tetracycline and Abnormalities--Drug-Induced

Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digoxin; Female; Fetus; Furosemide; Gentamicins; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Penicillins; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Tetracycline; Theophylline

Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcoholic Beverages; Animals; Anticonvulsants; Antineoplastic Agents; Diethylstilbestrol; Estrogens; Female; Fetal Death; Fetus; Humans; Hydantoins; Iodides; Organomercury Compounds; Pregnancy; Smoking; Teratogens; Tetracycline; Thalidomide; Thiourea; Warfarin

Topics: Abnormalities, Drug-Induced; Tetracycline; Tooth Discoloration; Tooth, Deciduous

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Gastrointestinal Diseases; Hepatitis; Humans; Kidney Diseases; Metabolic Diseases; Pharmacology; Photosensitivity Disorders; Pigmentation Disorders; Proteins; Tetracycline; Tooth Discoloration; Toxicology

Cardiovascular toxicity is a major challenge for the pharmaceutical industry and predictive screening models to identify and eliminate pharmaceuticals with the potential to cause cardiovascular toxicity in humans are urgently needed. In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis. All the tested drugs were delivered into zebrafish by direct soaking and yolk sac microinjection, respectively, and cardiovascular toxicity was quantitatively or qualitatively assessed at 4 and 24 h post drug treatment. The results showed that aspirin accelerated the zebrafish heart rate (tachycardia), whereas clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride induced bradycardia. Quinidine and terfenadine also caused atrioventricular (AV) block. Nimodipine treatment resulted in atrial arrest with much slower but regular ventricular heart beating. All the tested human cardiotoxic drugs also induced pericardial edema and circulatory disturbance in zebrafish. There was no sign of cardiovascular toxicity in zebrafish treated with non-cardiotoxic drugs gentamicin sulphate and tetracycline hydrochloride. The overall prediction success rate for cardiotoxic drugs and non-cardiotoxic drugs in zebrafish were 100% (9/9) as compared with human results, suggesting that zebrafish is an excellent animal model for rapid in vivo cardiovascular toxicity screening. The procedures we developed in this report for assessing cardiovascular toxicity in zebrafish were suitable for drugs delivered by either soaking or microinjection.

Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease Models, Animal; Edema; Gentamicins; Heart Diseases; Heart Rate; Heart Ventricles; Larva; Microinjections; Nimodipine; Pericardium; Quinidine; Terfenadine; Tetracycline; Toxicity Tests; Verapamil; Yolk Sac; Zebrafish

Topics: Abnormalities, Drug-Induced; Acne Vulgaris; Contraceptives, Oral, Hormonal; Drug Interactions; Female; Humans; Pregnancy; Tetracycline

The influence of a 50 Hz magnetic field (MF) on avian and mammalian embryogenesis, the MF level and vector, as well as the effect of exposure to MF (50 Hz, 10 mT) in combination with X-rays has been recently reported [2,3]. No significant alterations of chick or rat embryogenesis were found after repeated exposures to 50 Hz MF at 10 mT or 6 microT or with different vectors. However, X-ray chick embryotoxicity was significantly affected by repeated exposures of developing organisms to MF. A strong dependence of effect on the type of interaction was revealed. A decrease of X-ray induced teratogenicity was observed when MF preceded X-ray exposure (indirect interaction), while MF exposure applied immediately after X-ray radiation (direct interaction) non-significantly potentiated adverse developmental effects of ionizing radiation. This study deals with the effects of MF in combination with insulin or tetracycline. Exposure of chick embryos to MF influenced the sensitivity of embryonic morphogenetic systems to the subsequently administered chemical teratogens, insulin and/or tetracycline. A protective effect of MF was detected similarly as in the case of indirect interaction with ionizing radiation.

Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Electromagnetic Fields; Insulin; Teratogens; Tetracycline; X-Rays

Topics: Abnormalities, Drug-Induced; Female; Fetus; Humans; Pregnancy; Tetracycline

Topics: Abnormalities, Drug-Induced; Acne Vulgaris; Animals; Chick Embryo; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Tetracycline

Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Abortion, Induced; Anesthetics; Animals; Anticoagulants; Antineoplastic Agents; Aspirin; Congenital Abnormalities; Drug Evaluation; Drug Evaluation, Preclinical; Female; Hormones; Humans; Male; Methylmercury Compounds; Phenytoin; Pregnancy; Teratogens; Tetracycline; Thalidomide; Tranquilizing Agents; Trimethadione

Tetracycline and Fusidin have the ability to flow through the placenta in a high quantity. It is proved, that these preparations in the early stage of ontogenesis developed considerable embryotoxic quality. High danger in the pregnancy is given with Tetracycline. Therefore the application of these antibiotics during the pregnancy is not indicated.

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Embryo, Mammalian; Female; Fusidic Acid; Humans; Kanamycin; Maternal-Fetal Exchange; Oxacillin; Pregnancy; Pregnancy Trimester, First; Tetracycline

Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acne Vulgaris; Adult; Female; Humans; Pregnancy; Tetracycline

Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Chick Embryo; Cleft Palate; Congenital Abnormalities; Female; Hydrocortisone; Mice; Mice, Inbred Strains; Organ Culture Techniques; Pregnancy; Rubella virus; Tetracycline

Associations between drug consumption during pregnancy and the birth of children with oral clefts were studied in material from the Finnish Register of Congenital Malformations, consisting of 599 children with clefts and their matched controls. Information concerning maternal drug consumption was partly prospective. During the first trimester, analgesic, chemotherapeutic and antineurotic drugs had all been significantly more frequently used by the mothers of children with clefts, than by the control mothers. The consumption of drugs was in general more frequent among mothers of children with cleft lip, with or without cleft palate, than among those of children with cleft palate alone.

Topics: Abnormalities, Drug-Induced; Analgesics; Anticonvulsants; Chloramphenicol; Cleft Lip; Cleft Palate; Diazepam; Drug-Related Side Effects and Adverse Reactions; Female; Fetus; Finland; Humans; Insulin; Iron; Penicillins; Pregnancy; Pregnancy Trimester, First; Salicylates; Sulfonamides; Tetracycline; Vitamins

Morphocycline was administered intravenously to rats of Wistar line in doses of 100, 50 and 20 mg/kg at various periods of pregnancy. It was found that a single administration of morphocycline in the above doses to the rats on the 9th day of their pregnancy resulted in abortus in some female rats. Death and resorption of the fetus were more frequent after the antibiotic use in doses of 20 and 50 mg/kg. Repeated administrations of morphocycline in doses of 20 mg/kg resulted in abortus and postimplantation death of the fetus most pronounced in the animal groups treated with the antibiotic during the periods of the 7th to the 10th and from the 11th to the 14th days of pregnancy. The teratogenic activity of morphocycline was slightly pronounced. It was observed in some fetus after both single and repeated administrations of the antibiotic.

Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Anophthalmos; Corpus Luteum; Dose-Response Relationship, Drug; Embryo Implantation; Female; Fetal Death; Fetus; Injections, Intravenous; Microphthalmos; Morpholines; Pregnancy; Pregnancy, Animal; Rats; Tetracycline; Tetracyclines; Time Factors

Topics: Abnormalities, Drug-Induced; Bacterial Infections; Drug Resistance, Microbial; Female; Fetus; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications, Infectious; Tetracycline

Topics: Abnormalities, Drug-Induced; Alkylating Agents; Amphetamine; Androgens; Anticonvulsants; Antithyroid Agents; Carcinogens; Cerebral Palsy; Diethylstilbestrol; Estrogens; Female; Fetus; Folic Acid Antagonists; Gestational Age; Humans; Lead; Maternal-Fetal Exchange; Methylmercury Compounds; Neoplasms; Polychlorinated Biphenyls; Pregnancy; Progesterone; Streptomycin; Tetracycline; Thalidomide; Tooth; Transposition of Great Vessels; Warfarin

Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Antitubercular Agents; Congenital Abnormalities; Female; Fetal Diseases; Histamine H1 Antagonists; Humans; Infant, Newborn; Maternal Age; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Terminology as Topic; Tetracycline

