Infections; Streptomycin; Tetracycline; Tonsillitis; Tracheal Diseases

A comparative trial of the combination of mefloquine or MSP with tetracycline was carried out in fifty-one adult Thai male patients with acute falciparum malaria. The patients were randomized to receive either the combination of tetracycline (250 mg qid for 7 days) with mefloquine 4 tablets (1,000 mg) or with MSP 4 tablets (one tablet contains 250 mg mefloquine, 500 mg sulfadoxine and 25 mg pyrimethamine). Fifty patients had a complete 28-day follow-up period. Both regimens produced similar efficacy with no difference in adverse effects. In the mefloquine plus tetracycline group, the cure rate was 72% (18/25). One patient had an RIII response, the others showed initial response to the treatment with FCT and PCT of 40.7 +/- 27.4 and 76.2 +/- 34.2 hours (mean +/- SD) respectively. However, 6 patients developed recrudescence between days 17 and 29 (RI), 3 of these had vomiting. In the MSP plus tetracycline group, the cure rate was 76% (19/25). The means (+/- SD) of FCT and PCT were 44.7 +/- 38.0 and 80.6 +/- 25.0 hours, respectively. Six patients had recrudescence between days 17 and 31 (RI), 2 of these had vomiting. Although the addition of tetracycline improved the cure rate of mefloquine when compared with standard dose of mefloquine alone (3 tablets), these combinations seem to be useful in areas where alternative drugs are not available.

Topics: Acute Disease; Adolescent; Adult; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Prospective Studies; Pyrimethamine; Sulfadoxine; Tetracycline

The present study was undertaken to evaluate efficacy, safety and patient acceptability of three antibiotic regimens for the treatment of acute brucellosis. Six different centres were involved: three in France, one in Greece and two in Spain. The regimens were: oral rifampicin 900 mg/day plus oral doxycycline 200 mg/day for 45 days (A), oral doxycycline 200 mg/day for 45 days plus im streptomycin 1 g/day for 21 days (regimen B) [corrected] and the WHO regimen (C) combining oral tetracycline 2 g/day for 21 days plus im streptomycin, 1 g/day, for 14 days. Regimens A and B were randomly allocated in all centres, while regimen C was allocated only in two centres. All patients were suffering from acute brucellosis clinically and biologically proven. 143 patients were allocated for treatment and analysed. Their mean age was 41 years (range 13-70), 49 were female and 94 male, and their mean weight was 64 kg (range 35-98). Among these patients, 14% had localized disease (nine orchitis, eight osteo-articular involvement and one pleural effusion), but there was no statistical difference between the three regimens in regard to this localized disease. Forty-five per cent of the patients had positive blood cultures. The cure rate with regimen A was 95%, 96% with regimen B and 59% with regimen C. Thus regimen A presented the same efficacy rate as regimen B, but regimen C cannot be regarded as the treatment of choice for acute brucellosis.

Topics: Acute Disease; Adult; Anti-Bacterial Agents; Body Temperature; Brucellosis; Doxycycline; Drug Therapy, Combination; Female; Humans; Male; Rifampin; Streptomycin; Tetracycline

A study was carried out in 80 patients with acute intestinal amoebiasis to compare the efficacy of treatment with a single oral dose of 2 g secnidazole and a 5-day course of 750 mg tetracycline plus 1 g clioquinol per day. Patients were allocated at random into one or other treatment group and returned for clinical assessment and microscopic examination of stools for the presence of the trophozoite or haematophagous form of Entamoeba histolytica on Days 1 to 7, 14, 21 and 28. The results showed that secnidazole produced significantly faster and more effective treatment than tetracycline/clioquinol. At the end of the follow-up period, 7 of the 40 patients in the tetracycline/clioquinol group were classified as 'parasitological' failures but there were none in the secnidazole group. Moreover, there were no cases of relapse or persistence of clinical signs in the secnidazole-treated patients. Both treatments were well tolerated.

Topics: Acute Disease; Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Clioquinol; Drug Therapy, Combination; Dysentery, Amebic; Female; Humans; Hydroxyquinolines; Male; Metronidazole; Middle Aged; Random Allocation; Tetracycline; Time Factors

Four hundred adults presenting with acute watery diarrhoea were entered into a randomised, placebo controlled, double blind clinical trial of berberine, tetracycline, and tetracycline and berberine to study the antisecretory and vibriostatic effects of berberine. Of 185 patients with cholera, those given tetracycline or tetracycline and berberine had considerably reduced volume and frequency of diarrhoeal stools, duration of diarrhoea, and volumes of required intravenous and oral rehydration fluid. Berberine did not produce an antisecretory effect. Analysis by factorial design equations, however, showed a reduction in diarrhoeal stools by one litre and a reduction in cyclic adenosine monophosphate concentrations in stools by 77% in the groups given berberine. Considerably fewer patients given tetracycline or tetracycline and berberine excreted vibrios in stools after 24 hours than those given berberine alone. Neither tetracycline nor berberine had any benefit over placebo in 215 patients with non-cholera diarrhoea.

Topics: Acute Disease; Adult; Berberine; Berberine Alkaloids; Cholera; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Random Allocation; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Chile; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillin G; Penicillin G Procaine; Probenecid; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Sinusitis; Sulfalene; Sulfanilamides; Tetracycline; Trimethoprim

We conducted a double-blind, randomized, placebo-controlled trial in 40 patients to evaluate the need for antibiotics in acute exacerbations of chronic bronchitis. All patients were sufficiently ill to require hospitalization although none needed ventilatory support; the presence of pneumonia was excluded. Treatment consisted of bronchodilators, corticosteroids, and either tetracycline, 500 mg, or placebo by mouth every 6 hours for 1 week. Arterial blood gases, spirometric tests, bacteriologic evaluation of sputum, and patient and physician evaluation of the severity of illness were assessed at the beginning and end of the study. All patients improved both symptomatically and by objective measures of lung function. At the end of the study period there were no differences between those patients receiving tetracycline and those receiving placebo. We conclude that antibiotic therapy is not needed in moderately ill patients with exacerbations of chronic bronchitis.

Topics: Acute Disease; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Drug Evaluation; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Oxygen; Random Allocation; Tetracycline; Vital Capacity

In acute pancreatitis the standard treatment is with antibiotics given prophylactically. Available studies indicate that the usefulness of such chemotherapy in the milder form of the disease (degree of severity I) has not yet been fully established. In the absence of contradictory results, prophylactic antibiotic treatment can, however, be recommended in severe pancreatitis (degrees II and III) and in those conditions induced by ethyl or of idiopathic origin. In all forms showing underlying biliary tract disease and in pancreatitis complicated by infection, antibiotic treatment should invariably be administered. Administration of broad-spectrum antibiotics which can be excreted via the bile duct, e.g. ampicillin or tetracycline, is preferable.

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Clinical Trials as Topic; Humans; Pancreatitis; Prospective Studies; Random Allocation; Tetracycline

The results from the comparative clinical studies on the effectiveness of tetraolean and tetracycline are summed up about 1672 patients with acute and exacerbated infections of the respiratory organs (1036 patient, treated by ten teams, working on the theme given in advance "Comparative clinical studies between tetraolean and tetracyclin in acute pneumonia", 164 patients with postgrippe viral-bacterial pneumonia, treated during the grippe epidemy 1972/1973 and 445 patient treated at the Therapeutic Clinic, Sofia during 1967-1972). The total results reveal that, according to the adopted objective indices, the therapeutic effect of tetraolean is with a statistically significant superiority over tetracyclin. The beneficial results obtained in the treatment of 14 patients with endocarditis lenta are also reported. The mechanisms of that superior effect, defined as "clinical synergism" are discussed.

Topics: Acute Disease; Bulgaria; Chronic Disease; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Endocarditis, Subacute Bacterial; Humans; Influenza, Human; Lung Diseases; Oleandomycin; Pneumonia; Tetracycline

The effect on the aerobic faecal flora of a 10-day course of doxycycline or tetracycline hydrochloride was compared in 36 patients with acute infections mainly of respiratory origin. The patients were treated in hospital with a well-developed barrier nursing technique. The proportions of isolates of Escherichia coli resistant to tetracyclines were significantly lower after 10 days' treatment with doxycycline (80%) as well as one month later (24%), compared to the figures for tetracycline HCI (100% and 46%, respectively). The resistant strains selected during therapy probably represented the community flora. Only a small increase in multiresistant strains occurred and no identical strains were found in different patients. Thus, it seems possible to limit the biological side-effects of tetracyclines by a good barrier nursing technique. An increase in the number of E. coli resistant to tetracyclines cannot be avoided, but is more limited when doxycycline is used.

Topics: Acute Disease; Adult; Aged; Ampicillin; Chloramphenicol; Doxycycline; Escherichia coli; Feces; Female; Humans; Male; Middle Aged; Nitrofurantoin; Penicillin Resistance; Respiratory Tract Infections; Streptomycin; Sulfonamides; Tetracycline; Time Factors

Topics: Acetamides; Acute Disease; Adolescent; Adult; Aged; Bronchiectasis; Bronchitis; Clinical Trials as Topic; Drug Combinations; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Phenethylamines; Remission, Spontaneous; Respiratory Tract Infections; Sulfones; Tetracycline

Topics: Acute Disease; Ampicillin; Blood Bactericidal Activity; Child; Child, Preschool; Chloramphenicol; Clinical Trials as Topic; Dysentery, Bacillary; Feces; Humans; Infant; Nalidixic Acid; Penicillin Resistance; Shigella; Tetracycline

Topics: Acute Disease; Chloramphenicol; Clinical Trials as Topic; Gonorrhea; Humans; Penicillin G Procaine; Tetracycline

Topics: Acute Disease; Anti-Infective Agents; Bronchitis; Chronic Disease; Clinical Trials as Topic; Folic Acid Antagonists; Humans; Pyrimidines; Sputum; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Biguanides; Clinical Trials as Topic; Doxycycline; Female; Humans; Lung Diseases; Male; Methacycline; Middle Aged; Tetracycline; Urticaria

Topics: Acute Disease; Anti-Infective Agents, Local; Clinical Trials as Topic; Evaluation Studies as Topic; Gingivitis, Necrotizing Ulcerative; Humans; Idoxuridine; Mouthwashes; Stomatitis, Aphthous; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Australia; Clinical Trials as Topic; Gonorrhea; Humans; Male; Marriage; Middle Aged; Penicillin G Procaine; Probenecid; Sexual Behavior; Single Person; Tetracycline; Urethritis

Campylobacter infections are typically self-limited, but in cases with severe enteritis, immuno-compromised system and bacteremia, an appropriate antimicrobial treatment is demanding. Our study aim was to determine the isolation rate of Campylobacter among patients with acute enteritis in the capital of North Macedonia and its antimicrobial susceptibility.. A total number of 3820 patients clinically diagnosed as acute enteritis, were included in the study. Stool samples were collected and Campylobacter was isolated and identified by classical microbiological methods. Antimicrobial susceptibility of all isolates to Ceftriaxone, Amoxicillin-clavulonic acid, Erythromycin, Ciprofloxacin, Tetracycline and Gentamicin was determined by disc-diffusion technique. Additionally, minimal inhibitory concentrations of all Campylobacter isolates against erythromycin, ciprofloxacin and tetracycline were determined by Epsilon gradient tests.. Campylobacter species was isolated in 97 patients. Although the mean isolation rate of Campylobacter spp. during the whole study period was 2.53%, a statistically significant increase was detected in 2016 and 2017, in comparison with the data from previous four years of the study. The isolation rate of Campylobacter spp. didn't reveal statistically significant difference between males and females (p > 0.05). 46.4 % of patients with Campylobacter enteritis were children at the age under 15 years. Forty-three C. jejuni isolates were susceptible to all six antibiotics, but the remaining 44 isolates revealed resistance to at least one antibiotic. C. coli isolates were resistant to 3 antibiotics simultaneously. Two C. coli isolates only, were susceptible to all 6 antibiotics. 40.90% of C. jejuni and 50% of C. coli isolates were resistant to beta-lactams, fluoroquinolones and tetracyclines, simultaneously.. The increase of the isolation rate of Campylobacter from patients with acute enteritis indicates the need for permanent isolation and identification of Campylobacter from every clinically diagnosed patient, as acute enteritis. Erythromicin is the most effective antibiotic for treatment of Campylobacter enteritis in our patients. The high level of Campylobacter resistance to beta-lactams, fluoroquinolones and tetracyclines requires more rational approach in the treatment of Campylobacter enteritis.