Topics: Abnormalities, Drug-Induced; Berlin; Contraceptives, Oral; Cortisone; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Labyrinth Diseases; Lupus Erythematosus, Systemic; Pregnancy; Procainamide; Streptomycin; Substance-Related Disorders; Tetracycline; Thalidomide; Thromboembolism; Tuberculosis, Meningeal

Topics: Abnormalities, Drug-Induced; Animals; Biometry; Female; Mice; Molar; Odontogenesis; Pregnancy; Tetracycline; Tooth; Tooth Abnormalities; Vitamin A

Topics: Abnormalities, Drug-Induced; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dental Enamel Hypoplasia; Female; Fetus; Humans; Infant; Infant, Newborn; Maternal-Fetal Exchange; Photosensitivity Disorders; Pregnancy; Respiratory Tract Infections; Tetracycline

Topics: Abnormalities, Drug-Induced; Tetracycline

Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Maternal-Fetal Exchange; Pregnancy; Rats; Tetracycline

Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Chloramphenicol; Female; Humans; Infant, Newborn; Penicillins; Pregnancy; Pregnancy Complications; Teratogens; Tetracycline

Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Disease Models, Animal; Female; Pregnancy; Rabbits; Spine; Tetracycline

Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Ascorbic Acid; Body Weight; Corpus Luteum; Depression, Chemical; Embryo, Mammalian; Female; Fertility; Fetal Death; Gestational Age; Glycogen; Histocytochemistry; Nucleic Acids; Organ Size; Placenta; Placenta Diseases; Pregnancy; Rats; Tetracycline

Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Female; Fetus; Fluorescence; Maternal-Fetal Exchange; Oxytetracycline; Pregnancy; Rats; Tetracycline

Topics: Abnormalities, Drug-Induced; Arm; Child; Ectromelia; Face; Female; Humans; Male; Pregnancy; Pregnancy Complications; Tetracycline; Thalidomide; Tooth Abnormalities; Tooth Discoloration

Topics: Abnormalities, Drug-Induced; Animals; Fishes; Tetracycline

Topics: Abnormalities, Drug-Induced; Animals; Bone Development; Female; Fetal Diseases; Metatarsus; Oxytetracycline; Pregnancy; Rats; Tetracycline

Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Abortion, Threatened; Animals; Chlortetracycline; Embryo Implantation; Endometrium; Estradiol; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Mice; Ovary; Pregnancy; Progesterone; Prolactin; Tetracycline; Time Factors; Vaginal Smears

Topics: Abnormalities, Drug-Induced; Animals; Biguanides; Fetus; Mice; Rabbits; Tetracycline

Topics: Abnormalities, Drug-Induced; Adult; Androgens; Drug-Related Side Effects and Adverse Reactions; Erythroblastosis, Fetal; Female; Goiter; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange; Pregnancy; Syphilis, Congenital; Tetracycline; Thalidomide; Tooth Discoloration; Vaccination; Viral Vaccines; Virus Diseases

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Antitubercular Agents; Child; Child, Preschool; Chloramphenicol; Drug Hypersensitivity; Female; Gastrointestinal Diseases; Glossitis; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Diseases; Pregnancy; Stomatitis; Sulfonamides; Tetracycline

Topics: Abnormalities, Drug-Induced; Aminosalicylic Acids; Androgens; Animals; Chlordiazepoxide; Drug and Narcotic Control; Estrogens; Female; Gentamicins; Gestational Age; Humans; Iodine Isotopes; Meprobamate; Mice; Oxazepam; Pregnancy; Progestins; Rats; Streptomycin; Sulfonamides; Tetracycline; Thalidomide

Topics: Abnormalities, Drug-Induced; Animals; Mice; Osteogenesis; Tetracycline

Topics: Abnormalities, Drug-Induced; Child, Preschool; Chlortetracycline; Demeclocycline; Female; Humans; Infant; Infant, Newborn; Oxytetracycline; Pregnancy; Tetracycline; Tooth Discoloration

Topics: Abnormalities, Drug-Induced; Anesthesia, Dental; Anesthetics; Dental Caries; Dentistry; Female; Fetal Death; Fetal Diseases; Fluorides; Gingivitis; Humans; Hyperemesis Gravidarum; Hypotension; Periodontal Diseases; Pregnancy; Pregnancy Complications; Radiography, Dental; Stress, Physiological; Tetracycline

Topics: Abnormalities, Drug-Induced; Bone and Bones; Female; Humans; Pregnancy; Tetracycline; Tooth

Topics: Abnormalities, Drug-Induced; Acetaminophen; Acetazolamide; Anti-Bacterial Agents; Cardiovascular Agents; Cataract; Chloramphenicol; Communicable Diseases; Female; Histamine H1 Antagonists; Humans; Infant, Newborn; Infant, Newborn, Diseases; Meclizine; Muscle Relaxants, Central; Nitrofurantoin; Oxytetracycline; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Progesterone; Sulfamethoxypyridazine; Sulfisoxazole; Sympathomimetics; Tetracycline; Toxicology

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Tetracycline; Tetracyclines; Toxicology

Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyretics; Appetite Depressants; Cataract; Chloramphenicol; Female; Histamine H1 Antagonists; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meclizine; Oxytetracycline; Pregnancy; Progesterone; Pyridoxine; Sulfamethoxypyridazine; Sulfanilamide; Sulfanilamides; Sulfisoxazole; Sulfonamides; Tetracycline; Toxicology

Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Caffeine; Cortisone; Insulin; Lagomorpha; Meclizine; Mice; Oxytetracycline; Protein Synthesis Inhibitors; Rabbits; Rats; Research; Sodium Salicylate; Teratogenesis; Tetracycline; Thalidomide; Thyroxine; Toxicology

Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Barbiturates; Chloramphenicol; Demeclocycline; Female; Fetal Diseases; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meperidine; Oxytetracycline; Pregnancy; Progesterone; Reserpine; Streptomycin; Sulfisoxazole; Tetracycline; Thiouracil; Thyroxine; Toxicology; Vitamin K

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Child; Demeclocycline; Dental Calculus; Dental Caries; Erythromycin; Female; Fluorescence; Humans; Infant; Oxytetracycline; Pregnancy; Tetracycline; Tetracyclines; Tooth, Deciduous; Toxicology

Topics: Abnormalities, Drug-Induced; Blood Transfusion; Dental Enamel; Female; Humans; Infant; Infant, Newborn; Leukemia; Leukemia, Myeloid; Mercaptopurine; Prednisone; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Tetracycline; Tooth Discoloration; Tooth, Deciduous; Toxicology

Topics: Abnormalities, Drug-Induced; Androgens; Chickenpox; Congenital Abnormalities; Female; Hand Deformities; Humans; Hypoglycemic Agents; Infant; Infant, Newborn; Measles; Mumps; Poliomyelitis; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Progesterone; Rubella; Tetracycline; Thalidomide; Thiazines; Toxicology; Vaccinia; Virus Diseases

Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Anticoagulants; Antihypertensive Agents; Antineoplastic Agents; Barbiturates; Chlorpromazine; Gonadal Steroid Hormones; Hypoglycemic Agents; Pregnancy; Progestins; Streptomycin; Sulfonamides; Tetracycline; Thyroid Hormones; Toxicology; Vitamin K; Vitamins

Topics: Abnormalities, Drug-Induced; Amelogenesis; Drug Therapy; Female; Fetal Diseases; Fetus; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Diseases; Liver Diseases; Pregnancy; Pregnancy Complications; Tetracycline; Tooth Discoloration; Toxicology

A possible relationship between stability of a tetracycline and persistence in the foetal skeleton is discussed; it seems that the greater the stability of a tetracycline, the more it may interfere with bone-forming processes. Therefore, assuming that limited instability does not impair antibiotic potency in vivo, the use of a low-stability tetracycline seems to be a safer form of treatment in order to avoid undesired effects on the foetal skeleton.

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Bone Development; Chelating Agents; Chick Embryo; Chlortetracycline; Demeclocycline; Fetus; Fluorescence; Oxytetracycline; Research; Tetracycline; Toxicology

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Female; Fetal Diseases; Glutethimide; Humans; Infant, Newborn; Legislation, Medical; Phenmetrazine; Podophyllin; Podophyllum; Pregnancy; Prenatal Care; Protein Synthesis Inhibitors; Tetracycline; Thalidomide; Toxicology