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Campylobacter; Campylobacter Infections; Child; Child, Preschool; Ciprofloxacin; Cross-Sectional Studies; Drug Resistance, Bacterial; Enteritis; Erythromycin; Feces; Female; Humans; Infant; Male; Microbial Sensitivity Tests; Middle Aged; Republic of North Macedonia; Tetracycline; Young Adult

Salmonella and Shigella remain the major contributors to acute enteric infections and diarrhoea. Hence, the objective of this study was to isolate and determine the antimicrobial susceptibility pattern of Shigella and Salmonella species from children with acute diarrhoea in Mekelle Hospital and Semen Health Center.. A cross sectional study was conducted among 260 children with acute diarrhoea from November 2011 to March 2012 in Mekelle, Ethiopia. Stool specimen was collected from all study participants who presented with acute diarrhoea. Microscopy, culture and confirmatory identification were done by the pattern of biochemical reactions using a standard bacterial identification system (API 20E, BioMerieux, Marcy-l'Etoile, France) and polyvalent (Poly O and H) antiseras for Salmonella species and Vi for S.typhi. Isolated colonies were assessed for antimicrobial susceptibility profile using disk diffusion method. Data was entered and analyzed using SPSS version 16.0 software.. Out of the 260 study participants, 145(55.8%) were males while 115(44.2%) were females. The majority of the patients (44.2%) were of children under five years old. A total of 120 enteropathogens were isolated. The frequency of isolation was 19(7.3%), 18(6.9%) and 83(31.9%) for Salmonella species, Shigella species and intestinal parasites respectively. Most of the Shigella isolates were resistant to ampicillin (88.9%), Tetracycline (77.8), cotrimoxazole (55.6%) and chloramphenicol (55.6%). Among the Salmonella isolates, the highest resistance was observed to ampicillin (89.5%), Tetracycline (89.5%), chloramphenicol (78.9%) and cotrimoxazole (57.9%). Multi-drug resistance was noted in 19(100%) and 16(88.9%) of Salmonella and Shigella species respectively.. Shigella and Salmonella are still challenging pathogens in children < 5 years of age. High antibiotic resistance was observed among both isolates to ampicillin, tetracycline, chloramphenicol and cotrimoxazole.

Topics: Acute Disease; Adolescent; Ampicillin; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Cross-Sectional Studies; Diarrhea; Dysentery, Bacillary; Ethiopia; Feces; Female; Hospitals; Humans; Infant; Male; Microbial Sensitivity Tests; Pediatrics; Salmonella; Salmonella Infections; Shigella; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination

We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness District Clinician Manual (IMAI) criteria for septic shock, severe respiratory distress without shock, and severe pneumonia, and compare these etiologies against commonly used antimicrobials, including IMAI recommendations for emergency antibacterials (ceftriaxone or ampicillin plus gentamicin) and IMAI first-line recommendations for severe pneumonia (ceftriaxone and a macrolide). Among 423 participants hospitalized with febrile illness, there were 25 septic shock, 37 severe respiratory distress without shock, and 109 severe pneumonia cases. Ceftriaxone had the highest potential utility of all antimicrobials assessed, with responsive etiologies in 12 (48%) septic shock, 5 (14%) severe respiratory distress without shock, and 19 (17%) severe pneumonia illnesses. For each syndrome 17-27% of participants had etiologic diagnoses that would be non-responsive to ceftriaxone, but responsive to other available antimicrobial regimens including amphotericin for cryptococcosis and histoplasmosis; anti-tuberculosis therapy for bacteremic disseminated tuberculosis; or tetracycline therapy for rickettsioses and Q fever. We conclude that although empiric ceftriaxone is appropriate in our setting, etiologies not explicitly addressed in IMAI guidance for these syndromes, such as cryptococcosis, histoplasmosis, and tetracycline-responsive bacterial infections, were common.

Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Ampicillin; Anti-Infective Agents; Bacterial Infections; Ceftriaxone; Child; Cohort Studies; Cryptococcosis; Emergencies; Female; Gentamicins; Histoplasmosis; Humans; Infections; Macrolides; Male; Microbial Sensitivity Tests; Middle Aged; Pneumonia, Bacterial; Respiratory Distress Syndrome; Shock, Septic; Tanzania; Tetracycline; Young Adult

Although liver involvement is frequently seen in brucellosis, acute hepatitis is a rare clinical entity. In its progress, haematological findings are non-specific and vary in respect to severity. In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia. A 19-year-old man presented with a 2-week history of fever, sweating, low back and leg pain, lassitude, loss appetite, nausea and vomiting. He gave a history of raw milk ingestion and animal contact. Physical examination showed signs of icteric skin and sclera, tenderness in the right hypochondriac region and hepatosplenomegaly. On admission to hospital, laboratory tests showed WBC 3500/mmc (polymorphs 63% and lymphocytes 33%), haemoglobin 13.8 g/dL, platelet 89000/mmc, erythrocyte sedimentation rate 19 mm/h, and C-reactive protein 21.7 mg/dL (N<0.8 mg/dL). Biochemical tests were as follows: AST 771 U/L, ALT 471 U/L, ALP 355 U/L, GGT 432 U/L, total bilirubin 2.61 mg/dL, direct bilirubin 1.45 mg/dL and albumin 3.7 g/dL. Viral hepatitis markers were found to be negative (HBsAg, anti-HBc total, anti-HBc IgM, anti-HAV IgM, and anti-HCV). Blood culture grew Brucella melitensis. Leukopenia and thrombocytopenia returned to normal levels at the 7th and 14th day of his admission, respectively. Liver function tests improved at the 28th day. Treatment of the brucellosis was performed with antibiotics (tetracycline 500 mg orally four times daily for 6 weeks and streptomycin 1 g IM once daily for 21 days). Finally, a case of brucellosis with acute hepatitis and bicytopenia was treated with a successful outcome. In conclusion, we suggest that due consideration be taken of bicytopenia/pancytopenia and acute hepatitis in brucellosis cases in Turkey, an endemic region.

Topics: Acute Disease; Adult; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Drug Therapy, Combination; Hepatitis; Humans; Leukopenia; Male; Streptomycin; Tetracycline; Thrombocytopenia; Treatment Outcome; Turkey

To evaluate the suggested association between tetracycline and acute pancreatitis in a large pharmacoepidemiological study.. The use of tetracycline in relation to the risk of acute pancreatitis was examined in a nationwide case-control study of people aged 40-84 years between 2006 and 2008 in Sweden. The Swedish Patient Register was used to identify 6161 cases of first-episode acute pancreatitis. The Register of the Total Population was used to randomly select 61,637 control subjects from the general population using frequency-based density sampling, matched for age, sex, and calendar year. Tetracycline use was defined as 'current', 'recent', 'past' or 'former' if the drug had been dispensed 0-30 days, 31-180 days, 181-365 days or 1-3½ years before the index date, respectively. The risk of acute pancreatitis was estimated by unconditional logistic regression, providing ORs with 95% CIs, adjusted for potential confounding factors.. There was a 60% increased risk of acute pancreatitis among current users of tetracycline after adjustment for potential confounders (OR=1.6, 95% CI 1.2 to 2.1). There was no increased OR for any category of previous use.. Current use of tetracycline is associated with an increased risk of acute pancreatitis, verifying previous case reports.

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Case-Control Studies; Confidence Intervals; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Pancreatitis; Risk Factors; Sweden; Tetracycline

Six dental implants in six patients with periapical lesions were inserted and underwent trepanation and thorough curettage. During surgery, the lesion area was irrigated with copious natural saline and chlorhexidine and the bone defects were treated with tetracycline paste. The six implants were stable and asymptomatic postoperatively. The implants were loaded after 3 months. Radiologically, the radiolucency in the apical part disappeared gradually. These prostheses have functioned satisfactorily with no further complication during the follow-up period. For cases in which small lesions initially appear soon after implant placement, trepanation and curettage of the periapical lesion without resection of the apical part of the implant or bone substitute material and/or autogenous bone grafting is an effective management option. A rapid and exact diagnosis is important for treating implant periapical lesions.

Topics: Acute Disease; Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chlorhexidine; Curettage; Dental Implant-Abutment Design; Dental Implants; Dental Prosthesis, Implant-Supported; Female; Follow-Up Studies; Humans; Male; Middle Aged; Osseointegration; Osteotomy; Periapical Diseases; Tetracycline; Therapeutic Irrigation

European guidelines for treating acute cough/lower respiratory tract infection (LRTI) aim to reduce nonevidence-based variation in prescribing, and better target and increase the use of first-line antibiotics. However, their application in primary care is unknown. We explored congruence of both antibiotic prescribing and antibiotic choice with European Respiratory Society (ERS)/European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for managing LRTI. The present study was an analysis of prospective observational data from patients presenting to primary care with acute cough/LRTI. Clinicians recorded symptoms on presentation, and their examination and management. Patients were followed up with self-complete diaries. 1,776 (52.7%) patients were prescribed antibiotics. Given patients' clinical presentation, clinicians could have justified an antibiotic prescription for 1,915 (71.2%) patients according to the ERS/ESCMID guidelines. 761 (42.8%) of those who were prescribed antibiotics received a first-choice antibiotic (i.e. tetracycline or amoxicillin). Ciprofloxacin was prescribed for 37 (2.1%) and cephalosporins for 117 (6.6%). A lack of specificity in definitions in the ERS/ESCMID guidelines could have enabled clinicians to justify a higher rate of antibiotic prescription. More studies are needed to produce specific clinical definitions and indications for treatment. First-choice antibiotics were prescribed to the minority of patients who received an antibiotic prescription.

Topics: Acute Disease; Adult; Amoxicillin; Anti-Bacterial Agents; Cephalosporins; Ciprofloxacin; Cough; Drug Resistance, Bacterial; Europe; Female; Guideline Adherence; Humans; Male; Middle Aged; Primary Health Care; Prospective Studies; Respiratory Tract Infections; Tetracycline

Over six months, 129 consecutive brucellosis cases were diagnosed in females attending the outpatients' clinics the females in Al-Azhar and Ain Shams Universities Hospitals. Their ages ranged between 12-65 years old. 113 (87.6%) gave history of raw milk consumption, 13 (10%) gave history of home slaughtering of sheep, 2 (1.5%) gave history of animal contact, and one patient gave history of abortion, that partner had brucellosis. A total of 61.2% of patients gave serum agglutination test of 1: 640, who suffered acute or subacute infection. Titers of 1:320 (38.8%) were found in the majority of chronic cases. Causes of endemic parasitosis were excluded. Symptoms were fever (79.5%), headache (72.4%), generalized arthralgia (65.3%), sweating (65.3%), chills (63.8%), backache (34.6%), abdominal pain (27.5%), loss of appetite (25.5%), lassitude (17.2%), myalgia (14.2%), monoarthralgia (7.9%). Spinal involvement was in 15% patients, who had chronic brucellosis. 32/35 were successfully treated with a combination of streptomycin and tetracycline, 17/21 with streptomycin and septrin, 38/43 with tetracycline and septrin, and 26/26 (100%) with rifampicin and tetracycline or septrin, which treated all resistant patients.

Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Anti-Bacterial Agents; Brucellosis; Child; Chronic Disease; Drug Therapy, Combination; Egypt; Female; Fever; Humans; Middle Aged; Rifampin; Risk Factors; Streptomycin; Tetracycline; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination

The upsurge of multiple-drug-resistant microbes warrants the development and/or use of effective antibiotics. Triclosan, though used in cosmetic and dermatological preparations for several decades, has not been used as a systemic antibacterial agent due to problems of drug administration. Here we report the striking efficacy of triclosan in a mouse model of acute systemic bacterial infection. Triclosan not only significantly extends the survival time of the infected mice, it also restores blood parameters and checks liver damage induced by the bacterial infection. We believe that the excellent safety track record of triclosan in topical use coupled with our findings qualifies triclosan as a candidate drug or lead compound for exploring its potential in experimental systems for treating systemic bacterial infections.

Topics: Acute Disease; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Blood Chemical Analysis; Escherichia coli Infections; Liver; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Penicillins; Tetracycline; Triclosan; Tumor Necrosis Factor-alpha

We report the first case of bullous pemphigoid complicating radiation therapy for vulvar cancer. Shortly after completion of postoperative radiation therapy for a TIN1 vulvar carcinoma, the patient presented with a rash that started within, but continued to extend, well beyond the radiation field. A biopsy of the lesions confirmed the diagnosis of bullous pemphigoid, and she had prompt clinical resolution with systemic tetracycline and steroids.

Topics: Acute Disease; Aged; Anti-Inflammatory Agents; Carcinoma, Squamous Cell; Diagnosis, Differential; Female; Humans; Pemphigoid, Bullous; Radiodermatitis; Steroids; Tetracycline; Vulvar Neoplasms

Topics: Acne Vulgaris; Acute Disease; Adolescent; Drug Therapy, Combination; Humans; Isotretinoin; Male; Prednisone; Roxithromycin; Tetracycline

Exposure of a group of horses to tetracycline-contaminated feed resulted in acute colitis and subsequent death in one horse and milder diarrhea in 3 others. The most severely affected animal demonstrated clinical and pathological findings typical of colitis X. The other herdmates responded well to administration of zinc bacitracin.

Topics: Acute Disease; Animal Feed; Animals; Anti-Bacterial Agents; Colitis; Diarrhea; Fatal Outcome; Food Contamination; Horse Diseases; Horses; Male; Tetracycline

Seventy-three cases of acute brucellosis were studied in relation to fever duration and hospital stay following different drug combinations, including gentamicin plus cotrimoxazole, rifampicin plus doxycycline, rifampicin plus cotrimoxazole, rifampicin plus tetracycline, streptomycin plus doxycycline, doxycycline plus cotrimoxazole, tetracycline plus cotrimoxazole, and tetracycline plus streptomycin. No statistical significant difference was found between these combinations regarding early clinical response in human brucellosis.

Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Bacterial Agents; Antibiotics, Antitubercular; Brucella melitensis; Brucellosis; Child; Child, Preschool; Doxycycline; Female; Gentamicins; Humans; Infant; Male; Middle Aged; Retrospective Studies; Rifampin; Streptomycin; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination

To characterize antibody response in horses with clinical signs of Ehrlichia equi infection.. Prospective study.. 13 horses with confirmed acute E equi infection.. Sequential serum sampling was performed in Connecticut and New York during 1995 and 1996 to identify horses with naturally acquired equine granulocytic ehrlichiosis (EGE). Horses with clinical signs of EGE (i.e., fever without respiratory involvement) were confirmed as having E equi infection by polymerase chain reaction detection of ehrlichial DNA and by a minimum fourfold increase in total antibody titer by indirect fluorescent antibody staining methods. Infection was corroborated by use of DNA sequencing.. 11 of 13 horses did not have detectable antibody in serum samples obtained at onset of disease. Seroconversion was evident in samples obtained 19 to 81 days thereafter. Median time to peak antibody response was 46 days after onset and median titer was 1:320. For 11 of 13 horses, antibody titers were < or = 1:40 by 215 days after onset.. E equi was found in horses in the northeastern United States and caused EGE. Concentration of antibodies to E equi increased within 19 to 81 days of disease onset and were low during early weeks of infection. Therefore, antibody detection may be of limited value for early serologic diagnosis. We suggest that disease may develop from a reinfection, and retrospective serologic studies to determine exposure to E equi may reflect a disproportionate number of negative reactions.

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Convalescence; DNA, Bacterial; Ehrlichia; Ehrlichiosis; Fluorescent Antibody Technique, Indirect; Horse Diseases; Horses; Prospective Studies; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Chlamydia Infections; Chlamydophila pneumoniae; Coronary Disease; Humans; Macrophage Activation; Potassium Channels; Roxithromycin; Tetracycline

During 1995 and 1996, 393 and 566 strains of Streptococcus pneumoniae, isolated from acute otitis media, were respectively sent to the National Reference Center for Pneumococci by its corresponding centers.. The resistance rates for 1995 and 1996 were respectively: for penicillin: 65.4 and 70.3% (18.6 and 24.9% of intermediately resistant strains, 46.8 and 45.4% of fully resistant strains), for erythromycin: 57.5 and 68.5%, for tetracycline: 43.2 and 42.6%, for trimethoprim-sulfamethoxazole: 47.5 and 50.9%. Minimal inhibitory concentrations (MICs) of various betalactams were determined against a representative sample of strains (n = 99).. Amoxicillin, cefpodoxime and cefuroxime MICs remained low against numerous penicillin resistant strains, indicating that these three oral antibiotics (in combination with clavulanate for amoxicillin) have a useful potential for the treatment of acute otitis media when risk factors for pneumococcal penicillin-resistant infections are detected.

Topics: Acute Disease; Amoxicillin; beta-Lactam Resistance; beta-Lactams; Cefpodoxime; Ceftizoxime; Cefuroxime; Erythromycin; France; Humans; Microbial Sensitivity Tests; Otitis Media; Penicillin Resistance; Penicillins; Pneumococcal Infections; Serotyping; Streptococcus pneumoniae; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Acute Disease; Azathioprine; Furosemide; Humans; Pancreatitis; Sulfonamides; Tetracycline

We report 6 cases of marine typhus presented to us within a period of 3 months. The diagnoses were made based on the Weil-Felix reaction in the context of supportive clinical and epidemiological features, and response to appropriate antimicrobial therapy. This review serves to remind us that murine typhus is still an important cause of acute febrile illness in Singapore, especially among the migrant Indian workers.

Topics: Acute Disease; Administration, Oral; Adult; Agglutination Tests; Anti-Bacterial Agents; Doxycycline; Fever; Humans; Male; Middle Aged; Singapore; Tetracycline; Typhus, Endemic Flea-Borne

Several liver diseases that are characterized by chronic steatosis lead to steatohepatitis lesions in some susceptible subjects. We tested the hypothesis that acute or chronic steatosis may lead to lipid peroxidation.. Diverse steatogenic treatments were administered to mice, and lipid peroxidation was assessed by measuring thiobarbituric acid reactants in the liver and the exhalation of ethane in breath.. Administration of ethanol (5 g/kg), tetracycline, chlortetracycline, demeclocycline (0.25 mmol/kg each), amineptine (1 mmol/kg), amiodarone (1 mmol/kg), pirprofen (2 mmol/kg), or valproate (2 mmol/kg) led to microvesicular steatosis of the liver and lipid peroxidation. After tetracycline administration, hepatic triglycerides reached a maximum at 24 h and then declined; ethane exhalation followed a similar time course. Microvesicular steatosis and lipid peroxidation were also observed after 4 days of treatment with either ethionine (0.02 mmol/kg daily) or dexamethasone (0.25 mmol/kg daily) or after 7 days of tetracycline (0.25 mmol/kg daily) administration. Administration of ethanol in the drinking water for 5.5 months led to macrovacuolar and microvesicular steatosis, lipid peroxidation, and a few necrotic hepatocytes.. We conclude that acute or chronic fat deposition due to a variety of compounds was associated with lipid peroxidation in mice. We suggest that the presence of oxidizable fat in the liver leads to peroxidation, and that chronic lipid peroxidation might represent the common (but not exclusive) mechanism for the possible development of steatohepatitis lesions in conditions characterized by chronic steatosis.

Topics: Acute Disease; Animals; Chronic Disease; Disease Progression; Ethane; Ethanol; Fatty Liver; Lipid Peroxidation; Liver; Male; Mice; Tetracycline; Triglycerides

Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Lipid Metabolism; Male; Rats; Tetracycline; Triglycerides

This article describes a complication that occurred with root-form implants: an acute periodontal abscess associated with an implant during the maintenance phase. The clinical treatment is outlined, as are the results achieved.

Topics: Acute Disease; Aged; Cuspid; Dental Implants; Foreign Bodies; Humans; Male; Periodontal Abscess; Prosthesis-Related Infections; Tetracycline

The effect of ulcer healing with eradication of Helicobacter pylori (H pylori) on gastric function was investigated in nine patients with duodenal ulcer disease. One month after eradication there were significant reductions in both basal plasma gastrin concentration, from a median (range) of 19 (1-22) to 6 (2-15) pmol/l (p < 0.05), and of basal acid secretion from 8.3 (2.4-24) to 2.6 (1.4-8.1) mM H+/h, (p < 0.01). The peak acid secretion rate was unchanged from 37 (16-59) to 37 (21-59) mM H+/h. After treatment there was no change in the parietal cell sensitivity to stepped infusions of gastrin heptadecapeptide: the median concentration of gastrin required for 50% of maximal acid secretion (EC50) was 41 (14.8-126) before and 33 (23-125) pmol/l after eradication of H pylori. The metabolic clearance rate of gastrin was also unaffected by the eradication of H pylori. Thus eradication of H pylori infection from patients with active duodenal ulcers is accompanied by falls in both basal gastrin release and basal acid secretion without a change in the parietal cell sensitivity to gastrin. Cyclical changes in H pylori infection may cause the variations in basal acid secretion that are seen in duodenal ulcer disease.

Topics: Acute Disease; Adult; Aged; Bismuth; Drug Therapy, Combination; Duodenal Ulcer; Gastric Acid; Gastrins; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metronidazole; Middle Aged; Organometallic Compounds; Parietal Cells, Gastric; Tetracycline

Fatty tetracycline-induced steatosis is shown to reduce levels of mitochondrial and microsomal cytochromes. A decrease of microsomal cytochromes in the liver of hypoxia-resistant animals was similar to that of hypoxia-sensitive ones. This decrease was different for hypoxia-resistant and hypoxia-sensitive animals: for the former only cytochrome a declined, in the latter case cytochromes c+, c1 and a.

Topics: Acute Disease; Animals; Cytochromes; Fatty Liver; Hypoxia; Male; Microsomes, Liver; Mitochondria, Liver; Rats; Tetracycline

Chlamydia pneumoniae is emerging as a significant cause of respiratory disease, including pneumonia and bronchitis, in humans. In this recently completed study of infection due to C. pneumoniae in patients presenting with pneumonia to SUNY Health Science Center at Brooklyn, we identified two individuals for whom cultures were positive on multiple occasions over a 1-year period. To determine the frequency of persistent respiratory infection with C. pneumoniae, follow-up specimens were obtained from nine individuals with culture-documented C. pneumoniae infection. Five of these individuals had persistent infection: four had a flulike illness characterized by pharyngitis, and one had bronchitis with prominent bronchospasm. All five individuals appeared to have acute C. pneumoniae infection as determined by results of serologic tests (titers of IgM antibody for all individuals were greater than or equal to 1:16). For three patients, cultures remained positive for 11 months despite therapy with 10- to 21-day courses of tetracycline or doxycycline. These observations suggest that persistent infection with C. pneumoniae may follow acute infection and may persist for many months. Infection with C. pneumoniae may be very difficult to eradicate with use of currently available antibiotics even if there is a clinical response to therapy.

Topics: Acute Disease; Adolescent; Adult; Child; Child, Preschool; Chlamydia Infections; Chlamydophila pneumoniae; Chronic Disease; Doxycycline; Female; Follow-Up Studies; Humans; Infant; Male; Middle Aged; Pneumonia; Tetracycline

An occasional patient presents the classical symptoms of a disease that has become uncommon. Typhus is an example of such a disease, since it is now well contained through control of its rodent reservoir. It is readily treated with tetracycline or one of its long-acting analogues, doxycycline or minocycline. Because typhus is infrequently encountered, the physician may not initially include it in his differential diagnosis. Our case serves as a remainder that with the increasingly frequent movement of persons from one geographic area to another, the uncommon rickettsial infection, murine typhus, should continue to be in the differential of a febrile patient. Furthermore, our case underscores the importance of including typhus in the differential of typhoid fever.

Topics: Acute Disease; Adult; Doxycycline; Female; Humans; Tetracycline; Typhus, Endemic Flea-Borne

A study was performed on 321 patients with paratrachoma: acute follicular conjunctivitis-189, subacute-132. The first group of patients (108) received 1% Tetracycline ointment 4 to 5 times daily, the second group (103 patients)-1% Tetracycline ointment + 0.1% Dexamethasone eye drops, the third group (110 patients)-Eubetal ointment (tetracycline 0.5%, betamethasone 0.1%, chloramphenicol 1%, colistin). Therapeutic efficacy was higher in groups were antibiotics combined with corticosteroids. Cured in 4 weeks in group I-46.3%, in group II-72.8%, in group III-71.8%, cured in 6 weeks-75.9%, 88.3% and 86.4% respectively.

Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Betamethasone; Chlamydia Infections; Chloramphenicol; Colistin; Conjunctivitis, Inclusion; Dexamethasone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Ointments; Ophthalmic Solutions; Tetracycline; Treatment Outcome; Urethritis; Uterine Cervicitis

54 patients presented by history, physical examination and laboratory tests with suspected pelvic inflammatory disease (PID). The use of laparoscopy as a diagnostic tool proved in 13 cases (24%) that the presumptive diagnosis was incorrect. Bacteriological studies revealed chlamydial infection in 21 of 41 cases, in 6 cases only at laparoscopy in the pelvic cavity, gonococcal in 9 of 41 cases; mycoplasmas were identified in 15 cases, being the only pathogen in 7. In 9 cases, no recognized pathogens were isolated. Polymicrobism was frequent. Follow-up studies identified 5 cases of treatment failure; 2 of Gonococcus and 3 of Chlamydia, and detected 3 cases of Chlamydia which had not been identified initially. We discuss the use of laparoscopy in the diagnosis and for follow-up and treatment of PIDs.

Topics: Acute Disease; Adult; Ampicillin; Chlamydia Infections; Drug Therapy, Combination; Female; Gonorrhea; Humans; Laparoscopy; Metronidazole; Mycoplasma Infections; Netilmicin; Pelvic Inflammatory Disease; Penicillin G Procaine; Tetracycline; Tobramycin

Topics: Acute Disease; Adolescent; Anti-Infective Agents; Bacteria; Bacterial Infections; Chloramphenicol; Diarrhea; Feces; Female; Humans; Male; Norfloxacin; Quinolones; Randomized Controlled Trials as Topic; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Acute Disease; Chlamydophila psittaci; Diagnosis, Differential; Humans; Male; Middle Aged; Pneumonia; Psittacosis; Radiography; Tetracycline

Topics: Acute Disease; Adult; Dipyrone; Female; Humans; Middle Aged; Stevens-Johnson Syndrome; Tetracycline; Vitamin B Complex

41 cases of acute salpingitis were treated: either with the combination Augmentin + Tetracycline (A + T) including 21 severe cases treated intravenously for 4 days, then per os and 10 moderate cases treated per os from the beginning-or by Augmentin alone (A) per os for 10 other moderate cases. An accurate bacteriological diagnosis was made before treatment and, in case of failure, most often by celioscopy. A Chlamydia serology was performed. Patients were seen again after 8 days (41 cases), one month (39 cases) and several months (32 cases).. A Chlamydia infection was found responsible, by culture or serology, in one out of 2 cases; only one germ was found in 14 cases, 2 germs in 21 cases and none in 7 cases. The association A + T was effective in all moderate cases at 8 and 30 days; in severe forms, there was a failure at 8 days and 4 others at 30 days or 17%. Augmentin alone per os caused 5 failures out of 10 cases at 8 days. No new failure was observed after several months in cases cured at 30 days. The association A + T may be recommended as very effective in moderate forms of acute salpingitis.

Topics: Acute Disease; Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Clavulanic Acids; Drug Therapy, Combination; Female; Humans; Salpingitis; Tetracycline

We report on clinical and laboratory findings of 28 patients with tick-bite Borrelia burgdorferi-infection. In 5 cases chronic tertiary metaluetic manifestations were recognized. All were treated either with high-dose penicillin intravenously or tetracycline. Results of treatment and recommendations are given.

Topics: Acute Disease; Adult; Aged; Animals; Bites and Stings; Borrelia Infections; Chronic Disease; Female; Humans; Male; Middle Aged; Nervous System Diseases; Penicillin G; Tetracycline; Ticks

A 21-year-old man developed acute pancreatitis on two separate occasions after a short-term course (less than 10 days) of tetracycline in the presence of normal liver and renal function. Although tetracycline is frequently listed as a cause of pancreatitis, this is only the second documented case of tetracycline-induced pancreatitis in an otherwise healthy person. We review the pertinent literature.

Topics: Acute Disease; Adult; Humans; Male; Pancreatitis; Tetracycline; Urethritis

A conjugative R-plasmid PE004, Inc F11, conferring resistance to ampicillin, tetracycline, streptomycin, kanamycin and trimethoprim was obtained from an E. coli serotype 026 isolate from the stool of a child with acute diarrhoea. The R-plasmid PE004 also co-transfers an enteropathogenicity antigen without the production of enterotoxins or manifestation of invasiveness. It is not yet known whether this transferable antigen mediates enterocyte damage with consequent diarrhoea. The R-plasmid was of molecular weight 2.4 megadaltons (3.7 kilobase) with a transfer frequency of 6 x 10(-4) cfu/ml E. coli J53-1. The uncontrolled mediation with antibiotics in cases of acute diarrhoea could select gut bacteria not only possessing R-plasmids conferring resistance to several antibiotics but with associated undesirable extrachromosomal genes.

Topics: Acute Disease; Ampicillin; Child; Diarrhea; DNA, Bacterial; Escherichia coli; Escherichia coli Infections; Feces; Genes, Bacterial; Humans; Kanamycin; R Factors; Streptomycin; Tetracycline; Trimethoprim

93 publications concerning drug-induced pancreatitis are reviewed. A confirmed causal relationship between drug and acute pancreatitis so far exists only for 8 compounds: azathioprine, chlorothiazide, furosemide, sulfonamides, tetracycline, estrogens, valproic acid and L-asparaginase. There is less convincing, but still suggestive, evidence for a causal relationship with 5 other drugs, namely: corticosteroids, chlorthalidone, ethacrynic acid, phenformin and iatrogenic hypercalcemia. Due to inadequate or contradictory evidence, the link between a number of additional drugs and acute pancreatitis is considered possible, conditional or doubtful. Finally, the scant literature concerning the pathogenesis and histological lesions of drug-induced pancreatitis is briefly reviewed.

Topics: Acute Disease; Asparaginase; Azathioprine; Chlorothiazide; Drug-Related Side Effects and Adverse Reactions; Estrogens; Furosemide; Humans; Pancreatitis; Sulfonamides; Tetracycline; Valproic Acid

A 60-year-old man had pyogenic meningitis due to Francisella tularensis acquired by tick bite. His disease initially improved but later relapsed after a standard course of streptomycin. Complete resolution resulted from prolonged combined therapy with streptomycin and tetracycline. Successful treatment of acute tularemic meningitis has not previously been reported. Our experience suggests that therapy should include agents that reliably penetrate the CSF, that is, tetracycline or chloramphenicol, for optimal treatment of this rare form of tularemia.

Topics: Acute Disease; Chloramphenicol; Drug Therapy, Combination; Humans; Male; Meningitis; Middle Aged; Streptomycin; Tetracycline; Tularemia

Topics: Acute Disease; Adolescent; Adult; Aged; Diverticulitis; Emergencies; Female; Humans; Intraoperative Period; Male; Middle Aged; Peritonitis; Tetracycline; Therapeutic Irrigation

Topics: Acute Disease; Aminoglycosides; Anti-Bacterial Agents; Bacteriuria; Cystitis; Drug Combinations; Female; Fetus; Folic Acid; Humans; Male; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications, Infectious; Pyelonephritis; Recurrence; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections

Topics: Acute Disease; Adenylyl Cyclases; Adolescent; Adult; Cyclic AMP; Cyclic GMP; Dysentery, Bacillary; Furazolidone; Guanylate Cyclase; Humans; Middle Aged; Tetracycline

The assumption that tetracycline HCl can cause acute pancreatitis has been accepted since reports began to appear implicating it as a cause of fatty liver in pregnancy with associated pancreatitis. It is listed as an etiologic factor for acute pancreatitis in reference articles and standard medical textbooks without good documentation of this association in the absence of fatty liver. This report describes a documented case of tetracycline HCl-induced acute pancreatitis without associated overt liver disease.

Topics: Acne Vulgaris; Acute Disease; Adolescent; Female; Humans; Pancreatitis; Tetracycline

Thirty-eight cases of suspected yersinia arthritis occurring in southern Sweden in 1975-6 were reviewed four to five years later. In 31 cases the diagnosis was confirmed. At follow-up three of the patients had definite ankylosing spondylitis, three radiologically confirmed sacroiliitis, three extensor tenosynovitis, five isolated articular joint disease, and 10 localised arthralgias; one patient had developed seropositive rheumatoid arthritis. Only six of the 31 patients were free of joint symptoms. These results suggest that although the acute symptoms of yersinia arthritis disappear within 12 months, the long-term prognosis may be less favourable than previously thought.

Topics: Acute Disease; Adult; Aged; Arthritis, Infectious; Female; Follow-Up Studies; Humans; Joint Diseases; Male; Middle Aged; Prognosis; Tetracycline; Yersinia Infections

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Brucella abortus; Brucellosis; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Streptomycin; Tetracycline

Topics: Acute Disease; Carrier State; Chloramphenicol; Chronic Disease; Culture Media; Dysentery, Bacillary; Feces; Humans; Shigella; Tetracycline; Tetracyclines

The time-course of tetraolean concentrations (according to tetracycline) in the lymph, blood and urine of 10 patients with various complicated acute inflammatory diseases of the organs of the abdominal cavity was studied. It was found that tetraolean used intramuscularly in the early postoperative periods was well absorbed into the lymph, reached its maximum level within 2 hours and exceeded that in the blood. During the following 8 hours the concentration of the drug in the lymph decreased but still remained much higher than that in the blood. Lymph sorption lowered the antibiotic lymph level to 30 per cent, which indicated the necessity of an adequate increase in the drug dose.

Topics: Acute Disease; Adsorption; Adult; Drug Combinations; Female; Humans; Kinetics; Lymph; Middle Aged; Oleandomycin; Peritonitis; Tetracycline

Two cases of acute vulvar ulcer of Lipschuetz are reported. The present state of knowledge as to the etiology, signs and symptoms, clinical course and treatment of this rare and frequently misdiagnosed entity are discussed.

Topics: Acute Disease; Adolescent; Ampicillin; Female; Humans; Tetracycline; Ulcer; Vulvar Diseases

Topics: Acute Disease; Adolescent; Adult; Brucellosis; Endocarditis, Bacterial; Female; Fever of Unknown Origin; Humans; Lung Diseases; Male; Middle Aged; Spinal Diseases; Streptomycin; Tetracycline

Since 1967, 2480 appendectomies have been performed at the St. Lucas Hospital (Amsterdam) and the St. Annadal Hospital (Maastricht), of which 250 were for perforated appendicitis. A so-called 'combined method' of treatment was used in all these cases: during the operation saline was used to lavage the peritoneal cavity with the patients in the reverse-Trendelenburg position. Antibiotics were left in the peritoneal cavity. No intraperitoneal drainage was performed, but the wound was drained for 5 days. Postoperative treatment consisted of nasogastric suction and parenteral antibiotics for 5 days in combination with anticoagulation. With thus combined approach one death was seen in 250 cases. There were 20 cases of wound infection (8%), 7 pelvic abscesses (2.8%), and 2 retroperitoneal abscesses. No thromboembolic complications were seen because of the use of routine anticoagulation. For 191 patients (77%), total hospitalization was less than 14 days. This method of treatment is compared with recent reports in literature.

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendicitis; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Penicillins; Peritoneal Cavity; Postoperative Period; Tetracycline; Therapeutic Irrigation

Topics: Acute Disease; Amoxicillin; Appendicitis; Escherichia coli; Female; Humans; Male; Sudan; Tetracycline

Acute cholecystitis is a rare complication of systemic brucellosis. This report details the occurrence of acute noncalculous cholecystitis in which Brucella suis was cultured from both the blood and the gallbladder. A discussion of the various diagnostic tests and the recommended therapy for brucellosis is included.

Topics: Acute Disease; Adult; Brucella; Brucellosis; Cholecystitis; Gallbladder; Humans; Male; Tetracycline

Topics: Acute Disease; Adult; Amoxicillin; Ampicillin; Child; Drug Administration Schedule; Epididymitis; Female; Gonorrhea; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Ophthalmia Neonatorum; Penicillin G Procaine; Pregnancy; Pregnancy Complications, Infectious; Probenecid; Salpingitis; Tetracycline

Topics: Acute Disease; Adolescent; Ampicillin; Child; Child, Preschool; Dysentery, Bacillary; Female; Guanidines; Humans; Infant; Male; Sulfaguanidine; Tetracycline

Drug hepatitis emphasized the importance of a careful history including the question to the use of laxatives in all patients with both acute and chronic hepatitis. From predictable and unpredictable hepatotoxicity we should learn to be alert to the possibility of new and unrecorded hepatic lesions resulting from drugs and other chemical or environmental toxins.

Topics: Acetaminophen; Acute Disease; Amanita; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Methane; Methyldopa; Mushroom Poisoning; Oxyphenisatin Acetate; Tetracycline

To evaluate guidelines for outpatient treatment of acute pelvic inflammatory disease recommended by the Center for Disease Control we studied 197 afflicted women. The women were treated either with tetracycline or with procaine penicillin and ampicillin, and 92% were subsequently seen at least once to assess efficacy of clinical and microbiologic treatment. Neisseria gonorrhoeae was isolated from the lower genital tract in 68% of these women, and although they had a quicker symptomatic response than those with nongonococcal infection (P less than 0.01), the two regimens were equally effective in producing clinical cure. However, subsequent identification of a pelvic abscess was 10 times more common in women from whom N. gonorrhoeae was not isolated. Therapy for pelvic inflammatory disease must be empirical since it is impossible to distinguish clinically between gonococcal and nongonococcal infection, and our data indicate that both regimens recommended by the Center for Disease Control are effective.

Topics: Acute Disease; Adult; Ampicillin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Injections, Intramuscular; Neisseria gonorrhoeae; Pelvic Inflammatory Disease; Penicillin G Procaine; Probenecid; Tetracycline

Topics: Acute Disease; Anti-Infective Agents; Dysentery, Bacillary; Female; Furazolidone; Humans; Hydroxyquinolines; Male; Oxyquinoline; Tetracycline

5 young male patients with all the symptoms and signs of genito-urinary tuberculosis but in whom no organism could be cultured from the urine are described. 4 of them rapidly responded to a course of tetracycline. Various organisms are suggested as a cause of this condition, and careful bacteriological investigation in the future might discover the cause.

Topics: Acute Disease; Adolescent; Adult; Cystitis; Humans; Male; Tetracycline

Topics: Acute Disease; Erythromycin; Humans; Methacycline; Penicillins; Pneumonia; Streptomycin; Tetracycline

The accuracy of the scintigraphic diagnosis of acute myocardial infarction with 99mTc-pyrophosphate, 99mTc-tetracycline and 99mTc-glucoheptonate was assessed in 63 patients, 43 of whom had clinical evidence of acute myocardial infarction. In 15, studies with both 99mTc-tetracycline and 99mTc-pyrophosphate were performed. Accuracy was greatest with 99mTc-pyrophosphate (17/17 true positives, 8/10 true negatives) contrasted with 99mTc-tetracycline (12/25 true positives, 6/11 true negatives) and 99mTc-glucoheptonate (3/13 true positives, 2/2 true negatives). 99mTc-pyrophosphate was the most sensitive tracer for the detection of acute myocardial infarction. The diagnostic accuracy with 99mTc-glucoheptonate was poor.

Topics: Acute Disease; Diagnostic Errors; Diphosphates; Evaluation Studies as Topic; Heptoses; Humans; Myocardial Infarction; Radioisotopes; Radionuclide Imaging; Sugar Acids; Technetium; Tetracycline

The feasibility of acute infarct scintigraphy for the clinical evaluation of patients with known or suspected acute myocardial infarction is established. Further development of this methodologic approach may result in even better agents for the visualization of infarcts. Radiotracers with high affinity for the infarct, rapid blood clearance, and low concentrations in surrounding organs, such as liver and bone, would be more suitable than available radiopharmaceuticals for acute myocardial infarct scintigraphy. Ultimately, labeling these tracers and ultra-short-lived radionuclides will enable rapid sequential imaging to assess changes in the extent of infarction and to determine the efficacy of therapies aimed at limiting infarct size.

Topics: Acute Disease; Diphosphates; Humans; Mercury Radioisotopes; Myocardial Infarction; Myocardium; Radionuclide Imaging; Technetium; Tetracycline; Time Factors

Bonnamycin which is a new tetracycline group antibiotic isolated from a variant strain of Streptomyces rimosus and is identified chemically as doxycycline was investigated, comparing with tetracycline. The results are as follows: (1) In in vitro studies of anti-bacterial spectrum, doxycycline is widely effective against standard strains kept in our department. (2) The distribution of susceptibility of 75 Staphylococci, 62 Salmonella and 64 Shigella strains isolated from clinical materials was similar to that of tetracycline. (3) As to the therapeutic experiment in acute infection of Klebsiella pneumoniae in mice, the drugs were equally effective and the ED50 was both 70.8 mcg. (4) Doxycycline administrated orally or subcutaneously in rats was distributed in kidneys, livers, lungs and spleens at relatively high concentration among organs.

Topics: Acute Disease; Animals; Bacteria; Doxycycline; Drug Resistance, Microbial; Klebsiella Infections; Mice; Mice, Inbred Strains; Rats; Salmonella; Shigella; Staphylococcus; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Brucellosis; Chronic Disease; Doxycycline; Drug Combinations; Gentamicins; Humans; Streptomycin; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Acute Disease; Adolescent; Adult; Drug Combinations; Gonorrhea; Humans; Male; Oleandomycin; Sex Factors; Tetracycline

Topics: Acute Disease; Asia, Western; Blindness; Conjunctivitis; Diptera; Disease Models, Animal; Doxycycline; Endophthalmitis; Eyelid Diseases; Humans; Insect Control; Tetracycline; Trachoma

Good therapeutic results free of unwanted side-effects were observed in the management of acute and chronic non-tubercular bronchopneumopathies with an association of tetracyclin hydrochloride, proteolytic enzymes (trypsin and chymotrypsin), vanillic acid diethylamide and pyridophyllin.

Topics: Acute Disease; Adolescent; Adult; Aged; Bronchitis; Bronchopneumonia; Chronic Disease; Chymotrypsin; Drug Combinations; Drug Evaluation; Female; Humans; Lung Abscess; Lung Diseases; Male; Middle Aged; Tetracycline; Trypsin

During a three-year-period, 1971-73 inclusive, haemophili isolated from 96 children with severe infections, of whom 73 had meningitis and 19 acute epiglottitis, were serotyped and tested for sensitivity to antibacterial drugs. All strains were identified as Haemophilus influezae type b, and were sensitive to ampicillin, chloramphenicol, and trimethoprim. However, 3 isolates--from a boy aged 11 months and a girl aged 1 year with meningitis, and a girl aged 2 years with epiglottitis--were highly resistant to tetracycline, with a median minimal inhibitory concentration of 50 mug tetracycline hydrochloride per ml (resistance ratio greater than or equal to 50). Resistance was also demonstrated to doxycycline, oxytetracycline, and rolitetracycline and, in one strain, to minocycline. No evidence was obtained that the resistant organisms were capable of inactivating tetracyclines.

Topics: Acute Disease; Anti-Bacterial Agents; Child, Preschool; Drug Resistance, Microbial; Epiglottis; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Laryngeal Diseases; Male; Meningitis, Haemophilus; Microbial Sensitivity Tests; Serotyping; Tetracycline

Appropriate drugs and their proper use are described for the care of adult and pediatric patients with uncomplicated and complicated gonococcal infections in men and women. Special diagnostic considerations in some cases are indicated. These recommendations were established by the Venereal Disease Control Advisory Committee after deliberation with therapy consultants.

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Child; Female; Gonorrhea; Humans; Infant, Newborn; Male; Penicillin G; Pharyngeal Diseases; Pregnancy; Pregnancy Complications, Infectious; Probenecid; Salpingitis; Spectinomycin; Syphilis Serodiagnosis; Tetracycline; Urethra

Topics: Acute Disease; Ampicillin; Coitus; Female; Gonorrhea; Humans; Male; Penicillin G Procaine; Pharyngeal Diseases; Pregnancy; Pregnancy Complications, Infectious; Probenecid; Salpingitis; Spectinomycin; Syphilis Serodiagnosis; Tetracycline

Sensitivity of Shigella, pathogenic Escherichia, Proteus and Staphylococcus isolated from children with acute intestinal diseases was studied with respect to antibiotics widely used in medical practice: streptomycin, levomycetin, tetracycline, chlortetracycline, oxytetracycline and neomycin. The antibiotic sensitivity was determined with the method of indicator discs. It was found that sensitivity of shigella was: 44 percent to streptomycin, 69.5 per cent to levomycetin, 18.5 per cent to tetracycline, 18.5 per cent to chlortetracycline, 23 per cent to oxytetracycline and 94 per cent to neomycin. Sensitivity of pathogenic Eschericia was 28, 33, 14, 14, 25 and 74 per cent, sensitivity of staphylococci was 46, 56.5, 21, 21, 31.5 and 89.5 per cent, sensitivity of Proteus was 15, 31.5, 3.5, 3.5, 7.5 and 52.5 per cent respectively. Cross resistance with respect to tetracyclines was found in all the microbes studie. Intragenera differences in the antibiotic sensitivity were observed among Shigella and pathogenic Escherichia.

Topics: Acute Disease; Anti-Bacterial Agents; Child; Chloramphenicol; Chlortetracycline; Drug Resistance, Microbial; Escherichia; Georgia (Republic); Humans; Intestinal Diseases; Microbial Sensitivity Tests; Neomycin; Oxytetracycline; Proteus; Shigella; Species Specificity; Staphylococcus; Streptomycin; Tetracycline

The analysis of the efficacy of various methods of antibacterial therapy in 1382 patients with obliterated, light and moderately severe forms of dysentery as compared to the patients subjected only to patholgenic therapy showed that broad spectrum antibiotics lost their role in treatment of such patients. Furazolidon proved to be one of the most active drugs. The authors suppose that treatment of patients with obliterated forms of dysentery with antibacterial drugs is not obligatory and is indicated only in cases with repeated isolation of the causative agent.

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Chloramphenicol; Clioquinol; Drug Evaluation; Drug Therapy, Combination; Dysentery, Bacillary; Female; Furazolidone; Humans; Male; Middle Aged; Sulfathiazoles; Tetracycline; Time Factors

The therapeutic potencies of colistin methanesulfonate (CLM) was assessed quantitatively in acute infection of mice with clinically isolated strains of Escherichia coli and Pseudomonas aeruginosa, and effect of different routes of administration was compared. There was no detectable difference in the therapeutic effect of CLM when intramuscular (im) or intravenous (iv) administration was initiated one hour after the infection. On the other hand, a significant difference in ED50 given by im and iv administrations was observed, indicating the superiority of iv administration, when the treatment started 4 to approximately hours after the infection. No difference in the therapeutic effect of polymyxin B (PMB) and tetracycline (TC) administered via either im or iv route was found even in the delayed administration. In contrast to PMB and TC, lower toxicity of CLM was determined when it was administered iv rather than im.

Topics: Acute Disease; Animals; Bacterial Infections; Colistin; Escherichia coli; Escherichia coli Infections; Female; Injections, Intramuscular; Injections, Intravenous; Male; Mesylates; Mice; Polymyxins; Pseudomonas aeruginosa; Pseudomonas Infections; Tetracycline

Topics: Acute Disease; Aminophylline; Anti-Bacterial Agents; Blood Coagulation; Body Temperature; Chronic Disease; Erythromycin; Furosemide; Heparin; Humans; Nikethamide; Nystatin; Oleandomycin; Penicillins; Peptide Hydrolases; Physical Therapy Modalities; Plasma Substitutes; Pneumonia; Pneumonia, Staphylococcal; Streptomycin; Strophanthins; Sulfadimethoxine; Sulfanilamides; Tetracycline; Vitamins

Blood flow to the femoral head was assessed by 18F positron scintigraphy and tetracycline fluorescent labeling in 17 patients undergoing replacement of the femoral head with an endoprosthesis. Radioactivity was absent in the femoral head of 10 patients, normal in 5, and increased in 2. Normal or increased radioactivity indicated presence of blood flow to the femoral head; decreased or absent radioactivity indicated absence of blood flow. Results of 18F scintigraphy correlated with those of tetracycline labeling.

Topics: Acute Disease; Adolescent; Adult; Aged; Arthritis; Female; Femoral Neck Fractures; Femur Head; Fluorine; Humans; Male; Middle Aged; Prostheses and Implants; Radioisotopes; Radionuclide Imaging; Regional Blood Flow; Tetracycline

Topics: Acute Disease; Adult; Animals; Bacterial Infections; Clindamycin; Humans; Male; Rabbits; Sinusitis; Staphylococcal Infections; Tetracycline

The relative concentration of 99mTc(Sn)-tetracycline in infarcted myocardium was determined as a function of time after coronary artery occlusion in mongrel dogs. The concentration ratio (infarct-to-normal myocardium) was highest within the first 2 days after occlusion (6.7 +/- 0.5 at 1 day and 8.0 +/- 1.6 at 2 days). By 1 week after occlusion the ratio had fallen to 1.9 +/- 0.2. In the region of infarction, the concentration of 99mTc(Sn)-tetracycline was homogeneously distributed across the inner three-quraters of the myocardial wall; the outer quarter of the wall had substantially lower concentrations during the first 5 days after infarction. The present study confirms the observation suggested in initial investigations in man that scintigraphy performed with 99mTc(Sn)-tetracycline will distinguish between acute and chronic myocardial infarctions.

Topics: Acute Disease; Animals; Chronic Disease; Dogs; Myocardial Infarction; Radionuclide Imaging; Technetium; Tetracycline; Time Factors; Tin

Analysis of 302 side effects of antibiotic theraphy is presented. The side effects were studied comparatively as dependent on the antibiotic group. Dependence of the toxic and toxicoallergic reactions to the antibiotics on the antibiotic blood levels were noted. Previous sensitization resulted in more frequent and earlier side effects. The analysis and clinical observations showed that antibiotic therapy should take into account the results of the laboratory tests, i.e. examination of the kidney functional state, antibiotic levels in the blood and urine, tolerance of the drug by the patient.

Topics: Acute Disease; Adolescent; Adult; Aged; Aminoglycosides; Anaphylaxis; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Erythromycin; Female; Humans; Hypersensitivity, Delayed; Kidney; Leukocytes; Male; Middle Aged; Myocarditis; Oleandomycin; Penicillins; Skin; Streptomycin; Tetracycline; Urinary Tract

Topics: Acute Disease; Anti-Bacterial Agents; gamma-Globulins; Humans; Influenza, Human; Pneumonia, Viral; Tetracycline

Topics: Acute Disease; Administration, Oral; Ampicillin; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillins; Tetracycline; Urethritis; Valerates

Of 53 patients with acute uncomplicated gonorrhea treated with amoxicillin 2 g and probenecid 1 g orally as a single administration, six failed to return for follow-up examination, 10 developed postgonococcal urethritis and one was a treatment failure. The remainder achieved symptomatic cure in an average of 2.3 days. Adverse drug effects were infrequent, mild and transient. We conclude that this dose of amoxicillin and probenecid is a safe and effective treatment regimen.

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Amines; Drug Evaluation; Female; Follow-Up Studies; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Penicillins; Probenecid; Tetracycline; Urethritis

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Clioquinol; Enterococcus faecalis; Erythromycin; Erythromycin Ethylsuccinate; Escherichia coli; Feces; Furazolidone; Gastroenteritis; Humans; Methicillin; Nalidixic Acid; Neomycin; Oleandomycin; Oxytetracycline; Penicillin G; Phenanthrenes; Polymyxins; Proteus; Staphylococcus; Streptomycin; Tetracycline; Tetracyclines

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Alcoholism; Clindamycin; Fever; Hemoglobins; Heroin Dependence; Humans; Injections, Intramuscular; Injections, Intravenous; Length of Stay; Leukocyte Count; Lung Abscess; Male; Middle Aged; Penicillin G; Radiography; Seizures; Tetracycline; Time Factors

Topics: Acute Disease; Adult; Aged; Diagnostic Errors; Female; Gastrointestinal Diseases; Humans; India; Male; Middle Aged; Moscow; Pakistan; Salmonella; Senegal; Somalia; Tetracycline; Vibrio; Vibrio Infections

Topics: Acute Disease; Adult; Aminophylline; Anti-Infective Agents; Body Temperature; Camphor; Ephedrine; Erythromycin; Female; Humans; Male; Middle Aged; Nikethamide; Oleandomycin; Penicillins; Pneumonia; Sputum; Streptomycin; Sulfanilamides; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Bone Diseases; Clindamycin; Drug Therapy, Combination; Humans; Lincomycin; Moscow; Orthopedics; Penicillin G; Penicillin Resistance; Penicillins; Postoperative Complications; Pseudomonas Infections; Staphylococcal Infections; Streptomycin; Tetracycline; Wound Infection; Wounds and Injuries

Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Carrier State; Chloramphenicol; Drug Resistance, Microbial; Dysentery, Bacillary; Erythromycin Ethylsuccinate; Extrachromosomal Inheritance; Feces; Female; Furazolidone; Humans; Male; Mathematics; Middle Aged; Shigella flexneri; Shigella sonnei; Streptomycin; Sulfanilamides; Tetracycline; Time Factors

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Chronic Disease; Colitis; Dysentery; Enteritis; Erythromycin Ethylsuccinate; Escherichia coli Infections; Feces; Humans; Infant; Lactobacillaceae; Mice; Salmonella Infections; Seasons; Staphylococcal Infections; Tetracycline

Topics: Acute Disease; Adult; Amylases; Electrocardiography; Ethanol; Female; Heart Diseases; Humans; Hypertension; Infusions, Parenteral; Male; Meperidine; Middle Aged; Pancreatitis; Prospective Studies; Tetracycline; Vision Disorders

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Appendectomy; Appendicitis; Humans; Surgical Wound Infection; Tetracycline

Topics: Acute Disease; Appendectomy; Appendicitis; Humans; Postoperative Care; Surgical Wound Infection; Tetracycline

Topics: Acne Vulgaris; Acute Disease; Adolescent; Ampicillin; Anemia; Anti-Bacterial Agents; Cephalosporins; Erythromycin; Female; Fever; Follow-Up Studies; Humans; Joint Diseases; Leukemoid Reaction; Male; Nephritis; Prednisolone; Skin Diseases; Syndrome; Tetracycline; Triamcinolone

Topics: Acute Disease; Ampicillin; Appendectomy; Appendicitis; Cross Infection; Humans; Povidone; Povidone-Iodine; Surgical Wound Infection; Tetracycline

Topics: Acute Disease; Adult; Aged; Child; gamma-Globulins; Humans; Influenza Vaccines; Influenza, Human; Orthomyxoviridae Infections; Respiratory Tract Infections; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Acute Disease; Age Factors; Ampicillin; Anti-Bacterial Agents; Child, Preschool; Chloramphenicol; Colistin; Erythromycin; Haemophilus; Haemophilus Infections; Humans; Infant; Infant, Newborn; Microbial Sensitivity Tests; Otitis Media; Penicillins; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus; Streptococcal Infections; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline

Topics: Acute Disease; Airway Resistance; Anti-Bacterial Agents; Bronchitis; Chronic Disease; Humans; Long-Term Care; Pulmonary Diffusing Capacity; Tetracycline

Topics: Abscess; Acute Disease; Adolescent; Chronic Disease; Enterobacteriaceae Infections; Granuloma; Humans; Knee; Male; Methylamines; Serratia marcescens; Skin Diseases, Infectious; Suppuration; Tetracycline

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Doxycycline; Gonorrhea; Humans; Penicillins; Probenecid; Syphilis; Tetracycline

Topics: Acute Disease; Adult; Fever; Humans; Lung; Male; Mycoplasma Infections; Pain; Penicillin G; Pleural Effusion; Pleuropneumonia; Radiography; Tetracycline; Transients and Migrants

Topics: Acute Disease; Aged; Furosemide; Heart Failure; Humans; Lanatosides; Male; Morphine; Oxygen Inhalation Therapy; Pulmonary Edema; Reserpine; Tetracycline

Topics: Acute Disease; Aged; Bacterial Infections; Bronchitis; Bronchopneumonia; Female; Humans; Lung Diseases; Male; Middle Aged; Minocycline; Respiratory Tract Infections; Tetracycline

Topics: Acute Disease; Adult; Age Factors; Antifungal Agents; Female; Humans; Male; Tetracycline; Urethritis

Topics: Acute Disease; Adolescent; Child; Child, Preschool; Dexamethasone; Dyspnea; Erythromycin; Humans; Klebsiella pneumoniae; Male; Penicillins; Respiratory Tract Infections; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Tetracycline; Tracheotomy

Topics: Acute Disease; Adolescent; Adult; Age Factors; Bacteria; Child; Corynebacterium; Enterobacteriaceae; Escherichia coli; Exudates and Transudates; Haemophilus influenzae; Humans; Maxillary Sinus; Middle Aged; Neisseria; Penicillin Resistance; Penicillins; Proteus; Seasons; Sinusitis; Staphylococcus; Streptococcus; Streptococcus pneumoniae; Tetracycline

Topics: Abscess; Acute Disease; Bacteria; Cellulitis; Chloramphenicol; Erythromycin; Humans; Mouth Diseases; Osteomyelitis; Penicillin Resistance; Penicillins; Seasons; Staphylococcus; Streptomycin; Suppuration; Tetracycline; Tooth Diseases

Topics: Acute Disease; Acute Kidney Injury; Adult; Chronic Disease; Creatinine; Diet Therapy; Dietary Proteins; Female; Fever; Gastrointestinal Hemorrhage; Humans; Kidney Failure, Chronic; Lupus Erythematosus, Systemic; Male; Middle Aged; Peritoneal Dialysis; Pneumonia; Prednisone; Tetracycline; Urea; Uremia

Topics: Acute Disease; Adolescent; Adult; Antimalarials; Humans; Malaria; Male; Methylamines; Middle Aged; Plasmodium falciparum; Quinine; Tetracycline; Thailand

Topics: Acute Disease; Chloramphenicol; Conjugation, Genetic; Dysentery, Bacillary; Erythromycin Ethylsuccinate; Escherichia coli; Genetics, Microbial; Humans; Microbial Sensitivity Tests; Neomycin; Shigella flexneri; Streptomycin; Tetracycline

Topics: Acute Disease; Atrial Fibrillation; Cardiac Tamponade; Cortisone; Diagnosis, Differential; Electrocardiography; Humans; Male; Middle Aged; Pericardial Effusion; Pericarditis; Pleural Effusion; Rickettsia typhi; Tetracycline; Tuberculosis, Cardiovascular; Typhus, Endemic Flea-Borne

Topics: Acute Disease; Drug Combinations; Humans; Morpholines; Oleandomycin; Paronychia; Suppuration; Tetracycline

Topics: Acute Disease; Amines; Ampicillin; Benzyl Compounds; Cephalosporins; Gonorrhea; Humans; Male; Penicillins; Phenols; Probenecid; Recurrence; Tetracycline

Topics: Acute Disease; Ampicillin; Amylases; Anti-Bacterial Agents; Chloramphenicol; Humans; Lipase; Pancreatitis; Sulfonamides; Tetracycline

Topics: Acute Disease; Aged; Asthma; Bronchiectasis; Bronchitis; Bronchopneumonia; Chronic Disease; Humans; Injections, Intramuscular; Male; Middle Aged; Pulmonary Emphysema; Respiratory Tract Infections; Tetracycline

Topics: Acute Disease; Animals; Bites and Stings; Bone Regeneration; Carbenicillin; Child; Dogs; Female; Gentamicins; Humans; Humerus; Methicillin; Osteomyelitis; Pseudomonas Infections; Radiography; Tetracycline

Topics: Acute Disease; Amantadine; Ampicillin; Humans; Interferons; Penicillin G; Respiratory Tract Infections; Tetracycline; Tonsillitis; Vaccination

Topics: Acute Disease; Administration, Oral; Adult; Gonorrhea; Humans; Male; Tetracycline

Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Infective Agents; Bronchitis; Doxycycline; Drug Combinations; Evaluation Studies as Topic; Female; Folic Acid Antagonists; Humans; Male; Prednisone; Pyrimidines; Sarcoidosis; Sulfamethoxazole; Tetracycline; Trimethoprim

Topics: Acute Disease; Adult; Dysentery; Erythromycin; Female; Humans; Middle Aged; Tetracycline

Topics: Acute Disease; Amantadine; Ampicillin; Humans; Immunotherapy; Interferons; Respiratory Tract Infections; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Bromelains; Chronic Disease; Drug Combinations; Female; Genital Diseases, Female; Humans; Middle Aged; Parametritis; Pelvic Inflammatory Disease; Peritonitis; Salpingitis; Tetracycline

Topics: Acute Disease; Appendectomy; Appendicitis; Appendix; Bacitracin; Humans; Methods; Neomycin; Penicillins; Polymyxins; Streptomycin; Surgical Wound Infection; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Amine Oxidase (Copper-Containing); Depression, Chemical; Desensitization, Immunologic; Drug Hypersensitivity; Dysentery, Bacillary; Feces; Female; Histamine; Histamine H1 Antagonists; Humans; Injections, Intramuscular; Male; Middle Aged; Shigella dysenteriae; Shigella sonnei; Tetracycline

Topics: Acute Disease; Adolescent; Ampicillin; Appendicitis; Ascitic Fluid; Child; Child, Preschool; Depression, Chemical; Drug Synergism; Escherichia coli; Female; Humans; Kanamycin; Methicillin; Oleandomycin; Oxacillin; Penicillin Resistance; Penicillins; Peritonitis; Staphylococcus; Tetracycline

Topics: Acute Disease; Child; Cholesteatoma; Cholesterol; Chronic Disease; Drug Resistance, Microbial; Ear, Middle; Granuloma; Haemophilus Infections; Hearing Disorders; Humans; Mastoiditis; Mucous Membrane; Ossification, Heterotopic; Otitis Media; Streptococcal Infections; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Chloramphenicol; Erythromycin; Gonorrhea; Humans; India; Leucomycins; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin Resistance; Penicillins; Tetracycline; Urethritis

Topics: Acute Disease; Administration, Oral; Female; Gonorrhea; Humans; Male; Methylamines; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Sex Factors; Tetracycline; Urethra

Topics: Acute Disease; Adult; Chronic Disease; Diagnosis, Differential; Humans; Lung Diseases; Male; Melioidosis; Military Medicine; Osteoarthropathy, Secondary Hypertrophic; Pseudomonas; Tetracycline; Vietnam

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Child; Child, Preschool; Erythromycin; Humans; Infant; Otitis Media; Rifampin; Tetracycline

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Bromelains; Chronic Disease; Drug Combinations; Evaluation Studies as Topic; Female; Guaifenesin; Humans; Male; Middle Aged; Phosphates; Respiratory Tract Infections; Sodium; Tetracycline; Theophylline

Topics: Acute Disease; Child; Child, Preschool; Cloxacillin; Erythromycin; Fusidic Acid; Humans; Osteomyelitis; Penicillin Resistance; Penicillins; Staphylococcal Infections; Tetracycline

Topics: Acute Disease; Asthma; Bacteria; Bronchitis; Child; Child, Preschool; Chronic Disease; Complement Fixation Tests; Female; Hemagglutination Inhibition Tests; Humans; Infant; Infant, Newborn; Male; Penicillins; Tetracycline; Viruses

Topics: Acute Disease; Adult; Aged; Female; Guaifenesin; Humans; Lobeline; Lung Diseases; Male; Middle Aged; Respiratory Tract Infections; Tetracycline

Topics: Acute Disease; Animals; Bone Development; Bone Diseases; Bone Resorption; Kidney Failure, Chronic; Male; Nephrectomy; Osteogenesis; Rats; Tetracycline; Tibia; Time Factors; Uremia

Topics: Acute Disease; Adult; Arthritis, Reactive; Gonorrhea; Humans; Injections, Intramuscular; Male; Rolitetracycline; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Bacteria; Chloramphenicol; Chlortetracycline; Depression, Chemical; Enterococcus faecalis; Erythromycin; Erythromycin Ethylsuccinate; Female; Furazolidone; Humans; Male; Middle Aged; Neomycin; Nitrofurantoin; Oleandomycin; Oxytetracycline; Penicillin G; Penicillin Resistance; Penicillins; Pneumonia; Polymyxins; Ristocetin; Staphylococcus; Streptococcus; Streptomycin; Tetracycline; Urine

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Cephaloridine; Cephalothin; Depression, Chemical; Erythromycin; Erythromycin Ethylsuccinate; Fusidic Acid; Lincomycin; Mice; Microbial Sensitivity Tests; Neomycin; Novobiocin; Oxacillin; Penicillin G; Penicillin Resistance; Staphylococcal Infections; Staphylococcus; Tetracycline

Topics: Acute Disease; Ampicillin; Animals; Cephaloridine; Cephalothin; Depression, Chemical; Erythromycin Ethylsuccinate; Escherichia coli; Escherichia coli Infections; Mice; Microbial Sensitivity Tests; Neomycin; Penicillin Resistance; Proteus; Proteus Infections; Streptomycin; Tetracycline

Topics: Acute Disease; Carrier State; Chloramphenicol; Disease Outbreaks; Drug Resistance, Microbial; Dysentery, Bacillary; Escherichia coli; Genetics, Microbial; Humans; Shigella sonnei; Tetracycline

Each member of a group of 8 patients with acute cholera was treated with a mixture of four cholera bacteriophage preparations containing over 2 x 10(12) phage particles/ml. These massive doses were intended to kill immediately all vibrios in the intestine by "lysis from without". The numbers of Vibrio cholerae were drastically reduced rapidly. In 4 patients, V. cholerae was completely eliminated from the stools early in the treatment; the total stool volume and after-treatment of diarrhoea were reduced in comparison with a control group but were higher than in a group of patients treated with tetracycline. In the other 4 patients treated with phage, vibrios disappeard more slowly from the stools and there was no apparent clinical effect of the phage. In all the patients treated with phage, the duration of diarrhoea was longer than in patients in a control group who excreted vibrios for a similar length of time although the stool output was similar. This was interpreted as being due to the persistence of vibrios in foci of infection in the upper intestine.It is concluded that treatment of cholera with massive doses of bacteriophage is not as effective as treatment with tetracycline. However, phage can selectively eliminate the majority of vibrios without affecting the other intestinal flora and without any apparent toxic effect on the patient. Phage might therefore be useful as a research tool.

Topics: Acute Disease; Animals; Bacteriophages; Cholera; Diarrhea; Feces; Haplorhini; Humans; Rabbits; Tetracycline; Time Factors; Vibrio

Topics: Acute Disease; Adult; Chloramphenicol; Chlortetracycline; Chronic Disease; Depression, Chemical; Female; Gonorrhea; Humans; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Oxytetracycline; Penicillin Resistance; Penicillins; Streptomycin; Tetracycline

Topics: Acute Disease; Age Factors; Anti-Bacterial Agents; Child; Child, Preschool; Female; Femur; Haemophilus Infections; Humans; Humerus; Infant; Infant, Newborn; Male; Osteomyelitis; Penicillin Resistance; Penicillins; Proteus Infections; Radiography; Radius; Salmonella Infections; Seasons; Sepsis; Splints; Staphylococcal Infections; Streptococcal Infections; Tetracycline; Tibia; Ulna

Topics: Acute Disease; Adult; Age Factors; Aged; Chronic Disease; Drug Synergism; Female; Humans; Intestinal Absorption; Male; Middle Aged; Respiratory Tract Infections; Sepsis; Tetracycline; Time Factors; Urinary Tract Infections

Topics: Acute Disease; Administration, Topical; Anti-Inflammatory Agents; Antibodies; Betamethasone; Candidiasis, Oral; Humans; Hydrocortisone; Iatrogenic Disease; Immunoglobulin G; Immunoglobulin M; Stomatitis, Aphthous; Tetracycline; Triamcinolone

Topics: Acute Disease; Animals; Chloramphenicol; Oleandomycin; Penicillins; Radiation Injuries, Experimental; Radiometry; Rats; Streptomycin; Tetracycline; Time Factors

Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Bronchitis; Chronic Disease; Female; Humans; Male; Middle Aged; Oxadiazoles; Tetracycline

Topics: Acute Disease; Administration, Oral; Adolescent; Biopsy; Duodenum; Folic Acid; Humans; India; Intestine, Small; Male; New York; Radiography; Sprue, Tropical; Tetracycline

Topics: Acute Disease; Adult; Chloramphenicol; Gentamicins; Humans; Male; Melioidosis; Pseudomonas; Sepsis; Tetracycline; Wound Infection

Topics: Acute Disease; Cholecystitis; Cholelithiasis; Drainage; Postoperative Complications; Preoperative Care; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Animals; Child; Child, Preschool; Chronic Disease; Dogs; Female; Humans; Infant; Infant, Newborn; Injections; Male; Middle Aged; Osteomyelitis; Rabbits; Tetracycline

Topics: Acute Disease; Adult; Aged; Brucellosis; Chronic Disease; Female; Humans; Male; Middle Aged; Osteomyelitis; Radiography; Staphylococcal Infections; Tetracycline; Typhoid Fever

Topics: Acute Disease; Anti-Infective Agents; Chronic Disease; Hearing Disorders; Humans; Otitis Media; Penicillins; Pneumococcal Infections; Staphylococcal Infections; Streptococcal Infections; Sulfonamides; Tetracycline

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Antitoxins; Chloramphenicol; Colistin; Drug Synergism; gamma-Globulins; Mice; Oleandomycin; Oxacillin; Penicillin Resistance; Penicillins; Staphylococcal Infections; Tetracycline; Time Factors

Topics: Acute Disease; Adult; Amebiasis; Biopsy; Chloroquine; Complement Fixation Tests; Diarrhea; Dysentery, Amebic; Humans; Iodoquinol; Liver; Male; Military Medicine; Pain; Tetracycline; United States; Vietnam

Topics: Acute Disease; Adult; Aged; Bacteria; Child; Cystitis; Epididymitis; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Penicillin Resistance; Penicillin V; Pyelonephritis; Tetracycline; Urethritis; Urinary Tract Infections

Topics: Acute Disease; Bronchitis; Bronchopneumonia; Child; Child, Preschool; Escherichia coli; Female; Humans; Infant; Injections, Intramuscular; Lymphadenitis; Male; Mycoplasma Infections; Penicillin Resistance; Penicillin V; Respiratory Tract Infections; Staphylococcus; Tetracycline; Tonsillitis

Topics: Actinomycetales; Acute Disease; Adult; Animals; Demeclocycline; Dentin; Female; Humans; Male; Microbial Sensitivity Tests; Mouth; Mouth Diseases; Rats; Sputum; Staphylococcus; Streptococcus; Suppuration; Tetracycline

Topics: Acute Disease; Animals; Chronic Disease; Kidney; Proteus Infections; Pyelonephritis; Rats; Streptococcal Infections; Tetracycline; Tritium

Topics: Acute Disease; Adolescent; Female; Humans; Parapsoriasis; Prednisone; Tetracycline

Topics: Acute Disease; Adult; Chronic Disease; Female; Humans; Male; Middle Aged; Pneumonia; Tetracycline

Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Bronchitis; Chronic Disease; Drug Combinations; Female; Humans; Male; Middle Aged; Oxadiazoles; Tetracycline

Topics: Acute Disease; Adult; Appendectomy; Appendicitis; Gangrene; Hernia; Herniorrhaphy; Humans; Male; Pelvis; Tetracycline

Topics: Acute Disease; Adult; Aged; Bile; Biliary Tract Diseases; Exudates and Transudates; Female; Humans; Male; Middle Aged; Pancreatitis; Tetracycline

Topics: Acute Disease; Adenoidectomy; Adolescent; Age Factors; Audiometry; Child; Child, Preschool; Erythromycin; Follow-Up Studies; Humans; Infant; Otitis Media; Penicillin G; Prognosis; Seasons; Sulfonamides; Tetracycline; Tonsillectomy; Tympanic Membrane

Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Anti-Bacterial Agents; Bile; Biliary Tract Diseases; Child; Chloramphenicol; Cholecystitis; Cholelithiasis; Chronic Disease; Common Bile Duct; Enterobacteriaceae; Escherichia coli; Female; Humans; Klebsiella; Male; Middle Aged; Penicillins; Staphylococcus; Tetracycline

Topics: Acute Disease; Adult; Aged; Bronchitis; Chlortetracycline; Cholecystitis; Chronic Disease; Cystitis; Demeclocycline; Female; Humans; Male; Middle Aged; Pyelitis; Tablets; Tetracycline; Tuberculosis, Pulmonary; Vibrio Infections

Topics: Acute Disease; Adult; Bacteria; Chloramphenicol; Chlortetracycline; Chronic Disease; Cystitis; Demeclocycline; Epididymitis; Female; Humans; Male; Middle Aged; Penicillin G; Pyelonephritis; Streptomycin; Tablets; Tetracycline; Urinary Tract Infections

Topics: Acute Disease; Anti-Bacterial Agents; Bronchiolitis, Viral; Bronchitis; Chronic Disease; Cross Infection; Humans; Laryngitis; Penicillin Resistance; Penicillins; Pharyngitis; Pneumonia; Respiratory Tract Infections; Tetracycline; Tracheitis

Topics: Acute Disease; Anemia; Hemoglobinometry; Humans; Lung Abscess; Penicillin G; Tetracycline; Wound Healing

Topics: Acute Disease; Child, Preschool; Chromatography; Chromones; Fanconi Syndrome; Humans; Kidney Tubules; Male; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Chlortetracycline; Dysentery; Feces; Female; Humans; Injections, Intramuscular; Male; Methods; Middle Aged; Oxytetracycline; Protein Binding; Tetracycline

Topics: Acute Disease; Adult; Amylases; Child; Digestive System; Electrophoresis; Female; Hepatitis A; Humans; Male; Pancreatitis; Prednisone; Radiography; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Bronchitis; Child; Child, Preschool; Chloramphenicol; Chronic Disease; Communicable Diseases; Diarrhea, Infantile; Enteritis; Humans; Hypersensitivity; Meningitis; Pneumonia; Pyelonephritis; Sepsis; Skin Diseases; Staphylococcal Infections; Tetracycline; Tooth Diseases; Tooth, Deciduous; Vomiting; Whooping Cough

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Female; Humans; Infant; Male; Mastoiditis; Middle Aged; Otitis Media; Penicillins; Sulfonamides; Tetracycline

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Colistin; Dogs; Erythromycin; Female; Kanamycin; Kidney; Lincomycin; Liver; Pancreas; Pancreatic Juice; Pancreatitis; Staphylococcus; Tetracycline; Toxins, Biological

Topics: Acute Disease; Anti-Bacterial Agents; Blood Protein Electrophoresis; Blood Proteins; Chloramphenicol; Chronic Disease; Dysentery, Bacillary; Humans; Tetracycline

Topics: Acute Disease; Acute Kidney Injury; Adult; Enterocolitis, Pseudomembranous; Erythromycin; Humans; Isotonic Solutions; Male; Nephrosis; Pneumonia; Tetracycline; Ultrasonics

Topics: Acute Disease; Chlortetracycline; Diet Therapy; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Hepatitis A; Humans; Rest; Tetracycline

Topics: Acute Disease; Aged; Bromelains; Chloramphenicol; Female; Humans; Male; Middle Aged; Tetracycline; Vascular Diseases; Veins

Topics: Acute Disease; Chronic Disease; Dysentery, Bacillary; Feces; Humans; Injections, Intramuscular; Tetracycline

Topics: Acute Disease; Agglutination Tests; Antibody Formation; Complement Fixation Tests; Dysentery, Bacillary; Humans; Injections, Intramuscular; Mouth; Oxytetracycline; Phagocytosis; Tetracycline

Topics: Acute Disease; Adolescent; Adult; Dysentery; Female; Humans; Immunotherapy; Male; Middle Aged; Opsonin Proteins; Phagocytosis; Tetracycline

Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Bacterial Agents; Blood Protein Electrophoresis; Bone Marrow Examination; Drug Therapy; Humans; Leukemia; Prednisolone; Tetracycline

Topics: Acidosis, Respiratory; Acute Disease; Alkalosis; Blood Gas Analysis; Bronchodilator Agents; Catheterization; Chlorides; Dehydration; Heart Failure; Humans; Hypokalemia; Penicillin G; Potassium Chloride; Respiration, Artificial; Respiratory Insufficiency; Respiratory Tract Infections; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Child; Humans; Infant; Otitis Media; Penicillins; Pharynx; Sulfanilamide; Sulfanilamides; Sulfonamides; Tetracycline; Tissue Culture Techniques

Topics: Acute Disease; Adolescent; Dexamethasone; Drug Therapy, Combination; Exophthalmos; Fascia; Humans; Male; Oleandomycin; Orbital Myositis; Scleritis; Tetracycline; Thiamine; Vitamin B 12

Topics: Acute Disease; Anti-Bacterial Agents; Oleandomycin; Protein Synthesis Inhibitors; Respiratory Tract Infections; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Gonorrhea; Phosphates; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Acute Disease; Anti-Bacterial Agents; Humans; Nystatin; Protein Synthesis Inhibitors; Tetracycline; Urinary Tract Infections

Topics: Acute Disease; Anti-Bacterial Agents; Humans; Intestinal Obstruction; Novobiocin; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Child; Humans; Infant; Meningitis; Meningitis, Bacterial; Tetracycline

Topics: Acute Disease; Anti-Bacterial Agents; Humans; Protein Synthesis Inhibitors; Tetracycline; Urinary Tract Infections

Topics: Acute Disease; Anti-Bacterial Agents; Appendicitis; Humans; Streptomycin; Tetracycline; Tetracyclines